Fluticasone Furoate+Azelastine Hydrochloride

Uses	Allergic rhinitis
Therapy	Anti-Allergic
Side Effects	Taste changes (specifically a bitter or unpleasant taste), nosebleeds, and headaches

3 Step Quality
Assurance

Cash on delivery
available

NPPA
Regulated

Molecule Description

Fluticasone Furoate+Azelastine Hydrochloride is a nasal spray used to relieve moderate to severe allergy symptoms affecting the nose, such as sneezing, a runny or blocked nose, nasal itching, and watery eyes. It is especially helpful when symptoms are not well controlled by using a nasal antihistamine or a steroid spray alone. By targeting both allergy triggers and inflammation, it provides more complete relief from persistent allergic rhinitis. This medicine contains two active ingredients that work in different ways. Fluticasone furoate reduces nasal swelling, redness, and mucus production, thereby alleviating congestion and improving airflow. Azelastine hydrochloride blocks the effects of histamine, a substance released during allergic reactions, thereby quickly reducing sneezing, itching, and nasal congestion. Fluticasone Furoate+Azelastine Hydrochloride is used as a nasal spray and should be used exactly as prescribed. Regular use is important for optimal control of allergy symptoms. Proper spraying technique helps the medicine work effectively and reduces irritation inside the nose. Some people may experience mild side effects, such as nosebleeds, headaches, or an unpleasant taste or odour. Tiredness, dizziness, or weakness may also occur. If such symptoms impair alertness, activities such as driving or operating machinery should be avoided. This medicine should be used with caution in certain situations, such as during pregnancy or breastfeeding, or when used for an extended period. It is important to inform your doctor about other medicines you are taking and any ongoing health conditions. Regular follow-up helps ensure safe and effective use, especially with long-term treatment.

Uses

Fluticasone Furoate+Azelastine Hydrochloride is used to relieve symptoms of moderate to severe seasonal and year-round allergic rhinitis, such as sneezing, runny or blocked nose, nasal itching, and watery eyes, especially when using only a nasal antihistamine or a steroid spray alone does not give enough relief.

Contraindications

When should one not use Fluticasone Furoate+Azelastine Hydrochloride

If you are allergic to fluticasone furoate, azelastine hydrochloride, or any other ingredients of Fluticasone Furoate+Azelastine Hydrochloride.

Side effects

Common side effects of this drug are:

Epistaxis (nosebleed)
Headache
Dysgeusia (unpleasant taste)
Unpleasant smell

Precautions and Warnings

Pregnancy

Fluticasone Furoate+Azelastine Hydrochloride should be used during pregnancy only if your doctor decides that the benefit to you outweighs the possible risk to the unborn baby. There is limited information on its use in pregnant women, so always consult your doctor before using it during pregnancy.

Breast Feeding

It is not known whether Fluticasone Furoate+Azelastine Hydrochloride passes into breast milk. This medicine should be used while breastfeeding only if your doctor feels that the benefit to the mother is greater than the possible risk to the baby. Always consult your doctor before using it during breastfeeding.

Driving

Fluticasone Furoate+Azelastine Hydrochloride usually has little effect on the ability to drive or use machines. However, some people may feel tired, dizzy, weak, or exhausted after using it. If you experience these symptoms, avoid driving or operating machinery.

Alcohol

It is best to avoid or limit alcohol while using Fluticasone Furoate+Azelastine Hydrochloride. Alcohol may increase side effects such as drowsiness, dizziness, or weakness, which can affect alertness and coordination. Always consult your doctor before using it.

Other General Warnings

Talk to your doctor if

You are taking medicines like ritonavir, as using them together with Fluticasone Furoate+Azelastine Hydrochloride may increase the risk of steroid-related side effects.
You use this spray for an extended period or at higher doses than prescribed, as it may cause effects such as weight gain, facial swelling, or hormonal imbalance.
You have liver problems; this medication may remain longer in your body and increase the risk of side effects.
You experience unusual fatigue, weakness, or dizziness, particularly during stress, illness, or before surgery.
A child or adolescent is using this spray for an extended period, as growth may require monitoring.
You notice blurred vision, eye pain, or changes in vision, as these may be linked to eye conditions such as cataract or glaucoma.
You have a history of glaucoma, cataract, or increased eye pressure.
You are switching from oral steroids to this nasal spray because additional care may be required.
You have tuberculosis, an untreated infection, or have recently had surgery or injury to the nose or mouth.
You develop persistent nasal swelling, irritation, or blockage, especially with long-term use.

Mode of Action

How Does It Work?

Fluticasone furoate: Reduces inflammation in the nose. It helps reduce swelling, redness, and mucus production, thereby relieving nasal congestion, sneezing, and a blocked or runny nose caused by allergies.
Azelastine hydrochloride: Works by blocking the action of histamine, a chemical released during allergic reactions. This helps quickly relieve symptoms like sneezing, itching, a runny nose, and nasal irritation.

Interactions

Interactions with other medicines

Using Fluticasone Furoate+Azelastine Hydrochloride with medicines like ritonavir or cobicistat can greatly increase steroid levels in the body and may cause side effects such as weight gain, facial swelling, or hormone imbalance.
Strong CYP3A4 inhibitors (such as ketoconazole) may slightly increase steroid exposure, so caution is advised when used together.
Some medicines like erythromycin usually cause little or no meaningful interaction, but monitoring may still be needed.
Using this nasal spray with sedative medicines or drugs that act on the brain may increase drowsiness.
Drinking alcohol while using this nasal spray may enhance sleepiness or reduce alertness.

Interactions with food items

There are no known food interactions with this nasal spray.

Dosage

Overdose

If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.

Missed a Dose

If you missed a dose of the medicine, take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

Frequently Asked Questions (FAQs)

Nosebleeds, headache, unpleasant taste or smell, mild dizziness or tiredness. If symptoms are severe or persistent, inform your doctor.

Certain medicines, especially strong CYP3A4 inhibitors like ritonavir or ketoconazole, may increase steroid effects. Sedatives or alcohol may increase drowsiness. Always inform your doctor about other medicines you take.