Ursocol 300 Tablet
Description
Ursocol 300 Tablet is a medicine used to help dissolve gallstones and manage liver-related disorders such as cirrhosis, sclerosing cholangitis, and liver dysfunction. Gallstones are hardened deposits that form in the gallbladder due to an increase in the cholesterol content of bile. By reducing cholesterol in the bile, Ursocol 300 Tablet helps prevent further formation of gallstones and supports proper liver function.
The active ingredient in Ursocol 300 Tablet is ursodeoxycholic acid, which acts as a dissolving agent for gallstones. It works by gradually breaking down cholesterol-rich stones and improving the flow of bile from the liver to the gallbladder and intestines. This action helps alleviate symptoms associated with gallstones, including abdominal discomfort, nausea, and digestive issues.
Other medicines containing ursodeoxycholic acid include Golbi 300, Udiliv 300, Ursokem 300, and Ursolid 300 tablets. These medicines work in a similar way to dissolve gallstones and improve bile flow, but your doctor will prescribe the one best suited for your condition based on your liver health and overall medical history.
Ursocol 300 Tablet should be taken exactly as prescribed by your doctor, with the dosage and duration tailored to your specific condition. It is important to complete the full course of treatment and not stop the medicine on your own, even if you feel better. Regular follow-ups with your doctor may be recommended to monitor liver function and ensure the effective dissolution of gallstones.
While taking Ursocol 300 Tablet, it is advisable to avoid alcohol, as it can worsen liver problems and reduce the effectiveness of the medicine. Inform your doctor about all past medications, supplements, or medical conditions before starting treatment. When used responsibly under medical supervision, Ursocol 300 Tablet can help dissolve gallstones, improve liver health, and support proper digestive function.
Product Summary
Offer Price | ₹373.32 |
You Save | ₹175.68 (32% on MRP) |
Contains | Ursodeoxycholic Acid / Ursodiol(300.0 Mg) |
Uses | Gall stones |
Side effects | Nausea, vomiting, diarrhoea, sticky stools |
Therapy | DRUGS FOR CHOLELITHIASIS |
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Uses
- Ursocol 300 is used to dissolve gallbladder stones made of cholesterol in various liver-related disorders such as cirrhosis and sclerosing cholangitis.
- Liver dysfunction is associated with cystic fibrosis (a hereditary disease that affects the lungs and digestive system).
Contraindications
- If you are allergic to ursodeoxycholic acid or any ingredient of Ursocol 300 tablet.
- If you have a stomach or intestinal ulcer or bleeding.
- If you have a liver-related disorder and non-functional gall bladder.
- If you have recently had a surgery involving any part of your intestine.
- If you are suffering from inflammation/blockage of the gall bladder or biliary tract.
- If you are suffering from a liver or intestinal condition which affects the circulation of bile substances like bile duct blockage.
Side effects
- Vomiting
- Nausea
- Diarrhoea
- Sticky stool
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You experience persistent diarrhoea, and the doctor should discontinue the therapy immediately.
- If you have a history of liver disease or obstruction in bile passage, your doctor may ask you to do liver function tests regularly.
- It would be best if you avoid a high-cholesterol diet during the treatment, as it may affect the activity of this medicine.
- Your doctor may ask you for an ultrasound after six months of the treatment to check the therapeutic improvement.
- Women of childbearing age should use non-hormonal contraceptive measures (physical barrier) or low-oestrogen oral contraceptive pills. Combination oral contraceptive pills should not be taken with Ursocol 300 tablets....
Directions for Use
- Ursocol 300 tablet should be taken as directed by your doctor. Swallow it whole with a glass of water, after meals. Do not cut, break or chew the medicine. It would be best if you took it at a fixed time for optimal results and should not consume it more than that prescribed by your doctor....
Storage and disposal
Quick Tips
- Ursocol 300 tablet is a medicine used to dissolve gallstones. It should not be used for treating any other condition unless specified by the doctor.
- Take this medicine in the exact dose and duration as recommended. Do not take more than the prescribed dose.
- Before starting Ursocol 300 tablet, inform your doctor if you are pregnant, planning on becoming pregnant or breastfeeding. Also, inform your doctor about all your other medicines and complete medical history....
- Women should use effective birth control measures during treatment with this medicine. Contraception should be non-hormonal, like condoms or a low oestrogen contraceptive pill.
- Do not take any other medicine alone without confirming with your doctor during treatment with Ursocol 300 tablet.
- Diarrhoea and pasty stools can occur as side effects of this medicine. Inform your doctor if the side effects do not resolve even after completing the course of this medicine.
- Excessive dietary intake of calories and cholesterol should be avoided. It would be best if you preferably took a low-cholesterol diet during treatment.
Dosage
Overdose
Missed a Dose
Mode of Action
How Does It Work?
Interactions
Interactions with other medicines
- Some medicines can affect the way Ursocol 300 tablet works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
- Tell your doctor about all the medicines, supplements, or herbals you are taking to avoid any possible interaction.
- Concomitant use of cholesterol-lowering medicines such as cholestyramine, colestipol, and some antacids may reduce this medicine's efficacy. So, it should be taken between the gap of 2 hours at least.
- Contraceptive pills should not be used if you are being prescribed with Ursocol 300 tablet.
- Other medicines that may affect this medicine's absorption are charcoal, antibiotics like Ciprofloxacin, immunosuppressants like Ciclosporin, cholesterol-lowering medicines like Atorvastatin, and Dapsone used as an anti-infective. Hence, it should not be used concomitantly....
Interactions with food items
- Avoid high-cholesterol foods such as fried foods, fatty meats, and full-fat dairy, as they can reduce the effectiveness of Ursocol 300 in dissolving gallstones.
- Limit alcohol consumption, as it can worsen liver function and interfere with the medicine’s action.
- Avoid consuming very high-fat meals, as they may trigger gallstone-related symptoms and slow bile flow.
- Maintain a balanced diet with plenty of fruits, vegetables, and fibre to support digestion and liver health while taking Ursocol 300.
- Avoid large protein-rich meals in a single sitting, as they may increase bile secretion and cause discomfort.
Content Details

Dr. Arpit Verma
MBBS, MD, CCEBDM Diabetology

Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: Any precautions I need to take during the treatment with Ursocol 300 tablet?
Q: Does high blood cholesterol level cause gallbladder stones?
Q: Is Ursocol 300 tablet used for reducing high bilirubin?
Q: How to use the Ursocol 300 tablet?
- Ursocol 300 tablet should be taken as advised by your doctor at the prescribed dose and duration based on your condition and its severity.
- Swallow the Ursocol 300 as a whole with a glass of water or milk. You should take this medicine after food.
Q: Is Ursocol 300 a steroid?
Q: Is Ursocol 300 good for the liver?
Q: What is Ursocol 300 used for?
Q: Does Ursocol 300 prevent new gallstones from forming?
Q: Can Ursocol 300 cause nausea or vomiting?
References
- Ursodeoxycholic 150 mg tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 11 Sep 2025]
- CDSCO - Ursodeoxycholic acid [Internet]. Cdscoonline.gov.in. 2021 [cited 6 May 2022]
- URSO (ursodiol) tablets, for oral use, USP, [Internet]. Accessdata.fda.gov. 2021 [cited 6 May 2022]
- Lactmed - Ursodiol [Internet]. Ncbi.nlm.nih.gov. 2021 [cited 6 May 2022]
- Ursodeoxycholic 150 mg tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2021 [cited 11 Sep 2025]
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