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Macox Plus 450/300mg Tablet

6 Tablet(s) in Strip
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Macox Plus 450/300mg Tablet Description

Macox Plus is a type of anti-tubercular drug which is used in the treatment of tuberculosis. Tuberculosis is an infectious disease that affects the lungs caused by a bacteria, namely Mycobacterium tu

berculosis. Macox Plus is a combination of two drugs, namely Rifampicin and Isoniazid. It works by stopping the growth of bacteria responsible for causing tuberculosis.


Product Summary

Offer Price₹71.50
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ContainsRifampicin(450.0 Mg) + Isoniazid(300.0 Mg)
Side effectsNausea, vomiting, drowsiness, numbness/ tingling sensation, diarrhoea, heartburn, easy bruising/bleeding, change the colour of urine, sweat, or saliva to dark yellow.
Check more medicines with composition as Rifampicin(450.0 Mg) + Isoniazid(300.0 Mg)

Uses of Macox Plus 450/300mg Tablet

  • Specifically used for the treatment of tuberculosis.

Contraindications of Macox Plus 450/300mg Tablet

If you are allergic to Macox Plus or any of its ingredients. If you are taking antiviral medicines. If you have any type of liver disease/damage. If you have a visual disorder. If you have had dia...
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Side effects of Macox Plus 450/300mg Tablet

  • Nausea
  • Vomiting
  • Drowsiness
  • Dizziness
  • Headache
  • Numbness/ Tingling sensation
  • Diarrhoea
  • Heartburn
  • Easy Bruising/Bleeding
  • Can change the colour of urine, sweat, or saliva to dark yellow.

Precautions and Warnings of Macox Plus 450/300mg Tablet



Can I take Macox Plus during pregnancy?
Macox Plus is not recommended in pregnancy unless absolutely necessary. However, inform your doctor about pregnancy. Your doctor will consider all the things and will advise the best for you.

Breast Feeding

Can I take Macox Plus while breastfeeding?
Macox Plus has proven to be able to pass in human milk; hence it has to be avoided. However, inform your doctor if you are lactating. He will advise the best for you according to your situation.


Can I drive if I have taken the Macox Plus?
It is not recommended to drive after taking Macox Plus if you are having any visual problems or are feeling dizzy because of the medicine. You should avoid driving if you have any side effects to ensure safety.


Can I consume alcohol with the Macox Plus?
Alcohol consumption should be avoided if you are taking Macox Plus as it increases the risk of damaging the liver.

Other General Warnings

Talk to your doctor if
  • If you have to start with any vitamins or supplements along with the medication, even if the supplement is herbal, ayurvedic or any other category.
  • You experience vision issues, allergic reactions or joint pain after taking the medication.
  • Macox Plus tends to decrease the effectiveness of hormonal birth control, so one should adopt additional methods of contraception to ensure safety.
  • Not recommended for children below 15 years of age.
  • Seek immediate help if you notice any severe side effects or worsening of other side effects.
  • Do not stop taking the dose on your own if you start feeling better without consulting your doctor. It can worsen the situation.

Mode of Action of Macox Plus 450/300mg Tablet

How Does It Work?

Macox Plus contains two active ingredients: Rifampicin (450 mg) and Isoniazid(300 mg). Rifampicin works by inhibiting a bacterial enzyme that helps grow bacteria. Isoniazid works on the cell wall of...
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Directions for Use of Macox Plus 450/300mg Tablet

  • Macox Plus should be taken according to the recommendation of a doctor.
  • It is usually taken as a long term medicine in combination with other medicines.
  • It has to be taken on an empty stomach, preferably 1 hr before taking food or 2 hrs after the food. Try to maintain a schedule and have the medicine at the same time every day.
  • The tablet has to be swallowed whole orally with a glass of water. The tablet should not be chewed, crushed or broken.

Interactions of Macox Plus 450/300mg Tablet

Interactions with other medicines

  • Antiviral medicines
  • Antidepressant
  • MAO inhibitors
  • Blood thinners
  • Acetaminophen
  • Diltiazem
  • Ethambutol

Interactions with food items

  • Alcohol
  • Avoid consuming alcohol while taking Macox Plus. It can increase the risk of liver damage; hence you should avoid it.
  • Food
  • Avoid tyramine/histamine containing cheese, red wine, fish, soy, tuna, salmon, beer.

Storage and disposal of Macox Plus 450/300mg Tablet

Store the medicine at room temperature away from any source of direct heat. Try to avoid keeping the medicine in direct sunlight. The medicine does not need to be refrigerated. Keep it away from the r...
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Dosage of Macox Plus 450/300mg Tablet


  • Do not take medicine more than the advised dosage. In case of an allergic reaction like swelling of the face or tongue, rush to the hospital. Overdose can exhibit severe side effects. Seek immediate h...
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Missed a Dose

If you miss a dose, try to take the tablet as soon as you remember. If it is almost the time of the next dose, do not take the double dose. Try to stick to the previous schedule. Consider setting the...
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Content Details


Dr. Suneet Monga

BDS, MDS (Paediatric & Preventive Dentistry) MMCDSR


Dr. Varsha Parihar

MBBS, MD (Community Medicine)

Frequently Asked Questions (FAQs)


Q: I am bloated after Macox Plus. Can I take an antacid?

A: Antacid should be avoided one hr before or after taking Macox Plus as it delays the absorption.

Q: Why have my contact lenses discoloured after taking the Macox Plus?

  • Macox Plus tends to have a common side effect of turning sweat, saliva and tears red. Thus, lenses are discoloured and wearing the same should be avoided.
Product Details
Expires on or After
Last Updated on: 24 Jan 2022 | 03:39 PM (IST)
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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