Tramadol
Description
Tramadol is a medication used to relieve moderate to severe pain. It belongs to
a class called opioid analgesics and works by blocking pain signals in the brain and spinal cord, as well as by increasing the effects of chemicals like serotonin and noradrenaline. It inhibits the production of chemicals called prostaglandins that cause pain. Long-term use can lead to physical and psychological dependence, so it must be used under strict medical supervision for the shortest necessary period. Common side effects include dizziness, drowsiness, nausea, vomiting, constipation, and dry mouth. Drinking alcohol while taking this medication is unsafe because it can increase the risk of serious side effects. Be sure to inform your doctor about all other medications you're taking, especially other pain medications, antidepressants, and alcohol, to prevent harmful interactions.
Uses
Contraindications
When should one not use Tramadol
- If you are allergic to tramadol or similar medicines
- If you are suffering from epilepsy or fits which is not under control by your current treatment
- If you are taking sleeping pills, painkillers, or medicines that affect your mood, or if you consume alcohol regularly
- If you are taking certain medicines for the treatment of depression or Parkinson’s disease
Side effects
Common side effects of this drug are:
- Drowsiness
- Headache
- Dizziness
- Nausea
- Vomiting
- Constipation
- Sweating
- Dry mouth
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You are suffering from any liver or kidney problem
- You experience fits or seizures
- You suffer from any psychiatric illnesses and are on medication for the same.
- You are taking other medicines containing paracetamol or tramadol
- You develop any allergic symptoms or Serotonin syndrome
- You are taking medicines to treat pain (containing buprenorphine, nalbuphine or pentazocine)
- You notice any sleep-related breathing problems, contact your doctor immediately.
- You experience tiredness, lack of appetite, severe stomach pain, nausea, vomiting or low blood pressure, immediately contact your doctor.
Mode of Action
How Does It Work?
Interactions
Interactions with other medicines
- Some medicines can affect the way Tramadol works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
- Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
- Especially if you are taking medicines to treat your heart problems, psychiatric illnesses, fits, Parkinson’s disease, allergy, cough, pain or are taking sedative medicines, blood thinners, medications used to stop vomiting....
- This medicine should not be taken simultaneously or for atleast 2 weeks after treatment with certain medicines (monoamine oxidase inhibitors or MAOIs) used for psychiatric illnesses.
Dosage
Overdose
- In case of an overdose, seek urgent medical help
Missed a Dose
Content Details
Dr. Mansi Savla
B. Pharm, PharmD
Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: What is Tramadol used for?
Q: Is Tramadol addictive?
Q: How long does Tramadol take to work?
Q: What should I do if I miss a dose?
References
- Tramadol 50 mg capsules - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 3rd Nov 2025]
- Tramadol 50 mg capsules - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 3rd Nov 2025]
- CDSCO [Internet]. Cdscoonline.gov.in. 2025 [cited 3rd Nov 2025]









