Sertraline

Molecule Description

Sertraline is a prescription medication used for the treatment of depression an

d anxiety. It belongs to a group of medicines called SSRIs (Selective Serotonin Reuptake Inhibitors).

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Sertraline

Treatment and prevention of major depressive episodes
Anxiety disorder
A mental disorder in which a person fails to recover after watching or experiencing a terrible incident or accident (Post Traumatic Stress Disorder or PTSD)
Panic disorder, with or without fear of places and situations that may cause panic (agoraphobia)
A behavioral disorder in which a person repeatedly does the same thing (Obsessive Compulsive Disorder or OCD) (in adults and children and adolescents aged 6-17 years old)

Contraindications of Sertraline

When should one not use Sertraline

Allergic reactions or intolerance to Sertraline or any of the substances used in the tablet
A class of antidepressants called irreversible MAO (Monoamine Oxidase) inhibitors (Phenelzine, Selegiline, Moclobemide, Toloxatone, Brofaromine, Isocarboxazid)
Pimozide (an antipsychotic)

Side effects of Sertraline

Common side effects of this drug are:

Sleep disorders (sleeplessness or insomnia, excessive sleep)
Dizziness, headache
Dry mouth
Abdominal pain, upset stomach, diarrhea & constipation
Tremors, shaking muscular movements, numbness, and tingling
Ejaculation failure (failure to release sperm), menstrual irregularities in females
Increased sweating
Severe anxiety
Decreased appetite
Suicidal thoughts and behavior have been reported when using
Sertraline or immediately after discontinuation

Precautions and Warnings of Sertraline

Pregnancy

Can I take Sertraline during pregnancy?

Sertraline is not recommended in pregnancy unless there is no other alternative as it may be harmful for the unborn baby. Consult your doctor if you are pregnant or might be pregnant.

Breast Feeding

Can I take Sertraline while breastfeeding?

Sertraline is secreted into breast milk but not known to cause any harmful effects. But it is advised to use Sertraline while breastfeeding if your doctor feels it is necessary and there are no other alternatives.

Driving

Can I drive if I have consumed Sertraline?

Sertraline is a medicine that acts on the brain and may cause side effects like dizziness, headache, vision problems and altered mental states (though not in all cases). It is recommended to be extremely cautious while driving and it is advised not to drive for long distances.

Alcohol

Can I consume alcohol with Sertraline?

Do not drink alcohol while on the medication of Sertraline as alcohol also causes a high level of Sertraline and the combined effect may be harmful.

Other General Warnings

Talk to your doctor if

You have seizures (fits)
You have blurred vision, tunnel vision, eye pain or swelling, headache, confusion, memory problems, severe weakness, feeling unsteady (symptoms of low levels of sodium in the body)
You have racing thoughts, increased energy, unusual risk-taking behavior, extreme happiness, being irritable or talkative
You have diabetes or liver problems, bleeding disorders, serotonin syndrome (severe anxiety (agitation), tremors and persistent fever (hyperthermia)), neuroleptic malignant syndrome (a life threatenin...
Read more

Mode of Action of Sertraline

How Does It Work?

Serotonin is a natural substance produced in the body which acts as a messenger to transmit signals in the brain (neurotransmitter). It is known as ‘happy chemical’ as it promotes positive thoughts an...

Interactions of Sertraline

Interactions with other medicines

Medicines that may (prolong QT interval) cause irregular heartbeats and heart attack (Quinidine, Disopyramide, Procainamide, Propafenone, Amiodarone, Sotalol)
Medicines that increase the risk of bleeding (Warfarin, pain killers, Aspirin)
Muscle relaxing medicines (Mivacurium)
Medicines used to treat migraine (Triptans – Almotriptan, Sumatriptan, Naratriptan, Zolmitriptan)
Medicines to treat heart disease and high blood pressure (Digoxin, Atenolol, Verapamil, Diltiazem, Flecainide, Propafenone)
Medicines used to reduce stomach acid (Cimetidine, Omeprazole, Lansoprazole)
Anti-infectious medicines (Rifampicin, Clarithromycin, Erythromycin)
Antifungal medications (Ketoconazole, Itraconazole, Posaconazole, etc.)
Medicines to treat HIV/ AIDS (Ritonavir)
A class of antidepressants called MAO (Monoamine Oxidase) inhibitors (Phenelzine, Selegiline, Moclobemide, Toloxatone, Isocarboxazid)
Other medicines which depress brain function (Carbamazepine, Haloperidol, Phenytoin)
Linezolid
Pimozide (an antipsychotic)

Interactions with food items

Sertraline does not interact with food and can be taken before or after meals.

Dietary Restrictions of Sertraline

Sertraline must not be taken with grapefruit juice. It may increase the level of Sertraline in your body.

Dosage of Sertraline

Overdose

Being sick (vomiting)
Tremor
Feeling sleepy
Dizziness
Fast heart rate
Seizures

Missed a Dose

If you forget to take a dose, do not take the missed dose. Just take the subsequent dosage at the right time.

Content Details

WRITTEN BY

Dr. Mahesh Muthe

MBBS

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: Is there anything else I must know about Sertraline?

Sertraline is one of the better efficacious and safer medicines compared to other antidepressants
Most of the side effects occur within the first two weeks of starting the treatment and are less frequent and less severe compared to other medicines used to treat depression
Sertraline is associated with restlessness (akathisia), where the patient is unable to sit or stand still and has a desire to move around. This is often seen in the first few weeks and there is no cau...
Read more
Self-medication or self-adjusting the dosage of Sertraline is strictly not advised

Q: What is Serotonin syndrome?

A: When Sertraline is used with certain other medicines (e.g. irreversible Monoamine Oxidase (MAO) inhibitors like Selegiline, Moclobemide, etc.), it may cause levels of serotonin to increase leading to a condition called serotonin syndrome. Severe anxiety (agitation), tremors and high-temperature condition (hyperthermia).

References

Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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मशरूम (Mushroom in Hindi) के उपयोग, फ़ायदे, और न्यूट्रिशनल वैल्यू

परिचय: “बिना मशरूम के खाना बिना बारिश के दिन जैसा होता है”। मशरूम या अगरिकस बिस्पोरस न तो सब्ज़ी है और न ही फल, बल्कि यह खाई जाने वाली एक फंगस है। बाजार में इसकी अलग-अलग किस्में (ताजा व सूखा) उपलब्ध हैं; जिसमे ओएस्टर , पोर्सिनी और बटन सबसे आम किस्में हैं। आमतौर पर, मशरूम

आंवला (Gooseberry in Hindi) के उपयोग, फ़ायदे और न्यूट्रिशनल वैल्यू

परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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