Phenobarbitone+Phenytoin

• Phenobarbitone+Phenytoin is used to treat epilepsy. It can also help with symptoms of uncontrollable jerking motions and loss of awareness.

When should one not use Phenobarbitone+Phenytoin

• If you are allergic to phenobarbitone, phenytoin or any component of this medicine.

Common side effects of this drug are:

• Nausea
• Vomiting
• Vertigo
• Nystagmus (involuntary eye movement)
• Double vision
• Sleepiness
• Anaemia
• Peripheral neuropathy
• Gingival hypertrophy
• Softening of bones
• Abnormal hair growth

Other General Warnings

• You experience withdrawal symptoms. Do not abruptly stop taking this prescription without first consulting your doctor. In people with a history of epilepsy, it has the potential to cause status epilepticus.
• If you have suicidal behaviour. This medicine should be used with caution in people with a history of depression. It has the potential to raise the risk of suicidal ideation. Inform the user's caregivers of these signs and symptoms.
• You have skin reactions like toxicity to the skin (toxic epidermal necrolysis and Stevens-Johnson syndrome). This is a risk with this medication. If any symptoms of skin reactions emerge, seek medical help right away.
• You have impaired liver function. This medicine should be used with caution in people with liver disease. Liver function test results must be closely monitored. Contact your doctor if symptoms of liver problems occur. Do not stop taking this medicine without consulting your doctor.

How Does It Work?

Interactions with other medicines

• Phenobarbitone+Phenytoin may reduce the effect of other medicines (chloramphenicol, cimetidine, clozapine, corticosteroids, cyclosporine, disopyramide, doxycycline, ethosuximide, furosemide, griseofulvin, haloperidol, lamotrigine, methadone, nifedipine, oral contraceptives, phenothiazine, propafenone, psychotropics, quinidine, tacrolimus, Tricyclic antidepressants, theophylline, warfarin, and verapamil)
• Phenobarbitone+Phenytoin increases the metabolism of beta-blockers, lowering their serum concentrations. Consider a beta-blocker that has been renally eliminated (atenolol and nadolol).
• Phenobarbitone+Phenytoin may promote the development of toxic metabolites, which raise the hepatotoxic potential of acetaminophen.
• Phenobarbitone+Phenytoin increases the metabolism of corticosteroids, cyclosporine, disopyramide, griseofulvin, nifedipine, oral contraceptives, propafenone, quinidine, and verapamil. Dose adjustments may be useful.
• Felbamate may cause toxicity by increasing Phenobarbitone+Phenytoin concentrations.
• Phenobarbitone+Phenytoin may decrease the diuretic effect of furosemide.
• When Phenobarbitone+Phenytoin is taken with meperidine, the risk of central nervous system (CNS) depression increases.
• When Phenobarbitone+Phenytoin is taken with primidone, the serum concentrations of Phenobarbitone+Phenytoin rise.
• Phenobarbitone+Phenytoin metabolism is inhibited by valproic acid, resulting in higher serum phenobarbital levels, leading to increased chances of side effects.

Interactions with food items

• Protein-deficient diets: The duration of action of Phenobarbitone+Phenytoin is lengthened. Protein should not be restricted or eliminated from the diet unless a physician has addressed it. Maintain a steady protein intake while using Phenobarbitone+Phenytoin.
• Vitamin C-rich fruits: These fruits displace the medication from binding sites, resulting in enhanced barbiturate excretion through the urine. Patients should be informed about the possibility of Phenobarbitone+Phenytoin's anticonvulsant effect being reduced if they consume meals high in vitamin C.
• Vitamin D deficiency: In case of deficiency due to malabsorption, switch to a vitamin D-rich dietary intake. Vitamin D supplementation may be required.

Overdose

Missed a Dose