Oxaliplatin
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Molecule Summary
| Uses | Colon/rectal/colorectal cancer |
| Therapy | Anti-Neoplastic |
| Side Effects | Diarrhoea, nausea, vomiting |
Medicines
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Molecule Description
Oxaliplatin is used in the treatment of colon and rectal cancer. It works by stopping or slowing down the growth of cancer cells. This medication is administered as an injection by a qualified medical professional. Your doctor will determine the necessary dose and how often you need to receive it, based on your specific treatment needs, which may change over time. It is important to take it exactly as your doctor advises; taking it incorrectly or in excessive amounts can lead to serious side effects.
Uses
Oxaliplatin is used in the treatment of cancer of the large bowel (stage III colon cancer after surgery to remove the tumour) and advanced colon or rectal cancer/colorectal cancer.
Contraindications
When should one not use Oxaliplatin
- If you are allergic to oxaliplatin or any other ingredient of Oxaliplatin.
- If you are breastfeeding.
- If you have a reduced number of blood cells.
- If you have tingling and numbness in the fingers and/or toes and have difficulty performing delicate tasks, such as buttoning clothes.
- If you have severe kidney problems.
Side effects
Common side effects of this drug are:
- Diarrhoea
- Nausea
- Vomiting
- Inflammation of mouth/gut
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have ever suffered an allergic reaction to platinum-containing medicines such as carboplatin or cisplatin.
- You have kidney or liver problems.
- You have or had heart disorders such as an abnormal electrical signal called prolongation of the QT interval, an irregular heartbeat, or a family history of heart problems.
- You have recently received or plan to receive any vaccines.
Mode of Action
How Does It Work?
Oxaliplatin undergoes changes inside the body and interacts with DNA (genetic material). It causes certain changes in the DNA, resulting in problems in DNA synthesis leading to anti-cancer effects.
Interactions
Interactions with other medicines
- Some medicines can affect the way Oxaliplatin works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
- Tell your doctor about all medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
- Particular care should be taken if you are taking medicines like 5-fluorouracil/paclitaxel (anti-cancer medicine), erythromycin (antibiotic), salicylates (pain-relieving medicine), granisetron (antiemetic medicine), and sodium valproate (antiepileptic medicine).
Dosage
Overdose
Oxaliplatin will be given to you by a doctor or nurse, and hence, the chances of an overdose are unlikely.
Missed a Dose
It is unlikely that a dose of Oxaliplatin will be missed if you are monitored in a healthcare setup. However, if you have missed taking a dose of the medicine, inform the doctor or nurse immediately.
Frequently Asked Questions (FAQs)
Articles
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References:
- Oxaliplatin 5mg/ml concentrate for Solution for Infusion - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 13 June 2026]
- Oxaliplatin 5mg/ml concentrate for Solution for Infusion - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 13 June 2026]
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