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Oxaliplatin

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Molecule Summary

Uses
Colon/rectal/colorectal cancer
Therapy
Anti-Neoplastic
Side Effects
Diarrhoea, nausea, vomiting
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Molecule Description

Oxaliplatin is used in the treatment of colon and rectal cancer. It works by stopping or slowing down the growth of cancer cells. This medication is administered as an injection by a qualified medical professional. Your doctor will determine the necessary dose and how often you need to receive it, based on your specific treatment needs, which may change over time. It is important to take it exactly as your doctor advises; taking it incorrectly or in excessive amounts can lead to serious side effects.

Uses

Oxaliplatin is used in the treatment of cancer of the large bowel (stage III colon cancer after surgery to remove the tumour) and advanced colon or rectal cancer/colorectal cancer.

Contraindications

When should one not use Oxaliplatin

  • If you are allergic to oxaliplatin or any other ingredient of Oxaliplatin.
  • If you are breastfeeding.
  • If you have a reduced number of blood cells.
  • If you have tingling and numbness in the fingers and/or toes and have difficulty performing delicate tasks, such as buttoning clothes.
  • If you have severe kidney problems.

Side effects

Common side effects of this drug are:

  • Diarrhoea
  • Nausea
  • Vomiting
  • Inflammation of mouth/gut

Precautions and Warnings

Pregnancy

Pregnancy

There is limited information on the effect of Oxaliplatin during pregnancy, and hence should not be used in pregnant women. This medicine should only be used in pregnant women if recommended by the doctor after assessing the need and the risk.

Breast Feeding

Breast Feeding

Oxaliplatin is contraindicated for use in breastfeeding women.

Driving

Driving

There is limited information on the effect of Oxaliplatin on driving ability. However, if you experience any effects after taking this medicine that may affect your ability to drive safely, it is advised to avoid driving.

Alcohol

Alcohol

There is limited information available on the interaction of alcohol with Oxaliplatin. Ask your doctor for advice on alcohol intake along with this medicine.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have ever suffered an allergic reaction to platinum-containing medicines such as carboplatin or cisplatin.
  • You have kidney or liver problems.
  • You have or had heart disorders such as an abnormal electrical signal called prolongation of the QT interval, an irregular heartbeat, or a family history of heart problems.
  • You have recently received or plan to receive any vaccines.

Mode of Action

How Does It Work?

Oxaliplatin undergoes changes inside the body and interacts with DNA (genetic material). It causes certain changes in the DNA, resulting in problems in DNA synthesis leading to anti-cancer effects.

Interactions

Interactions with other medicines

  • Some medicines can affect the way Oxaliplatin works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
  • Tell your doctor about all medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
  • Particular care should be taken if you are taking medicines like 5-fluorouracil/paclitaxel (anti-cancer medicine), erythromycin (antibiotic), salicylates (pain-relieving medicine), granisetron (antiemetic medicine), and sodium valproate (antiepileptic medicine).

Dosage

Overdose

Oxaliplatin will be given to you by a doctor or nurse, and hence, the chances of an overdose are unlikely.

Missed a Dose

It is unlikely that a dose of Oxaliplatin will be missed if you are monitored in a healthcare setup. However, if you have missed taking a dose of the medicine, inform the doctor or nurse immediately.

Frequently Asked Questions (FAQs)

Oxaliplatin is used in the treatment of cancer of the large bowel (stage III colon cancer after surgery to remove the tumour) and advanced colon or rectal cancer/colorectal cancer.

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