Losartan+Chlorthalidone / Chlortalidone

Uses	High blood pressure
Therapy	Anti-Hypertensive
Side Effects	Headache, nausea, dizziness, low blood pressure, facial swelling, increased potassium level, rash

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Molecule Description

Losartan+Chlorthalidone / Chlortalidone is an antihypertensive combination medicine containing losartan and chlorthalidone as its main active ingredients. Losartan belongs to the Angiotensin Receptor Blocker (ARBs) class of medicine, and chlorthalidone is a diuretic. It is used to treat high blood pressure and also helps to reduce other heart problems. It also helps lower blood pressure by increasing the amount of water and sodium your body removes through urine. While taking Losartan+Chlorthalidone / Chlortalidone you should follow a healthy diet and should also exercise regularly. It should be taken as directed by the doctor, in the prescribed doses and duration. It can be taken with or without food. Do not stop taking this medicine unless asked to do so by your doctor. The doctor may also suggest avoiding potassium supplements during treatment, as they may increase potassium levels in the bloodstream. It is essential to monitor your blood pressure regularly. Your doctor may request a few kidney tests during treatment to check if Losartan+Chlorthalidone / Chlortalidone is functioning properly. You should provide a complete medical history along with a family history to your doctor before starting Losartan+Chlorthalidone / Chlortalidone. Do not stop taking this medication suddenly, as it can cause health problems. Common side effects include headache, nausea, facial swelling, increased potassium level, rash, and dizziness. Consult your doctor if these side effects bother you. Before taking Losartan+Chlorthalidone / Chlortalidone, inform your doctor about any existing kidney or liver problems. Pregnant or breastfeeding women should also consult their doctor. Tell your doctor about all other medications you are currently taking, as they may interact with Losartan+Chlorthalidone / Chlortalidone.

Uses

Losartan+Chlorthalidone / Chlortalidone is used to treat high blood pressure. It is also used as a supportive treatment to reduce swelling caused by fluid accumulation in the body, such as that caused by heart, liver, or kidney disease.

Contraindications

When should one not use Losartan+Chlorthalidone / Chlortalidone

If you are allergic to losartan, chlorthalidone or any other ingredients of Losartan+Chlorthalidone / Chlortalidone.
If you are pregnant.
If you have severe liver or kidney disease.
If your urine output in 24 hours is very low (less than 100ml).

Side effects

Common side effects of this drug are:

Headache
Nausea
Dizziness
Low blood pressure
Facial swelling
Increased potassium level
Rash

Precautions and Warnings

Pregnancy

Do not take Losartan+Chlorthalidone / Chlortalidone if you are pregnant, suspect you may be pregnant, or are planning to have a baby, as this medicine may harm your baby.

Breast Feeding

Losartan+Chlorthalidone / Chlortalidone is not recommended during breastfeeding. It is advisable to consult a doctor to find a safer alternative.

Driving

You may experience dizziness or drowsiness that can influence your ability to drive or operate machines. Hence, caution is advised while driving any vehicle when on Losartan+Chlorthalidone / Chlortalidone.

Alcohol

Caution is advised as alcohol makes blood pressure drop and can increase side effects like sedation or drowsiness. Please consult your doctor if you drink frequently.

Other General Warnings

Talk to your doctor if

You ever had angioedema (swelling of the face, lips, throat, tongue).
You have vomiting or diarrhoea.
Your blood vessels leading to your kidneys are narrow, or you have a kidney transplant.
You are taking high blood pressure medicines like Diuretics.
You have a liver problem.
You are suffering from heart failure or any heart disease.
Caution is required if you are diabetic and taking medicines like Enalapril, Lisinopril, Ramipril.
Your blood pressure is low or you have dehydration.
You are on a salt-restricted diet.
The use of Losartan+Chlorthalidone / Chlortalidone may cause low levels of electrolytes in the body. It is advisable to monitor electrolytes periodically.

Mode of Action

How Does It Work?

Angiotensin-II released in your body causes the blood vessels to narrow, which leads to an increase in blood pressure. Losartan+Chlorthalidone / Chlortalidone prevents the binding of Angiotensin-II to its receptors, thus causing the blood vessels to relax and lowering the blood pressure. Losartan+Chlorthalidone / Chlortalidone lowers blood pressure by increasing the excretion of water and sodium through urine.

Interactions

Interactions with other medicines

Sometimes Losartan+Chlorthalidone / Chlortalidone may interact with other medicines or vice versa. Therefore, discuss with your doctor about all the medicines, supplements or herbal preparations you are taking.
Especially if you are on certain medications like blood thinners (warfarin or heparin), anti-cancer medicines, anti-depressants like lithium, potassium supplements or medicines containing potassium, other anti-hypertensives like water pills (furosemide), medicines for heart-related disorders like digoxin etc.
If you have diabetes, do not take aliskiren along with this medicine.
Taking this medicine with lithium decreases the excretion of lithium through urine, leading to the accumulation of lithium in the body.
Concomitant use of Losartan+Chlorthalidone / Chlortalidone and painkillers should be avoided as it may impair kidney functions
Other medicines that should be used with caution are anti-bacterial medicines such as Trimethoprim, corticosteroids used to treat the inflamed area of body parts etc.
Also, you should inform your doctor if you have a planned surgery or vaccination schedule.

Interactions with food items

Losartan+Chlorthalidone / Chlortalidone can be taken with or without food; taking it with food may help to reduce gastrointestinal discomfort for some individuals. It is advisable to avoid foods high in potassium.

Dosage

Overdose

Symptoms of an overdose of Losartan+Chlorthalidone / Chlortalidone include dizziness, weakness, nausea, elevated potassium levels in the blood, kidney failure, and loss of consciousness.
If you have taken an excessive amount of Losartan+Chlorthalidone / Chlortalidone, please contact your doctor or reach out to the nearest hospital immediately.

Missed a Dose

If you miss any dose of Losartan+Chlorthalidone / Chlortalidone, take it as soon as you remember. If it is time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose of Losartan+Chlorthalidone / Chlortalidone to make up for a missed one.

Frequently Asked Questions (FAQs)

Yes, avoid high potassium-containing foods (spinach, banana, peas, kidney beans). A low-salt diet is preferred. Avoid fruits, foods and health supplements with a high potassium content.

Losartan+Chlorthalidone / Chlortalidone increases the level of uric acid in blood by decreasing its excretion through urine, leading to the accumulation of uric acid in the blood, which might play a role in precipitating gout.