Molecule Description

Estriol is similar to the naturally occurring hormone estrogen. It is used as Ho...
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Uses of Estriol

  • Osteoporosis (which cause weakening of bones)
  • Hormone replacement therapy
  • Vaginal dryness (topical cream/gel)

Contraindications of Estriol

When should one not use Estriol

  • Do not take this medicine if:
  • You are allergic to this medicine
  • You have breast cancer
  • You have liver disease
  • You have clots in blood
  • You have cancer of the womb lining (endometrial cancer)
  • You have an extensive thickening of the womb lining (endometrial hyperplasia)
  • You have any unexplained vaginal bleeding
  • You have porphyria

Side effects of Estriol

Common side effects of this drug are:

  • Nausea and vomiting
  • Breast tenderness
  • Headache
  • Vaginal spotting
  • Pain during urination
  • Stomach upset
  • Skin rash
  • Pain in legs
  • Difficulty to breath and swallow
  • Jaundice
  • Swelling of face or throat
  • Increase blood pressure

Precautions and Warnings of Estriol



Can I take Estriol during pregnancy?
It is probably unsafe to use this medicine during pregnancy as it may harm the unborn baby.

Breast Feeding

Can I take Estriol while breastfeeding?
Limited data available for the amount of medicine passing in breast milk during breastfeeding. Therefore avoid this medicine if you are breastfeeding.


Can I drive if I have consumed Estriol?
Limited data are available about the effect of this medicine on driving.


Can I consume alcohol with Estriol?
No study available about the interaction of this medicine with alcohol.

Other General Warnings

Talk to your doctor if
  • You have abnormal growth in womb inside or outside
  • You have high blood pressure, heart disease, liver disease, kidney disease or diabetes
  • You have gallbladder stone, migraine, headache, seizures or asthma
  • You have a high triglyceride level and autoimmune disease called Systemic Lupus Erythematosus (SLE)

Mode of Action of Estriol

How Does It Work?

Estriol helps in maintaining the estrogen levels in postmenopausal females.

Interactions of Estriol

Interactions with other medicines

  • Medicines for epilepsy(like Barbiturates, Lamotrigine, Hydantoins, and Carbamazepine)
  • Medicines for infections (like Griseofulvin and Rifamycin)
  • Medicines for viral infections (like Nevirapine, Efavirenz, Ritonavir or Nelfinavir)
  • Corticosteroids
  • Theophylline or Succinylcholine

Interactions with food items

No specific interactions with food have been reported yet.

Dietary Restrictions of Estriol

No information is available on dietary restrictions while you are taking this medicine, so consult your doctor or pharmacist for further details.

Dosage of Estriol


The effect of an overdose may be harmful and need immediate medical attention. The symptoms of overdose can be nausea, vomiting and headache. If you happen to take an overdose of the medicine, seek em...
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Missed a Dose

Take the missed dose of medicine as early as you remember. Skip the missed dose and do not take extra medicine to compensate for the missed dose.

Content Details


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking Estriol?

  • Inform the doctor about your detailed medical, surgical and allergy history
  • Inform your physician if you have any of the following conditions -
  • Uterine fibroids, endometriosis
  • Breast cancer
  • Blood pressure, stroke
  • Liver disease
  • Gallbladder disease
  • Seizures
  • Asthma
  • Inform if you are pregnant, lactating or planning a pregnancy
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)
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