Molecule Description

Disopyramide belongs to the class of antiarrhythmic medicines. It helps to corre...
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Uses of Disopyramide

  • Prevention and treatment of arrhythmias occurring after myocardial infarction
  • Maintenance of normal rhythm after electro conversion e.g. atrial fibrillation, atrial flutter
  • Persistent ventricular extrasystoles
  • Control of arrhythmias following the use of digitalis or similar medicines
  • Suppression of arrhythmias during surgical procedures e.g. cardiac catheterization
  • Prevention of paroxysmal supraventricular tachycardia

Contraindications of Disopyramide

When should one not use Disopyramide

  • Known hypersensitivity to this medicine
  • Those with cardiomyopathy (an acquired or hereditary disease of the heart muscle)
  • Cardiogenic shock
  • Patients with complete heart block
  • Glaucoma (increased pressure inside the eyes)
  • Predisposition to urinary retention
  • Myasthenia gravis (rapid fatigue and weakness of muscles under voluntary control)
  • Sinus node disease in the absence of pacemaker in children

Side effects of Disopyramide

Common side effects of this drug are:

  • Abnormal heart rhythm
  • Dry mouth
  • Constipation
  • Urinary retention
  • Blurred vision
  • Double vision
  • Worsening of pre-existing glaucoma (eye conditions that can cause blindness)

Precautions and Warnings of Disopyramide



Can I take Disopyramide during pregnancy?
You should not take this medicine during pregnancy. It is because the safety of this medicine for use during pregnancy has not been established.

Breast Feeding

Can I take Disopyramide while breastfeeding?
This medicine passes into breast milk, but the effect on a nursing infant is not known. It is advisable to consult your doctor before breastfeeding.


Can I drive if I have consumed Disopyramide?
This medicine may cause dizziness or decreased alertness. If you feel the same, do not drive.


Can I consume alcohol with Disopyramide?
It is unsafe to consume alcohol with this medicine.

Other General Warnings

Talk to your doctor if
  • This medicine may cause low blood sugar if you have diabetes
  • Tell your doctor if you have a history of:
  • Heart failure
  • Decreased kidney or liver function
  • Nutrition problems

Mode of Action of Disopyramide

How Does It Work?

The heart sends electrical signals which prompt the heart’s muscles to contract. With every contraction, blood is pumped all over the body. When the electrical signals are disrupted, heart pumping and...
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Interactions of Disopyramide

Interactions with other medicines

  • Other antiarrhythmic agents
  • Phenytoin
  • Antimuscarinic medicines
  • Beta-blockers
  • Verapamil
  • Digitalis
  • Tricyclic antidepressants
  • Rifampicin
  • Saquinavir
  • Phenytoin
  • Ketoconazole

Interactions with food items

No specific interactions with food have been reported yet.

Dosage of Disopyramide


Symptoms of Disopyramide overdose are loss of consciousness, fall in blood pressure, respiratory arrest, episodes of temporary cessation of breathing, conduction disturbances of the heart, arrhythmias...
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Missed a Dose

If you missed any dose, take it as early as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of medicine to comp...
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Content Details


Dr. Rukman Mecca

MBBS, MD (Community Medicine)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking Disopyramide?

  • Give a detailed account of your medical and surgical history. Tell your doctor if you have a history of:
  • Heart failure
  • Decreased kidney or liver function
  • Nutrition problems

Q: Any special precautions to be taken while on treatment with this medicine?

A: Inform your doctor if you have diabetes or your potassium levels are not normal. Special precautions should be taken during conduction disorders, liver and kidney impairment. Be cautious if you have a family history of glaucoma.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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