Dapoxetine+Sildenafil
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Molecule Summary
| Uses | Erectile dysfunction, Premature ejaculation |
| Therapy | Drugs For Erectile Dysfunction |
| Side Effects | Nausea, vomiting, dizziness, blurred vision, dry mouth |
Medicines
available
19k pincodes
Molecule Description
Dapoxetine+Sildenafil is a prescription medicine used to manage two common male sexual health concerns: erectile dysfunction (ED) and premature ejaculation (PE). It combines two active ingredients, sildenafil and dapoxetine, which work together to treat both conditions.
The sildenafil in Dapoxetine+Sildenafil works by relaxing blood vessels and increasing blood flow to the penis. This makes it easier to achieve and maintain a firm erection during sexual stimulation. Dapoxetine, on the other hand, is a selective serotonin reuptake inhibitor (SSRI) that specifically targets premature ejaculation. It helps men last longer during intercourse by delaying the ejaculation reflex. Together, these actions address both conditions in men who experience them together.
Like any medication, Dapoxetine+Sildenafil may cause side effects in some individuals. Commonly reported effects include headache, nausea, dry mouth, dizziness, vomiting, and nosebleeds. These side effects are usually mild and temporary. However, if you experience chest pain, irregular heartbeat, fainting, or severe mood changes, it is important to seek medical attention immediately.
Before starting treatment, always inform your doctor if you have any history of heart disease, liver or kidney problems, seizures, or depression. This medication may not be suitable for people with certain pre-existing conditions or those taking nitrate medicines for chest pain, as dangerous interactions can occur. Your doctor will assess your overall health before prescribing the right dose for you.
For best results, take Dapoxetine+Sildenafil exactly as prescribed, usually before planned sexual activity. Avoid alcohol and recreational drugs, as they may reduce its effectiveness or increase side effects. Follow your doctor's guidance for safe use of this medicine.
Uses
- Dapoxetine+Sildenafil is used to treat erectile dysfunction and premature ejaculation in adult men.
Contraindications
When should one not use Dapoxetine+Sildenafil
- If you have an allergic reaction to any component of Dapoxetine+Sildenafil
- If you are taking medicine that contains nitrates
- If you have a serious heart condition, such as heart failure or a pacemaker
- If you have existing liver problems
- If you have retinitis pigmentosa, a rare eye disease, or any other retinal disorder
- If you have low blood pressure
- If you have recently suffered from a stroke or heart attack
- If you have any lung-related conditions
- If you have conditions such as mood disorders, bipolar disorder, depression, or mania.
Side effects
Common side effects of this drug are:
- Dizziness
- Flushing (warmth sensation on the face)
- Excessive sweating
- Blurred vision
- Increased tiredness
- Dry mouth
- Prolonged and painful erection
Precautions and Warnings
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have glaucoma (an eye condition); exercise extreme caution before taking this medicine.
- You have kidney disease.
- You have a fungal infection and are taking anti-fungal medication.
- You are taking HIV antiviral medications.
- You have a heart condition with blocked blood vessels and are currently on medication.
- You have any condition that requires you to avoid physical exercise.
- You are an older male adult over 65.
Mode of Action
How Does It Work?
Dapoxetine+Sildenafil contains two active ingredients: sildenafil and dapoxetine. Sildenafil works by widening and relaxing the blood vessels around the penis, which increases blood flow and helps achieve an erection. It is particularly beneficial for individuals experiencing erectile dysfunction. Dapoxetine, on the other hand, is a selective serotonin reuptake inhibitor (SSRI). It boosts serotonin levels, which helps delay ejaculation. This makes dapoxetine effective in treating conditions such as premature ejaculation.
Interactions
Interactions with other medicines
- If you are on treatment with medicines containing nitrates, consult your doctor before taking Dapoxetine+Sildenafil.
- If you are on anti-fungals like ketoconazole, blood thinners, beta-blockers, high blood pressure medication, seizure medication, or HIV medication, inform your doctor before taking Dapoxetine+Sildenafil. These medicines can cause severe reactions if taken with Dapoxetine+Sildenafil.
Interactions with food items
- If you take this medicine, avoid consuming large amounts of grapefruit or its juice. This fruit can increase the levels of Dapoxetine+Sildenafil in the body and delay its effects.
Dosage
Overdose
An overdose of Dapoxetine+Sildenafil can cause symptoms like low blood pressure, fainting, dizziness, chest pain, body heating, and stomach upset. It can also cause a prolonged erection. If you experience these symptoms after taking this medicine, consult a doctor and seek medical treatment immediately.
Missed a Dose
The dose and duration of this medicine are not fixed. If you use Dapoxetine+Sildenafil for erectile dysfunction or premature ejaculation, missing a dose is highly unlikely, as it is used only before sexual intercourse.
Frequently Asked Questions (FAQs)
Articles
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References:
- Sildenafil: Medlineplus Drug Information [Internet]. U.S. National Library of Medicine. medlineplus.gov [cited 15 June 2026]
- TMCMGS. Efficacy and Safety of Dapoxetine/Sildenafil Combination Tablets in the Treatment of Men with Premature Ejaculation and Concomitant Erectile Dysfunction: DAP-speed Study [Internet]. International Journal of Impotence Research. U.S. National Library of Medicine [cited 15 June 2026]
- McMahon CG. Efficacy of Dapoxetine in the Treatment of Premature Ejaculation [Internet]. Clinical Medicine Insights. Reproductive Health. Libertas Academica. 2011 [cited 15 June 2026]
- Dresser MJ, Desai D, Gidwani S, Seftel AD, Modi NB. Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors. Int J Impot Res. 2006 Jan-Feb;18(1):104-10. [cited 15 June 2026]
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