Casirivimab+Imdevimab

Description

Casirivimab and imdevimab is a combination of two monoclonal antibodies. It is

used for the treatment of confirmed cases of mild to moderate COVID-19 disease in individuals over 12 years of age (weighing at least 40 kg) who are at high risk of developing severe COVID-19 disease and do not require oxygen. High risk is defined as patients over 60 years of age, obesity, existing heart, lung, kidney and liver condition, diabetes, asthma, cancer, HIV, immunocompromised state, someone who has undergone organ transplant and are on medicine that can weaken/suppress the immune system. The use of this medicine should be based on the treating physician's discretion after careful assessment of the condition for an individual patient. This comes as an injection that is given/administered by a healthcare professional either via the intravenous route (takes about 20 to 30 minutes) or subcutaneous route at four different sites on the abdomen or thigh.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Casirivimab+Imdevimab

For the treatment of confirmed cases of mild to moderate coronavirus disease in patients over 12 years of age (weighing at least 40 kg) who are at risk of developing serious COVID-19 disease.

Contraindications of Casirivimab+Imdevimab

When should one not use Casirivimab+Imdevimab

You are hospitalised due to COVID-19 disease and are on oxygen support due to COVID-19 disease.
Individuals requiring an increase in baseline oxygen flow rate due to COVID-19 who are already on oxygen support due to non-COVID-19 related comorbidity.

Side effects of Casirivimab+Imdevimab

Common side effects of this drug are:

There is limited information available about the side effects of this medicine. Injection site reaction like pain, swelling can occur.
Inform your doctor if you experience fever, chills, nausea, stomach upset, uneven heart rhythm, weakness, confusion, dizziness, chest pain, breathlessness, swelling of lips, face, rash after the infus...
Read more

Precautions and Warnings of Casirivimab+Imdevimab

Pregnancy

Can I take casirivimab and imdevimab antibody cocktail during pregnancy?

There is limited data available about the safety of this medicine during pregnancy.

Breast Feeding

Can I take casirivimab and imdevimab antibody cocktail while breastfeeding?

There are no available data on the safety of this medicine in breastfeeding women and it's not known if the component of this injection pass in breast milk.

Driving

Can I drive if I have taken casirivimab and imdevimab antibody cocktail injection?

It is not known if this medicine affects your driving abilities. Individuals with COVID-19 disease should stay home in isolation to avoid the spread of infection.

Alcohol

Can I consume alcohol with casirivimab and imdevimab antibody cocktail?

There is no interaction known between alcohol and this medicine.

Other General Warnings

Talk to your doctor if

You experience allergic reactions after taking this injection or have any allergy.
You are pregnant or breastfeeding.
You have any serious medical condition.
You are taking any prescription medicine, supplement or herbals.
Your symptoms worsen and you experience difficulty in breathing, fever, uneven heart rate, fatigue and altered mental status.
This injection should not be used for the treatment of patients who are hospitalized due to COVID-19 disease and are on oxygen support.

Mode of Action of Casirivimab+Imdevimab

How Does It Work?

This injection contains an antibody cocktail (combination) of two antibodies. Monoclonal antibodies are laboratory-made proteins that imitate the immune system’s ability to fight off harmful pathogens...

Interactions of Casirivimab+Imdevimab

Interactions with other medicines

Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.

Content Details

WRITTEN BY

Dr. Arpit Verma

MBBS, MD CCEBDM Diabetology

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: What do you mean by patients with a high risk of developing COVID-19 disease?

A: High risk is defined as patients over 60 years of age, obesity, existing heart, lung, kidney or liver condition. Certain medical state such as diabetes, asthma, HIV, cancer, sickle cell anaemia, thalassemia, and prolonged use of immune-weakening medications. This also includes someone who has received a transplanted organ recently, have low or week immunity (immunocompromised).

Q: What is an antibody cocktail?

A: It is a combination of two man-made antibody or monoclonal antibody combination containing casarivimab and imdevimab. It is authorised to use under emergency condition for the treatment of mild to moderate COVID-19 disease in patients over 12 years of age who are at high risk of developing severe COVID-19 disease.

Q: What should I discuss with my doctor before taking this injection?

A: Tell your doctor if you are pregnant, breastfeeding, have any allergy, serious illness and about any medicines which you are currently taking.

References

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Last Updated on: 02 Jun 2021 | 05:48 PM (IST)

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Disclaimer

The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.