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Depsonil Pm 75mg Capsule

10 Capsule(s) in Strip
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Depsonil Pm 75 MG Description

Depsonil PM is used to treat depression. It is a type of tricyclic antidepressant medication. It is also used to treat bed-wetting in children. These medications work on the brain and change the leve

ls of certain chemicals to treat the symptoms of depression. You may not notice any significant improvement in the symptoms of depression after the first few weeks. Therefore, it is important to have regular checkups during this phase. It has been noted that suicidal risk may increase during the initial stage of recovery. Sudden discontinuation of Depsonil PM could cause withdrawal symptoms. To avoid this, consult your doctor before you stop the medicine.


Product Summary

Offer Price₹53.38
You Save₹9.42 (15% on MRP)
ContainsImipramine(75.0 Mg)
UsesTreatment of depression and to manage the problem of night bed-wetting by children.
Side effectsConfusion, feeling dizzy, fatigue, drowsiness, nausea, yellowing of the skin or white eyes, children may have behavioural changes.
Check more medicines with composition as Imipramine(75.0 Mg)

Uses of Depsonil Pm 75 MG

  • Treatment of depression.
  • To manage the problem of night bed-wetting by children.

Contraindications of Depsonil Pm 75 MG

  • If you are allergic to imipramine, other tricyclic antidepressants or other substances used in the product.
  • If you suffer from a heart condition like abnormal heart rhythm, heart block or had a heart attack.
  • If you have any mental illness (mania).
  • If you have severe liver disease.
  • If you have a blood disorder (porphyria).
  • If you have eye problems (glaucoma).
  • If you are currently taking or have used monoamine oxidase inhibitors (MAOI) in the last 14 days.

Side effects of Depsonil Pm 75 MG

  • Confusion
  • Feeling dizzy (postural hypotension)
  • Fatigue
  • Drowsiness
  • Nausea
  • Yellowing of the skin and/or whites of the eyes
  • Children may show behavioural changes.

Precautions and Warnings of Depsonil Pm 75 MG



Can I take Desponil PM during pregnancy?
Depsonil PM is not recommended for use during pregnancy. The baby may have breathing problems, lethargy, fussing when taken in the last three months of pregnancy.

Breast Feeding

Can I take Depsonil PM while breastfeeding?
Depsonil PM is not recommended for use while breastfeeding, as it may pass into the breastmilk.


Can I drive if I have taken Depsonil PM?
Depsonil PM can cause a decrease in mental alertness, drowsiness, and hazy vision. Do not drive if you have any of these symptoms till they wear off.


Can I consume alcohol with the Depsonil PM?
Alcohol should not be used while taking Depsonil PM as it can increase the sedative effects of alcohol.

Other General Warnings

Talk to your doctor if
  • You or your child has any mental illness (schizophrenia or mania).
  • You have epilepsy, use medicines to treat convulsions or have a history of any brain injury.
  • You have an enlarged prostate gland.
  • You have thyroid problems or are undergoing treatment for the same.
  • You have low blood pressure or poor circulation.
  • You develop kidney disease.
  • You have a tumour of the adrenal gland.
  • You have panic attacks.
  • You have chronic constipation.
  • You use contact lenses.
  • You are scheduled for surgery, including dental, or any procedure involving anaesthesia.

Mode of Action of Depsonil Pm 75 MG

How Does It Work?

The active ingredient in Depsonil PM is Imipramine. It acts by changing certain chemicals in the brain (serotonin and norepinephrine). These chemicals help stabilise the mood and have a positive effec...
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Directions for Use of Depsonil Pm 75 MG

  • Take Depsonil PM as instructed by your doctor.
  • Swallow the whole capsule with water.

Interactions of Depsonil Pm 75 MG

Interactions with other medicines

  • Medicines to treat epilepsy such as barbiturates, phenytoin, carbamazepine. Phenobarbital could potentially cause an increase in the depressant action of Depsonil PM, such as increased sleepiness, con...
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  • Benzodiazepines such as diazepam, nitrazepam, oxazepam, alprazolam can further increase the depressant action of Depsonil PM, causing confusion, anxiety etc.
  • Medications used to treat depression, such as selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and fluvoxamine, can add to its effect by increasing concentration levels of Depsonil ...
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  • Medication to treat substance abuse such as nicotine replacement therapy or disulfiram for alcohol addiction can increase effects of drowsiness, headache, lack of mental alertness etc.
  • Methylphenidate (used to treat attention-deficit/hyperactivity disorder) should be given at a lower dose to prevent it from causing a spike in the blood concentration of Depsonil PM.
  • Blood-thinning medications such as warfarin can cause increased anticoagulant effects.
  • Depsonil can increase the effects of certain medications such as phenothiazine, antiparkinson medications, antihistamines, atropine, biperiden on the eye, bowel and bladder, brain.
  • Apraclonidine and brimonidine (to treat glaucoma) are not recommended.
  • Muscle relaxants such as baclofen can show enhanced muscle relaxant effects.
  • Painkillers such as nefopam and tramadol should be used with caution as they can cause side effects such as convulsions, sedation or abnormal heart rhythm.
  • Medications to treat certain heart conditions such as diltiazem, verapamil, labetalol, propranolol, quinidine can cause an increase in Depsonil PM concentrations in the body, potentially increasing al...
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  • Medications to treat angina such as glyceryl trinitrate, isosorbide and dinitrate should not be used concomitantly.
  • Medications used in treating high blood pressure such as guanethidine, debrisoquine, bethanidine or diuretics may not be effective in lowering the blood pressure when used with Depsonil PM.
  • Medicines to treat some mental illnesses such as thioridazine and chlorpromazine can cause heart rhythm irregularities.
  • Cimetidine (to treat ulcers) would require dose adjustment when used in combination as it causes an increase in the effects of Depsonil.
  • Oral contraceptives or hormone replacement therapy (HRT) may decrease the blood concentration levels of Depsonil PM and therefore decrease its effect.
  • Depsonil PM can cause sympathomimetic medications such as adrenaline (epinephrine), ephedrine, isoprenaline, noradrenaline (norepinephrine), phenylephrine and phenylpropanolamine (present in cough and...
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  • Ritonavir (to treat HIV) can increase the blood concentration levels of Depsonil PM, increasing its effects.
  • Buprenorphine/opioids may interact with Imipramine tablets and cause a potentially life-threatening condition.

Interactions with food items

  • No dietary precautions are required.

Storage and disposal of Depsonil Pm 75 MG

Store Depsonil PM at room temperature in a dry place. Keep the medication out of reach of children. Do not use the medication after the expiry date mentioned on the box. Dispose of medication no longe...
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Dosage of Depsonil Pm 75 MG


Overdose symptoms include abnormal heartbeat, low blood pressure, sleepiness, seizures, restlessness, muscle rigidity, nausea, vomiting, fever or coma. Contact your doctor immediately if you suspect y...
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Missed a Dose

Take the missed dose as soon as you can, and then continue with your regular dosing schedule. Do not double your dose to compensate for the missed dose.

Content Details


Dr. Varsha Parihar

MBBS, MD (Community Medicine)

Frequently Asked Questions (FAQs)


Q: Can Depsonil PM be used to treat children of all ages?

A: No, Depsonil PM is not recommended for use in children below the age of six.

Q: What precautions should be taken while treating elderly patients with Depsonil PM?

A: Decreased sodium levels (hyponatremia) have been seen with the use of this medication, usually in elderly patients, and they may show symptoms like excessive sleepiness, disorientation or fits. They may also have some problems with cardiac function. It may also cause intestinal obstructions (paralytic ileus), especially in bedridden patients. Close monitoring of elderly patients is therefore needed while treating with Depsonil PM.

Q: Why do we need regular dental checkups while using Depsonil PM?

A: Regular dental visits are recommended while undergoing long-term treatment with Depsonil PM as there is a reported increase in tooth decay or cavities.
Product Details
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Last Updated on: 10 Mar 2022 | 10:41 AM (IST)
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