Depsonil Pm 75Mg Capsule

• Treatment of depression.
• To manage the problem of night bed-wetting by children.

• If you are allergic to imipramine, other tricyclic antidepressants or other substances used in the product.
• If you suffer from a heart condition like abnormal heart rhythm, heart block or had a heart attack.
• If you have any mental illness (mania).
• If you have severe liver disease.
• If you have a blood disorder (porphyria).
• If you have eye problems (glaucoma).
• If you are currently taking or have used monoamine oxidase inhibitors (MAOI) in the last 14 days.

• Confusion
• Feeling dizzy (postural hypotension)
• Fatigue
• Drowsiness
• Nausea
• Yellowing of the skin and/or whites of the eyes
• Children may show behavioural changes.

Other General Warnings

• You or your child has any mental illness (schizophrenia or mania).
• You have epilepsy, use medicines to treat convulsions or have a history of any brain injury.
• You have an enlarged prostate gland.
• You have thyroid problems or are undergoing treatment for the same.
• You have low blood pressure or poor circulation.
• You develop kidney disease.
• You have a tumour of the adrenal gland.
• You have panic attacks.
• You have chronic constipation.
• You use contact lenses.
• You are scheduled for surgery, including dental, or any procedure involving anaesthesia.

• Take Depsonil PM as instructed by your doctor.
• Swallow the whole capsule with water.

Overdose

Missed a Dose

How Does It Work?

Interactions with other medicines

• Medicines to treat epilepsy such as barbiturates, phenytoin, carbamazepine. Phenobarbital could potentially cause an increase in the depressant action of Depsonil PM, such as increased sleepiness, confusion, dry mouth, seizure, and headache.
• Benzodiazepines such as diazepam, nitrazepam, oxazepam, alprazolam can further increase the depressant action of Depsonil PM, causing confusion, anxiety etc.
• Medications used to treat depression, such as selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and fluvoxamine, can add to its effect by increasing concentration levels of Depsonil PM in the body, causing fits, confusion etc.
• Medication to treat substance abuse such as nicotine replacement therapy or disulfiram for alcohol addiction can increase effects of drowsiness, headache, lack of mental alertness etc.
• Methylphenidate (used to treat attention-deficit/hyperactivity disorder) should be given at a lower dose to prevent it from causing a spike in the blood concentration of Depsonil PM.
• Blood-thinning medications such as warfarin can cause increased anticoagulant effects.
• Depsonil can increase the effects of certain medications such as phenothiazine, antiparkinson medications, antihistamines, atropine, biperiden on the eye, bowel and bladder, brain.
• Apraclonidine and brimonidine (to treat glaucoma) are not recommended.
• Muscle relaxants such as baclofen can show enhanced muscle relaxant effects.
• Painkillers such as nefopam and tramadol should be used with caution as they can cause side effects such as convulsions, sedation or abnormal heart rhythm.
• Medications to treat certain heart conditions such as diltiazem, verapamil, labetalol, propranolol, quinidine can cause an increase in Depsonil PM concentrations in the body, potentially increasing all its effects.
• Medications to treat angina such as glyceryl trinitrate, isosorbide and dinitrate should not be used concomitantly.
• Medications used in treating high blood pressure such as guanethidine, debrisoquine, bethanidine or diuretics may not be effective in lowering the blood pressure when used with Depsonil PM.
• Medicines to treat some mental illnesses such as thioridazine and chlorpromazine can cause heart rhythm irregularities.
• Cimetidine (to treat ulcers) would require dose adjustment when used in combination as it causes an increase in the effects of Depsonil.
• Oral contraceptives or hormone replacement therapy (HRT) may decrease the blood concentration levels of Depsonil PM and therefore decrease its effect.
• Depsonil PM can cause sympathomimetic medications such as adrenaline (epinephrine), ephedrine, isoprenaline, noradrenaline (norepinephrine), phenylephrine and phenylpropanolamine (present in cough and cold medicines or local anaesthetics) to have an increased effect.
• Ritonavir (to treat HIV) can increase the blood concentration levels of Depsonil PM, increasing its effects.
• Buprenorphine/opioids may interact with Imipramine tablets and cause a potentially life-threatening condition.

Interactions with food items

• No dietary precautions are required.