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Molecule Description

Raloxifene is used to treat postmenopausal osteoporosis (a condition in which bones become weak and brittle).

Uses of Raloxifene

To treat and prevent osteoporosis and breast cancer in postmenopausal women.

Contraindications of Raloxifene

When should one not use Raloxifene

  • Do not take this medicine if you are allergic to Raloxifene
  • Do not take this medicine if you have a history of blood clots in your legs, lungs or eyes or unexplained vaginal bleeding
  • Do not take this medicine if you are suffering from severe kidney or liver disease
  • Do not take this medicine if there is a possibility to get pregnant

Side effects of Raloxifene

Common side effects of this drug are:

  • Hot flashes
  • High blood pressure
  • Headache, joint pain, and leg cramps, swelling of hands, feet and legs
  • Nausea, stomach upset, vomiting
  • Mild breast symptoms like pain, enlargement and tenderness

Precautions and Warnings of Raloxifene


Can I take Raloxifene during pregnancy?
Do not take this medicine during pregnancy as it may harm the unborn baby. Generally, it is advised to postmenopausal women.

Breast Feeding

Can I take Raloxifene while breastfeeding?
It is unsafe to take this medicine during breastfeeding.


Can I drive if I have consumed Raloxifene?
Usually, it does not affect your ability to drive.


Can I consume alcohol with Raloxifene?
No information is available on interactions of Raloxifene when taken with alcohol, consult your doctor or pharmacist for further details.

Other General Warnings

Talk to your doctor if
  • You are immobilized for some time such as using a wheelchair, needing to be admitted to a hospital or having to stay in bed while recovering from an operation or an unexpected illness as these may increase your risk of blood clots (deep vein thrombosis, pulmonary embolism or retinal vein thrombosis)
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  • You have had a cerebrovascular accident (e.g. stroke)
  • You have liver disease or suffering from breast cancer
  • You are receiving oral oestrogen therapy

Mode of Action of Raloxifene

How Does It Work?

Raloxifene acts like estrogen and decreases bone loss and thinning of bones in women after menopause, thereby preventing the bones from the risk of fracture. It reduces the risk of invasive breast cancer and uterine cancer by blocking estrogen in breast and uterine tissues.
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Interactions of Raloxifene

Interactions with other medicines

  • Cholestyramine (lipid-lowering medicine)
  • Anticoagulants/ blood thinners (Warfarin) because it may decrease the effectiveness of Raloxifene

Interactions with food items

No information is available on interactions of this medicine when taken with food, consult your doctor or pharmacist for further details.

Dietary Restrictions of Raloxifene

No information is available on dietary restrictions while you are taking Raloxifene, consult your doctor or pharmacist for further details.

Dosage of Raloxifene


Overdose of this medicine may lead to cause symptoms such as diarrhea, flushing, loss of coordination, severe leg cramps, tremors and vomiting. Seek immediate medical care in case of an overdose of this medicine.
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Missed a Dose

Take the missed dose as early as you remember. Skip the missed dose if it is too late and continue as per schedule. Do not take extra medicine to compensate for the missed dose.

Content Details


Dr. Rukman Mecca

MBBS, MD (Community Medicine)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking this medicine?

A: Give a detailed account of your medical and surgical history. Also, notify your doctor of all the prescription and non-prescription medicines, herbal preparations and nutritional supplements that you may be taking before starting this medication.

Q: What special precautions should I follow?

A: If you are traveling while taking this medicine, try to avoid sitting in one place for a long time to prevent the risk of clotting.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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