Ivabradine

Molecule Description

Ivabradine is used to lower the heart rate and chest pain in patients who do no

t tolerate regular medications, and whose pumping efficiency of the heart is low.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Ivabradine

Prolonged standing chest pain which has a definite pattern of the same intensity and is aggravated by the same factors (chronic stable angina) in patients who are not tolerating regular medicines (Iva...

Contraindications of Ivabradine

When should one not use Ivabradine

Allergy to Ivabradine or any of its components
If your heart rate (at rest) before treatment is slow (less than 70 beats per minute)
Low blood pressure due to impaired pumping ability of the heart (cardiogenic shock)
Abnormal heart rhythms
Low blood pressure, prone to heart attacks
Sudden, severe irregular chest pain with no definite pattern (unstable angina)
If you have an artificial pacemaker
Severe liver disease (under treatment)

Side effects of Ivabradine

Common side effects of this drug are:

Visual disturbances (alternating between normal and increased brightness, a condition known as luminous visual phenomena)
Slowing down of heart rate
Rapid, irregular heartbeats, heavy heartbeats (palpitations - you can feel the pulse), high blood pressure, headache, feeling dizzy, spinning of the head (vertigo), blurry vision
Feeling sick, difficulty in breathing, loose motions, constipation, stomach pain, muscle cramps, vision problems, double vision
High levels of uric acid, eosinophils (white blood cells increased in allergy), creatinine in the blood
Skin rashes, swollen face, tongue, throat, and difficulty in breathing (angioedema)
Low blood pressure, feeling tired and weak, abnormal ECG
Red, itchy, skin rashes due to allergy (urticaria or hives), feeling sick

Precautions and Warnings of Ivabradine

Pregnancy

Can I take Ivabradine during pregnancy?

Ivabradine can cause harm to the unborn baby and is not recommended during pregnancy or if you are planning to become pregnant.

Breast Feeding

Can I take Ivabradine while breastfeeding?

As Ivabraine is secreted in breast milk and has the potential to cause harm to the newborn baby, so the medicine is not recommended if you are breastfeeding.

Driving

Can I drive if I have consumed Ivabradine?

Ivabradine may cause visual disturbances and strict caution is advised especially at nights. But if you have experienced any such symptoms or dizziness or lightheadedness, it is recommended to avoid driving.

Alcohol

Can I consume alcohol with Ivabradine?

Both alcohol and Ivabradine reduce your heart rate and blood pressure and hence alcohol consumption is not recommended as it may cause any unwanted effects.

Other General Warnings

Talk to your doctor if

Irregular heartbeats (atrial fibrillation) and heart rhythm, chest pain, abnormal ECG
Heart symptoms such as difficulty in breathing, feeling tired or dizzy
High pulse rate at rest (over 110 beats per minute)
Recent brain stroke (high blood pressure causing rupture of blood vessels in the brain)
Uncontrolled blood pressure (high or low)
Reduced pumping efficiency of the heart due to defective signaling (bundle branch block)
Eye, liver or kidney problems

Mode of Action of Ivabradine

How Does It Work?

The sinoatrial node or the SA node is a specialized structure in the heart which is known as the natural pacemaker because it controls and regulates the heart rate. Ivabradine works by a unique mechan...

Interactions of Ivabradine

Interactions with other medicines

Rifampicin (used to treat TB)
Fluconazole (antifungal)
Medicines used to treat seizure, anxiety (Phenytoin, Barbiturates)
Anti-psychotic/ anti-depressant medicines (Pimozide, Ziprasidone, Sertindole, St. John’s wort)
Medicines used to treat heart rhythm abnormalities (Quinidine, Disopyramide, Ibutilide, Sotalol, Amiodarone)
Anti-malarial medicines (Mefloquine, Halofantrine)
Bepridil (used to treat chest pain, high blood pressure)
Cisapride (increases motility of the intestines)
Certain medicines used to high blood pressure and associated swelling (Diuretics - Furosemide, Hydrochlorthiazide, Indapamide)
Antifungals (Ketoconazole, Itraconazole)
Certain antibiotics when given orally (Clarithromycin, Erythromycin, Telithromycin, Josamycin)
Medicines used to treat HIV/ AIDS (Nelfinavir, Ritonavir)
Nefazodone (anti-depressant)
Diltiazem, Verapamil (used to treat high blood pressure or chest pain)

Interactions with food items

Food slightly increases the efficacy of Ivabradine and hence is advised to be taken with meals.

Dietary Restrictions of Ivabradine

Grapefruit juice should be avoided as it can increase the levels of Ivabradine and therefore reduce your heart rate.

Dosage of Ivabradine

Overdose

The overdose of Ivabradine will slow down the heart rate significantly and hence caution is advised. If you experience any symptoms such as feeling dizzy, head spinning, fainting or low pulse or heart...

Missed a Dose

If you forget the dose of Ivabradine, skip the missed dose and continue with the regular schedule. Do not take a double dose to compensate for a missed dose.

Content Details

WRITTEN BY

Dr. Arpit Verma

MBBS, MD CCEBDM Diabetology

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: How is Ivabradine different from other regular heart medicines?

A: Ivabradine has a unique mechanism of action and should not be used in all patients. It acts on a specialized muscle that regulates the heart rate in our body (called the pacemaker) and reduces the heart rate. If you have to use Ivabradine, the heart should be in normal rhythm called the sinus rhythm (which means you should not have any irregular heartbeats or abnormal rhythms), your heart rate should not be abnormally low (not less than 70 beats per minute), and your heart is pumping lesser blood than what is safe (ejection fraction ≤ 35%).

Q: Is there anything else I need to know while taking Ivabradine?

A: While using Ivabradine, you may experience bright visions for brief moments (called luminous visual phenomena). This may be accompanied by colored flashes, multiple images, bright circles (halo), etc. These symptoms mostly occur when you start treatment with Ivabradine and will resolve in the first two months. Hence you are advised not to discontinue the medicine if you experience any visual symptoms within the first two months and inform your doctor if they persist beyond two months. Ivabradine has to be stopped if there is no improvement in symptoms within 3 months of starting this medicine. Inform your doctor if this applies to you. The dose of Ivabradine has to be reduced if your heart rate falls below 50 beats per minute. If it remains low and does not improve after decreasing the dose, the medicine may have to be discontinued.

References

Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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एक स्वस्थ जीवन जीने और वज़न कम करने के लिए हम अलग-अलग तरीकों और स्वास्थ्यवर्धक काढ़ों जैसी चीज़ें आज़माते रहते हैं। अनगिनत स्वास्थ्य लाभों का वादा करने के अलावा, ये शरीर को डिटॉक्स करने और वज़न घटाने में मदद करने का भी दावा करते हैं। लेकिन एक पेय (ड्रिंक) है जो ऐसा करने में कामयाब

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परिचय: “बिना मशरूम के खाना बिना बारिश के दिन जैसा होता है”। मशरूम या अगरिकस बिस्पोरस न तो सब्ज़ी है और न ही फल, बल्कि यह खाई जाने वाली एक फंगस है। बाजार में इसकी अलग-अलग किस्में (ताजा व सूखा) उपलब्ध हैं; जिसमे ओएस्टर , पोर्सिनी और बटन सबसे आम किस्में हैं। आमतौर पर, मशरूम

आंवला (Gooseberry in Hindi) के उपयोग, फ़ायदे और न्यूट्रिशनल वैल्यू

परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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