Aqueous humor is a clear watery fluid produced in the eye whose primary function is to maintain the shape of the eye and nourish it. This fluid is continuously produced, and hence an efficient fluid handling network is required to balance the new fluid produced and the old fluid. There are two kinds of pathways that the eye uses to remove the old fluid – the main pathway (trabecular outflow) and a second pathway (uveosacral outflow). Blockage of either or both of the paths will raise the pressure of this fluid in the eye and causes glaucoma. Uncontrolled pressure will affect the optic nerve which transmits signals from the eye to the brain. Damage to this nerve will result in blindness. If the main pathway (trabecular outflow) is blocked (which is common with increasing age), the condition is called open-angle glaucoma and if both the pathways are blocked, it is known as ‘closed-angle glaucoma’. While open-angle glaucoma is not painful and the patient usually does not know about the progression of the disease and it may be late by the time this condition is detected. When diagnosed, this condition is treated with eye drops. Surgery may be required if eye drops don’t work. Closed-angle glaucoma is a painful and emergency condition and the pressure is relieved by laser procedures.

Brimonidine

Q: How should I use Brimonidine eye drops?

Wash your hands before using the eye drops , Tilt your head in such a way that you are facing the ceiling. Pull the lower lid gently and squeeze a drop from the bottle into your eye , Close the eye and press it with your finger for 1 minute to prevent any leakage , Do not touch the dropper to the eye. Once used, close the cap tightly , If more than one topical ophthalmic product (eye product) is being used, the products should be administered at least 5-15 minutes apart , Brimonidine should not be used in children below 12 years of age

Molecule Description

Brimonidine is useful as eye drops for lowering the eye pressure in conditions

like glaucoma where there are vision problems due to increased pressure of fluids in the eyes. It belongs to a class of medicines called Alpha Agonists.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Brimonidine

Brimonidine is used to lower the pressure in the eyes (intraocular pressure) of the patients whose eye pressure is raised to block drainage of the eye fluid (open-angle glaucoma) or due to any other c...
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This medicine can be used alone or in combination with other medicines for this treatment

Contraindications of Brimonidine

When should one not use Brimonidine

Allergy to Brimonidine or any other components of the medicine
Children below the age of 2 years (neonates and infants)
If you are taking any antidepressants or anti-psychotic medicines (Rasagiline, Selegiline, Amitriptyline, Imipramine, etc.)

Side effects of Brimonidine

Common side effects of this drug are:

Irritation, redness, burning or white spots on the eye, blurred vision, dry eyes
Swelling of eyelids, sticky eyes, increased sensitivity to light, vision problems, mild infection of the eye (conjunctivitis)
Headache, dry mouth, tiredness, weakness, drowsiness, cold, feeling dizzy, stomach pain and discomfort, abnormal taste
Dry nose, depression, irregular heartbeats, general allergic reactions, breathing problems

Precautions and Warnings of Brimonidine

Pregnancy

Can I take Brimonidine during pregnancy?

Adequate data is not available. Brimonidine can be used in pregnancy only if it is necessary and alternatives are not available. The decision has to be taken by your doctor.

Breast Feeding

Can I take Brimonidine while breastfeeding?

It is unknown if Brimonidine secretes in breast milk. It is advised not to use this medicine while breast-feeding.

Driving

Can I drive if I have consumed Brimonidine?

Brimonidine can cause fatigue, drowsiness, blurred, or abnormal vision. Stay away from driving if you experience any of these symptoms. Be cautious while taking this medicine, especially at night.

Alcohol

Can I consume alcohol with Brimonidine?

Brimonidine can cause drowsiness and depression which are also caused by alcohol. Hence, only occasional drinking is recommended while taking this medicine.

Other General Warnings

Talk to your doctor if

You have depression, lower blood supply to brain, heart, kidney or liver problems (past history) and blocked blood vessels or blood pressure disorders.

Mode of Action of Brimonidine

How Does It Work?

In conditions like glaucoma, the regulation that balances production and drainage of the watery fluid (aqueous humor), that nourishes the eye is lost leading to increased volume of this fluid, this bu...
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Brimonidine works by a dual action of blocking the production of this fluid by increasing the drainage (removal of the fluid from the eye)

Interactions of Brimonidine

Interactions with other medicines

Antidepressants or anti-psychotic medicines (Rasagiline, Selegiline, Amitriptyline, Imipramine, etc.)
Medications that cause depressive effects on the brain (anti-anxiety medicines, sleeping pills, anesthesia medicines)
Other medicines used to treat hypertension or heart conditions (Isoprenaline, Prazosin, etc.)

Interactions with food items

A person can use Brimonidine before or after the meals.

Dietary Restrictions of Brimonidine

No information is available on dietary restrictions while you are taking Brimonidine, consult your doctor or pharmacist for further information.

Dosage of Brimonidine

Overdose

If you use more eye drops than required, it may not be harmful. Inform your doctor in case of symptoms like drowsiness, eye irritation or swelling, or sometimes low blood pressure. But if in case of a...

Missed a Dose

Take the missed dose as early as you remember. Skip the missed dose if it is too late and do not take extra medicine or double dose to compensate for the missed dose.

Content Details

WRITTEN BY

Dr. Ravi Kakarla

MBBS, MBA

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: What is glaucoma?

Aqueous humor is a clear watery fluid produced in the eye whose primary function is to maintain the shape of the eye and nourish it. This fluid is continuously produced, and hence an efficient fluid h...
Read more

Q: How should I use Brimonidine eye drops?

Wash your hands before using the eye drops
Tilt your head in such a way that you are facing the ceiling. Pull the lower lid gently and squeeze a drop from the bottle into your eye
Close the eye and press it with your finger for 1 minute to prevent any leakage
Do not touch the dropper to the eye. Once used, close the cap tightly
If more than one topical ophthalmic product (eye product) is being used, the products should be administered at least 5-15 minutes apart
Brimonidine should not be used in children below 12 years of age

References

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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मशरूम (Mushroom in Hindi) के उपयोग, फ़ायदे, और न्यूट्रिशनल वैल्यू

परिचय: “बिना मशरूम के खाना बिना बारिश के दिन जैसा होता है”। मशरूम या अगरिकस बिस्पोरस न तो सब्ज़ी है और न ही फल, बल्कि यह खाई जाने वाली एक फंगस है। बाजार में इसकी अलग-अलग किस्में (ताजा व सूखा) उपलब्ध हैं; जिसमे ओएस्टर , पोर्सिनी और बटन सबसे आम किस्में हैं। आमतौर पर, मशरूम

आंवला (Gooseberry in Hindi) के उपयोग, फ़ायदे और न्यूट्रिशनल वैल्यू

परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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