Warfarin

Molecule Description

Warfarin prevents the formation of clots in blood vessels and their migration a

long the blood flow to distant parts. It belongs to a class of medicines called anticoagulants.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Warfarin

Atrial fibrillation (rapid, irregular heartbeats)
Rheumatic heart disease (disease of heart valves)
Deep Vein Thrombosis (DVT) (blood clots in deeper veins, usually the legs)
Pulmonary embolism (a blood clot passes along blood flow and blocks arteries that supply the lungs, most commonly from deep veins of the leg)
Transient Ischemic Attack (TIA) (clots in the blood vessels supplying the brain causing temporary damage)

Contraindications of Warfarin

When should one not use Warfarin

Allergy/ allergic reactions to Warfarin or any other ingredients of the medicine
Uncontrolled bleeding
Open wounds
Active ulcer disease; infection of the outer lining of the heart (pericarditis)
Rupture of blood vessels in the brain (haemorrhagic stroke)
Recent brain, eye or spinal cord injury or surgery (within 72 hours)
Liver or kidney disease
Uncontrolled hypertension
Any condition that causes easy bruising (Cushing’ syndrome, haemophilia, end-stage kidney disease, etc.)

Side effects of Warfarin

Common side effects of this drug are:

Unexplained bleeding from the nose
Black or red stools due to internal bleeding
Dark red or brown urine which may be due to your kidney or bladder conditions
Fever
Nausea and vomiting
Allergic reactions
Skin rashes & hair loss
Diarrhea
Purple discolouration of the skin (bruising)
Jaundice (yellowing of skin or white of eyes)
Changes in the quantity of urine you pass
Painful skin rash that may lead to severe complications (serious but rare)

Precautions and Warnings of Warfarin

Pregnancy

Can I take Warfarin during pregnancy?

Warfarin has the potential to cross the placental barrier and causes severe damage to the unborn baby and is not recommended during or if you are planning a pregnancy.

Breast Feeding

Can I take Warfarin while breastfeeding?

Warfarin does not pass into breast milk but caution is advised while breastfeeding. It is recommended that a woman who wishes to breastfeed while taking Warfarin should consult with a doctor.

Driving

Can I drive if I have consumed Warfarin?

Warfarin does not affect your driving ability.

Alcohol

Can I consume alcohol with Warfarin?

Large amounts of alcohol while may reduce Warfarin levels in the blood and hence occasional mild to moderate alcohol consumption is permitted.

Other General Warnings

Talk to your doctor if

You have blood disorders (such as anemia, hemophilia)
Bleeding problems (bleeding of the stomach/ intestines)
Bleeding in the brain
Blood vessel disorders (such as aneurysms)
Recent major injury/ surgery
Kidney and liver disease
Alcohol use
Mental/ mood disorders (including memory problems)
Frequent falls/ injuries, risk of haemorrhage (any clotting factor deficiency)
Ulcers in the stomach (or elsewhere)
Any planned surgeries or dental procedures
Thyroid disorders
To monitor prothrombin time (time taken for the blood to clot) in the initial days of starting the therapy

Mode of Action of Warfarin

How Does It Work?

Warfarin helps to keep blood flowing smoothly in your body by decreasing the amount of certain substances (clotting proteins) derived from Vitamin K in your blood. Effectively, Warfarin works by reduc...

Interactions of Warfarin

Interactions with other medicines

NSAIDs (painkillers) medications increases the risk of gastrointestinal bleeding
Other similar medicines that reduce clotting (Clopidogrel, Bivalirudin, Dabigatran, Dipyramidole, Fondaparinux, Rivaroxaban, Tirofiban, Abciximab, Prostacyclin, Aspirin, etc.)
Medicines that increase the effect of Warfarin (Allopurinol, Erlotinib, Disulfiram, Ketoconazole, Fluconazole Statins, Erythromycin, Metronidazole, Omeprazole, Amiodarone, pain killers, Zafirlukast)
Medicines that decrease the effect of Warfarin (Phenobarbital, Phenytoin, Carbamazepine, Griseofulvin, oral contraceptives, Rifampicin, Azathioprine, etc.)
Antidepressant medications (Fluoxetine, Paroxetine, Sertraline, Citalopram, Duloxetine, Venlafaxine, Desvenlafaxine, etc.)
Some HIV medicines (Protease inhibitors - Nelfinavir, Ritonavir)
Corticosteroids (Prednisolone, Betamethasone, Triamcinolone, etc.)
Fibrinolytic drugs (Streptokinase, Alteplase)
Other medicine used to prevent or treat clot formation

Interactions with food items

Warfarin can be taken without regard to food – before or after meals.

Dietary Restrictions of Warfarin

Foods rich in Vitamin K include beef liver, broccoli, sprouts, cabbage, soya beans, spinach may interact with Warfarin
Drinking cranberry juice or taking other cranberry products (for example capsules or concentrates), might increase Warfarin’s “thinning” effect of the blood
Limit intake of garlic, ginger, gingko (used for mental disorders) and horse chestnut (used for healthy veins)

Dosage of Warfarin

Overdose

If you take an overdose of Warfarin, the complications may be fatal. Speak to your doctor immediately. Depending on your condition and overdosage, you may require hospital admission for treatment and ...

Missed a Dose

Take the missed dose as early as you remember. Skip the dose if it is almost time for your next scheduled dose. Do not take two doses in a day to compensate the missed dose as the complications can be...

Content Details

WRITTEN BY

Dr. Ravi Kakarla

MBBS, MBA

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: What is the best time to take Warfarin?

A: Warfarin can be taken at any time before or after meals but it is usually preferred in the evening. This is because the prothrombin test (to check the time taken for the blood to clot) is generally performed in the early morning and if a dose change is required, it can be done the same day after the blood test result.

Q: How to store this medicine?

A: Store in a cool dark place (not above 25-degree Celcius), in original package out of reach of children and pets. Check the expiry date at the time of buying.

References

Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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मशरूम (Mushroom in Hindi) के उपयोग, फ़ायदे, और न्यूट्रिशनल वैल्यू

परिचय: “बिना मशरूम के खाना बिना बारिश के दिन जैसा होता है”। मशरूम या अगरिकस बिस्पोरस न तो सब्ज़ी है और न ही फल, बल्कि यह खाई जाने वाली एक फंगस है। बाजार में इसकी अलग-अलग किस्में (ताजा व सूखा) उपलब्ध हैं; जिसमे ओएस्टर , पोर्सिनी और बटन सबसे आम किस्में हैं। आमतौर पर, मशरूम

आंवला (Gooseberry in Hindi) के उपयोग, फ़ायदे और न्यूट्रिशनल वैल्यू

परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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