Nimesulide+Drotaverine

• Nimesulide+Drotaverine is used to relieve abdominal pain caused usually by muscle spasms.
• It can be also used to relieve pain caused due to menstrual cramps.

When should one not use Nimesulide+Drotaverine

• If you are allergic to nimesulide, drotaverine or any other components of Nimesulide+Drotaverine.
• If you have a history of allergic reaction to pain killers of class NSAIDs (non-steroidal anti-inflammatory drugs).
• If you have a history of liver damage due to consumption of pain killers.
• If you have severe heart, liver or kidney problems.
• If you are suffering from porphyria (a rare inherited metabolic disorder).
• If you are suffering from or have a history of stomach and digestive system related ulcers and bleeding disorders.
• If you are suffering from or have a history of blood clotting disorders, brain-related bleeding disorders.
• If you are pregnant (especially in the last 3 months of the pregnancy) or are breastfeeding.
• This medicine should not be used in children below 12 years old.

Common side effects of this drug are:

• Nausea
• Vomiting
• Diarrhoea

Other General Warnings

• You are pregnant or planning a pregnancy.
• You develop an allergic reaction after taking Nimesulide+Drotaverine.
• You experience decreased hunger, nausea, vomiting, headache, stomach pain, tiredness and dark urine. Immediately contact your doctor.
• You are suffering from the digestive system or sores in the upper portion of the small intestine, disorders like ulceration or bleeding in the stomach.
• You have severe liver or kidney problems.
• You have experienced abnormal bleeding issues, blood clotting disorders.
• You have a fever.
• You have heart-related disorders like heart failure.
• You have low blood pressure.
• You consume alcohol regularly.
• You are taking painkillers.
• This medicine is to be administered to elderly patients carefully.
• Nimesulide+Drotaverine is not recommended in children.

How Does It Work?

• Nimesulide+Drotaverine works by the combined action of both its components - Nimesulide and Drotaverine.
• Nimesulide is a painkiller that relieves pain by blocking the production of a substance known as prostaglandin, which is produced by the body causing symptoms like pain and swelling.
• Drotaverine is a medicine of class antispasmodic medication that works by relaxing the muscles.

Interactions with other medicines

• Concomitant use of Nimesulide+Drotaverine along with medicines used to relax the blood vessels to increase blood supply especially during chest pain and heart failure (Isosorbide mononitrate) should be done with caution as drotaverine increases the effect of this medicine.
• It is not advised to administer Nimesulide+Drotaverine in individuals who are on blood thinners (warfarin) and other non-steroidal anti-inflammatory agents like acetylsalicylic acid as it may increase the risk of abnormal bleeding.
• Concomitant use of Nimesulide+Drotaverine with water pills (furosemide) is not advised as nimesulide interferes with the action of furosemide on sodium-potassium concentrations delaying its excretion from the kidney.
• Caution is advised with the concomitant use of levodopa (antiparkinson medicine), as the antiparkinsonian effect of levodopa may be reduced and muscle rigidity and tremors may worsen due to drotaverine.
• Nimesulide, the active ingredient in Nimesulide+Drotaverine interacts with the medicine methotrexate (an anticancer and immunosuppressant medicine) increasing its toxic effect.
• This medicine inhibits an enzyme CYP2C9, which is essential in the metabolism of various medicines of class pain killers, oral diabetic medications and blood thinners.
• Nimesulide, the active ingredient in Nimesulide+Drotaverine when given with cyclosporine (ciclosporins - class of medicine used to suppress the immune system) may increase the risk of poisonous/harmful effects on the kidney.
• Discuss with your doctor about any other medicine, herbal preparation and supplements you are taking currently to avoid any possible drug interactions.

Interactions with food items

Overdose

Missed a Dose