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Flupentixol / Flupenthixol

Molecule Description

Flupentixol is an antipsychotic neuroleptic medicine that is used in combinatio

n with drugs for schizophrenia in patients who have poor compliance with the previous medication and suffer from frequent relapses of illness.


Uses of Flupentixol / Flupenthixol

  • It is used in the treatment of schizophrenia
  • It is also used to treat other psychoses

Contraindications of Flupentixol / Flupenthixol

When should one not use Flupentixol / Flupenthixol

  • If you are allergic (hypersensitive) to Flupentixol or any other Thioxanthene drugs or antipsychotic drugs or any of the other ingredients of this medicine
  • If you are feeling less alert than usual or are feeling drowsy or sleepy, or have serious problems with your blood circulation
  • If you are excited or agitated

Side effects of Flupentixol / Flupenthixol

Common side effects of this drug are:

  • Rigidity
  • Tremors
  • Restlessness
  • Insomnia
  • Dryness of mouth
  • Weight gain
  • Sexual dysfunction
  • Galactorrhea
  • Menstrual disturbances

Precautions and Warnings of Flupentixol / Flupenthixol



Can I take Flupentixol / Flupenthixol during pregnancy?
If you are pregnant or you think that you might be pregnant, tell your doctor. It must not be used during pregnancy unless necessary.

Breast Feeding

Can I take Flupentixol / Flupenthixol while breastfeeding?
It should not be used when breastfeeding as small amounts of the medicine can pass into the breast milk.


Can I drive if I have consumed Flupentixol / Flupenthixol?
There is a risk of feeling drowsy or dizzy when being treated with Flupentixol, especially at the start of your treatment. If this happens, do not drive.


Can I consume alcohol with Flupentixol / Flupenthixol?
Flupentixol may increase the sedative effects of alcohol, making you drowsier. It is recommended not to drink alcohol during treatment with this.

Other General Warnings

Talk to your doctor if
  • If you have a heart condition, including an irregular heartbeat (such as a slower heartbeat); have had a recent heart attack or have problems that cause ankle swelling or shortness of breathe
  • If you have severe breathing problems (such as asthma or bronchitis), have liver, kidney or thyroid problems
  • If you have epilepsy or have been told that you are at risk of having fits (for example because of a brain injury or because of alcohol withdrawal)

Mode of Action of Flupentixol / Flupenthixol

How Does It Work?

These medicines act on nerve pathways in specific areas of the brain by blocking the D1 and D2 (dopamine receptors) and helps to correct specific chemical imbalances in the brain that are causing the ...
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Interactions of Flupentixol / Flupenthixol

Interactions with other medicines

  • Interactions with other medicines
  • Tell your doctor if you are under any of the following medications:
  • Tricyclic antidepressants
  • Barbiturates or other medicines that make you feel drowsy
  • Anticoagulant drugs like Warfarin (used to prevent blood clots)
  • Anticholinergic drugs (contained in some cold, allergy or travel sickness remedies as well as other medicines)
  • Metoclopramide (to treat nausea and other stomach conditions)
  • Piperazine (used to treat worm infections)
  • Levodopa or other medicines used to treat Parkinson’s disease
  • Sibutramine (used to reduce appetite)
  • Digoxin (to control heart rhythm)
  • Corticosteroids (e.g., Prednisolone)
  • Medicines that are used to lower the blood pressure such as Hydralazine, alpha-blockers (e.g., Doxazosin), beta-blockers, Methyldopa, Clonidine or Guanethidine
  • Medicines that can cause a disturbance in your water or salt balance (too little potassium or magnesium in your blood)
  • Medicines that can increase the concentration of Flupentixol in your blood
  • Medicines used to treat epilepsy
  • Medicines used to treat diabetes

Interactions with food items

This medicine increases the effects of alcohol on the brain, such as delirium, tremors, euphoria.

Dosage of Flupentixol / Flupenthixol


Flupenthixol appears to be relatively safe in overdose. Symptoms like low blood pressure, low blood volume shock, agitation, hallucinations or convulsions have been reported. Coma is also reported in ...
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Missed a Dose

Take the missed dose as early as you remember. Skip the missed dose if it is almost time for the next scheduled dose. Do not take extra medicine to compensate for the missed dose.

Content Details


Dr. Arpit Verma

MBBS, MD (Pharmacology)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: How long should the medicine be taken?

A: It may take between four and six months before you feel better. Your doctor will decide the duration of treatment.

Q: Can I stop the medicine if I feel better?

A: You must continue your medicine at regular intervals even if you are feeling completely well because the underlying illness may persist for a long time. If you stop your treatment too early, your symptoms may return.
Last Updated on: 24 Dec 2020 | 01:48 PM (IST)

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