Nateglinide

Molecule Description

Nateglinide is an oral anti-diabetic medicine which helps to lower your blood s

ugar (glucose) after meals.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Nateglinide

Type II diabetes

Contraindications of Nateglinide

When should one not use Nateglinide

Type 1 diabetes
Liver disease
Kidney disease
Diabetic ketoacidosis
Allergy to this medicine

Side effects of Nateglinide

Common side effects of this drug are:

Low blood glucose level (if meal is delayed or skipped)
Weight gain
Allergic reaction
Loose stools
Abdominal discomfort

Precautions and Warnings of Nateglinide

Pregnancy

Can I take Nateglinide during pregnancy?

It is not recommended for pregnant women, consult your doctor for safer alternatives.

Breast Feeding

Can I take Nateglinide while breastfeeding?

It is not secreted into breast milk. But still, do not breastfeed while you are taking Nateglinide without consulting your doctor because this medicine has the potential to cause low blood sugar in breastfed infants.

Driving

Can I drive if I have consumed Nateglinide?

You may experience blurred vision, drowsiness or dizziness due to extremely low or high blood sugar level. So it is advised not to drive or use machinery.

Alcohol

Can I consume alcohol with Nateglinide?

It is not recommended to consume alcohol while taking this medicine as alcohol may affect blood glucose levels in patients with diabetes and interferes with the activity of Nateglinide.

Other General Warnings

Talk to your doctor if

Be very careful about symptoms of low blood sugar like sweating, anxiety, fast heartbeat, headache, intense hunger, restlessness, dizziness, irritability. If you experience these, immediately ext suga...
Read more
Eat something sweet as soon as possible. If the symptoms persist even after this, seek emergency medical help
Tell your doctor if:
You have an allergy to this medicine
You have liver or kidney disease
Your body does not produce enough red blood cells
All your ongoing medications

Mode of Action of Nateglinide

How Does It Work?

Nateglinide works by blocking potassium channels, results in stimulating the release of insulin from the pancreas and lowers blood glucose levels.

Interactions of Nateglinide

Interactions with other medicines

Medicines used to control high blood pressure
Barbiturates
Carbamazepine
Chlorpromazine
Olanzapine
Clarithromycin
Erythromycin
Aspirin
Clopidogrel
Cyclosporine
Gemfibrozil
Ketoconazole and Itraconazole
Rifamycins and Rifabutin

Interactions with food items

Grapefruit or grapefruit juice.

Dietary Restrictions of Nateglinide

You should avoid trans fats, white bread, pasta and rice, fruit-flavored yogurt, sweetened breakfast cereals, flavored coffee drinks, grapefruit, honey, etc.

Dosage of Nateglinide

Overdose

If you happen to take an excessive dose of this medicine, it may lead to a drop in your blood sugar, leading to symptoms of hypoglycemia such as cold sweats, increase in heart rate, tremors, anxiety a...

Missed a Dose

If you missed a dose, take the next dose as usual but do not double the dose.

Content Details

WRITTEN BY

Dr. Mansi Savla

B. Pharm, PharmD

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: What precautions should one follow before starting treatment?

A: Nateglinide should be used with caution in elderly patients because they may be more sensitive to it. Nateglinide may cause changes in your blood sugar levels. One should be aware of the symptoms of high (hyperglycaemia) or low (hypoglycaemia) blood sugar episodes and be prepared to treat them.

Q: Can Nateglinide be taken during pregnancy or lactation?

A: Nateglinide is not safe in pregnancy. Consult your doctor before starting treatment. However, the patient is generally put on insulin therapy instead. It is not secreted into breast milk. But still, avoid breastfeeding while you are taking Nateglinide without consulting your doctor.

Q: What precautions should one take before going out for travel?

A: One should always carry some glucose, sugary food or fruit juice in case if experiences symptoms of low blood glucose level (hypoglycaemia ) such as cold sweats, increase in heart rate, tremors and anxiety.

References

Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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