Eltrombopag

Molecule Description

Eltrombopag belongs to a bunch of medicines known as Thrombopoietin Receptor Ag

onists. It is used to help increase the number of platelets in your blood. Platelets help to reduce or prevent bleeding.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Eltrombopag

Severe Aplastic Anemia
Chronic Immune Thrombocytopenia
Chronic Hepatitis C-associated Thrombocytopenia
Thrombocytopenic Purpura (ITP)

Contraindications of Eltrombopag

When should one not use Eltrombopag

If you are allergic to this medicine
If you have liver problems
If you have cataracts (the lens of the eye-getting cloudy)
If you have another blood condition such as Myelodysplastic Syndrome (MDS)

Side effects of Eltrombopag

Common side effects of this drug are:

Common side effects:
Common cold
Nausea
Diarrhea
Abdominal pain
Cough
Infection in the nose, sinuses, throat and upper airways, common cold (upper respiratory tract infection)
Muscle pain, muscle spasm, muscle weakness
Back pain, bone pain
Heavy menstrual period
Sore throat and discomfort when swallowing
Eye problems like dry eye, eye pain, and blurred vision
Vomiting
Flu (influenza)
Pneumonia
Hair loss
Loss of appetite
Swelling in the hands or feet
Serious side effects
High risk of blood clots
Liver problems- yellowing of the skin or eyes (jaundice), unusually dark-coloured urine, increased of liver enzymes
Bleeding or bruising after stopping treatment
Disturbances of heart rhythm (QT prolongation)

Precautions and Warnings of Eltrombopag

Pregnancy

Can I take Eltrombopag during pregnancy?

It is not advisable for pregnant women. The patient should use a reliable method of contraception. The patient should avoid taking it unless your doctor specifically recommends it.

Breast Feeding

Can I take Eltrombopag while breastfeeding?

Do not breastfeed while you are taking Eltrombopag. It is unknown if this medicine passes into breastmilk.

Driving

Can I drive if I have consumed Eltrombopag?

It can make you dizzy and have other side effects that make you less alert. Don’t drive until you feel alert or active.

Alcohol

Can I consume alcohol with Eltrombopag?

Make sure that you consult with your doctor before you take medicine under the influence of alcohol.

Other General Warnings

Talk to your doctor if

Inform doctor:
If you feel swelling, pain or tenderness in one leg
If you experience sudden shortness of breath especially together with sharp pain in the chest or rapid breathing
If you feel abdominal (stomach) pain, enlarged abdomen, blood in your stools

Mode of Action of Eltrombopag

How Does It Work?

Eltrombopag acts like a specific natural substance (Thrombopoietin) that binds to the Thrombopoietin Receptor and stimulates to produce more platelets in the bone marrow.

Interactions of Eltrombopag

Interactions with other medicines

Antacid medicines to treat indigestion, heartburn or stomach ulcers
Medicines called Statins - to lower cholesterol
Medicines to treat HIV infection, such as Lopinavir and Ritonavir
Ciclosporin used in the context of transplantations or immune diseases
Minerals such as iron, calcium, magnesium, aluminium, zinc which may be found in vitamin and mineral supplements
Medicines such as Methotrexate and Topotecan, to treat cancer

Interactions with food items

The patient should avoid taking dairy foods or drinks as the calcium in dairy products affects the absorption of the medicine.

Dosage of Eltrombopag

Overdose

If you overdose on the medicine, you may see symptoms such as severe disorders of blood cells and harmful effects of the bone marrow. Contact your doctor immediately.

Missed a Dose

If you missed a dose, take the next dose at the usual time. Do not take more than one dose.

Content Details

WRITTEN BY

Dr. Arpit Verma

MBBS, MD (Pharmacology)

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: How long does it take for the medicine to take effect?

A: You will feel the effect of this medicine in about 2 to 6 hours after the dose has been taken.

Q: How long does the effect of the medicine last?

A: No research indicates how long the medicine’s effect lasts in the body.

Q: What are the precautions to be taken while taking this medicine?

A: Swallow the tablet whole, with some water. Make sure that 4 hours before or 2 hours after you take this medicine, you don’t consume any of the following: dairy foods such as yoghurt, cheese, butter or ice cream, drinks containing milk, yoghurt or cream, milk or milkshakes, antacids (a type of medicine for indigestion and heartburn), some mineral and vitamin supplements including iron, calcium, aluminium, magnesium, selenium and zinc.

Q: What are the liver problems seen while taking this medicine?

A: There will be yellowing of the skin or eyes (jaundice), unusually dark coloured urine, increase of liver enzymes.

References

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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