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Molecule Description

Divalproex belongs to the group of medicine called anticonvulsants. It is used to control and manage a certain type of seizures.

Uses of Divalproex

  • To treat various types of seizure disorders
  • To treat manic episodes that are related to bipolar disorder (manic depression)
  • To prevent migraine headaches

Contraindications of Divalproex

When should one not use Divalproex

  • Depression
  • Dysfunction of the brain
  • Liver problems
  • High levels of ammonia in blood (associated with N Acetyl Glutamate Synthase deficiency)
  • Neurologic dysfunction
  • Inflammation of the pancreas
  • Pophyria
  • Pregnancy
  • Low amount of albumin proteins in the blood
  • Hereditary liver metabolism disorder
  • Decreased blood platelets
  • In those having thoughts of suicide
  • Known allergic reaction to the medicine and its analogues

Side effects of Divalproex

Common side effects of this drug are:

  • Drowsiness
  • Muscle Weakness
  • Diarrhea
  • Constipation
  • Upset stomach
  • Change in your menstrual periods
  • Enlarged breasts
  • Weight changes
  • Tremors
  • Hair loss
  • Vision changes
  • Unusual or unpleasant taste in your mouth
  • Unsteadiness
  • Changes in behaviour and mood

Precautions and Warnings of Divalproex


Can I take Divalproex during pregnancy?
You should not take this medicine during pregnancy as it may harm the unborn baby.

Breast Feeding

Can I take Divalproex while breastfeeding?
This medicine passes into breast milk, but if the mother requires Divalproex after the doctor’s consultation, it is not necessarily a reason to discontinue breastfeeding. Follow your doctor’s advice.


Can I drive if I have consumed Divalproex?
This medicine may cause problems with your vision and alertness, so it is not advisable to drive when taking this medicine.


Can I consume alcohol with Divalproex?
It is unsafe to consume alcohol with this medicine.

Other General Warnings

Talk to your doctor if
  • Older adults are more sensitive to the side effects of this medicine
  • Tell your doctor if:
  • You are pregnant
  • Diagnosed for any liver or kidney disease
  • Have a history of depression
  • You have conditions like rash or itching to skin, abnormal voice changes, trouble to breathe or swallow or in case any swelling to your hands, face, or mouth while taking this medicine
  • Any other medical conditions

Mode of Action of Divalproex

How Does It Work?

This medicine works by controlling abnormal electrical activity of the brain and balancing the levels of certain chemical substances in the brain.

Interactions of Divalproex

Interactions with other medicines

  • Certain antidepressants like Amitriptyline, Nortriptyline
  • Certain antibiotics like Carbapenems
  • Other medications for seizure
  • Antimalarial medicines like Mefloquine or Chloroquine
  • Rifampin
  • Warfarin
  • Vorinostat
  • Zidovudine

Interactions with food items

No specific data available

Dosage of Divalproex


Seek emergency medical attention or ask for help if you think you have used too much of this medicine. Symptoms of Divalproex overdose may include coma, extreme sleepiness, trouble in breathing and heart problems.
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Missed a Dose

If you missed any dose, take it as early as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosage schedule. Do not take a double dose of medicine to compensate for the missed one.
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Content Details


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking this medicine?

A: You should not use this medicine if you are allergic to it; or if you have liver disease, a urea cycle disorder, or a genetic mitochondrial disorder such as Alpers disease or Alpers Huttenlocher syndrome (especially in children younger than 2 years old). Discuss all your medical conditions with your doctor before taking medicine. Also, mention all your ongoing prescription and non-prescription medicines that you may be taking before you start on this medicine.

Q: When and how to consume medicine?

A: Take this medicine with a glass of water. Take it exactly as directed by your doctor. Do not take more or lesser dose than prescribed or for a shorter or longer duration than prescribed.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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