Divalproex

• To treat various types of seizure disorders
• To treat manic episodes that are related to bipolar disorder (manic depression)
• To prevent migraine headaches

When should one not use Divalproex

• Depression
• Dysfunction of the brain
• Liver problems
• High levels of ammonia in blood (associated with N Acetyl Glutamate Synthase deficiency)
• Neurologic dysfunction
• Inflammation of the pancreas
• Pophyria
• Pregnancy
• Low amount of albumin proteins in the blood
• Hereditary liver metabolism disorder
• Decreased blood platelets
• In those having thoughts of suicide
• Known allergic reaction to the medicine and its analogues

Common side effects of this drug are:

• Drowsiness
• Muscle Weakness
• Diarrhea
• Constipation
• Upset stomach
• Change in your menstrual periods
• Enlarged breasts
• Weight changes
• Tremors
• Hair loss
• Vision changes
• Unusual or unpleasant taste in your mouth
• Unsteadiness
• Changes in behaviour and mood

Other General Warnings

• Older adults are more sensitive to the side effects of this medicine
• Tell your doctor if:
• You are pregnant
• Diagnosed for any liver or kidney disease
• Have a history of depression
• You have conditions like rash or itching to skin, abnormal voice changes, trouble to breathe or swallow or in case any swelling to your hands, face, or mouth while taking this medicine
• Any other medical conditions

How Does It Work?

Interactions with other medicines

• Certain antidepressants like Amitriptyline, Nortriptyline
• Certain antibiotics like Carbapenems
• Other medications for seizure
• Antimalarial medicines like Mefloquine or Chloroquine
• Rifampin
• Warfarin
• Vorinostat
• Zidovudine

Interactions with food items

Overdose

Missed a Dose