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Molecule Description

Desonide is a cream or ointment preparation commonly used for itchy, reddened skin rashes, which may be associated with skin peeling. It belongs to a class of medicines called ‘topical corticosteroids.’ Desonide is a mild corticosteroid.
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Uses of Desonide

  • To treat a variety of skin conditions involving rashes, itching, redness of skin with or without blisters or peeling off (e.g., eczema, dermatitis, allergies), that respond to this class of medicines (corticosteroids)
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  • To reduce the swelling, itching, and redness that can occur in these types of conditions due to over-reactive immune response (and not due to infections)

Contraindications of Desonide

When should one not use Desonide

In patients who experience allergic reaction to Desonide or any of its components.

Side effects of Desonide

Common side effects of this drug are:

  • Headache, rashes and burning at the region where medicine is applied
  • Itching, burning, dryness of mouth, irritation or stripes covering skin
  • Dilated blood vessels on skin (spider veins)
  • Infections of the hair follicle (folliculitis), loss of skin color
  • Rashes around the mouth, heat rashes, or rashes due to contact with clothes, watches or any objects regularly used (contact dermatitis), acneform eruptions (ruptured pimples) and secondary infections

Precautions and Warnings of Desonide


Can I take Desonide during pregnancy?
Enough data is not available. But medicines similar or closely related to Desonide (corticosteroids) are known to harm the baby. Hence, it is not recommended for use during pregnancy or unless the doctor feels no other alternatives are available.

Breast Feeding

Can I take Desonide while breastfeeding?
Due to lack of reliable data, Desonide is recommended to be used in breastfeeding mothers only if the doctor feels it is necessary and cannot be substituted. It is essential to ensure that the infant's skin does not come into direct contact with the areas of skin where this cream is applied.


Can I drive if I have consumed Desonide?
It is unknown if Desonide affects your ability to drive. Caution is advised in the presence of symptom such as headache.


Can I consume alcohol with Desonide?
No data available about the interaction of this medicine with alcohol. But it should be noted that liquor lowers immunity (which is also suppressed by Desonide) and delays the process of healing.

Other General Warnings

Talk to your doctor if
  • Higher dose or sensitivity to Desonide or using it for long periods can cause symptoms due to increased levels of corticosteroids in the body such as Cushing's syndrome (round and fatty face, weight gain, excess hair growth, irritability, menstrual irregularities, etc.), high blood sugars or unmasking of previously existing diabetes
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  • Periodic check-ups for these symptoms is required while on treatment with this medicine
  • Use of more than one medicine from this class (corticosteroids) at a time should be avoided

Mode of Action of Desonide

How Does It Work?

Desonide works by suppressing the immune response and preventing the formation of substances that the body secretes in case of over-reactivity of the immune system due to a triggering factor. These substances are responsible for symptoms such as rashes, itching, skin blisters, and peeling, and Desonide provides relief by suppressing this reactivity.
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Interactions of Desonide

Interactions with other medicines

  • Avoid:
  • Treatment with other medicines of the same class (corticosteroids or oral steroid therapy)
  • Use with caution
  • Ritodrine (used to delay preterm delivery)
  • Inform your doctor about all the medicines you are using (including prescription medicines, non-prescription medicines, and herbal products)

Interactions with food items

Desonide can be taken with or without food.

Dosage of Desonide


Accidental overdose of Desonide may not be harmful. But, if you experience any symptoms like burning, itching, rashes, headache or dry mouth, consult your doctor.

Missed a Dose

  • If you missed any application, reapply it as early as you remember. Desonide is usually prescribed twice a day and hence ensure there is enough time gap between 2 applications. If it is time for the next application, skip the missed one and continue your regular application schedule
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  • Do not apply twice to compensate for a missed application

Frequently Asked Questions (FAQs)


Q: Is there anything else I need to know before using Desonide?

  • Desonide acts by suppressing the immune response, and the activity of certain useful substances may also be decreased when treated with Desonide. Hence do not use this medicine for longer than necessary, ideally for not more than 4 weeks
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  • It can be given in adults, adolescents and children greater than 3 months of age
  • Do not apply it anywhere near the eyes, mouth or vagina
  • Be careful when using Desonide in children, and do not apply in skin folds such as underarms or groin areas, without the supervision of a doctor
  • Avoid applying tight bandages for longer periods or using other stronger medicines of the same class (corticosteroids)
  • Inform the doctor if you develop a skin irritation or infections or if the symptoms are not improving
  • Do not use Desonide for diaper rashes

Q: How should I use Desonide?

  • Desonide is available in foam, gel and lotion forms
  • The foam may have flammable properties. Avoid smoking or going near flames for some time after application
  • Use this medicine as directed by your doctor. Check the label on the medicine for exact dose instructions
  • Apply a small amount of this medicine to the affected areas
  • Wash your hands thoroughly before and after using the cream
  • Do not cover the treated area with bandages or other dressings for an extended period
  • Do not apply for more than 2-3 times a day
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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