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Combutol 400mg Tablet

10 Tablet(s) in Strip
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Combutol 400 MG Description

Combutol 400 mg Tablet belongs to the antitubercular group of medicines. The active ingredient in Combutol 400 mg Tablet is ethambutol. This medicine is an antibiotic used as a first-line medicine in

the treatment of tuberculosis along with the combination of other medicines. Tuberculosis affects different organs in our body like lungs in pulmonary tuberculosis, intestine in abdominal tuberculosis, etc. Ethambutol is represented by the letter ‘E’ in the chemotherapy of WHO proposed 6-8 month multi-medicine ‘short course’ regimens in the treatment of tuberculosis by categorising the patients. All the regimens have an initial intensive phase with 4-5 medicines lasting for 2-3 months with a goal of rapidly killing the bacteria. Added to the triple medicine regimen of RHZ (combination of rifampicin, isoniazid, and pyrazinamide), ethambutol has been found to hasten the rate of sputum conversion and to prevent the development of resistance. One of the main purposes of using ethambutol in first-line therapy is to prevent the development of resistance. Disclaimer: If you are experiencing cough along with the sputum for more than 2 weeks, it is better to consult a physician for the evaluation of tuberculosis


Product Summary

Offer Price₹21.05
You Save₹3.71 (15% on MRP)
ContainsEthambutol(400.0 Mg)
Side effectsEye-related problems, Skin rashes, Nausea (vomiting sensation), Vomitings, Diarrhoea, Pain and swelling of joints, Chills, Tense skin over affected joints, Yellowing of eyes (Jaundice)
Check more medicines with composition as Ethambutol(400.0 Mg)

Uses of Combutol 400 MG

  • Combutol 400 mg Tablet is used in,
  • Treatment of tuberculosis affecting various organs like pulmonary tuberculosis, tuberculous meningitis (affecting membranes around the brain), abdominal tuberculosis, urogenital tuberculosis (affectin...
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  • Re-treatment and prophylactic treatment of tuberculosis.

Contraindications of Combutol 400 MG

  • If you are allergic to ethambutol or any of its excipients
  • If you have any pre-existing health conditions like optic neuritis (inflammation of nerve fibres behind your eyes)
  • If you are suffering from serious liver conditions
  • If you are suffering from serious kidney problems

Side effects of Combutol 400 MG

  • Decreased vision,
  • Blurred vision
  • Optic neuritis (usually observed with higher dosage or overdose).
  • Skin rashes
  • Nausea (vomiting sensation)
  • Vomiting
  • Diarrhoea
  • Cardiac problems
  • Pain and swelling of joints
  • Chills
  • Tense skin over affected joints
  • Yellowing of eyes (Jaundice)

Precautions and Warnings of Combutol 400 MG



Can I take Combutol 400 mg Tablet during pregnancy?
Combutol 400 mg Tablet belongs to Category C medicine. There is not much evidence regarding its effects on pregnancy, but animal studies showed reproductive toxicity. So, it is advised to inform your doctor about your pregnancy or related future plans so that they can give you the appropriate treatment.

Breast Feeding

Can I take Combutol 400 mg Tablet while breastfeeding?
Combutol 400 mg Tablet or its metabolites may pass into breast milk. However, there is no proper evidence regarding the effect of this medicine on infants or newborns. It is advised to inform your doctor about the medicines you are using before breastfeeding.


Can I drive if I have taken Combutol 400 mg Tablet?
Combutol Tablet may affect your eyes and may cause sight-related problems. There are more chances of the problem if you have a pre-existing eye-related problem. So, it is firmly advised not to drive vehicles or operate any heavy machinery if you are taking Combutol 400 mg.


Can I consume alcohol with Combutol 400 mg?
There is not much evidence regarding the interaction of alcohol with Combutol Tablet. However, it is not advised to take alcohol while you are taking Combutol 400 mg as it may affect your liver. It should be avoided, especially if you have any pre-existing liver diseases or eye-related problems.

Other General Warnings

Talk to your doctor if
  • You have a history of liver disease, kidney disease, gout, eye-related problems.
  • You are pregnant, are planning a pregnancy, or you conceive during the course of medication.
  • You observe any changes in your vision or any eye-related problems while you are on Combutol 400 mg. It is advised to have regular eye checkups, especially if you have any pre-existing eye-related pro...
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  • You have had tuberculosis in the past. Inform your doctor about treatment history and medicines used so that appropriate medicines can be prescribed.
  • You experience side effects that persist or worsen in time.
  • Do not stop taking Combutol 400 mg abruptly without consulting your physician.

Mode of Action of Combutol 400 MG

How Does It Work?

Ethambutol is the active ingredient of Combutol Tablet. The mechanism of action of ethambutol is not fully understood. But it has been found to inhibit arabinosyltransferase(an enzyme involved in arab...
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Directions for Use of Combutol 400 MG

  • Take Combutol 400 mg Tablet exactly as prescribed by your physician.
  • Do not exceed the prescribed dosage or miss a dose.
  • Do not discontinue the medication until the completion of the course or as directed by your physician even if the symptoms disappear.
  • Take Combutol Tablet as a whole, with a glass of water.
  • Do not break this medicine or chew it.
  • For optimal pharmacological effects, it is better to take the tablet at the same time every day.
  • It is advised to note down the days of consumption of the tablet in a week in order to avoid missing the doses or to avoid overdose.

Interactions of Combutol 400 MG

Interactions with other medicines

  • Inform your physician about any other medicines or supplements you are taking to avoid side effects associated with medicine interaction.
  • It is advised to take Combutol 400 mg Tablet 2 hours before you take antacids. Antacids containing Aluminium hydroxide are known to decrease the absorption of Combutol 400 mg. Your doctor may advise a...
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  • Vitamin supplements may also interact with Combutol 400 mg Tablet. So, it is advised to inform your physician about your treatment history before prescribing the medications.

Interactions with food items

  • Combutol 400 mg Tablet can be taken with or without food. There is no proper evidence of its interaction with the food. However, if you observe any difficulty while taking Combutol 400 mg Tablet along...
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Storage and disposal of Combutol 400 MG

Combutol Tablet should be stored at room temperature in a dry container. Keep it out of reach of children. Avoid exposing the medicine to heat, sunlight, or moisture. Open the seal only before taking ...
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Dosage of Combutol 400 MG


Overdose of Combutol Tablet may cause symptoms like vomiting, fever, headache, dizziness, disorientation, etc. Additionally, if you experience any side effects like vision problems, skin-related probl...
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Missed a Dose

If you miss a dose of Combutol Tablet, take it as soon as you remember. But if it's almost the time for the next dose, avoid taking the missed dose. Inform your physician about your missed dose. The g...
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Content Details


Dr. Varsha Parihar

MBBS, MD (Community Medicine)

Frequently Asked Questions (FAQs)


Q: What happens if I stop taking Combutol 400 mg after my symptoms subside?

A: If you start the short-course regimen, your symptoms may subside by the 2nd month. Usually, many people discontinue taking Combutol Tablet from then onwards. It may be harmful as it may lead to the development of resistant bacteria, and you may land into MDR-TB ( Multidrug-resistant tuberculosis). It is a condition where the bacteria in your body have developed resistance, and you may have to add more medications to your list to control it for extended durations.

Q: What symptoms should I observe if I have a history of liver disease?

A: You should keep an eye on the symptoms like yellowing of skin or eyes, dark urine, stomach upset, etc. Consult your physician immediately if you observe any.

Q: Can I use Combutol in other doses if Combutol 400 mg is not available?

A: No, you should not take Combutol in other doses if Combutol 400 mg is not available. You should bring it to your doctor’s notice.

Q: What symptoms should I observe if I have a history of eye-related problems?

A: Bring it to your doctor’s notice if you observe decreased or blurred vision, Optic neuritis (usually observed with higher dosage or overdosage). Early detection of these problems may help prevent the deterioration of the condition as these changes are reversible by stopping or decreasing the dose of the medicine as advised by your doctor.
Product Details
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Last Updated on: 15 Feb 2022 | 03:36 PM (IST)
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