Spenzo Depot 40mg Injection 2ml
2ml Injection in AmpouleWe do not sell this product
Made by
INTAS PHARMACEUTICALS LTD
Dosage
INJECTION
Expiry
Product Summary
| Salt Content | Flupentixol / Flupenthixol(40.0 Mg) |
| Uses | Management of schizophrenia, psychogenic depression, and other forms of psychoses. |
| Therapy | Anti-psychotics |
| Side effects | Drowsiness, dry mouth, constipation, vomiting, abdominal pain, nausea, |
Assurance
available
Regulated
Medical Description
Spenzo is a prescription medication. It is available in the form of a depot injection. The active component of Spenzo is Flupentixol. Spenzo is an antipsychotic used to manage schizophrenia and other forms of psychosis and depression associated with psychotic symptoms.
Schizophrenia is a disorder where patients have an altered perception of reality, affecting how they feel, think, and behave. They can present with hallucinations, delusions, altered perceptions, mood changes, and disorderly thinking. There are certain chemical messengers (neurotransmitters), and pathways in the brain that are thought to produce the symptoms of schizophrenia, chief among which is the hyperactivity of one neurotransmitter called Dopamine.
Depression is characterized by complaints like feeling low, decreased motivation, feelings of hopelessness and dread, and loss of interest in daily activities. Psychogenic depression can manifest with psychotic symptoms, like hallucinations and delusions, with severe loss of interest in activities and even suicidal ideation.
Depot injections are designed to release small amounts of the medication over an extended period. This reduces the number of times the medicine has to be administered to the patient.
Uses
- Schizophrenia
- Psychoses
- Psychogenic Depression
Contraindications
- If you’re hypersensitive to Flupentixol or any component in this injection.
- If you’ve a decreased level of consciousness due to any cause or coma.
- If you have severe liver disease or kidney failure.
- If you have any heart disease.
- If you have severe respiratory failure, obstructive sleep apnea, or any conditions resulting in respiratory depression.
- If you have known epilepsy or any condition that predisposes seizures like alcohol withdrawal.
- If you have Parkinson’s disease.
- If you have prolactin-dependent tumours such as pituitary prolactinomas and breast cancer.
- If you have dementia with Lewy body.
- If you have narrow-angle glaucoma, urinary retention, or prostate enlargement.
- If you have thyroid disorders (hypothyroidism or hyperthyroidism).
- If you’ve Myasthenia gravis, a condition that affects muscle strength and respiration.
- If you have Phaeochromocytoma, a tumour of the adrenal glands.
Side effects
Extrapyramidal effects, especially in the initial phase of the treatment, such as rigidity, muscle spasms, slowness of movements, tremors, irregular movements, etc.
Drowsiness
Dry mouth
Increased appetite
Weight gain
Constipation
Urinary retention
Increased prolactin levels
Fall in blood pressure on change in position (orthostatic hypotension)
Sleepiness
Restlessness
Nervousness
Sexual dysfunction
Decreased blood sugar control in diabetics
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have a history of seizures or are taking any medications known to decrease seizure potential.
- You witness any sudden mood changes or worsening symptoms of schizophrenia
Directions for Use
- Spenzo should be used as directed by your treating physician only.
- It should be administered only by a trained healthcare professional.
- Do not self-administer Spenzo.
- Spenzo should not be administered outside of a healthcare facility setting.
- Do not use it if the solution is not clear or has any suspended matter.
- It is recommended to finish the entire course of Spenzo as prescribed by your treating doctor. Abrupt stoppage of the medicine can cause recurrence/ worsening of symptoms. Consult your doctor before stopping Spenzo.
- Inform your doctor regarding other medications you may be taking to review and prevent any medicine interaction-associated effects.
Storage and disposal
Store in a cool and dry place away from direct light and moisture. Do not use the medicine after the date of expiration. Keep it away from children and pets. Do not flush the medication down the toilet. Dispose of it with biomedical waste only.
Dosage
Overdose
Overdose is characterised by sedation, extreme agitation, excitement, confusion, sleepiness, coma, convulsions, and hyperthermia or hypothermia. Extrapyramidal symptoms or respiratory and circulatory collapse may also occur. It can also result in abnormal heart rhythm activities.
In case of overdose, symptomatic treatment should be initiated with airway management. Immediately rush the patient to the nearest tertiary care centre for emergency management as it is life-threatening.
Missed a Dose
Spenzo should be administered only by a trained healthcare professional. In case you miss a dose, contact your treating physician immediately. Do not self-administer this injection under any circumstance. Do not increase the dose.
Mode of Action
How Does It Work?
Flupentixol is a non-sedating, first-generation antipsychotic medication. It acts on two chemicals that act as signals in the brain, otherwise known as neurotransmitters. The neurotransmitters involved here are primarily Dopamine and, to some extent, Serotonin. Flupentixol effectively blocks the dopamine and serotonin receptors. This produces therapeutic effects in managing psychotic symptoms associated with schizophrenia and depression and other forms of psychoses.
Interactions
Interactions with other medicines
- The concomitant use of Flupentixol with CNS depressants like alcohol and barbiturates can potentiate their effects resulting in marked CNS depression.
- Flupentixol enhances the effects of general anaesthetics resulting in prolonged anaesthesia.
- It can increase the effect of anticoagulant medications resulting in bleeding.
- It increases the anticholinergic effects of medicines like atropine etc., resulting in marked urinary retention, constipation, orthostatic hypotension, pupillary constriction, sedation, hallucinations, and memory impairment.
- It should not be used with Metoclopramide, Piperazine, or anti-Parkinson medicines. This may increase the risk of Tardive Dyskinesia, a severe side effect characterised by uncontrollable, jerky movements of lips, face, trunk, and extremities.
- Spenzo can enhance the blood pressure lowering effects of medications like hydralazine, methyldopa, and alpha-blockers, resulting in marked hypotension.
- It enhances the cardiac depressant effects of quinidine and should not be used concomitantly.
- The combined use of lithium and sibutramine can result in increased neurotoxicity.
- It must not be used in combination with other medications that cause heart rhythm abnormalities.
- Spenzo inhibits the metabolism of tricyclic anti-depressants.
Interactions with food items
- Spenzo does not have any specific interaction with any food.
Frequently Asked Questions (FAQs)
Articles
View All
Chronic Condition Articles
View All
Did you find this helpful?
Explore More at Pharmeasy
Manufacturer Details
Brand:SPENZO
Manufacturer Name:INTAS PHARMACEUTICALS LTD
Address:<p>1. Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.</p>
Country of Origin:India
Vendor Details
Fulfillment Information: Spenzo Depot 40 MG Injection (2) will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.
References:
In Case of Any Issues Contact Us
Email Id:care@pharmeasy.in
Phone Number:7666100300
Address:D-37/1, Opp. Sandoz, TTC Industrial Area, MIDC Industrial Area, Turbhe, Navi Mumbai, Maharashtra 400703
Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
