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Spenzo Depot 40mg Injection 2ml

2ml Injection in Ampoule
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Spenzo Depot 40 MG Description

Spenzo is a prescription medication. It is available in the form of a depot injection. The active component of Spenzo is Flupentixol. Spenzo is an antipsychotic used to manage schizophrenia and other

forms of psychosis and depression associated with psychotic symptoms. Schizophrenia is a disorder where patients have an altered perception of reality, affecting how they feel, think, and behave. They can present with hallucinations, delusions, altered perceptions, mood changes, and disorderly thinking. There are certain chemical messengers (neurotransmitters), and pathways in the brain that are thought to produce the symptoms of schizophrenia, chief among which is the hyperactivity of one neurotransmitter called Dopamine. Depression is characterized by complaints like feeling low, decreased motivation, feelings of hopelessness and dread, and loss of interest in daily activities. Psychogenic depression can manifest with psychotic symptoms, like hallucinations and delusions, with severe loss of interest in activities and even suicidal ideation. Depot injections are designed to release small amounts of the medication over an extended period. This reduces the number of times the medicine has to be administered to the patient.


Product Summary

Offer Price₹298.00
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ContainsFlupentixol / Flupenthixol(40.0 Mg)
UsesManagement of schizophrenia, psychogenic depression, and other forms of psychoses.
Side effectsDrowsiness, dry mouth, constipation, vomiting, abdominal pain, nausea,
Check more medicines with composition as Flupentixol / Flupenthixol(40.0 Mg)

Uses of Spenzo Depot 40 MG

  • Schizophrenia
  • Psychoses
  • Psychogenic Depression

Contraindications of Spenzo Depot 40 MG

  • If you’re hypersensitive to Flupentixol or any component in this injection.
  • If you’ve a decreased level of consciousness due to any cause or coma.
  • If you have severe liver disease or kidney failure.
  • If you have any heart disease.
  • If you have severe respiratory failure, obstructive sleep apnea, or any conditions resulting in respiratory depression.
  • If you have known epilepsy or any condition that predisposes seizures like alcohol withdrawal.
  • If you have Parkinson’s disease.
  • If you have prolactin-dependent tumours such as pituitary prolactinomas and breast cancer.
  • If you have dementia with Lewy body.
  • If you have narrow-angle glaucoma, urinary retention, or prostate enlargement.
  • If you have thyroid disorders (hypothyroidism or hyperthyroidism).
  • If you’ve Myasthenia gravis, a condition that affects muscle strength and respiration.
  • If you have Phaeochromocytoma, a tumour of the adrenal glands.

Side effects of Spenzo Depot 40 MG

Extrapyramidal effects, especially in the initial phase of the treatment, such as rigidity, muscle spasms, slowness of movements, tremors, irregular movements, etc. Drowsiness Dry mouth Increased a...
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Precautions and Warnings of Spenzo Depot 40 MG



Can I take Spenzo during pregnancy?
Flupentixol is a category C medication. It is unsafe in pregnancy and should not be taken while pregnant or if the patient intends to conceive. Consult your doctor for the usage of Spenzo in such cases.

Breast Feeding

Can I take Spenzo while breastfeeding?
Spenzo is not to be taken while breastfeeding. It is excreted in breast milk and may cause harm to the feeding infant. Consult your doctor for more information.


Can I drive if I’ve taken Spenzo?
Driving and operating other heavy machinery while on Spenzo is not recommended as it may cause drowsiness and blurring vision.


Can I consume alcohol with the Spenzo?
Alcohol consumption while on Spenzo is contraindicated as mixing alcohol with Spenzo may cause increased sedation, respiratory depression, and other neurological side effects.

Other General Warnings

Talk to your doctor if
  • You have a history of seizures or are taking any medications known to decrease seizure potential.
  • You witness any sudden mood changes or worsening symptoms of schizophrenia

Mode of Action of Spenzo Depot 40 MG

How Does It Work?

Flupentixol is a non-sedating, first-generation antipsychotic medication. It acts on two chemicals that act as signals in the brain, otherwise known as neurotransmitters. The neurotransmitters involve...
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Directions for Use of Spenzo Depot 40 MG

  • Spenzo should be used as directed by your treating physician only.
  • It should be administered only by a trained healthcare professional.
  • Do not self-administer Spenzo.
  • Spenzo should not be administered outside of a healthcare facility setting.
  • Do not use it if the solution is not clear or has any suspended matter.
  • It is recommended to finish the entire course of Spenzo as prescribed by your treating doctor. Abrupt stoppage of the medicine can cause recurrence/ worsening of symptoms. Consult your doctor before s...
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  • Inform your doctor regarding other medications you may be taking to review and prevent any medicine interaction-associated effects.

Interactions of Spenzo Depot 40 MG

Interactions with other medicines

  • The concomitant use of Flupentixol with CNS depressants like alcohol and barbiturates can potentiate their effects resulting in marked CNS depression.
  • Flupentixol enhances the effects of general anaesthetics resulting in prolonged anaesthesia.
  • It can increase the effect of anticoagulant medications resulting in bleeding.
  • It increases the anticholinergic effects of medicines like atropine etc., resulting in marked urinary retention, constipation, orthostatic hypotension, pupillary constriction, sedation, hallucinations...
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  • It should not be used with Metoclopramide, Piperazine, or anti-Parkinson medicines. This may increase the risk of Tardive Dyskinesia, a severe side effect characterised by uncontrollable, jerky moveme...
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  • Spenzo can enhance the blood pressure lowering effects of medications like hydralazine, methyldopa, and alpha-blockers, resulting in marked hypotension.
  • It enhances the cardiac depressant effects of quinidine and should not be used concomitantly.
  • The combined use of lithium and sibutramine can result in increased neurotoxicity.
  • It must not be used in combination with other medications that cause heart rhythm abnormalities.
  • Spenzo inhibits the metabolism of tricyclic anti-depressants.

Interactions with food items

  • Spenzo does not have any specific interaction with any food.

Storage and disposal of Spenzo Depot 40 MG

Store in a cool and dry place away from direct light and moisture. Do not use the medicine after the date of expiration. Keep it away from children and pets. Do not flush the medication down the toile...
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Dosage of Spenzo Depot 40 MG


Overdose is characterised by sedation, extreme agitation, excitement, confusion, sleepiness, coma, convulsions, and hyperthermia or hypothermia. Extrapyramidal symptoms or respiratory and circulatory ...
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Missed a Dose

Spenzo should be administered only by a trained healthcare professional. In case you miss a dose, contact your treating physician immediately. Do not self-administer this injection under any circumsta...
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Content Details


Dr. Bhavika Shah

MBBS, MD (Dermatology), DNB (Dermatology)

Frequently Asked Questions (FAQs)


Q: I have felt drowsy since I started Spenzo. Should I stop the tablet?

A: Drowsiness is a common side effect of Spenzo. Your doctor can guide you on how to manage these symptoms. Continue taking Spenzo tablet as advised until you consult your doctor.

Q: How often do I need to take Spenzo?

A: This is a depot injection. Once administered, it slowly releases controlled quantities of Flupentixol over an extended period. Consult your doctor for more information. A depot of Flupentixol can last for weeks at a time.

Q: I have taken the Spenzo injection, but I feel famished since then, and my weight has increased. What can I do?

A: The depot Spenzo injection releases its contents slowly. It can cause an increase in appetite and weight gain. Discuss your options for managing side effects with your doctor.
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Last Updated on: 11 Apr 2022 | 08:58 AM (IST)
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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