Pentothal Sodium 0.5gm Dry Vial Of 1 Powder For Injection

• Pentothal Sodium Injection is administered under the following conditions:
• To produce an anaesthetic effect for brief (15 minutes) procedures
• To be used as an anaesthetic agent along with other medications in regional or general anaesthesia
• For pain relief and as a muscle relaxant
• To manage convulsions or seizures when the affected person is under anaesthesia
• To lower intracranial pressure when the affected person is under anaesthesia (in some cases of neurosurgical procedures)

• Pentothal Sodium injection should not be administered or given with caution:
• If you have a known hypersensitivity to Thiopental or any of the components of this injection
• If you have any type of respiratory obstruction, severe asthma, shock or muscle disorders
• If you have porphyria (a disorder in the red blood cells)
• If you have a history of alcohol or substance abuse; Thiopental can cause addiction
• If you are not at a place where emergency oxygen and intubation is available
• If you have fluctuating potassium levels
• If you have inflammation in the mouth, jaw, and throat
• If you have acute heart failure conditions and other heart diseases
• If you have severe liver impairment

• Side effects of Pentothal Sodium injection include:
• Heart rhythm disorders
• Drowsiness
• Low blood pumping from the heart
• Low blood pressure
• Delayed awakening
• Headache
• Dizziness

Other General Warnings

• You have low blood volume or severe bleeding, burns, etc.
• You have a history of heart disease.
• You have myasthenia gravis, raised intracranial pressure, or raised blood urea levels. Caution is needed in such cases.
• You are in shock, dehydration, have severely low haemoglobin, thyroid hormone problems, etc. A reduced dose is probably required.
• You are habituated to this medicine or have an addiction to alcohol or drugs of abuse. The dose is increased in such cases.
• You have a bleeding disorder.
• You use any herbal products like St John's wort.
• You have diabetes, high blood pressure, or other underlying conditions.

• An anesthesiologist should strictly administer pentothal Sodium injection or a person qualified to give anaesthesia.
• This injection is only given in facilities where emergency intubation equipment and oxygen is available.
• A person qualified in the use of anaesthetics should be available throughout the whole procedure.
• Do not self-administer.
• This injection is given intravenously (into a vein).
• Do not eat before taking this injection and follow your doctor's advice.

Overdose

Missed a Dose

How Does It Work?

Interactions with other medicines

• Pentothal Sodium Injection has been shown to interact with sulphafurazole (antibiotic). The dose needs to be adjusted.
• Metoclopramide and droperidol (stomach-related medicines) reduce the dose of Pentothal Sodium Injection required to induce anaesthesia.
• Pentothal Sodium Injection with other central nervous system (CNS) depressant medications (like midazolam) can cause increased anaesthetic induction. Consequently, this injection is sometimes administered with other similar medicines for procedures.
• Pretreatment with probenecid has been shown to potentiate thiopental sodium anaesthesia.
• The action of antihypertensive medication is increased when this injection is given. It results in low blood pressure.
• Pentothal Sodium Injection enhances the effects of antibiotics like sulphonamides, resulting in allergy-like reactions.
• When this injection is used with antipsychotics, tricyclic, or other antidepressants, etc., there is an increased risk of arrhythmias and blood pressure changes.
• Using opioid pain relievers with this injection can increase respiratory depression (further lowers breathing).
• Herbal medicines such as valerian and St John's Wort may prolong the effects of this injection.

Interactions with food items

• In the case of anaesthesia, it is not advised to eat anything prior to being administered this injection.
• If the affected person is unconscious and needs to be ventilated, eating before can cause aspiration into the lungs, which can be dangerous.