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Pentothal Sodium 0.5gm Injection 1'S

1 Injection(s) in Vial
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Pentothal 0.5 G Description

Pentothal Sodium Injection is a prescription medicine used as an anaesthetic, alone or with other medications. It is used to induce general anaesthesia, reduce pressure inside the skull, and reduce c

onvulsions. It produces the effect of hypnosis and is used as the only anaesthetic agent in brief procedures of less than 15 minutes. The main ingredient in Pentothal Sodium Injection is Thiopental. It belongs to a class of medications called Barbiturate. The mode of action of Pentothal Sodium injection is to increase the activity of a chemical messenger in a certain part of the brain. This injection should be administered intravenously or IV (into the vein) for the induction of general anaesthesia or the production of complete anaesthesia of short duration. Small doses of this medicine have been shown to be anti-analgesic (reduces pain) by lowering the pain threshold. It should be strictly administered by a doctor or a healthcare professional in a hospital or clinical setting. Side effects of the Pentothal Sodium Injection include central nervous system depression (steady decline of breathing). The effects and safety of this injection in children are not known.


Product Summary

Offer Price₹34.00
You Save₹6.00 (15% on MRP)
ContainsThiopentone / Thiopental / Penthiobarbital(0.5 G)
UsesAnaesthesia, Pain relief, Muscle relaxation, Solo anaesthetic in small procedures
Side effectsHeart rhythm disorders, Drowsiness, Low blood pumping from heart, Low blood pressure, Delayed wakening, Headache, Dizziness
Check more medicines with composition as Thiopentone / Thiopental / Penthiobarbital(0.5 G)

Uses of Pentothal 0.5 G

  • Pentothal Sodium Injection is administered under the following conditions:
  • To produce an anaesthetic effect for brief (15 minutes) procedures
  • To be used as an anaesthetic agent along with other medications in regional or general anaesthesia
  • For pain relief and as a muscle relaxant
  • To manage convulsions or seizures when the affected person is under anaesthesia
  • To lower intracranial pressure when the affected person is under anaesthesia (in some cases of neurosurgical procedures)

Contraindications of Pentothal 0.5 G

  • Pentothal Sodium injection should not be administered or given with caution:
  • If you have a known hypersensitivity to Thiopental or any of the components of this injection
  • If you have any type of respiratory obstruction, severe asthma, shock or muscle disorders
  • If you have porphyria (a disorder in the red blood cells)
  • If you have a history of alcohol or substance abuse; Thiopental can cause addiction
  • If you are not at a place where emergency oxygen and intubation is available
  • If you have fluctuating potassium levels
  • If you have inflammation in the mouth, jaw, and throat
  • If you have acute heart failure conditions and other heart diseases
  • If you have severe liver impairment

Side effects of Pentothal 0.5 G

  • Side effects of Pentothal Sodium injection include:
  • Heart rhythm disorders
  • Drowsiness
  • Low blood pumping from the heart
  • Low blood pressure
  • Delayed awakening
  • Headache
  • Dizziness

Precautions and Warnings of Pentothal 0.5 G



Can I take Pentothal Sodium Injection during pregnancy?
Some studies have concluded that Pentothal Sodium injection can be used in pregnant women in small doses without any adverse effects. However, a few studies in animals have shown toxicity. So, when considering the use of Pentothal Sodium Injection, the doctor will weigh the benefits and risks in your case and decide accordingly.

Breast Feeding

Can I take Pentothal Sodium Injection while breastfeeding?
No. Do not use this injection if you are breastfeeding. Pentothal Sodium Injection readily appears in breast milk. Therefore, nursing should be temporarily stopped (for at least 12 hours), or breast milk should be expressed before using this medicine.


Can I drive if I have taken Pentothal Sodium Injection?
Pentothal Sodium injection causes sleep and unconsciousness within a few seconds. So, you cannot drive after taking this injection.


Can I consume alcohol with Pentothal Sodium injection?
No. Avoid consuming alcohol with Pentothal Sodium injection. It can cause severe side effects.

Other General Warnings

Talk to your doctor if
  • You have low blood volume or severe bleeding, burns, etc.
  • You have a history of heart disease.
  • You have myasthenia gravis, raised intracranial pressure, or raised blood urea levels. Caution is needed in such cases.
  • You are in shock, dehydration, have severely low haemoglobin, thyroid hormone problems, etc. A reduced dose is probably required.
  • You are habituated to this medicine or have an addiction to alcohol or drugs of abuse. The dose is increased in such cases.
  • You have a bleeding disorder.
  • You use any herbal products like St John's wort.
  • You have diabetes, high blood pressure, or other underlying conditions.

Mode of Action of Pentothal 0.5 G

How Does It Work?

Pentothal Sodium injection contains Thiopental as its main component. It belongs to the class of barbiturates (medicines that cause relaxation and sleepiness). It causes inhibition of the central nerv...
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Directions for Use of Pentothal 0.5 G

  • An anesthesiologist should strictly administer pentothal Sodium injection or a person qualified to give anaesthesia.
  • This injection is only given in facilities where emergency intubation equipment and oxygen is available.
  • A person qualified in the use of anaesthetics should be available throughout the whole procedure.
  • Do not self-administer.
  • This injection is given intravenously (into a vein).
  • Do not eat before taking this injection and follow your doctor's advice.

Interactions of Pentothal 0.5 G

Interactions with other medicines

  • Pentothal Sodium Injection has been shown to interact with sulphafurazole (antibiotic). The dose needs to be adjusted.
  • Metoclopramide and droperidol (stomach-related medicines) reduce the dose of Pentothal Sodium Injection required to induce anaesthesia.
  • Pentothal Sodium Injection with other central nervous system (CNS) depressant medications (like midazolam) can cause increased anaesthetic induction. Consequently, this injection is sometimes administ...
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  • Pretreatment with probenecid has been shown to potentiate thiopental sodium anaesthesia.
  • The action of antihypertensive medication is increased when this injection is given. It results in low blood pressure.
  • Pentothal Sodium Injection enhances the effects of antibiotics like sulphonamides, resulting in allergy-like reactions.
  • When this injection is used with antipsychotics, tricyclic, or other antidepressants, etc., there is an increased risk of arrhythmias and blood pressure changes.
  • Using opioid pain relievers with this injection can increase respiratory depression (further lowers breathing).
  • Herbal medicines such as valerian and St John's Wort may prolong the effects of this injection.

Interactions with food items

  • In the case of anaesthesia, it is not advised to eat anything prior to being administered this injection.
  • If the affected person is unconscious and needs to be ventilated, eating before can cause aspiration into the lungs, which can be dangerous.

Storage and disposal of Pentothal 0.5 G

Store Pentothal Sodium injection in the same container it comes in. Store it at room temperature, away from excess heat and humidity at 20 to 25℃. Do not freeze. Keep this injection out of reach of ki...
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Dosage of Pentothal 0.5 G


An overdose occurs due to rapid or repeated injections. Rapid injection results in an alarming fall in blood pressure, leading to shock. Repeated injections can cause sleep depression, occasional spas...
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Missed a Dose

Pentothal Sodium Injection is administered only in a hospital or clinical setting. It is not for everyday use. It is given only when needed. Hence, missing a dose is highly unlikely.

Content Details


Dr. Varsha Parihar

MBBS, MD (Community Medicine)

Frequently Asked Questions (FAQs)


Q: Does Pentothal Sodium Injection cause addiction or dependency?

A: Yes. Pentothal Sodium Injection is shown to have habit-forming potential. This group of medications (barbiturates) are considered highly addictive. So, users must take this injection only under a doctor's care.

Q: Can we give a Pentothal Sodium injection to a child?

A: There is not enough data available on the safety of Pentothal Sodium Injection in children and infants. However, a doctor may administer this injection in an emergency.

Q: How long does it take for Pentothal Sodium Injection to work?

A: Pentothal Sodium injection has a rapid onset of action when given intravenously. It induces hypnosis (a trance-like state) and anaesthesia within 30 to 40 seconds. It may take up to 30 minutes after an adequate dose is given. Repeated injections can prolong anaesthesia because it goes into fatty tissue.
Product Details
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Last Updated on: 24 Mar 2022 | 09:40 PM (IST)
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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