SGPT / ALT (Alanine Transaminase) Test

The SGPT (ALT) test, with ALT standing for alanine aminotransferase, is a blood test used to detect liver damage. The liver is one of the important organs of the human body carrying out several vital roles. The liver helps produce bile, which in turn helps to digest food. It also helps remove waste products and toxins from the blood and produce proteins and cholesterol.

Occurrence of diseases such as cirrhosis and hepatitis or intake of certain drugs can cause harm to the liver.

The enzyme alanine aminotransferase is mainly found in the liver. The body uses this ALT enzyme for the breakdown of food and the production of energy. At normal times, ALT is found inside the liver cells. But in case of liver damage or disease, ALT is released into the bloodstream. This results in higher levels of ALT in the blood, often the first sign of liver damage.

The SGPT (ALT) test is therefore done to determine the levels of ALT in the blood. This would, in turn, help to determine liver damage or disease. Symptoms that call for the SGPT (ALT) test include dark urine, nausea, stomach pain, vomiting and yellowish eyes and skin. Patients with any of these symptoms are advised by doctors to undergo the test immediately.

Liver disease has been stated as the tenth most common disease in India by the World Health Organization. Liver diseases are known to affect every one in five Indians. The most common of them is cirrhosis. Currently, the primary cause of liver cirrhosis is excessive alcohol consumption, Hepatitis B and C and non-alcoholic fatty liver disease. Cirrhosis can be associated with other complications, such as ascites, variceal bleeding and other infections.

Other names of Alanine Transaminase (SGPT / ALT) test

• ALT test
• Serum Glutamic-Pyruvic Test (SGPT)
• Glutamic-Pyruvic Test (GPT)

What does the test detect/measure and who is this prescribed for?

The Alanine Transaminase (SGPT / ALT) test measures the ALT level in the blood, which helps to indicate the presence of any liver damage or liver disease.

The test is prescribed by doctors for individuals who have symptoms of liver damage or disease that include:

• Pain in the stomach, along with swelling
• Vomiting
• Nausea
• Yellow eyes and skin
• Fatigue
• Weakness
• Dark-coloured urine and light-coloured poop
• Itchy skin

A few other reasons why an individual may be prescribed the test are:

• Exposure to the hepatitis virus
• Excessive consumption of alcohol
• A family history of liver disease
• Intake of medication known to cause liver damage
• To monitor the progression of liver disease
• To evaluate whether treatment for liver diseases might be implemented
• To determine whether and how well the treatment is working

Blood samples are required to carry out the Alanine Transaminase (SGPT / ALT) test. Most often, the blood is collected from a vein in the arm.

Test Preparation

No special preparation is required for the SGPT (ALT) test. The patients may be asked not to eat anything 8 to 12 hours before the test. No preparation is needed once the test is over. Depending on the test results, the doctor might prescribe medications.

The doctor must be informed about all the medications taken by the patient before the test, as some drugs can affect the test results.

Test inclusions: What parameters are included?

The only parameter included in the test is the level of ALT in the blood. This level helps to determine either the presence or absence of liver disease. Low levels of ALT are normal, whereas higher ALT levels are of concern as they are indicative of liver disease.

The normal range of ALT in the blood is generally considered to be less than 35 units per litre of blood. If the results are higher than this, it may suggest the presence of liver damage or disease. However, this range can be affected by a few factors, such as age and gender. Therefore, the result must be specifically discussed with doctors.

The following table indicates the variations that may be seen in the normal range of ALT in different age groups, both in females and males:

The normal values, parameters, and reference ranges of the test may vary from lab to lab. Please refer to the ranges mentioned in the report and consult a doctor to understand the interpretation of lab reports.

If the range of ALT is found to be higher than the normal range, it may suggest the presence of liver damage or disease. Increased ALT can result from several conditions, such as:

• Cirrhosis
• Hepatitis
• Death of liver tissue
• Cancer or tumour in liver
• Lack of blood flow to the liver
• Hemochromatosis, which is the build-up of iron in the body
• Mononucleosis, which is an infection caused by the Epstein-Barr virus
• Pancreatitis

If the results indicate liver disease or damage, the patients might have to undergo further tests to determine the cause of the problem and also the best way it can be treated.

Most often, lower levels of ALT are suggestive of a healthy liver. However, recent studies have found lower than normal levels of ALT may be associated with increased mortality. Therefore, in both cases, the test results must be consulted with a doctor.

Cirrhosis, Hepatitis, Liver Cancer, Mononucleosis

The price of an SGPT Test can differ based on the city and the laboratory. Typically, an SGPT test falls within the range of INR 169 to INR 399. For a better understanding, here is the average cost of an SGPT test in some major cities in India: