Dolo 650 Tablet
15 Tablet(s) in Strip
Product Summary
Dolo 650 mg Tablet is a medicine used for fever, headache, toothache and body pain, made by Micro Labs. It contains paracetamol 650 mg, a pain reliever and fever reducer. Paracetamol blocks the formation of chemicals involved in pain and fever, helping address these common symptoms.
Medically Reviewed by Dr. Nikhil Kamdi
Last updated on: 13 October 2026 | 5:58 PM (IST)
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Dose Form
TABLET
Expiry
General Information
| Therapy | Analgesic/antipyretic |
| Composition | Paracetamol / Acetaminophen(650.0 Mg) Paracetamol / Acetaminophen 650.0 Mg |
Paracetamol / Acetaminophen 650.0 Mg
℞Ranbaxy Laboratories (sun Pharma)
₹19.02 ₹17.12
₹1.71/Tablet
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*Offer applicable on orders above ₹1000About Dolo 650
Dolo 650 Tablet is a widely used and trusted medicine for relieving pain and reducing fever. It contains paracetamol (acetaminophen) as its main ingredient, which helps manage various types of pain, including headache, toothache, menstrual cramps, muscle pain, joint pain, and discomfort from the common cold or flu. It is also effective in lowering high body temperature caused by infections or other illnesses.
It acts centrally to reduce pain and fever; it has minimal anti-inflammatory activity at usual doses. As a result, it provides quick relief and helps you feel better quickly. Dolo 650 is usually well tolerated when taken as directed, making it suitable for most adults and teenagers. However, it is important to follow the dosage instructions carefully for safe and effective results.
Always take Dolo 650 exactly as prescribed by your doctor or as mentioned on the label. It can be taken with or without food, but taking it after a meal helps reduce the chance of stomach upset. Do not exceed the recommended dose and avoid taking more than 4 tablets in 24 hours. Overdosing can harm your liver, so it's important to follow medical advice strictly.
Inform your doctor if you have liver or kidney problems, or if you regularly consume alcohol, as these conditions can increase the risk of side effects. It's also important to let your doctor know about any other medicines or supplements you are taking to prevent drug interactions. Mild side effects, such as nausea or fatigue, are rare but can occur in sensitive individuals.
Dolo 650 is safe for short-term use, but if your pain or fever does not improve within a few days, consult your doctor for further evaluation. Store the medicine in a cool, dry place, out of reach of children. Using Dolo 650 responsibly can help you recover quickly and maintain your comfort while you’re ill.
Uses
- Dolo 650 is primarily used as an effective fever reducer for adults and children above 12 years.
- It also provides quick relief from migraines and headaches (stress-related and tension).
- In a few cases, Dolo 650 is used to treat body aches, fever, and general discomfort caused by cold and flu.
- Some doctors prescribe it to treat toothaches, minor joint discomfort, mild to moderate back pain, and soreness after immunisations.
- Dolo 650 also helps in managing period-related cramps and discomfort.
- Dolo 650 can be used for ear pain relief. However, it only treats the symptom of pain, not the underlying cause of the earache.
Contraindications
- It is advised not to use Dolo 650 if you have an allergy or hypersensitivity to paracetamol or any of its components.
- If you are suffering from severe kidney disease, active liver disease, liver failure, or chronic or severe malnutrition.
- Use with caution and ask a doctor first if you are dehydrated.
Side effects
- Nausea or stomach discomfort
- Loss of appetite
- Mild skin rash
- Dizziness (rare)
- Severe allergic reactions - Difficulty breathing, swelling of the face or throat
- Unusual bleeding or bruising
- Persistent nausea or vomiting
- Dark urine or pale stools
- Severe stomach pain
- Yellowing of skin or eyes (jaundice)
- Stevens-Johnson syndrome
- Acute generalised exanthematous pustulosis
- Toxic epidermal necrolysis
Precautions and Warnings
Alcohol
WITH CAUTIONAvoid drinking alcohol while taking Dolo 650 mg tablet. Alcohol increases the risk of liver damage when combined with paracetamol. If you must drink, limit it to a minimum and only if your doctor permits. For safety, do not mix alcohol with medicines to prevent serious side effects or health issues.
Pregnancy
WITH CAUTIONYes, you can take Dolo 650 mg tablet during pregnancy, but only on your doctor’s advice. It should be used in the lowest dose for the shortest duration. Avoid frequent or long-term use. Always consult your gynaecologist before taking any medicine during pregnancy for your and your baby’s safety.
Breastfeeding
SAFEDolo 650 mg tablets are considered safe for use while breastfeeding. Paracetamol, the main ingredient, passes into breast milk in very small amounts that do not harm your baby. However, it is always better to use it only when necessary and in the recommended doses, after consulting your doctor for safety.
Driving
SAFEYes, you can drive after taking Dolo 650 mg tablet. This medicine does not usually cause drowsiness, dizziness, or affect your alertness. It is safe for daily activities, such as driving or operating machines. If you feel weak or unwell due to a fever or pain, avoid driving until you feel better.
Other General Warnings
- You have a history of liver disease, kidney disease, or heart disease.
- You have high blood pressure.
- You are taking any other medications or products that contain paracetamol.
- You are consuming too much alcohol or consuming alcohol regularly.
- You are suffering from chronic malnutrition.
Doctor’s suggestion
Directions for use
- For adults and children above 12 years, the recommended dosage of Dolo 650 mg is one tablet every 4 to 6 hours as required for relief from fever or pain.
- The maximum limit is 4 tablets in 24 hours, and it is essential to maintain a minimum gap of 4 hours between doses.
- Dolo 650 mg tablet should be taken with a full glass of water.
- You can take it with or without food, but taking it after meals may help prevent stomach discomfort.
- Always swallow the tablet whole; do not crush, chew, or break it.
- Avoid overuse of the recommended dose, as an overdose can cause liver damage.
- Stop taking Dolo 650 mg once your fever or pain reduces, as unnecessary use may harm the liver.
- If symptoms persist for more than 3 days, consult a doctor instead of self-medicating.
- Always keep track of other medicines you are taking, since many cold and flu tablets already contain paracetamol. Combining them with Dolo 650 mg can cause an overdose.
- For safe and effective use, always take Dolo 650 mg only in the recommended dose and duration as prescribed by your doctor.
Storage and disposal
- Dolo 650 tablets should be stored at room temperature, not exceeding 25 °C (77°F).
- Keep in original packaging away from light and moisture.
- Store in a dry place away from the bathroom and kitchen.
- Keep it out of the reach of children and pets.
- Do not flush unused Dolo 650 mg tablets into toilets or sinks.
- Remove or black out all personal information from packaging and dispose of it.
Quick tips
- Wait at least 4 to 6 hours between doses. To stay safe, do not take more than four tablets in a 24-hour period without consulting your doctor first.
- For fever, do not use for more than 3 days. For pain, limit use to 5 days. If your symptoms don't improve, you must see a healthcare provider.
- Dolo 650 mg tablet is not recommended for children under 12 years of age. Always consult a doctor for pain or fever relief in younger children. Use only a doctor-recommended paediatric paracetamol formulation and dose based on the child’s weight.
- While generally considered safe, you must consult your doctor before using Dolo 650 during pregnancy or while breastfeeding to ensure the safety of you and your baby.
- Inform your doctor about all medications you take, especially blood thinners or other pain relievers. Taking Dolo 650 mg tablets with antibiotics is generally safe, but it's always best to consult a doctor for confirmation.
- Avoid long-term use of the Dolo 650 mg tablet unless prescribed. It can lead to serious side effects like stomach bleeding or kidney problems. Regular medical check-ups are necessary for extended use.
- A diabetic patient can usually take Dolo 650 (paracetamol) for pain or fever, but dosage caution is important, especially if there are liver or kidney problems or other medicines are being used, so consult your doctor before taking it.
Dosage
Overdose
Missed a dose
How Dolo 650 works
- Dolo 650 mg tablet works through a dual mechanism. For pain, it works by blocking the brain's pain signals and reducing the production of chemicals (prostaglandins) that cause pain and inflammation.
- To lower a fever, it acts on the hypothalamus, the part of your brain that functions as the body's thermostat. This helps reset your internal temperature to a normal level, efficiently bringing down the fever by promoting heat loss through sweating.
- After taking a Dolo 650 tablet, you can expect to feel relief relatively quickly, as it begins to work within 30 to 60 minutes. The tablet reaches its maximum effectiveness, providing peak relief from pain and fever, between one and three hours after consumption.
- The effects of a single dose are designed to last for a duration of four to six hours, helping you stay comfortable before another dose may be necessary.
Interactions
Drug interactions of Dolo 650 with other medicine salt
Food interactions
Frequently asked questions
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References
- U.S. Food and Drug Administration. Acetaminophen [Internet]. Silver Spring (MD): U.S. Food and Drug Administration; 2025 Aug 14 [cited 2025 Sep 4].
- Orandi BJ, McLeod MC, MacLennan PA, Lee WM, Fontana RJ, Karvellas CJ, McGuire BM, Lewis CE, Terrault NM, Locke JE; US Acute Liver Failure Study Group. Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure. JAMA. 2023 Mar 7;329(9):735–744. doi:10.1001/jama.2023.1080. [cited 2025 Sep 4].
- World Health Organization. WHO Model List of Essential Medicines – 23rd list, 2023 [Internet]. Geneva: World Health Organization; 2023 Jul 26 [cited 2025 Sep 4].
- Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013 Jun;21(3):201–232. doi: 10.1007/s10787-013-0172-x. [cited 2025 Sep 4].
- U.S. Food and Drug Administration. FDA issues agency-initiated proposed order regarding OTC monograph drugs containing acetaminophen [Internet]. Silver Spring (MD): U.S. Food and Drug Administration; 14 June 2024 [cited 2026 May 18].
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