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Syndopa Plus Tablet

15 Tablet(s) in Strip
By SUN PHARMA
Salt: Carbidopa 25.0 Mg+Levodopa 100.0 Mg
MRP ₹41.44
₹31.49 24% OFF
₹2.1/Tablet (Inclusive of all taxes)
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30 days easy return policy
✱Offer applicable on order above ₹1000

Product Summary

Syndopa Plus Tablet is a dopamine-replacement and antiparkinson combination from Sun Pharma containing carbidopa 25 mg and levodopa 100 mg, used to treat Parkinson's disease symptoms such as tremor and muscle stiffness. Levodopa is converted into dopamine in the brain, while carbidopa reduces its breakdown before it reaches the brain.

Made by

SUN PHARMA

Dose Form

TABLET

Expiry

General Information

Therapy
Anti-parkinsonian
Composition
Carbidopa(25.0 Mg)+Levodopa(100.0 Mg) Carbidopa 25.0 Mg+Levodopa 100.0 Mg
Syndopa Plus Tablet
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Syndopa Plus Tablet
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About Syndopa

Syndopa Plus Tablet is a medication primarily used in the treatment of Parkinson’s disease, a central nervous system disorder that affects movement and coordination. The disease is characterized by symptoms such as tremors, spasms, muscle stiffness, difficulty in walking, and poor balance. These symptoms occur due to low dopamine levels in the brain, as the neurons that produce dopamine gradually die.

Syndopa Plus Tablet contains two active ingredients: Levodopa and Carbidopa. Levodopa, a central nervous system agent, is converted into dopamine in the brain, which helps improve movement and control. Carbidopa, a decarboxylase inhibitor, prevents the breakdown of Levodopa in the bloodstream, ensuring that more Levodopa reaches the brain and remains effective.

This medication should be taken exactly as prescribed by your doctor, and its use should continue as directed. Common side effects include nausea, vomiting, loss of appetite, light-headedness, lowered blood pressure, confusion, and dyskinesia (involuntary muscle movements). These side effects usually resolve over time and do not require medical attention unless they persist or worsen. If you experience severe or persistent side effects, consult your doctor promptly.

It is important to inform your doctor if you are allergic to any components of the medication or have a medical history that includes glaucoma, asthma, dizziness, mental illness, or intense urges such as gambling, overeating, or increased sexual impulses. Additionally, Syndopa Plus should not be taken during pregnancy or breastfeeding without medical advice. Levodopa must also be discontinued at least 12 hours before starting this medication. Always communicate openly with your doctor about your medical condition and any concerns before beginning Syndopa Plus Tablet.

Syndopa CR tablet, Tidomet Plus tablet and LCD tablet are a few other medicines containing levodopa and carbidopa.

Uses

Syndopa Plus tablet is used for the treatment of Parkinson's disease characterised by impaired posture and balance, shakiness, stiffness of muscle and inability to perform basic body movements.

Contraindications

  • If you are allergic to levodopa, carbidopa or any ingredients of Syndopa Plus tablet.
  • If you have a history of skin cancer called melanoma or the presence of moles on the skin, which a doctor has not clinically checked.
  • If you are taking medicines for psychiatric health disorders belonging to a class, MOAIs like Rasagiline should be stopped at least 14 days before you start taking this medicine.
  • If you have raised pressure in the eyes, it is a condition called narrow-angle Glaucoma.
  • If you are diagnosed with any serious psychiatric illness.
  • If you are pregnant or planning to get pregnant, or if you are a breastfeeding mother.

Side effects

  • Uncontrolled movements
  • Headache
  • Nausea
  • Vomiting
  • Dry mouth
  • Diarrhoea
  • Reduced appetite
  • Drowsiness

Precautions and Warnings

Alcohol

Alcohol

UNSAFE

You should avoid alcohol consumption while taking Syndopa Plus tablet.

Pregnancy

Pregnancy

WITH CAUTION

Insufficient data is available regarding Syndopa Plus Tablet's possible side effects on the foetus. Thus, pregnant women or women who are planning to get pregnant must take this medicine on doctor's prescription only.

Breast feeding

Breastfeeding

UNSAFE

It is not advised to take Syndopa Plus tablet if you are breastfeeding your baby as levodopa passes into breast milk.

Driving

Driving

UNSAFE

It is not advised to drive or operate heavy machinery if you have taken Syndopa Plus tablet as it makes you dizzy and drowsy and can also affect your balance and movements.

General warnings

Other General Warnings

Talk to your doctor if
  • You experience mood changes, sleep attacks or excessive sleepiness.
  • You have a history of fits.
  • You have or had an ulcer in your stomach or intestine.
  • You have had a heart attack, heart disorder, or breathing problems.
  • You have had kidney, liver or hormonal problems.
  • You have a due surgery or operation.
  • If you have an eye condition called 'glaucoma’, you will need to have regular checks on the pressure in your eye.

Directions for use

  • Take Syndopa Plus tablet as a whole with a sufficient amount of water.
  • Try to take it at a fixed time every day as advised by your doctor.
  • Do not skip the doses even if you feel better.

Storage and disposal

  • Store Syndopa Plus tablet at a temperature below 30°C.
  • Keep it out of the reach of children and pets.

Quick tips

  • Follow your doctor's prescribed dose and duration, and do not take a double dose if you miss one.
  • Lifestyle changes such as daily exercise (20-30 minutes), avoiding smoking, and limiting alcohol are also recommended.
  • Inform your doctor if you're pregnant, planning to become pregnant, or breastfeeding. If you become pregnant while using this medication, stop immediately and consult your doctor.
  • Report any side effects like dry mouth, headache, reduced appetite, diarrhea, uncontrolled movements, or nausea/vomiting.

Dosage

Overdose

If you happen to take more than the prescribed dose of Syndopa Plus tablet, report to the nearest hospital immediately. It may cause rapid, irregular heartbeats, uncontrolled muscular twitching and loss of consciousness.

Missed a dose

If you missed any dose of Syndopa Plus tablet, take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and take the next dose at the scheduled time. Do not take a double dose to compensate for the missed dose.

How Syndopa works

Syndopa Plus offers relief in symptoms of Parkinson’s disease by increasing the levels of dopamine in the brain. Levodopa gets converted into Dopamine. This dopamine gives relief from symptoms of Parkinson's disease. Carbidopa helps in maintaining an optimal level of levodopa by inhibiting its breakdown by enzymes before it reaches the brain.

Interactions

Interactions with other medicines

  • Some medicines can affect the way the Syndopa Plus tablet works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
  • Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.
  • Especially if you are taking any other medicine especially to treat Parkinson’s disease.
  • If you are taking any iron preparations, it may decrease the effectiveness of the Syndopa Plus tablet when used concomitantly.
  • Medicine for any psychiatric illness may cause worsening of side effects; the dose needs to be adjusted.
  • The patient’s response should be monitored when taking Syndopa Plus tablet with anticholinergic preparations like Benzatropine and Procyclidine.
  • You may experience low blood pressure on standing suddenly from lying posture if you are on any antihypertensives.
  • Medicine for tuberculosis and epilepsy may require a change in dosage.

Food interactions

Syndopa Plus can be taken with or without food. However, it is generally better to take it with a small meal or snack to minimize nausea.

Frequently asked questions

Syndopa Plus Tablet is used to treat Parkinson's disease and parkinsonism. It reduces the tremor, muscle stiffness and slowness of movement caused by a shortage of dopamine in the brain, improving mobility and the ability to carry out everyday activities.
Levodopa is the substance the brain converts into dopamine, but if given alone most of it is broken down in the bloodstream before reaching the brain, causing severe nausea. Carbidopa blocks that breakdown outside the brain without entering it itself, so far more levodopa reaches its target and far less nausea occurs.
Levodopa is absorbed from the gut by a transporter it shares with amino acids from protein, and it must use the same transporter again to cross into the brain. A high-protein meal floods both systems with competitors, so less levodopa gets through and the dose works poorly. Take it thirty to sixty minutes before meals where possible.
As Parkinson's progresses, the benefit of each dose lasts less long and symptoms return before the next one is due. This is called wearing off and it is a feature of the illness rather than the medicine failing. Tell your doctor, who can adjust the dose, the timing or add another treatment.
These are involuntary writhing or fidgety movements, often of the head, trunk or limbs, that appear when levodopa levels peak. They usually emerge after some years of treatment. They are not a sign of damage but do need the dose reviewing, so report them rather than simply enduring them.
Abrupt withdrawal can cause a dangerous reaction resembling neuroleptic malignant syndrome, with high fever, severe muscle rigidity, confusion and unstable blood pressure. This is a medical emergency. Any reduction must be made gradually under your doctor's supervision.
Yes, and this is important. Levodopa can cause sudden onset of sleep, sometimes without any warning drowsiness beforehand. If this has ever happened to you, you must not drive or operate machinery until you have discussed it with your doctor and it has been resolved.
Some people on dopamine treatments develop urges they cannot resist, such as compulsive gambling, excessive shopping, binge eating or a marked increase in sexual urges. These can be devastating and people rarely connect them to the medicine. Family members should be told to watch for them and report them.
Levodopa breakdown products can colour urine, sweat and saliva dark red, brown or almost black, and may stain clothing. This is harmless and needs no action, though it can be alarming if you are not expecting it.
Not at the same time. Iron binds levodopa in the gut and substantially reduces how much is absorbed. Separate iron supplements, and multivitamins containing iron, from your dose by at least two hours.
Mention heart disease, an irregular heartbeat, a previous heart attack, glaucoma, stomach ulcer, asthma, kidney or liver disease, diabetes, any history of melanoma or suspicious skin lesion, and any psychiatric illness. Tell your doctor about all your medicines, particularly any antipsychotic or antidepressant.
Take it as soon as you remember unless your next dose is nearly due, in which case skip it. Do not take a double dose. Timing matters more with this medicine than most, so if you frequently forget, ask about an alarm or a dosing aid.

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