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High Platelet Count: Unraveling the Causes and Implications

By Dr. Nayana Shetty +2 more

Key Highlights: 

  • What are platelets and their function in the body? 
  • Causes of high platelet count include reactive thrombocytosis and essential thrombocythaemia. 
  • Common symptoms and severe conditions related to high platelet count. 
  • Complications associated with high platelet count, including blood clots, pregnancy issues, and progression to blood cancers. 
  • Laboratory and imaging diagnostic tests for high platelet count. 
  • Different management options depending on cause and severity. 
  • Importance of regular check-ups, maintaining a healthy lifestyle, and early intervention. 
     

Introduction 

In this article, we will explore what platelets are and their functions. See where high platelet count could come from, what issues it can cause, and how we test for it. We’ll even provide a guide on how to manage it. All while exploring the importance of staying healthy and proactive.  

What are Platelets? 

Role of platelets in the body 

Platelets, also called thrombocytes, are small. But they play a big role in stopping blood loss after injury. 

high platelet count

  • Blood clotting 

When you get a cut, platelets bind together to form a plug. This is called clotting. It helps to stop bleeding. 

  • Wound repair 

Platelets also help wounds repair. They release growth factors that help your body recover quicker. 

Platelet count and its significance 

  • Normal platelet count range 

The normal platelet count falls between 150,000 to 450,000 per microliter of blood.  

  • Platelet count blood test 

Your healthcare provider may suggest a platelet count blood test. This test helps find how many platelets are in your blood. Weird platelet levels could point to health issues that need extra tests or solutions. 

Did you know?

  • High platelet count is more common in individuals with rheumatoid arthritis. source: PubMed
  • High platelet count is associated with an increased risk of thromboembolic events. source: PubMed
  • High platelet counts can lead to confusion, migraines, seizures, and upper body discomfort. source: nhlbi.nih.gov
  • People with high platelet counts may have a larger than normal spleen. source: nhlbi.nih.gov

Causes of High Platelet Count 

High platelet count falls into two groups: reactive thrombocytosis and essential thrombocythaemia. 

1. Reactive thrombocytosis 

Most often high platelets come from reactive thrombocytosis. This means having high plates due to an existing health issue. Some sources of reactive thrombocytosis are: 

2. Infections 

Certain kinds of bacteria are common culprits. These include MRSA and Escherichia coli to name a few. 

3. Chronic inflammatory diseases 

Diseases like COPD and lupus can also force platelet numbers up. 

4. Allergic conditions 

Conditions linked to allergies, like hay fever or food allergies, can increase platelet counts. 

  • Anaemia 

Low red blood cells and  haemoglobin can send platelet numbers up. This happens with iron-deficiency  anaemia and hemolytic  anaemia. 

  • Asplenia 

The absence of the spleen can also cause high platelets. This can be because of surgery or the spleen not working right. 

5. Medications 

Some drugs disrupt the normal balance of blood cells. This can lead to high platelets. Such drugs include certain beta-lactum antibiotics and corticosteroids. 

6. Post-surgery or trauma 

Injuries or surgeries can also cause reactive thrombocytosis as the body tries to repair the wounds. 

7. Essential  thrombocythaemia 

This is also known as primary thrombocytosis. It happens when there’s excess platelet production in the bone marrow. No clear cause for this can be found. It’s not common, but some gene changes are linked to it. 

  • Genetic factors 

About half of those with essential thrombocythaemia have a specific JAK2 gene change. This plays a big part in causing this disorder. 

  • Cancer 

Essential thrombocythaemia is seen as a rare blood cancer. Too many platelets are made in this condition. 

Symptoms of High Platelet Count 

Common symptoms 

  • Fatigue 

Tiredness is one. Doing day-to-day tasks could be difficult. It also impacts the overall quality of life. 

  • Headache 

Headache is another sign. It can make you uncomfortable. Sometimes, it might even be very painful. 

  • Dizziness 

Some people also report dizziness. This can disrupt balance and coordination. 

Severe conditions 

In some cases, high platelet counts can cause more serious health problems. These include the following.

  • Blood clots 

A high platelet count can increase the risk of blood clots forming. These clots can cause dangerous health problems like a heart attack or a stroke. 

  • Bleeding problems 

While rare, very high platelet counts can cause weird bleeding. This can be things like nosebleeds or bloody stools. 

The majority of thrombocytosis cases are identified around age 60. Essential thrombocythemia is diagnosed in women twice as frequently as in men.

Dr. Siddharth Gupta, B.A.M.S, M.D

Complications Associated with High Platelet Count 

Those with a high platelet count face certain risks. These include: 

  • Blood clots 

Blood clots due to high platelet count can cause heart attacks or strokes. These need quick medical help and can be deadly if not treated. 

  • Pregnancy complications 

If an expecting mother has an uncontrolled high platelet count, risks are increased. These risks are miscarriage, high blood pressure during pregnancy, and premature birth. This is why regular tests and the right medical care are vital. 

  • Progression to blood cancers and disorders 

In rare cases, essential thrombocythaemia can turn into blood cancers or disorders. These include  leukaemia and other rare blood disorders. Quick action can lessen these risks. 

To my knowledge, thrombocytopenia (increased platelet count) is commonly seen in both mild and serious dengue conditions. One should consult their doctors to analyse the blood test reports precisely.

Dr. Rajeev Singh, BAMS

Diagnosis of High Platelet Count 

Once a high platelet count is found via blood tests, your healthcare provider will suggest further tests. These might include the following. 

1. Laboratory tests 

  • Complete blood count (CBC) 

A CBC test looks at all blood cells. This includes white blood cells, red blood cells, and platelets. 

  • Blood smear 

A blood smear lets doctors see cells under a microscope.  

2. Imaging studies 

  • Ultrasound 

An ultrasound can help  detect any issues with organs like the liver or spleen. Things to look out for are swelling or inflammation. 

  • CT scan 

In some cases, a CT scan is needed to look at organs in more detail. 

  • MRI 

Also, an MRI could be used to get a clear picture of the organs and vessels. 

3. Bone marrow biopsy 

The final step might be a bone marrow biopsy. This means taking a small sample of bone marrow for checking. Doing this can see how cells grow and if there are signs of disease. 

Also Read: How To Increase Platelet Count Naturally

Management Options for High Platelet Count 

1. Addressing the underlying cause 

  • Managing infections 

Any infections might need antibiotics or antiviral drugs. Treating them can lower high platelets. 

  • Managing chronic diseases 

Proper control of long-term health problems may have a positive impact on high platelets. 

2. Medications 

  • Antiplatelet therapy 

These drugs may help avoid blood clots in those with high platelets. 

  • Blood thinners 

Blood thinners may also help lower the chances of blood clots. They disrupt the body’s ability to clot blood. 

3. Lifestyle changes and self-care 

  • Exercise 

Having a regular workout may keep you healthy and your blood flowing smoothly. 

  • Nutrition 

Eating a varied, healthy diet may help your body fight off illness. It also supports overall wellness. 

  • Stress management 

Paying attention to reduce stress may help lessen platelet count and function. This could be through things like meditation or therapy. 

Measures to reduce the Risk 

  • Regular check-ups 

Getting medical check-ups on a regular schedule helps to track your health. This helps notice issues early and work on them. 

  • Maintaining a healthy lifestyle 

Keeping a balanced life with good exercise, diet, and stress control may keep off many health issues. 

  • Early detection and intervention 

Working quickly on any health concerns  reduces risks. Therefore, don’t wait before talking to your healthcare provider if anything seems off. 

Conclusion 

In short, it’s really important to know about and manage high platelet count for overall health. Being proactive in your health, including regular doctor visits, healthy living, and quick action is key. With all the information in this article, you’re now better equipped.  

Also Read: Natural Blood Thinners: Research-Based Guide for Safe Alternatives

Frequently Asked Questions (FAQs) 

What does it mean if your platelets are high? 

A high platelet count, or thrombocytosis, means more than normal platelets are in your blood. This might point to a deeper health concern or it could be just a reaction to infection, inflammation, or a temporary issue. 

Is 500 a high platelet count? 

Yes, 500 (or 500,000 per microliter) is seen as a high count. This is because normal levels are from 150,000 to 450,000 per microliter of blood. 

What is the alarming level of platelets? 

Any count above 450,000 per microliter is worrisome. The severity of the situation depends on the root cause and any possible health issues. Concerns might include a higher risk of blood clots or bleeding issues. 

What cancers cause high platelet count? 

Several cancer types have been linked to high platelets. These include ovarian, lung, and breast cancer as well as some other types like lymphoma and leukaemia. 

When should I be concerned about high platelet count? 

It’s time to worry if a high platelet count comes with signs like tiredness, headache, dizziness, blood clots, or bleeding. Speaking to your healthcare provider is vital to find out the root cause and what therapy might help. 

Can a high platelet count cause blood clots? 

High platelets can increase the risk of blood clots being formed. This can lead to serious problems like deep vein thrombosis, pulmonary embolism, heart attack, and stroke. 

How is a high platelet count diagnosed? 

High platelets are often first found via laboratory tests like a CBC. Further tests like a CT scan or bone marrow biopsy might be used if required.  

What are some common symptoms of high platelet count? 

The most common signs of high platelets are fatigue, headache, and dizziness. But that being said, many times there are no symptoms. And people find out in routine blood checks. 

References: 

  1. National Center for Biotechnology Information (NCBI). Etiology of Thrombocytosis in a General Medicine Population: Analysis of 801 Cases With Emphasis on Infectious Causes – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513424 
  1. World Health Organization (WHO). Anaemia [Internet]. [cited 2024 Feb 13]. Available from: https://www.who.int/health-topics/anaemia#tab=tab_1 
  1. National Center for Biotechnology Information (NCBI). Thrombocytosis following splenectomy: with or without additional organ resection [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/22580653 
  1. National Center for Biotechnology Information (NCBI). Thrombocytopenia [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542208 
  1. National Center for Biotechnology Information (NCBI). Platelet function and ageing – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935731 
  1. Centers for Disease Control and Prevention (CDC). Are You At Risk for Clots? [Internet]. [cited 2024 Feb 13]. Available from: https://www.cdc.gov/ncbddd/dvt/features/blood-clot-risk.html#:~:text=Who%20is%20at%20risk%20for,can%20increase%20a%20person’s%20risk. 

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