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Normal Platelet Count: Understanding the Research-Based Range

By Dr. Nayana Shetty +2 more

Key Highlights: 

  • Importance of understanding normal platelet count. 
  • Overview of platelets and their function. 
  • Factors that influence platelet count. 
  • Causes and symptoms of abnormal platelet counts. 
  • Diagnostic and management options for abnormal platelet counts. 
  • Complications and risks associated with abnormal platelet counts. 
  • Impact of COVID-19 on platelet count. 

Introduction 

A healthy platelet count is a vital aspect of our overall health, as it helps our blood clot appropriately in response to injury. Understanding the normal range of platelets is essential in detecting any imbalances or deviations from the norm that could lead to complications. 

In this article we will delve into the world of platelet counts, providing valuable information about what constitutes a normal range, as well as the factors that can affect these counts. We will explore the causes and symptoms of abnormal platelet counts and discuss diagnostic and management options available. Lastly, we will touch upon the impact of the COVID-19 pandemic on platelet counts and how to maintain good health. 

normal platelet count

Did you know?

Overview of Platelets and Their Function 

Platelets, also known as thrombocytes, play a significant role in maintaining our health by facilitating blood clotting and wound repair. 

What are platelets? 

These colourless, disc-shaped cell fragments are produced in the bone marrow and lack a nucleus. They are critical for our body’s blood clotting process. 

Formation of platelets 

Our bone marrow produces platelets in a process named megakaryopoiesis. These platelets come from larger cells known as megakaryocytes. They break off tiny fragments as they mature and form platelets. 

Functions of platelets in the body 

Platelets perform several key roles, which are as follows.  

  • Starting blood clots in response to injury. 
  • Helping wound repair by releasing growth agents. 
  • Supporting the immune system by releasing antimicrobial peptides. 
  • Teaming up with other blood cells, like white blood cells, for the right immune response. 

How do platelets stop bleeding? 

When a blood vessel is damaged, platelets become active. They stick to the injured area and form a  patch. They then release blood clot forming chemicals. The result is a blood clot that stops the wound from bleeding and helps it heal. 

Understanding Normal Platelet Count 

It is important to know the normal range for platelet count and what factors may change this count. 

Normal platelet range for adults and children 

The normal count of platelets in both adults and kids falls between 150,000 and 450,000/mcL of blood. But research shows some small differences based on whether you’re male or female. 

Factors influencing the platelet count 

Things like age, gender, genes, and health issues can all affect platelet count.  

  • Age: The number of platelets may drop as we age, and that’s normal. 
  • Gender: Studies show men and women may have a slightly different platelet count range. 
  • Genetic and ethnic changes: Your genes or race can alter the normal platelet count range. 
  • Health conditions: Some health issues can impact platelet counts example in cases of anaemia or cancer. 

Platelet count blood tests 

A complete blood count (CBC) test can provide vital data about your platelets. 

  • What happens during a platelet count test? 

Usually, a health worker will take some blood from a vein in your arm to measure the platelet count. Then the sample goes to a laboratory for analysis. The test checks how many platelets are in your blood on average. 

You may have an inherited or acquired platelet disease such as Bernard-Soulier Syndrome (BSS) if the findings of your platelet function test are abnormal. You may inherit genetic illnesses from your family. Although the abnormalities exist from birth, symptoms might not appear until later in life. Disorders that are acquired do not exist at birth. They might be brought on by medications, environmental exposure, or other illnesses. There are instances where the cause is unclear.

Dr. Siddharth Gupta, B.A.M.S, M.D

Causes of Abnormal Platelet Counts 

Abnormal platelet counts can be a result of a few things. This could be because of health issues, medicine, and various other causes. 

Low platelet count (Thrombocytopenia) 

If your platelet count dips below 150,000/mcL, this is known as thrombocytopenia. The cause might be that the body isn’t making enough platelets or too many platelets might be destroyed or stored up in certain organs. 

1. Problems with bone marrow 

Conditions like aplastic anaemia or certain types of cancers may affect platelet production. 

2. Fast destruction of platelets 

Several health issues can make the body destroy platelets at a quick pace,  they are as follows.  

  • Autoimmune diseases, such as lupus or immune thrombocytopenia (ITP) 
  • Severe bacterial infections involving the blood (bacteremia), and viral fevers like dengue. 

3. Medicines and substances that can cause a low platelet count 

Some drugs and substances may affect platelet production or how they work. These include the following.

  • Blood-thinning drugs 
  • Chemotherapeutic drugs 
  • Quinine present in tonic water, or certain leg cramp drugs 
  • Drinking a lot of alcohol 

High platelet count (Thrombocytosis) 

A platelet count above 450,000/mcL is known as thrombocytosis. This count could be due to an innate issue with the bone marrow or it could be due to an external factor or another health problem. 

1. Causes of high platelet counts 

A few things can result in high platelet counts.  These are as follows.  

  • Infections 
  • Iron deficiency anaemia 
  • Hemolytic anaemia 
  • Inflammatory bowel disease 
  • Certain kinds of cancers 
  • Tuberculosis 

Symptoms of Abnormal Platelet Counts 

The signs that point to abnormal platelet counts can be different. It depends on whether the platelet count is high or low. 

Low platelet count symptoms 

Signs of thrombocytopenia could include the following.  

  • Bruising easily (purpura) 
  • Small bleedings into the skin that looks like a rash of tiny red-purple dots (petechiae) 
  • Long-lasting bleeding from cuts 
  • Bleeding from gums or nose 
  • Blood in urine or stool 
  • Heavy menstrual bleeding 
  • Feeling tired 
  • Bigger size of spleen 

Petechiae 

Petechiae are tiny red or purple dots that can appear on the skin when platelet count is low. They may look like a rash. Usually, they’re spotted on the lower legs. 

When to see a doctor? 

If you notice signs of thrombocytopenia, it’s good to  discuss with your doctor. Unstoppable bleeding calls for immediate medical help. 

High platelet count symptoms 

Often, people with a high platelet count don’t notice any symptoms. But sometimes, those with thrombocytosis may have abnormal bruising or bleeding. They might show signs similar to a stroke. 

Diagnosis and Manangement of Abnormal Platelet Counts 

Finding the cause of an odd platelet count is key to manage it well. 

How is a low platelet count diagnosed? 

To find out if a person has a low platelet count, a health expert will perform a physical examination following taking a medical history. They’ll also review the person’s medical past. Further tests like blood tests or bone marrow aspiration and biopsy may be needed. 

1. Physical examination 

During the physical examination, the doctor will look for evidence of bruising, petechiae, or an enlarged spleen. 

2. Medical history 

Finding out about the person’s past health history and family history can help to identify possible causes. This can include medicines, a family history of bleeding disorders, or certain health problems. 

3. Tests 

Blood tests such as a CBC, platelet antibodies, and blood smear tests, can offer critical data about one’s platelet count. Sometimes, bone marrow aspiration and biopsy are needed to assess platelet production. 

  • Blood tests 

These tests can check platelet count and provide more detail about underlying causes. 

  • Ultrasound 

An ultrasound may be performed if there is a suspicion of an enlarged spleen. 

  • Bone marrow aspiration and biopsy 

A health expert may do a bone marrow aspiration and biopsy. This is to look into platelet production and find the cause of a low platelet count. 

Management for low and high platelet count 

Management for unusual platelet counts will depend on how severe the condition is and its root cause. Management options may include the following.  

  • Blood or platelet transfusions. 
  • Changing medications that cause a low platelet count. 
  • Steroids, immune globulin, or other medicines that suppress the immune system.  
  • Removing the spleen (in cases related to the spleen and a low platelet count). 

1. Guide to managing the condition 

For individuals with abnormal platelet counts, a good way to manage it could be by avoiding risky activities that may cause them some kind of cuts that may bleed. They could also keep track of their platelet levels regularly and they may need to change their diet or way of life. 

2. Screening 

Regular visits to the doctor  and blood tests on time may help detect abnormal platelet counts early. Discussing personal and family histories and any medicines or health aids being taken with the doctor is also very important. This can help find possible causes and make informed decisions about  management. 

Complications and Risks Associated with Abnormal Platelet Counts 

Abnormal platelet counts can result in serious, even life-threatening, problems. 

Issues that come from low platelet count 

If a person’s platelet count falls below 10,000/mcL, dangerous internal bleeding can happen. Severe thrombocytopenia can lead to bleeding in the brain. This can be deadly. 

Problems that come from high platelet count 

When platelet count is too high, it can cause blood clots to form. This can lead to deep vein thrombosis, blockage in the lung (pulmonary embolism), or stroke. These can be life-threatening  as well. 

The Impact of COVID-19 on Platelet Count 

As the COVID-19 pandemic goes on, it’s key to be aware of its possible impact on platelet count and overall health. 

How the virus may affect platelet count? 

Studies show that if we have a mild COVID-19 infection, the platelet count may increase. But if the illness is severe, our platelet count may decrease. It’s a critical part of overall health. 

Monitoring and management during the pandemic 

Regular visits and consultations with health personnel, as well as sticking to public health rules, may help watch and keep platelet counts. This may help with general health during these troubled times. 

Also Read: How To Increase Platelet Count Naturally

Conclusion 

Understanding the importance of keeping a healthy platelet count is crucial for best health. If we understand the signs of abnormal platelet counts and seek timely medical advice, we may be able to manage any health issues impacting our platelets. 

With the right knowledge and sticking to public health rules, we can keep watching our platelet counts.  

Frequently Asked Questions (FAQs) 

What are normal platelet levels? 

Usually, platelet count for adults and kids is between 150,000 and 450,000/mcL of blood. 

What is an unsafe platelet count? 

An unsafe platelet count will depend on your unique conditions. But in general, a count below 150,000/mcL is low and raises bleeding risks. A count above 450,000/mcL is high and raises clot formation risks. 

Is 120 a low platelet count? 

Yes, having a platelet count of 120,000/mcL is low. The normal range is between 150,000 and 450,000/mcL. But a slightly low count may not show symptoms or need urgent medical care. It’s advised to go see your doctor for personal guidance. 

Is 70 a low platelet count? 

Yes, a count of 70,000/mcL is low as it’s below the normal range of 150,000 to 450,000/mcL. This count points to thrombocytopenia and raises the risk of bleeding. Always consult a health expert to find the cause and the right  management.  

References: 

  1. National Center for Biotechnology Information (NCBI). Thrombocytopenia [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542208 
  1. National Center for Biotechnology Information (NCBI). Platelet function and ageing – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935731 
  1. National Center for Biotechnology Information (NCBI). Mechanism Action of Platelets and Crucial Blood Coagulation Pathways in Hemostasis – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767294 
  1. ScienceDirect. Your Browser is out of date. [Internet]. [cited 2024 Feb 13]. Available from: https://www.sciencedirect.com/science/article/pii/B9780702051012000662 
  1. ScienceDirect. Your Browser is out of date. [Internet]. [cited 2024 Feb 13]. Available from: https://www.sciencedirect.com/science/article/pii/B9781437717389000177 
  1. PubMed. Laboratory testing for platelet antibodies [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/23757218 

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