Sacubitril+Valsartan

When should one not use Sacubitril+Valsartan

• If you are allergic to sacubitril, valsartan or any other ingredients of this medicine.
• If you have diabetes or kidney disease and taking aliskiren-containing blood pressure-lowering medicine.
• If you have severe liver disease.
• If you are pregnant and pregnancy is of more than 3 months.
• If you are taking any medicines from the angiotensin-converting enzyme (ACE) inhibitor group of medicine used for the treatment of high blood pressure or heart failure, you should wait for at least 36 hours after taking the last dose, before taking Sacubitril+Valsartan.
• If you or any member of your family has a history of swelling of lips, face, tongue, or throat after taking any medicine from the ACE inhibitor group of medicine or angiotensin II receptor blocker group of medicine.

Common side effects of this drug are:

• Dizziness
• Light-headedness
• Nausea
• Headache
• Fainting
• Loose motions
• Cough
• Tiredness or weakness
• Pain in stomach
• Spinning sensation

Other General Warnings

• You are taking medicines such as aliskiren and any medicine from the angiotensin II receptor blocker group of medicine.
• You have swelling of lips, face, tongue, and throat after taking this medicine.
• You have low blood pressure or taking any other medicine to lower blood pressure.
• You have vomiting, loose motions or have dehydration, and your age is more than 65 years.
• You have kidney disease and low blood pressure.
• You have severe kidney disease or liver disease.
• Your kidney artery has been narrowed.

How Does It Work?

• Sacubitril lowers blood pressure by causing blood vessel relaxation, excretion of sodium through urine and increasing urination.
• Valsartan works by relaxation of blood vessels so that the heart pumps blood more easily through blood vessels to the body.

Interactions with other medicines

• Sacubitril+Valsartan can interact with several other medications, potentially leading to serious side effects.
• ACE Inhibitors: Combining Sacubitril+Valsartan with ACE inhibitors (like enalapril or lisinopril) significantly increases the risk of angioedema, a severe allergic reaction causing facial swelling.
• Aliskiren: Concomitant use with aliskiren (another blood pressure medication) can dangerously lower blood pressure, increase potassium levels, and impair kidney function.
• Sildenafil (Viagra): Combining Sacubitril+Valsartan with sildenafil can further decrease blood pressure, potentially causing dizziness or fainting.
• Potassium-Sparing Diuretics: Medications like triamterene, amiloride, spironolactone, and eplerenone, along with potassium supplements or salt substitutes, can increase potassium levels when taken with Sacubitril+Valsartan.
• NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): In elderly individuals with dehydration or kidney disease, combining Sacubitril+Valsartan with NSAIDs (like ibuprofen or naproxen) can worsen kidney function.

Interactions with food items

Overdose

Missed a Dose