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MPV Blood Test: Understanding Its Importance and Results

By Dr. Shubham Pandey +2 more

Key Highlights: 

  • The MPV blood test measures the mean platelet volume in your blood, revealing the average size of your platelets. 
  • Proper MPV levels help maintain normal blood clotting and wound  repair. 
  • How to prepare for the MPV blood test? 
  • Causes of high MPV include cancer and recovery from blood loss or injury, while low MPV can occur due to bone marrow disorders or iron deficiency anaemia. 
  • Thrombocytopenia is a condition associated with low platelet count; its management may involve medications or lifestyle changes. 

Introduction 

Platelets are the cells in your blood that help in clotting and repairing wounds.  Well, it is necessary to check their health. That’s where the Mean Platelet Volume (MPV) blood test comes into picture. 

In this article, we’ll explore the world of MPV blood tests. We’ll learn what MPV is, how to get ready for the test, analyze the results, and see what happens when the levels are not right. Lastly, we will answer some questions associated with this topic.  

mpv blood test

Understanding MPV Blood Test 

In this section, we will try to understand MPV and its role in maintaining our health. 

What is MPV? 

The Mean Platelet Volume (MPV) is a laboratory finding. It measures the average size of platelets present in your blood. These small, colourless cell fragments are crucial for clotting, wound  repair, and fending off infection. They take birth in the bone marrow and then enter the bloodstream. The MPV test gives us the information regarding any abnormality in platelet size. This helps us to detect any issue that may be affecting these cells. 

Importance of MPV Test 

The following are the reasons why the MPV test is done. 

  • It checks how healthy our platelets are. 
  • It can find disorders linked with abnormal platelet sizes or numbers. 
  • It aids in checking if the therapy given for blood-related disorders is working or not. 
     

Did you know?

  • MPV tests are commonly used to evaluate platelet function and production. source: medlineplus.gov
  • High MPV (mean platelet volume) may indicate platelet dysfunction or bone marrow disorders. source: medlineplus.gov
  • MPV can be influenced by factors such as age, sex, smoking, and hormonal changes. source: PMC
  • MPV levels may decrease during an acute exacerbation of COPD. source: PMC
  • A cutoff value of less than 8.5fl for MPV has a sensitivity of 92% and specificity of 100% in predicting SLE. source: PMC

MPV Blood Test Process 

The procedure involved in conducting the MPV test is quite simple and is explained in the section below.  

How to Prepare for an MPV Test? 

For an MPV blood test, you don’t need to do anything special. Have a discussion with your doctor in case they advise any other test along with MPV that might require any special preparation like fasting.  Also, you need to disclose your current health conditions, family history, and the drugs and supplements you may be currently on, as they may influence the results of the test.  

What to Expect During an MPV Test? 

  • Testing procedure 

The MPV blood test is easy and quick. A phlebotomist takes blood from your arm vein with a needle, while maintaining hygiene. They save the sample in a test tube. Once done, remove the needle and apply a bandage on your arm. The entire process is over in a few minutes with maybe slight discomfort or bruising at the site of needle puncture. 

  • Interpreting test results 

After the test, they send the blood sample to a laboratory where they check your MPV. Once the laboratory report is ready, your healthcare provider shares it with you. It’s important to discuss the results with them. This will give you a clear picture of your overall health. 

Causes and Implications of Abnormal MPV Results 

Your MPV blood test results can show high or low MPV.  The causes and possible issues due to abnormal MPV are discussed below. 

1. Causes of High MPV 

If your MPV result shows higher than the normal range (more than 12 femtoliters), it might be due to the following.  

  • Cancer 

Some types of cancer can lead to an increase in platelet size, causing a rise in MPV. But don’t worry as high MPV doesn’t always mean you have cancer. If there is a history of cancer in your family or other risk factors, further testing may be suggested by your doctor. 

  • Other potential causes 

Apart from cancer, many other factors can make your MPV  increase. The potential causes are as follows.  

  •  After loss of blood due to surgery or injury 
  • Hyperthyroidism 
  • Heart disease 
  • Diabetes 
  • Lack of Vitamin D 
  • High blood pressure 
  • Stroke 
  • Atrial fibrillation 
     

2. Causes of Low MPV 

On the flip side, a low MPV (less than 8 femtoliters) hints that your platelets are mostly old. This is because the production of new platelets in your bone marrow has slowed down. Some common causes of low MPV are as follows. 

  • Bone marrow failure 
  • Lupus 
  • Chemotherapy 
  • Hypothyroidism 
  • Iron deficiency anaemia 
  • HIV/AIDS 
     

Implications of High and Low MPV Results 

  • Associated risks and complications 

 High MPV can lead to blood clot formation. This is because larger platelets are more active. Increased blood clots  bring risks such as stroke or deep vein thrombosis (DVT). A low MPV might mean more bleeding or bruising. This is because smaller, older platelets may not work as well. 

  • Relation to certain medical conditions 

Remember high or low MPV levels alone cannot decide anything. Your healthcare provider will use all factors including your past health and other test results to find out what’s causing the abnormal MPV levels. 

Certain studies indicate that MPV may be higher in COVID-19-positive people than in COVID-19-negative people. However, more research is needed to completely understand the association between the results of an MPV blood test and the severity of COVID-19 infection.

Dr. Siddharth Gupta, B.A.M.S, M.D

Thrombocytopenia and MPV 

Thrombocytopenia is when you have a low platelet count.  

What is Thrombocytopenia? 

Thrombocytopenia happens when your blood has fewer platelets than normal. Since platelets help in clotting, a low count of platelets can cause  excess bleeding or easy bruising. 

How is Thrombocytopenia diagnosed? 

To find out if you have thrombocytopenia, doctors conduct a complete blood count (CBC) test. It includes a platelet count and MPV check. If results show thrombocytopenia, more tests may be done to find the root cause. These may include a bone marrow biopsy or other blood tests. 

Management options for Thrombocytopenia 

The management for thrombocytopenia depends on how severe it is, and its causes.  

  • Medications 

Doctors may give medicines to raise platelet production or they may give medicine to slow down the immune system if that’s causing thrombocytopenia. Some common medicines used include corticosteroids or immunoglobulins. 

  • Lifestyle and home remedies 

Those with thrombocytopenia should be careful to avoid injuries and bleeding risk. So, it’s important to watch your physical activities, take care with medicines that can make bleeding worse (for example,  blood thinners or NSAIDs), and live a healthy life to boost overall wellness. 

Research has indicated that stress, both emotional and physical, might have an impact on platelet count. Heavy exercise for an extended period of time can raise MPV. Higher-than-normal MPV is possible in people with panic disorders.

Dr. Rajeev Singh, BAMS

Preparing for an Appointment with a Healthcare Provider 

  • What to expect during a consultation? 

In your appointment, your healthcare provider will go over your past health, current symptoms, and test results. They might order more testing if needed. You should get ready to discuss any concerns, answer questions about your lifestyle, medicines you are currently taking, and about your family medical history. 

  • Questions to ask your healthcare provider? 

It’s a good plan to prepare a list of questions for your healthcare provider. These could  the following.  

  • Why is my MPV level not normal? 
  • Do I have to make any lifestyle changes? 
  • Should I go for more tests or future appointments? 
  • Are there any risks or issues related to my MPV levels? 
  • Can you tell me where to find more information about MPV and linked health conditions? 

Also Read: CRP Test Report: Interpreting Results and Their Medical Implication

Conclusion 

Getting to know your MPV blood test results is key for maintaining health. This article gives a complete and easy-to-understand guide to help you understand MPV tests, their weightage, and what it means when results are not normal. 

While MPV can hint at health issues, it’s always important to consult with a healthcare expert. They will help put the results in context and may order more test.  

Frequently Asked Questions (FAQs) 

What does it mean when your MPV is high? 

If your MPV is high, it suggests that your platelets are larger than normal. This might be due to many reasons such as cancer, recovering from injuries, heart disease, and more. Your healthcare provider will consider all factors to find out the real reason for the high MPV. 

What does MPV mean in a blood test when it is low? 

A low MPV suggests that most of your platelets are old. This hints that your bone marrow production of new platelets has reduced. The reason could be bone marrow failure, lupus, chemotherapy, hypothyroidism, iron deficiency anaemia, or HIV/AIDS among others. 

What is a normal MPV level for a woman? 

For women, usual MPV levels are between 8-12 femtoliters. But always consult a healthcare expert to correctly understand your MPV result and what it means for your health. 

What cancers cause low MPV? 

Some cancers that hit the bone marrow, such as leukaemia or lymphoma, might cause low MPV. They disrupt the normal process of producing platelets. Remember only measuring MPV can’t tell for sure if it’s cancer. An in-depth examination by a healthcare expert is needed. 

References: 

  1. National Center for Biotechnology Information (NCBI). Thrombocytopenia [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542208 
  1. National Center for Biotechnology Information (NCBI). Platelet function and ageing – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935731 
  1. National Center for Biotechnology Information (NCBI). Relation between indices of end-organ damage and mean platelet volume in hypertensive patients [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/22576288 
  1. National Center for Biotechnology Information (NCBI). Mean platelet volume and vitamin D level [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24624344 
  1. National Center for Biotechnology Information (NCBI). The relationship between mean platelet volume and thrombosis recurrence in patients diagnosed with antiphospholipid syndrome [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24671503 
  1. National Center for Biotechnology Information (NCBI). Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/21330610 
  1. National Center for Biotechnology Information (NCBI). Usefulness of mean platelet volume for predicting stroke risk in atrial fibrillation patients [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23080368 

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