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RDW Blood Test: Interpreting Results and Understanding its Importance

By Dr. Nayana Shetty +2 more

Key Highlights: 

  • RDW measures the variability in the size and volume of red blood cells. 
  • Helps in diagnosing different types of anaemia and other health conditions. 
  • Specific preparations to be followed if instructed by your healthcare provider for the RDW test. 
  • High, normal, and low RDW results indicate various underlying factors affecting red blood cell distribution width. 
  • Lifestyle factors and underlying medical conditions can affect RDW values. 

Introduction 

Red blood cell distribution width (RDW) is an important factor when it comes to understanding the health of your blood cells. An indicator of the variations in the size and volume of red blood cells, RDW plays a crucial role in diagnosing and differentiating various health conditions, including anaemia. In this article, we will discuss the purpose of the RDW blood test, how it is conducted, and how the results are interpreted. We will also delve into the significance of RDW in monitoring therapy progress, as well as the factors that may affect RDW values. 

rdw blood test

Did you know?

  • Iron deficiency, different types of anemia, thalassemia, and sickle cell anemia can be diagnosed using RDW results. source: MedlinePlus
  • RDW blood test measures the variation in size and volume of red blood cells. source: MedlinePlus
  • RDW blood test provides valuable information about red blood cell characteristics. source: MedlinePlus
  • Normal RDW values can vary slightly depending on the laboratory and testing method used, but generally fall within the range of 11.5% to 14.5%. source: medlineplus.gov
  • RDW results should be interpreted in conjunction with other blood test results and clinical information to make an accurate diagnosis. source: medlineplus.gov

What is the RDW Blood Test? 

Definition and purpose 

Red cell distribution width (RDW) is a crucial measure in blood tests. It shows how much the size and volume of red blood cells differ from each other. The job of these cells is to transport oxygen from the lungs to the different body parts. A non-normal RDW result might mean problems with body functions that affect oxygen flow. However, knowing about extra tools, like mean corpuscular volume (MCV), is key to understanding blood health. 

Analyzing Red Blood Cell Distribution Width 

Red blood cells usually stay at a size of 6 to 8 micrometers across. Higher RDW test results mean the sizes of cells vary more. In short, the higher the RDW results, the more diverse the sizes of red blood cells. It’s key to use RDW results with other blood tests, like the MCV, for a more accurate diagnosis. 

Relation with other blood tests 

RDW tests often go alongside a complete blood count (CBC). This test looks at the types,  numbers, and traits of your blood cells. Included are red and white blood cells and platelets, haemoglobin levels, etc.  

Why is the RDW Test Done? 

Differentiating various anaemia types 

The main aim of RDW blood tests is to diagnose anaemia and its cause. The types of anaemia that are linked to different RDW results include iron lack anaemia, anaemia caused by a lack of B12 or folate, and others. Doctors can accurately diagnose the type of anaemia using the RDW test. This information is essential for making a good management plan. 

Diagnosing various health conditions 

Aside from anaemia, the RDW test can also point out the presence of other health problems, such as thalassaemia, diabetes, heart disease, liver disease, and cancer. Early spotting of these health problems means an early start to effective  management. 

Monitoring therapy progress 

RDW tests help in tracking the progress of therapies used for different health problems. For example, a falling RDW after starting anaemia management might show that the therapy is working and that all the red blood cells are returning to normal size. 

How to Prepare for an RDW Test? 

Pre-test preparations 

An RDW blood test doesn’t need much preparation. However, if your healthcare provider adds other tests to the RDW in a complete blood count, you might need to fast or follow special instructions. 

Doctor’s instructions 

It’s key to follow any unique instructions given by your healthcare provider before an RDW test. Be sure to tell your doctor about any medications, supplements, or vitamins you’re taking. This information could impact the test results. 

Depending on the results of your test, your doctor will design a treatment plan to increase the amount of oxygen your red blood cells can carry in case you have a chronic blood disorder, such as anaemia. Your provider may suggest iron supplements, medicines, and/or dietary changes based on your specific condition.

Dr. Siddharth Gupta, B.A.M.S, M.D

Understanding RDW Test Results 

1. High RDW results 

  • Possible causes 

High RDW results might point to an underlying health problem, such as a lack of iron, folate, or B12. High RDW can also be linked to macrocytic anaemia, where the body does not make enough normal red blood cells. The leftover cells then grow larger than average. Microcytic anaemia, where red blood cells are smaller than normal, can also raise RDW. 

  • Associated risks 

A high RDW result could mean a raised risk of health issues. This includes heart disease, liver problems, and some cancers. A comprehensive look at RDW and other blood tests, like MCV, is needed to work out the best course of action. 

2. Normal RDW results 

  • What it means? 

Normal RDW results mean the red blood cells are typically the same in size and shape. However, even if the RDW results are normal, there could still be an underlying health concern. That’s why healthcare providers must consider other blood tests during a check-up before confirming any kind of diagnosis. 

  • Maintaining a healthy RDW range 

To keep RDW healthy, focus on a well-balanced diet packed with essential nutrients, regular workouts, and enough sleep, these may help.  

3. Low RDW results 

  • Possible causes 

No exact blood disorders is linked to a low RDW result. Yet, a low RDW shows that red blood cells are fairly the same in size and shape. This is often viewed as ideal for overall health. 

  • Associated risks 

A low RDW result doesn’t come with clear risks or worries. A consistently low RDW might mean overall good health, as long as there are no other symptoms or health issues. 

Many studies have demonstrated a correlation between the baseline RDW value and long-term adverse events in both acute and chronic conditions, including peripheral artery disease, acute myocardial infarctions (MI), heart failures, stable angina, stroke, and angina.

Dr. Rajeev Singh, BAMS

Factors Affecting RDW Values 

Age 

As we get older, the size, shape, and spread of red blood cells may alter. This may lead to a rise in RDW values. 

Lifestyle 

Lifestyle choices, like smoking too much, drinking alcohol, not exercising, and eating badly, might raise RDW values. 

Underlying medical conditions 

Several health issues, like long-term liver disease, kidney disease, heart disease, and inflammatory/autoimmune diseases, can affect RDW values.  

How to Lower a High RDW? 

Dietary changes 

Adding a balanced diet full of essential nutrients especially iron, vitamin B12, and folate may counter any deficiencies causing a high RDW. 

Maintaining a healthy lifestyle 

Quitting smoking, lessening alcohol intake, getting regular exercise, and getting enough sleep may all help lower a raised RDW.  

Medical interventions 

If there are any underlying health problems, they should be managed with the right medical management, as advised by healthcare providers. This may aid in controlling RDW values and keeping overall health in check. 

Studies have shown that overall cancer mortality might be correlated with elevated RDW. RDW may be able to somewhat forecast cancer patients’ mortality risk.

Dr. Smita barode, B.A.M.S, M.S.

RDW and Other Blood Tests 

The other tests that can be combined with the RDW test to give more insight are as follows.  

Other Blood Tests Importance 
Mean Corpuscular Volume Helps differentiate between types of anaemia 
Red Blood Cell Count Shows the quantity of red blood cells 
Other Indices in CBC Gives insights into overall health 

Conclusion 

The RDW blood test is a key tool in examining the health of your red blood cells and diagnosing anaemia and other health issues. By understanding your RDW results and working with a healthcare provider, you can deal with any underlying health issues and keep healthy. Always remember, the RDW test is just one tool among many used to check overall health.  

Frequently Asked Questions (FAQs) 

What does it mean if RDW is high? 

A high RDW might mean there’s an underlying issue including a lack of nutrients or various health problems like anaemia, autoimmune conditions, and liver or kidney disease. Make sure you discuss your RDW results with your healthcare provider to find the main cause and outline the right management plan. 

What does it mean if RDW is low? 

A low RDW means that your red blood cells are pretty much the same in size and shape. This is often considered ideal for optimal health. This indicates no known blood problems are affecting your RDW test results. 

Does high RDW cause fatigue? 

While high RDW does not directly bring about fatigue, it could be due to anaemia or another health problem that leads to fatigue. If you have high RDW and feel tired, discuss your results and symptoms with your healthcare provider to find the main problem. 

What cancers cause high RDW? 

Certain cancers could lead to high RDW, including blood cancers like leukaemia, and lung and colon cancer. A raised RDW may also indicate a less favourable outcome for cancer patients. However,  diagnosing cancer with just RDW alone is not possible. Extra tests and studies are needed for a firmed cancer diagnosis. 

References: 

  1. PubMed. Poikilocytosis [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/32965812 
  1. National Center for Biotechnology Information (NCBI). The role of red blood cell distribution width (RDW) in cardiovascular risk assessment: useful or hype? – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861793 
  1. National Center for Biotechnology Information (NCBI). Macrocytic Anemia [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459295 
  1. PubMed. Red blood cell distribution width is increased in patients with psoriasis vulgaris: A retrospective study on 261 patients [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/25819386 
  1. PubMed. Baseline Red Blood Cell Distribution Width Correlates with Disease Activity and Therapeutic Outcomes in Patients with Systemic Lupus Erythematosus, Irrespective of Anemia Status [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/28164513 
  1. PubMed. Clinical Significance of Red Blood Cell Distribution Width and Inflammatory Factors for the Disease Activity in Rheumatoid Arthritis [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/28164544 
  1. PubMed. The effects of blood transfusion on red blood cell distribution width in critically ill patients: a pilot study [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/29770452 
  1. PubMed. The effect of smoking on chronic inflammation, immune function and blood cell composition [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/33173057 
  1. National Center for Biotechnology Information (NCBI). Association between alcohol-induced erythrocyte membrane alterations and hemolysis in chronic alcoholics – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281527 
  1. PubMed. Sleep duration and sleep disorder with red blood cell distribution width [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/26018095 
  1. PubMed. Relationships between sedentary behaviour, physical activity levels and red blood cell distribution width in children and adolescents [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/29744311 
  1. PubMed. The association between muscle strengthening activities and red blood cell distribution width among a national sample of U.S. adults [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/25602910 
  1. PubMed. The relationship between red cell distribution width and all-cause and cause-specific mortality in a general population [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/31700048 

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