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MCV Blood Test: Decoding its Significance in Your Health Report

By Dr. Nayana Shetty +2 more

Key Highlights: 

  • MCV is the mean corpuscular volume of red blood cells. 
  • Normal MCV ranges between 80-100 fL; it can vary based on age, gender, and population. 
  • Low MCV levels associated with microcytic anaemia (e.g., iron deficiency, thalassaemia). 
  • High MCV levels associated with macrocytic anaemia (e.g., vitamin B12/folate deficiency, liver disease). 
  • Medical conditions related to MCV may require lifestyle changes or medical management.  
  • A complete understanding of MCV blood tests may help manage overall health. 
     

Introduction 

Managing your overall health requires an understanding of your blood test results. The MCV blood test is a key part of this. In this article, we will delve into the value of MCV blood test. We will take you through its role in making sense of your health report. 

 We will  also discuss the MCV blood test. What it measures, why it matters. We’ll look at how the test works, what normal ranges look like, and which health issues linked to high or low MCV values. Lastly, we will answer some frequently asked questions regarding this topic.  

mcv blood test

What is MCV (Mean Corpuscular Volume)? 

Healthcare providers study your red blood cells. They check the average size or volume of these cells using the MCV. The MCV blood test is done to find out what type of anaemia a person might have. Detecting the exact type of anaemia is key as it offers hints to the deep-rooted cause of the issue. This allows for a direct and pinpointed course of  management. 

Did you know?

  • Factors such as diet, activity level, and medications can affect MCV test results. source: MedlinePlus
  • High MCV is associated with increased all-cause mortality and cancer mortality in non-anemic individuals. source: NCBI
  • MCV levels can be affected by a menstrual period. source: medlineplus.gov


The MCV Blood Test Process 

In this section, we will discuss the steps involved in the testing process. 

What happens during an MCV-level blood test? 

For an MCV blood test, a small blood sample is all that’s needed. It’s usually drawn from the vein in the arm. There’s no need to prepare specially for the test. However, let’s go through the order of the process, potential risks, and how to decipher the test results. 

1. Procedure 

Getting an MCV blood test is easy and fast. A laboratory technician or phlebotomist takes a small blood sample from you. A needle goes into a vein in your arm for this. The sample then heads to a laboratory. Here, it’s  studied, and the results are put out. 

2. Risks 

The MCV blood test is accompanied with very little discomfort or risk. You might feel a small tingle when the needle goes in. Blood drawing can have side effects like bleeding, blue patches, infection, or feeling dizzy, but when the procedure is followed correctly, and hygiene is maintained throughout these side effects rarely occur. Even if bruising, bleeding, or dizziness occurs it is mild and lasts only a short time. 

3. Interpretation of results 

Healthcare providers review the data from the MCV blood test. They check it alongside other tests. These include those in the complete blood count (CBC). This helps them detect any odd results, say, microcytic or macrocytic anaemia. These can signal certain health issues that need to be dealt with. 

Normal Ranges and Variations 

MCV ranges might differ based on age, gender, or group of people. The common levels for men, women, and children are not the same but vary slightly. However, the range for all groups is generally between 80 and 100 femtoliters (fL). 

1. What is a normal MCV level? 

A typical MCV level for an adult is 80–100 fL. Remember that these average values can change subject to age and  gender. For kids aged 6-12 years, the MCV is roughly 86 fL.  

Offered values can differ from one laboratory to another. So, discuss with your healthcare provider if your MCV results increase or decrease below this range. 

2. Significance of age and gender 

Different ages and genders have different MCV levels. This is due to differences in red blood cell production and renewal. Men usually have higher MCV levels than women. Younger people might have lower MCV compared to older  people. Knowing these changes helps healthcare providers read your MCV test results. 

3. Low MCV level 

A low MCV level means your red blood cells are smaller than they should be. This means you might have microcytic anaemia. The causes and effects of this could vary. Common health conditions related to low MCV levels include iron lack anaemia and thalassaemia. 

4. High MCV level 

A high MCV level tells us that your red blood cells are bigger than they should be. This signals macrocytic anaemia. Dietary deficiency or weak immunity could be behind this kind of anaemia. 

A Von Willebrand Factor and/or thyroid panel may be prescribed by the doctor if the patient is a menstruating woman with an MCV under 80 to ascertain the underlying cause of menorrhagia and to obtain a complete menstrual history.

Dr. Siddharth Gupta, B.A.M.S, M.D

Association with Medical Conditions 

Abnormal MCV levels can hint at specific health conditions. But it’s key to know that these test results don’t mean a sure diagnosis. Instead, your healthcare provider will weigh them with your medical background and other tests to find the right diagnosis. 

  • Is a high MCV an indicator of cancer? 

Because high MCV is linked at times to some cancers, like myelodysplastic syndromes. But there are other, more common causes for high MCV, like dietary deficiencies, liver disease, and certain medicines. It’s key to remember that a high MCV doesn’t mean you have cancer; more investigations and examinations are needed to confirm or rule out cancer. 

  • Relationship between MCV and anaemia 

Low or high MCV levels can signal different types of anaemia. Microcytic anaemia has low MCV because of smaller red blood cells. Macrocytic anaemia features high MCV because of larger red blood cells. Both kinds of anaemia need correct diagnosis and management.  

  • Non-anaemia uses of MCV testing 

MCV testing can also offer valuable inputs for other health conditions or therapy progress. MCV may help predict what’s in store for kidney diseases. It may help predict death rates in esophageal and colorectal cancer. It may help assess how well older adults think and recall. So, while MCV testing is often linked to anaemia, it offers vital details about your overall health. It can guide possible medical management. 

  • Other potential causes of high MCV 

Several factors could cause high MCV levels. These include the use of certain medicines, drinking alcohol, lack of vitamins, and liver disease. Knowing what’s driving high MCV helps your healthcare provider decide the right management plan. It’ll focus on addressing your specific health issues. 

How is a High MCV Managed? 

Just a high MCV without any symptoms often doesn’t need any management. But if high MCV is causing symptoms or concerns, managing the root cause may help. Below we have described what may be done to manage it.  

  • Fix the root cause, for instance, increasing vitamins or nutrients in that are deficient in the person.  
  • Bring changes to diet and lifestyle that may boost overall health. 
  • Carry out medical management options or slight changes  to existing  therapy, as advised by the healthcare provider 
     

Limitations of MCV Blood Tests 

MCV blood tests are handy tools in diagnosis, but they have their limits. Many factors can affect MCV results and introduce errors. Some examples are as follows.  

  • Factors affecting MCV values: high sugar in the blood, recent blood  transfusion, mixed anaemias, or clotting of blood. 
  • Interpretation of MCV levels goes by age, gender, and  race/ethnicity. This may lead to some changes in results. 

Despite these limitations, MCV blood tests stay vital in managing your overall health and screening for potential conditions. 

Related Tests and Measures 

MCV blood tests are often studied alongside other red blood cell measures. They help offer a more detailed picture of your blood cell health. Some examples of linked tests and measures are as follows.  

  • Red blood cell count: The total tally of red blood cells in your blood flow. 
  • Hemoglobin concentration: The concentration of the protein carrying oxygen within red blood cells. 
  • Mean corpuscular hemoglobin concentration (MCHC): The average hemoglobin count in a given volume of packed red blood cells. 
     

When to Contact a Doctor? 

If you sense symptoms linked to abnormal MCV levels such as feeling tired, weak, your skin getting pale, or feeling dizzy, it is key to consult your healthcare provider. Regular checks and blood tests, including MCV  test, can help detect, and monitor possible health threats before they  progress. 

Conclusion 

MCV blood tests play a vital role in figuring out your red blood cell health and triggering healthcare conditions tied to abnormal levels. Knowledge of MCV values and their impact will get you ready to manage your overall health. It’ll set you on the path to a long, healthy life. 

Remember, always to talk to your healthcare provider if you are worried about your MCV levels or any other aspect of your health. 

Frequently Asked Questions (FAQs) 

What does a high MCV level in a blood test mean? 

A high MCV level might mean macrocytic anaemia. Here, red blood cells are bigger than normal. Major causes of macrocytic anaemia include lack of vitamin B12 and folate, liver disease, and certain drugs. 

What does a low MCV level in a blood test indicate? 

A low MCV level signals microcytic anaemia. Here, red blood cells are smaller than normal. Iron-deficient anaemia and thalassaemia are common causes of a low MCV. 

How do doctors use an MCV blood test to diagnose health conditions? 

Doctors use MCV blood tests as part of a whole blood count (CBC) to review the size and volume of red blood cells. This helps them detect cases of anaemia. This can hint at hidden health issues like lack of vitamins or thalassaemia. 

Can MCV levels be affected by diet and lifestyle choices? 

Yes, diet and lifestyle choices may help maintain normal MCV levels. For instance, heavy drinking, poor diet, and certain drugs can push MCV levels up high. 

What is the relationship between MCV and red blood cell indices? 

MCV is one of the red blood cell  indices. This also includes mean corpuscular hemoglobin concentration (MCHC) and mean corpuscular hemoglobin (MCH). These figures are used to review red blood cell health and diagnose anaemia types. 

References: 

  1. National Center for Biotechnology Information (NCBI). Mean Corpuscular Volume [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545275 
  1. National Center for Biotechnology Information (NCBI). The effect of smoking on chronic inflammation, immune function and blood cell composition – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655856 
  1. National Center for Biotechnology Information (NCBI). Macrocytosis [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560908 
  1. Centers for Disease Control and Prevention (CDC). What is Thalassemia? [Internet]. [cited 2024 Feb 13]. Available from: https://www.cdc.gov/ncbddd/thalassemia/facts.html 
  1. National Center for Biotechnology Information (NCBI). Autoimmune gastritis – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065578 
  1. National Center for Biotechnology Information (NCBI). 3Best practice in phlebotomy and blood collection [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK138496 
  1. American Cancer Society. Key Statistics for Myelodysplastic Syndromes [Internet]. [cited 2024 Feb 13]. Available from: https://www.cancer.org/cancer/myelodysplastic-syndrome/about/key-statistics.html 
  1. American Cancer Society. What Are Myelodysplastic Syndromes? [Internet]. [cited 2024 Feb 13]. Available from: https://www.cancer.org/cancer/myelodysplastic-syndrome/about/what-is-mds.html 
  1. National Center for Biotechnology Information (NCBI). Clinical Significance of Mean Corpuscular Volume in Patients With Locally Advanced Esophageal Squamous Cell Carcinoma – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463929 
  1. PubMed. The mean corpuscular volume as a prognostic factor for colorectal cancer [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/28795308 
  1. PubMed. Mean corpuscular volume levels and all-cause and liver cancer mortality [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/26630695 
  1. National Center for Biotechnology Information (NCBI). Clinical significance of mean corpuscular volume as a prognostic indicator of radiotherapy for locally advanced lung cancer: a retrospective cohort study – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840020 
  1. National Center for Biotechnology Information (NCBI). Diagnosis and treatment of macrocytic anemias in adults [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689413 
  1. National Center for Biotechnology Information (NCBI). Machine learning-based improvement of MDS-CBC score brings platelets into the limelight to optimize smear review in the hematology laboratory – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464379 

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