PharmEasy Blog

Does Air Fryer Cause Cancer? Unveiling the Facts Behind the Question

Key Highlights: 

Introduction 

In recent years, air fryers have emerged as a popular kitchen appliance, offering a seemingly healthier way to enjoy the taste and texture of fried foods without the guilt. People believe that by using considerably less cooking oil than traditional frying methods, air frying may provide a similar taste and texture while significantly reducing the amount of fat and calories consumed. In this article, we aim to delve into the world of air frying and unveil the facts behind the link of air fryers with cancer.  

What is an Air Fryer and How Does It Work? 

Air fryers are liked due to their low oil usage. They still give that fried food texture. Grasping the technology of air frying can help us weigh its health effects. 

The technology behind air frying 

Air fryers cook by moving hot air around the food. This crisps the outside, while the inside stays soft. A heating piece at the top starts this process. A fan then moves the hot air and oil bits all through the cooking room. 

Comparison with traditional deep-frying methods 

Deep frying soaks food in hot oil, which leads to high fat and calorie counts. Air frying only needs a small bit of oil for similar results. So, air frying reduces your overall fat and calorie intake. It seems a much healthier choice.  

Did you know?

  • The use of air fryers can reduce the amount of oil used in cooking by up to 75%. Source: NCBI
  • Air fryers can produce acrylamide, a potential carcinogen when cooking starchy foods at high temperatures. Source: cdc.gov
  • Air fryers can cause burns and injuries if not used properly, with hot surfaces and steam being potential hazards. Source: cpsc.gov

Is Cooking with an Air Fryer Healthy? 

To find out if air frying is indeed more healthy, we need to consider a couple of things. One, how much fat and calories it does reduce, and two, if it lessens the production of harmful compounds as we cook. 

1. Reducing fat content and aiding weight loss 

One big factor is its ability to bring down the fat in the food we fry. 

As mentioned, air frying allows you to use less oil than deep frying, which significantly lowers your fat and calorie intake. Studies show that air-fried food may have up to 75% less fat and calories than food that’s been deep-fried. 

As obesity-related health issues rise worldwide, creating ways to cut calories and fat without losing flavour is a game-changer. Air frying lets people enjoy fried foods whilst helping them keep a balanced, healthy diet. 

2. Reducing the formation of harmful compounds 

Beyond being low on fat and calories, air frying may reduce the formation of harmful compounds.  

Acrylamide is a chemical that may form in food cooked at high heat, such as when deep frying. It’s been called a “likely human cancer-causing agent” by the International Agency for Research on Cancer. Air frying is said to reduce acrylamide content by up to 90% compared to deep-frying. 

PAHs are a second group of possibly harmful chemicals formed during high-heat cooking. When you cook with less oil, like with air frying, exposure to PAHs also drops. Further research is needed to see just how much this reduction is. 

Potential Benefits of Using Air Fryers 

Though air frying may not replace roast, grill, or steam methods, it does have some potential benefits. These make them a solid pick for a health-focused kitchen. 

With its ability to cut back on the fat and oils used in frying, air frying may support a healthier diet. It helps cut back saturated and trans fats that are linked to heart disease and other health issues. Also as mentioned earlier, air frying reduces the presence of harmful compounds like acrylamide and possibly PAHs. By doing that, it lowers the risk linked to eating these substances and may reduce cancer risk. 

Air fryers also offer more safety benefits than traditional deep frying. Deep fryers carry a higher risk of burns from hot oil and fires caused by large amounts of flammable oil. Air fryers use minimal oil, and their cooking chambers are fully enclosed, reducing these risks quite a bit. Also, many air fryers come with built-in timers and auto-shut-off features. These not only make sure your food doesn’t overcook, but they also reduce kitchen accident risks. 

For healthier veggies, air-frying may be a good option. Air-frying retains more of the good substances like phenolic and flavonoid content compared to other cooking methods, making your food better for you. It’s a smart way to cook that helps keep the nutrients in your veggies.

Dr. Siddharth Gupta, B.A.M.S, M.D

Cons of Using Air Fryers 

While air fryers do have potential benefits, there are some negatives too.  

Though nutrient loss in air frying may be lesser than other high-heat cooking methods, it’s important to note that certain vitamins may still be lost during the process. Vitamins like C and some B Vitamins can lessen when you cook. 

Air frying may need some trial and error to get the desired results for different foods. Most fryers come with guidelines, but the best cooking times and temperatures may differ based on personal preference and specific appliance models. 

Debunking myths and misconceptions 

Understanding the impact of cooking temperature and food choices on health is key in assessing if air frying may indeed reduce cancer risk. 

Just because food is cooked at a high temperature doesn’t mean it’s unhealthy. Some cooking methods, like searing and stir-frying, may retain nutrients while still providing crispiness and flavour. 

Air frying is a healthier alternative to deep frying, but it can’t ensure optimal health alone. The quality of your diet, including eating whole unprocessed foods and limiting processed and sugary foods, plays a massive role in your overall health. 

The Bottom Line 

While air frying may bring some health and safety benefits in comparison to deep frying, it’s crucial to see this cooking method as part of a larger picture. A balanced diet rich in whole, unprocessed foods alongside a variety of cooking methods is key for overall health. 

In the end, your diet and lifestyle choices influence your risk of getting cancer and your overall health. Eating a diet filled with fruits, vegetables, whole grains, lean proteins, and healthy fats and cutting back on processed and sugary foods is essential for good health. 

Air fryers may be a useful tool to reduce fat and calorie intake and to decrease the formation of potentially harmful compounds. But they are not a magic solution to achieving optimal health. Balancing air frying with other healthy cooking methods and maintaining a balanced diet may have a bigger impact on your overall well-being. 

It’s crucial to remember that many factors add up to increased cancer risk. These include genetic factors, environmental exposure, and lifestyle choices like physical activity, smoking, and drinking alcohol. Air frying may play a part in reducing some risks, but it’s important to adopt a comprehensive approach to reduce risk of cancer. 

Conclusion 

In conclusion, air fryers may be a valuable addition to the health-conscious kitchen, offering the taste and texture of deep-fried foods with fewer adverse health effects. By reducing fat and calorie content and minimizing the formation of harmful compounds, air frying may contribute to a healthier lifestyle, but it’s essential to remember that it’s just one piece of the puzzle. Emphasizing a balanced diet and employing a variety of cooking methods is the key to maintaining good health and reducing cancer risk. Armed with this knowledge, you may now make informed decisions regarding air frying and your health. 

Frequently Asked Questions (FAQs) 

Do air fryers emit harmful radiation? 

No, they do not. They cook by moving hot air around the food, which is not like ionizing radiation from microwaves. 

Is air frying better than deep frying for overall health? 

Yes, it can be seen as a healthier option. Air frying uses much less oil, so it reduces fat and calorie content and lessens the formation of harmful compounds like acrylamide and PAHs. 

Can air frying food still provide the same taste and texture as traditional deep frying? 

Air frying can give a similar taste and texture to deep-fried foods, with a crispy outside and moist inside. But, the texture might not be the same, as it uses much less oil. 

Are there any specific cooking tips for using an air fryer for healthier cooking? 

Some tips are use minimal oil or a spray bottle for control, follow cooking times and temperature guides from the manufacturer, and clean the air fryer regularly to keep it working well. 

Can I reduce the potential risk of cancer when using an air fryer? 

To lessen the risk when using an air fryer, try to use different cooking methods, have a balanced diet, focus on whole, unprocessed  foods, and reduce processed and sugary foods. Air frying may help reduce some risks, but a full approach is needed to reduce the risk of cancer. 

References: 

  1. PubMed. Impact of Maillard reaction products on nutrition and health: Current knowledge and need to understand their fate in the human digestive system [Internet]. [cited 2024 Feb 20]. Available from: https://pubmed.ncbi.nlm.nih.gov/28901784 
  1. PubMed. Assessment of acoustic-mechanical measurements for texture of French fries: Comparison of deep-fat frying and air frying [Internet]. [cited 2024 Feb 20]. Available from: https://pubmed.ncbi.nlm.nih.gov/32247460 
  1. National Center for Biotechnology Information (NCBI). A comparative study of the characteristics of French fries produced by deep fat frying and air frying [Internet]. [cited 2024 Feb 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25619624 
  1. National Center for Biotechnology Information (NCBI). Omega-6 vegetable oils as a driver of coronary heart disease: the oxidized linoleic acid hypothesis – PMC [Internet]. [cited 2024 Feb 20]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196963 
  1. PubMed. Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality [Internet]. [cited 2024 Feb 20]. Available from: https://pubmed.ncbi.nlm.nih.gov/30971107 
  1. PubMed. Fried-food consumption and risk of overweight/obesity, type 2 diabetes mellitus, and hypertension in adults: a meta-analysis of observational studies [Internet]. [cited 2024 Feb 20]. Available from: https://pubmed.ncbi.nlm.nih.gov/33825582 
  1. PubMed. Acrylamide: a common food toxin related to physiological functions and health [Internet]. [cited 2024 Feb 20]. Available from: https://pubmed.ncbi.nlm.nih.gov/27982682 
  1. PubMed. Acrylamide in human diet, its metabolism, toxicity, inactivation and the associated European Union legal regulations in food industry [Internet]. [cited 2024 Feb 20]. Available from: https://pubmed.ncbi.nlm.nih.gov/30907623 
  1. National Center for Biotechnology Information (NCBI). Effect of pretreatments and air-frying, a novel technology, on acrylamide generation in fried potatoes [Internet]. [cited 2024 Feb 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25872656 
  1. PubMed. Avocado Oil: Characteristics, Properties, and Applications [Internet]. [cited 2024 Feb 20]. Available from: https://pubmed.ncbi.nlm.nih.gov/31185591 
  1. PubMed. A comparative study of the characteristics of French fries produced by deep fat frying and air frying [Internet]. [cited 2024 Feb 20]. Available from: https://pubmed.ncbi.nlm.nih.gov/25619624 
  1. PubMed. Effect of pretreatments and air-frying, a novel technology, on acrylamide generation in fried potatoes [Internet]. [cited 2024 Feb 20]. Available from: https://pubmed.ncbi.nlm.nih.gov/25872656 
  1. PubMed. Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health [Internet]. [cited 2024 Feb 20]. Available from: https://pubmed.ncbi.nlm.nih.gov/31861217 
  1. Centers for Disease Control and Prevention (CDC). Health Effects of Overweight and Obesity [Internet]. [cited 2024 Feb 20]. Available from: https://www.cdc.gov/healthyweight/effects/index.html 
  1. National Center for Biotechnology Information (NCBI). Intake of Toxic and Carcinogenic Volatile Organic Compounds from Secondhand Smoke in Motor Vehicles [Internet]. [cited 2024 Feb 20]. Available from: https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=25398951 
  1. National Center for Biotechnology Information (NCBI). n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials [Internet]. [cited 2024 Feb 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/21118617 
  1. National Center for Biotechnology Information (NCBI). Vegetable oil induced inflammatory response by altering TLR-NF-κB signalling, macrophages infiltration and polarization in adipose tissue of large yellow croaker (Larimichthys crocea) [Internet]. [cited 2024 Feb 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27818336 
  1. National Center for Biotechnology Information (NCBI). Food Processing and Maillard Reaction Products: Effect on Human Health and Nutrition – PMC [Internet]. [cited 2024 Feb 20]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745522 
  1. National Center for Biotechnology Information (NCBI). Dietary Acrylamide and Human Cancer: A Systematic Review of Literature – PMC [Internet]. [cited 2024 Feb 20]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164905 
  1. PubMed. Effects of Thawing and Frying Methods on the Formation of Acrylamide and Polycyclic Aromatic Hydrocarbons in Chicken Meat [Internet]. [cited 2024 Feb 20]. Available from: https://pubmed.ncbi.nlm.nih.gov/32375322 
  1. PubMed. n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials [Internet]. [cited 2024 Feb 20]. Available from: https://pubmed.ncbi.nlm.nih.gov/21118617 
  1. PubMed. Vegetable oil induced inflammatory response by altering TLR-NF-κB signalling, macrophages infiltration and polarization in adipose tissue of large yellow croaker (Larimichthys crocea) [Internet]. [cited 2024 Feb 20]. Available from: https://pubmed.ncbi.nlm.nih.gov/27818336 
  1. National Center for Biotechnology Information (NCBI). Effects of Thawing and Frying Methods on the Formation of Acrylamide and Polycyclic Aromatic Hydrocarbons in Chicken Meat – PMC [Internet]. [cited 2024 Feb 20]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278627 

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

2

High MCH: Understanding Its Implications and Causes Based on Research

Key Highlights: 

Introduction 

Mean Corpuscular Haemoglobin (MCH) plays a vital role in determining the overall health of your body. A high MCH level can indicate various medical conditions that demand prompt attention. It’s crucial to understand the implications and causes of high MCH based on research to ensure proper diagnosis and  management. 

In this article, we will explore what MCH is, its role in blood tests, its normal range, and the implications of high and low MCH values. We will also discuss the diagnosis and management options for MCH level imbalances and the outlook and measures to reduce risk that may help maintain optimum MCH levels.  

Understanding MCH 

What is MCH? 

Mean Corpuscular Haemoglobin (MCH) is the average amount of haemoglobin, a protein molecule, in each red blood cell.  Haemoglobin holds onto oxygen and hauls it from the lungs to the cells and tissues all over your body. Because of this, MCH is a key marker we use to check your body’s ability to carry oxygen. 

Role of MCH in blood tests 

MCH is part of a complete blood count (CBC) test. These tests help us to check our overall health status and to find diseases like anaemia, infection, and inflammation. MCH values are very important when doctors have to identify different types of anaemia and other similar conditions. 

How MCH level is determined? 

MCH level is found by dividing the total amount of haemoglobin in the blood sample by the number of red blood cells present. We usually measure the result in picograms (pg) for each red blood cell. This fact makes it vital to know your body’s ability to transport oxygen. 

Did you know?

  • Liver disease, such as alcoholic liver disease or hepatitis, can cause high MCH levels. source: medlineplus.gov
  • High MCH levels can be a result of certain medications, such as antiretroviral drugs used to treat HIV. source: aidsinfo.nih.gov
  • High MCH levels can be seen in individuals with certain types of cancer, such as leukemia. source: cancer.org

MCH Ranges 

For adults, a normal MCH level ranges from 27 to 31 picograms (pg) per red blood cell. However, different laboratories might use slightly different ranges. It is important to ask your healthcare provider about how to correctly read your results. 

High MCH (>31 pg) values may show underlying problems such as macrocytic anaemia or vitamin deficiencies. In contrast, low MCH (<27 pg) values might hint at iron deficiency anaemia,  thalassaemia, or other similar conditions. 

High MCH: Causes and Implications 

1. What does it mean if my MCH is high? 

A high MCH value means there’s a lot of haemoglobin in each red blood cell. This can come from many conditions like macrocytic anaemia, lack of nutrients, or hemolytic anaemia, where red blood cells are weak and break down easily. 

2. Medical conditions associated with high MCH 

There are quite a few medical conditions that can make MCH values increase. These include autoimmune hemolytic anaemia, liver disease, thyroid gland being too active, and complications arising from some cancers or infections. 

3. Causes of high MCH 

High MCH levels can come from several internal and external causes. 

1. Nutritional deficiencies 

High MCH can come from a lack of key vitamins like vitamin B12 and folate. These play a big part in making red blood cells. If these nutrients are low in our diet or don’t get absorbed well, this can lead to more haemoglobin in red blood cells. 

2. Hemolytic anaemia 

An inherited genetic condition called hereditary spherocytosis can make the outer parts of red blood cells weak. This happens when the body’s defense system wrongly attacks and wipes out red blood cells, leading to a high MCH level. 

3. Liver disease 

Liver diseases can often lead to anaemia or abnormal MCH values due to the liver not storing and processing haemoglobin well. When the liver function is not great, this can destroy red blood cells and cause high MCH levels. 

4. Thyroid problems 

An active thyroid gland (hyperthyroidism) could disrupt red blood cell production and cause an increase in MCH values. 

5. Autoimmune disorders 

Autoimmune disorders, like lupus or rheumatoid arthritis, can lead the body to attack its own red blood cells. This can make the MCH levels high. 

4. Symptoms of high MCH 

Some common signs tied to high MCH levels are: 

If any of these appear, a healthcare provider must take a closer look to see if it’s because of high MCH or something else. 

According to research, a high MCH may indicate that red blood cells are carrying the higher amount of total haemoglobin. This may suggest that newborns might have higher total haemoglobin concentrations in fewer, bigger cells.

Dr. Siddharth Gupta, B.A.M.S, M.D

Should I be concerned if my MCH is high? 

If you have a steadily high MCH value, it’s key to have a discussion with a healthcare provider. They may help find out why and deal with the cause right away. Quick diagnosis and management may help stop any complications and manage the condition well. 

Low MCH: Causes and Implications 

Low MCH values can also hint at health issues that need to be seen. This section will study the causes and effects of low MCH values and their linked symptoms. 

1. What does it mean if my MCH is low? 

A low MCH value means there’s less haemoglobin for each red blood cell. This may come from conditions like lack of iron (anaemia), microcytic anaemia, or sicknesses changing haemoglobin such as sickle cell anaemia and thalassaemia. 

2. Medical conditions associated with low MCH 

Many types of conditions can cause low MCH values. These include lack of iron (anaemia), microcytic anaemia, and sicknesses altering haemoglobin. 

3. Causes of low MCH 

Lack of iron in the blood, also known as iron deficiency anaemia, is one of the main causes of low MCH levels. If there’s not enough iron in our diet, bad absorption, or heavy bleeding, this can lead to a lack of iron in the blood. 

Vitamin B12 plays a big role in producing red blood cells and haemoglobin. Lack of this key vitamin can lead to low MCH levels. 

Folate is another key food we need for healthy red blood cell production. Lack of it can give us low MCH levels. 

Serious blood loss due to injury, surgery, or bleeding in the gut can use up the body’s iron stores and lead to low MCH values. 

Long-lasting inflammation from conditions like lupus or rheumatoid arthritis can disrupt the production of red blood cells. This can prompt a decrease in MCH levels. 

4. Symptoms of low MCH 

Should I worry if my MCH is low? 

A low MCH value can mean a hidden issue that your healthcare provider should look at. Finding out what’s causing it and getting help may stop any problems down the line. It may also manage the condition well. 

Diagnosis and  Management 

It’s very important to know if MCH levels are not right and manage them correctly. In this section, we’ll talk about the Complete Blood Count (CBC) test, which evaluates MCH levels along with other blood parameters. We’ll also look at the different ways to manage imbalances in MCH levels. 

Complete Blood Count (CBC) test 

The CBC test gives  information on the white blood cells, red blood cells, and platelets in a person’s blood. It measures several indices, including the MCH levels. This helps doctors to  detect, diagnose, and watch certain conditions. 

A CBC test is often part of a routine health check-up to see how a person’s overall health is doing. It helps to  detect, diagnose, or keep an eye on conditions like  anaemia, infection, and inflammation. 

We can find out MCH levels by dividing the total amount of  haemoglobin in a blood test by the number of red blood cells present. MCH levels help healthcare providers in figuring out a person’s ability to carry oxygen and judge their overall health status. 

Management options for MCH level imbalances 

 Management for imbalances in MCH levels can change based on what is causing them. You healthcare provider may suggest the following in order to correct your MCH levels.  

1. Diet changes 

Increasing iron-rich foods and those with vitamin B12 and folate in our diet may help increase MCH levels. 

2. Supplements 

Taking supplemental iron, vitamin B12, or folate can boost MCH levels or manage deficiencies. 

3. Medication 

Your doctor may prescribe medicines to deal with the root cause of the imbalance in the MCH level. For instance, iron chelators for too much iron or certain medicines for issues tied to the thyroid. 

4. Managing underlying medical conditions 

Dealing with the root cause of the imbalance in the MCH level may also help. For instance, managing an ongoing inflammatory condition or controlling a thyroid disorder may help balance out MCH levels and overall health. 

Outlook and Measures To Reduce Risk 

What’s the outlook for a person with low or high MCH levels? 

An individual with MCH outside the normal range largely depends on the root cause. If the cause is found, receiving the correct management and having regular check-ups may help to keep the situation under control. This way, we may avoid complications and stay healthy overall. 

Importance of timely diagnosis and management 

Detecting the issue and  managing it immediately may positively influence the health of the individual.  

Lifestyle factors to maintain healthy MCH levels 

To maintain MCH levels, you may try a balanced diet, exercise often, cut down on alcohol, quit smoking, and try to lessen stress. 

Measures To Reduce Risk 

Seeing healthcare providers on a routine basis, including taking CBC tests often, may help detectany low or high MCH levels. We can then deal with them before they become big issues. 

Eating a balanced diet with lots of iron, vitamin B12, and folate, along with other key nutrients, is key for maintaining  MCH levels. 

Alcohol and tobacco use can hurt MCH levels and add to many health issues. Reducing these substances may help to stay healthy. 

Conclusion 

Keeping MCH levels just right is key for your body’s overall health. MCH levels fluctuation can be a sign of underlying health issues that need to be looked at and managed timely. By understanding the effects and causes of high and low MCH values, seeking the right medical care, and putting in place measures to reduce risk, you may work towards maintaining your health.  

Frequently Asked Questions (FAQs) 

What does it mean if MCH is low? 
 

Low MCH levels may hint at lack of haemoglobin in red blood cells. This could be due to conditions like iron deficiency anaemia, microcytic anaemia, or haemoglobinopathies. 
 

What does it mean if MCH is high? 
 

High MCH levels may hint at more haemoglobin for each red blood cell. This can come from conditions like macrocytic anaemia or lack of nutrients. 
 

How do you treat low haemoglobin? 

To manage low haemoglobin, you may eat a balanced diet, supplement as needed, take medicine, and manage medical conditions. 
 

What level of MCH is concerning? 
 

A normal MCH range for adults is between 27 and 31 picograms (pg) per red blood cell. Values above or below this range could hint at an issue that needs further looking into. 
 

Should I worry if my MCH is low? 

Low MCH levels can be a sign of an underlying issue. Your healthcare provider should look more into it. Finding the cause and getting management may help avoid any complications and deal with the condition well. 
 

What is a dangerously high haemoglobin level? 
 

Dangerously high levels of haemoglobin are generally above 20 grams per deciliter (g/dL). They may signal life-threatening conditions, such as polycythaemia vera, heart failure, or kidney or liver cancer. 
 

References: 

  1. National Center for Biotechnology Information (NCBI). Chapter 152Red Cell Indices [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK260/#:~:text=MCHC%20indicates%20the%20amount%20of,34%20%C2%B1%202%20g%2Fdl. 
  1. PubMed. Autoimmune hemolytic anaemia [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/30193520 
  1. National Center for Biotechnology Information (NCBI). Daily supplementation with 5 mg of folic acid in Brazilian patients with hereditary spherocytosis – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065022 
  1. National Center for Biotechnology Information (NCBI). Macrocytosis [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560908 

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

1

High Red Cell Distribution Width in Blood: Interpreting Lab Results and Its Clinical Significance

Key Highlights: 

Introduction 

When your healthcare provider orders a blood test, you may come across the term “red cell distribution width” (RDW). This parameter measures the variation in the size and volume of your red blood cells. Maintaining uniform red blood cell sizes helps transport oxygen efficiently throughout the body. High RDW values indicate abnormalities in your red blood cells, which can be due to nutrient deficiencies, anaemia, or other underlying conditions. In this article, we will delve into the importance of RDW in blood tests, how it’s used to interpret laboratory results, and its clinical significance in diagnosing various diseases. 

Red Cell Distribution Width (RDW) Test 

Purpose of the RDW test 

Here are the reasons why an RDW test is done.  

Preparing for the RDW test 

You don’t need any special preparation for this test. If other tests are planned too, there might be a request to fast. If there’s any need for preparation, your healthcare provider will guide you. 

How is the RDW test performed? 

The RDW test is a basic blood draw. The test needs about 5 minutes for sample collection. After that, the sample heads to the laboratory for testing. Blood is taken from an arm vein with a tiny needle. Once your blood fills in the tube, the needle is taken out, pressure gets applied, and a small band is placed. If you notice excessive bleeding after the draw, inform your doctor at once. 

Did you know?

  • High red blood cell distribution width (RDW) is closely associated with the risk of carotid artery atherosclerosis in patients with hypertension. source: PMC
  • RDW is a marker for the presence and poor prognosis of cardiovascular disease. source: PMC
  • High RDW is associated with increased mortality among patients with heart failure, myocardial infarction, and coronary artery disease. source: PMC
  • RDW levels are highly correlated with troponin levels in patients with acute coronary syndrome. source: PMC
  • Elevated red cell distribution width (RDW) is associated with an increased risk of all-cause mortality in patients without known heart disease. source: PMC
  • RDW frequently elevated among patients with acute heart failure and independently predicts one-year mortality in acute heart failure. source: PMC

Interpreting RDW Results 

1. Normal RDW range 

Adult females should have RDW between 12.2% to 16.1%, and in adult males, it must range from 11.8% to 14.5%. If your levels don’t match this range, you need extra tests to find the cause. 

2. High RDW results 

High RDW shows a big change in the size and shape of red blood cells. The causes and importance of high RDW are described below. 

High RDW can assist doctors in finding and differentiating anaemia types and other health issues. More blood tests, such as mean corpuscular volume (MCV), grant key data for correct diagnosis and advice on management. 

3. Low RDW results 

Low RDW levels show same-sized and shaped red blood cells. No blood disorders have been linked with low RDW results. 

There are certain factors that may cause RDW to fluctuate, making it tricky to interpret. Blood infusions can momentarily change blood makeup, leading to changes in RDW. Further, blood thinners and MCV errors can also affect the RDW test results. 

To fully grasp RDW results, we need to analyse them with other blood parameters, like MCV. This pair may aid healthcare providers in distinguishing anaemia types and planning management. 

Here’s how RDW and MCV connect for correct interpretation of results.  

Studies have shown that if the blood test reports show RDW value is on the higher side, it may indicate an underlying inflammatory condition and might indicate an increased risk of heart disease.

Dr. Siddharth Gupta, B.A.M.S, M.D

Clinical Applications and Significance of RDW 

In this section, we explore the role of RDW in diagnosing  anaemia, its association with cardiovascular health, inflammatory conditions, cancer, and mortality. 

1. Role of RDW in diagnosing anaemia 

RDW is a handy tool for finding and setting apart anaemia types. By checking changes in red blood cell size and  volume, healthcare providers can point out possible nutrient deficiency and other causes of  anaemia. Also, RDW results can help in picking the best management plan to address the diagnosed  anaemia type. 

2. RDW and cardiovascular health 

A lot of studies have linked high RDW levels with an increased risk of heart disease, heart failure, and heart attacks. More research is needed to find out if high RDW levels could be a useful marker for finding people at higher risk for heart disease. 

3. RDW and inflammatory conditions 

There’s a growing link found between high RDW levels and many inflammatory and autoimmune problems, such as skin rashes, lupus, and rheumatoid arthritis. It’s still not clear if RDW is a cause or an effect of these problems, but its link with disease activity helps its potential use as a diagnostic tool. 

4. RDW and cancer 

Many studies have found links between high RDW levels and an increased risk of getting certain types of cancers. These include blood-related cancers, lung cancer, and colon cancer, among others. Moreover, high RDW levels were tied with a worse outcome in patients with these cancers. More research is needed to see if RDW might serve as a useful indicator of how the patient may fare. 

5. RDW and mortality 

Research hints that high RDW levels are tied to an increased risk of dying from various causes. Checking RDW levels in routine blood tests could give early signs for people at greater risk of death or those in need of preventive care. More research is needed to corroborate the link.  

I recently came across an article suggesting that one metric in complete blood cell counts is red blood cell distribution width (RDW), which has been identified as an inflammatory biomarker. It is well established that inflammatory microenvironments are linked to multiple myeloma (MM). RDW, which reflects systemic inflammation, would be an easy-to-use and readily available biomarker of MM symptoms.

Dr. Rajeev Singh, BAMS

Managing Abnormal RDW Levels 

It’s crucial to take charge of any odd RDW levels as this can enhance patient outcomes. Healthcare providers should aim to find the root of odd RDW levels and take proper steps to manage the condition. 

It depends on its root cause. Depending on the specific reason found, healthcare providers may suggest the following.  

It’s important to diagnose and manage the root cause of odd RDW levels early to enhance patient outcomes. Advice for handling these root causes will vary based on the specific condition found. Each patient should get a custom management plan, making sure both RDW levels and any health problems are taken care of. 

Regular checks of RDW levels allow healthcare providers to detect changes in your red blood cell health early. By keeping a check on RDW levels over time, doctors can rate how effectively therapy is working, watch disease  fluctuations, and make changes if needed so you get the best possible results. 

Conclusion 

Understanding the importance of RDW in blood tests is key for diagnosing and managing a range of health issues, including different types of  anaemia, and underlying nutrient shortages. By correctly reading RDW results along with other blood test parameters and addressing any abnormal levels, healthcare providers can detect potential health risks and build custom management plans to enhance patient outcomes. Be sure to discuss with your healthcare provider if you are worried about your RDW levels and seek advice on proper steps for managing any identified issues. 

Frequently Asked Questions (FAQs) 

What does it mean if your RDW is high? 

A high RDW shows a larger difference in the size and shape of your red blood cells. This can hint at nutrient lacks, anaemia, or other hidden problems that need more tests and management from a healthcare provider. 

What is a normal RDW range? 

The normal RDW range for adult women lies between 12.2% to 16.1%, and for adult men, it ranges from 11.8% to 14.5%. 

How do you prepare for an RDW test? 

You don’t need to do anything special before an RDW test. But, if your healthcare provider has ordered extra blood tests, they may ask you to fast before the test. 

What does it mean when red blood cell distribution width is high? 

A high red blood cell distribution width (RDW) shows a bigger change in the size and shape of your red blood cells due to possible nutrient shortage, anaemia, or other hidden problems. 

What to do if RDW is high? 

If you find your RDW is high, talk with your healthcare provider about possible causes and the right steps to take. This could involve more tests, changes in eating habits, or advice on management made just for you. 

What is an alarming RDW count? 

An RDW count much higher than the normal range for adults could hint at severe nutrient lacks,  anaemia, or other hidden problems. It’s key to discuss with a healthcare provider to find the cause and craft  the right management plan. 

Does high RDW mean leukaemia? 

While a high level of RDW on its own doesn’t directly point to leukaemia, it’s seen in a few blood-related cancers. More tests would be needed to prove or disprove  leukaemia. If you’re concerned about your RDW levels and the possible risk of  leukaemia, discuss with a healthcare provider for more tests and advice. 

References: 

  1. PubMed. Poikilocytosis [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/32965812 
  1. National Center for Biotechnology Information (NCBI). The role of red blood cell distribution width (RDW) in cardiovascular risk assessment: useful or hype? – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861793 
  1. National Center for Biotechnology Information (NCBI). Macrocytic Anaemia [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459295 
  1. PubMed. Red blood cell distribution width is increased in patients with psoriasis vulgaris: A retrospective study on 261 patients [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/25819386 
  1. PubMed. Baseline Red Blood Cell Distribution Width Correlates with Disease Activity and Therapeutic Outcomes in Patients with Systemic Lupus Erythematosus, Irrespective of Anaemia Status [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/28164513 
  1. PubMed. Clinical Significance of Red Blood Cell Distribution Width and Inflammatory Factors for the Disease Activity in Rheumatoid Arthritis [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/28164544 
  1. PubMed. The effects of blood transfusion on red blood cell distribution width in critically ill patients: a pilot study [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/29770452 
  1. PubMed. The effect of smoking on chronic inflammation, immune function and blood cell composition [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/33173057 
  1. National Center for Biotechnology Information (NCBI). Association between alcohol-induced erythrocyte membrane alterations and hemolysis in chronic alcoholics – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281527 
  1. PubMed. Sleep duration and sleep disorder with red blood cell distribution width [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/26018095 
  1. PubMed. Relationships between sedentary behaviour, physical activity levels and red blood cell distribution width in children and adolescents [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/29744311 
  1. PubMed. The association between muscle strengthening activities and red blood cell distribution width among a national sample of U.S. adults [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/25602910 
  1. PubMed. The relationship between red cell distribution width and all-cause and cause-specific mortality in a general population [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/31700048 
  1. National Center for Biotechnology Information (NCBI). Elevated red blood cell distribution width predicts mortality in acute exacerbation of COPD [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=29542313 
  1. National Center for Biotechnology Information (NCBI). A novel method utilising markers of altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10870111 
  1. National Center for Biotechnology Information (NCBI). Red blood cell distribution width and cardiovascular diseases [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26623117 
  1. National Center for Biotechnology Information (NCBI). Red blood cell distribution width and cardiovascular diseases – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635283 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Wei%20Zhang 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Yadan%20Wang 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jun%20Wang 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Shaochun%20Wang 
  1. National Center for Biotechnology Information (NCBI). ΔRDW: A Novel Indicator with Predictive Value for the Diagnosis and Treatment of Multiple Diseases [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=34849010 
  1. National Center for Biotechnology Information (NCBI). ΔRDW: A Novel Indicator with Predictive Value for the Diagnosis and Treatment of Multiple Diseases – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627260 
  1. National Center for Biotechnology Information (NCBI). Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32965501 
  1. National Center for Biotechnology Information (NCBI). Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512057 
  1. National Center for Biotechnology Information (NCBI). Oxidation and erythrocyte senescence [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10698298 
  1. National Center for Biotechnology Information (NCBI). Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=31845889 
  1. National Center for Biotechnology Information (NCBI). Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917488 
  1. National Center for Biotechnology Information (NCBI). Proteins in the pathway from high red blood cell width distribution to all-cause mortality [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=35065420 
  1. National Center for Biotechnology Information (NCBI). Proteins in the pathway from high red blood cell width distribution to all-cause mortality – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784626 
  1. National Center for Biotechnology Information (NCBI). Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19017793 
  1. National Center for Biotechnology Information (NCBI). Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587583 
  1. National Center for Biotechnology Information (NCBI). Human cytomegalovirus inhibits erythropoietin production [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24722450 
  1. National Center for Biotechnology Information (NCBI). Human Cytomegalovirus Inhibits Erythropoietin Production – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116070 
  1. National Center for Biotechnology Information (NCBI). Near-wall excess of platelets induced by lateral migration of erythrocytes in flowing blood [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8476101 
  1. National Center for Biotechnology Information (NCBI). Concentration profile of blood platelets differs in arterioles and venules [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1566903 
  1. National Center for Biotechnology Information (NCBI). Flow effects on coagulation and thrombosis [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16741150 
  1. National Center for Biotechnology Information (NCBI). The effect of shear rate on platelet interaction with subendothelium exposed to citrated human blood [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7382854 
  1. National Center for Biotechnology Information (NCBI). Finite platelet size could be responsible for platelet margination effect [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22004736 
  1. National Center for Biotechnology Information (NCBI). Finite Platelet Size Could Be Responsible for Platelet Margination Effect – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192962 
  1. National Center for Biotechnology Information (NCBI). Lattice Boltzmann simulation of blood flow in digitized vessel networks [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19343080 
  1. National Center for Biotechnology Information (NCBI). Lattice Boltzmann simulation of blood flow in digitized vessel networks – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390865 
  1. National Center for Biotechnology Information (NCBI). Blood cell interactions and segregation in flow [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18188702 
  1. National Center for Biotechnology Information (NCBI). Blood Cell Interactions and Segregation in Flow – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752714 
  1. National Center for Biotechnology Information (NCBI). <em>In vivo</em> brain imaging with multimodal optical coherence microscopy in a mouse model of thromboembolic photochemical stroke [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32016131 
  1. National Center for Biotechnology Information (NCBI). In vivo brain imaging with multimodal optical coherence microscopy in a mouse model of thromboembolic photochemical stroke – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977401 
  1. National Center for Biotechnology Information (NCBI). In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26554396 
  1. National Center for Biotechnology Information (NCBI). In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692682 
  1. National Center for Biotechnology Information (NCBI). Influence of erythrocyte aggregation on leukocyte margination in postcapillary venules of rat mesentery [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11009430 
  1. National Center for Biotechnology Information (NCBI). The interaction of leukocytes and erythrocytes in capillary and postcapillary vessels [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7360047 
  1. National Center for Biotechnology Information (NCBI). Forces on a wall-bound leukocyte in a small vessel due to red cells in the blood stream [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23062353 
  1. National Center for Biotechnology Information (NCBI). Forces on a Wall-Bound Leukocyte in a Small Vessel Due to Red Cells in the Blood Stream – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471476 
  1. National Center for Biotechnology Information (NCBI). Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8580357 
  1. National Center for Biotechnology Information (NCBI). Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes. [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236447 
  1. National Center for Biotechnology Information (NCBI). Erythrocyte hemolysis and haemoglobin oxidation promote ferric chloride-induced vascular injury [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19276082 
  1. National Center for Biotechnology Information (NCBI). Erythrocyte Hemolysis and Haemoglobin Oxidation Promote Ferric 
    Chloride-induced Vascular 
    Injury – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676043 
  1. National Center for Biotechnology Information (NCBI). Red Blood Cells and Haemoglobin in Human Atherosclerosis and Related Arterial Diseases [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32942605 
  1. National Center for Biotechnology Information (NCBI). Red Blood Cells and Haemoglobin in Human Atherosclerosis and Related Arterial Diseases – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554753 
  1. National Center for Biotechnology Information (NCBI). Red blood cells mediate the onset of thrombosis in the ferric chloride murine model [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23343833 
  1. National Center for Biotechnology Information (NCBI). Red blood cells mediate the onset of thrombosis in the ferric chloride murine model – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643770 
  1. National Center for Biotechnology Information (NCBI). Sickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in culture [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7635951 
  1. National Center for Biotechnology Information (NCBI). Sickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in culture. [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC185305 
  1. National Center for Biotechnology Information (NCBI). Simultaneous polymerization and adhesion under hypoxia in sickle cell disease [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=30190429 
  1. National Center for Biotechnology Information (NCBI). Simultaneous polymerization and adhesion under hypoxia in sickle cell disease – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156668 
  1. National Center for Biotechnology Information (NCBI). Role of endothelin-1 in hypertension and vascular disease [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11411770 
  1. National Center for Biotechnology Information (NCBI). Monocyte chemoattractant protein 1-mediated migration of mesenchymal stem cells is a source of intimal hyperplasia [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23599443 
  1. National Center for Biotechnology Information (NCBI). The role of shear-induced transforming growth factor-β signaling in the endothelium [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23968981 
  1. National Center for Biotechnology Information (NCBI). The role of shear-induced TGF-β signaling in the endothelium – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129450 
  1. National Center for Biotechnology Information (NCBI). Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32478094 
  1. National Center for Biotechnology Information (NCBI). Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232582 
  1. National Center for Biotechnology Information (NCBI). Assessment of the flow velocity of blood cells in a microfluidic device using joint spectral and time domain optical coherence tomography [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24104312 
  1. National Center for Biotechnology Information (NCBI). Measurement of fluid-flow-velocity profile in turbid media by the use of optical Doppler tomography [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18250655 
  1. National Center for Biotechnology Information (NCBI). Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21946257 
  1. National Center for Biotechnology Information (NCBI). Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195466 
  1. National Center for Biotechnology Information (NCBI). Allogenic immune response promotes the accumulation of host-derived smooth muscle cells in transplant arteriosclerosis [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15639493 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sharan%20Ananthaseshan 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Krzysztof%20Bojakowski 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Mariusz%20Sacharczuk 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Piotr%20Poznanski 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dominik%20S.%20Skiba 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Lisa%20Prahl%20Wittberg 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jordan%20McKenzie 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anna%20Szkulmowska 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Niclas%20Berg 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Piotr%20Andziak 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hanna%20Menkens 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Maciej%20Wojtkowski 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dorota%20Religa 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Fredrik%20Lundell 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Tomasz%20Guzik 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Zbigniew%20Gaciong 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Piotr%20Religa 

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

1

Low Red Cell Distribution Width in Blood: Interpreting Your Blood Test Results

Key Highlights: 

Introduction 

Understanding blood test results is essential for getting the right care and maintaining good health. Red cell distribution width (RDW) is an important aspect that can provide clues about your overall well-being. 

In this article, you will learn about what RDW is, why it is measured, how to interpret your RDW results, and the potential influence of these results on your health. Together with other blood test indicators, RDW may help you and your healthcare provider come up with a comprehensive management plan tailored to your specific health needs. 

Did you know?

  • Low red cell distribution width (RDW) in blood is associated with a decreased risk of cardiovascular events. source: PMC
  • RDW is associated with inflammation, as indicated by an elevated C-reactive protein level. source: PMC
  • RDW results are usually evaluated in conjunction with other blood tests to provide a more complete picture of red blood cells. source: medlineplus.gov
  • RDW is a measure of heterogeneity in the size of circulating erythrocytes. source: medlineplus.gov
  • RDW results help diagnose conditions like iron deficiency, anemia, thalassemia, and sickle cell anemia. source: medlineplus.gov

Red Cell Distribution Width (RDW) Test 

RDW aids in checking the state of your red blood cells. 

What is RDW? 

Red cell distribution width (RDW) is a measure of the difference in size and volume of your red blood cells. It’s part of a complete blood count (CBC). This routine blood test gives us a picture of your overall health. RDW is key for detecting possible blood disorders and tracking existing  illnesses.  

Why is the RDW test done? 

RDW tests aim to help detect and keep track of certain health issues. Working with other blood test checks, RDW helps in finding out if you have the following.  

How do you prepare for the test? 

Getting ready for an RDW test is simple. No need to fast or make any other special  changes. Just go by your healthcare provider’s orders before the test.  

Interpreting RDW Results 

Understanding RDW ranges 

RDW values are given as a percent. They tell us about the sizes of your red blood cells. For adults, the normal range is between 11.5% and 15.4%. This can change based on the laboratory and instrument used.  

RDW ranges come in three types: normal, high, and low. 

Factors affecting RDW 

Many things may affect RDW levels.  

Research has demonstrated that RDW is linked to a bad outcome in individuals with multiple myeloma and lung cancer. Additionally, it may predict cancer in those who have lost weight inadvertently.

Dr. Siddharth Gupta, B.A.M.S, M.D

Low Red Cell Distribution Width 

Low RDW mainly shows your red blood cells are the same in size and shape.  Some factors might fake a low RDW. These  are as follows. 

Low RDW doesn’t directly cause trouble. But conditions tied to low RDW might impact your health.  

If your blood test reveals low red cell distribution width, your healthcare provider will check your signs and symptoms and may look at other blood test parameters to assess the reason behind this. 
 

Other Important Blood Test Indicators 

Besides RDW, other blood tests are vital in gauging your health. 

Mean corpuscular volume (MCV) is another key blood  test. It finds out the mean size of your red blood cells. It’s often part of a CBC. MCV results can give helpful information about the kind of anaemia you might have or if you’re at risk of lacking certain nutrients. The bond between RDW and MCV can shed light on your health state. 

Haemoglobin and hematocrit levels also matter a lot in blood tests. Haemoglobin is a protein in red blood cells that carries oxygen. Hematocrit tells us the red blood cells’ volume percentage in the blood. 

In reading RDW results, thinking about haemoglobin and hematocrit levels together is key. This combination gives a full view of your blood health. It helps healthcare providers make smart choices about your health. 

Management 

The right care and steps are vital for handling the root cause of low RDW. 

1. Addressing the underlying cause 

In managing low RDW, dealing with the root cause is most important. This means making the right  tests, knowing the exact issue, and modifying the management plan accordingly. In some cases, your healthcare provider may suggest drugs, supplements, or lifestyle changes. 

2. Dietary and lifestyle changes 

Eating a balanced diet rich in iron aids a lot in improving RDW levels. Having foods high in vitamins, minerals, and key nutrients may help. Moreover, regular exercise and enough water intake may also help improve your blood health. 

3. Monitoring and follow-up tests 

Doing regular blood tests are key for tracking your RDW levels and for controlling any ongoing health issues. This ensures your management plan is made to meet your exact  requirements. It also allows for needed changes in your health plan. 

Conclusion 

Knowing the value of low RDW and using this key information may help you maintain health. By tracking your RDW results and working in sync with your healthcare provider, you may manage your health well. 

Moreover, fixing the root cause of low RDW and implementing the lifestyle and dietary changes required is vital.  

Frequently Asked Questions (FAQs) 

What does it mean when your red blood cell distribution width is low? 

A low RDW shows that your red blood cells have the same size and shape. This is often seen as normal. It points to no blood problems. But, if other blood test results aren’t normal, dealing with the possible root causes with your healthcare provider is key. 

What is red blood cell distribution width in heart failure? 

A high red blood cell distribution width has been linked to  a higher chance of heart failure. The exact reasons for this correlation aren’t fully known yet. But it’s thought that inflammation, oxidative stress, and other factors tied to red blood cell production could play a part. 

What does the red cell distribution width RDW indicate on the peripheral blood smear? 

On the peripheral blood smear, the red cell distribution width (RDW) stands for the variance in size and volume of the red blood cells. A bigger RDW hints at a bigger variance, which could point to the presence of certain health issues, such as anaemia or nutrient deficiencies. 

What does it mean when you have low MCV? 

A low mean corpuscular volume (MCV) shows your red blood cells are smaller than usual. This could show certain types of anaemia, such as a lack of iron in the blood or thalassaemia. 

How often should I have my RDW levels tested? 

The frequency of RDW tests is based on your exact health needs and your healthcare provider’s advice. Regular blood checks, including RDW, might be advised if you have an ongoing blood issue or risk of having certain health issues. In any case, getting advice from your healthcare provider  is always key. 

References: 

  1. PubMed. Poikilocytosis [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/32965812 
  1. National Center for Biotechnology Information (NCBI). The role of red blood cell distribution width (RDW) in cardiovascular risk assessment: useful or hype? – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861793 
  1. National Center for Biotechnology Information (NCBI). Macrocytic Anemia [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459295 
  1. PubMed. Red blood cell distribution width is increased in patients with psoriasis vulgaris: A retrospective study on 261 patients [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/25819386 
  1. PubMed. Baseline Red Blood Cell Distribution Width Correlates with Disease Activity and Therapeutic Outcomes in Patients with Systemic Lupus Erythematosus, Irrespective of Anemia Status [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/28164513 
  1. PubMed. Clinical Significance of Red Blood Cell Distribution Width and Inflammatory Factors for the Disease Activity in Rheumatoid Arthritis [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/28164544 
  1. PubMed. The effects of blood transfusion on red blood cell distribution width in critically ill patients: a pilot study [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/29770452 
  1. PubMed. The effect of smoking on chronic inflammation, immune function and blood cell composition [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/33173057 
  1. National Center for Biotechnology Information (NCBI). Association between alcohol-induced erythrocyte membrane alterations and hemolysis in chronic alcoholics – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281527 
  1. PubMed. Sleep duration and sleep disorder with red blood cell distribution width [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/26018095 
  1. PubMed. Relationships between sedentary behaviour, physical activity levels and red blood cell distribution width in children and adolescents [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/29744311 
  1. PubMed. The association between muscle strengthening activities and red blood cell distribution width among a national sample of U.S. adults [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/25602910 
  1. PubMed. The relationship between red cell distribution width and all-cause and cause-specific mortality in a general population [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/31700048 
  1. National Center for Biotechnology Information (NCBI). Elevated red blood cell distribution width predicts mortality in acute exacerbation of COPD [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=29542313 
  1. National Center for Biotechnology Information (NCBI). A novel method utilising markers of altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10870111 
  1. National Center for Biotechnology Information (NCBI). Red blood cell distribution width and cardiovascular diseases [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26623117 
  1. National Center for Biotechnology Information (NCBI). Red blood cell distribution width and cardiovascular diseases – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635283 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Wei%20Zhang 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Yadan%20Wang 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jun%20Wang 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Shaochun%20Wang 
  1. National Center for Biotechnology Information (NCBI). ΔRDW: A Novel Indicator with Predictive Value for the Diagnosis and Treatment of Multiple Diseases [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=34849010 
  1. National Center for Biotechnology Information (NCBI). ΔRDW: A Novel Indicator with Predictive Value for the Diagnosis and Treatment of Multiple Diseases – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627260 
  1. National Center for Biotechnology Information (NCBI). Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32965501 
  1. National Center for Biotechnology Information (NCBI). Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512057 
  1. National Center for Biotechnology Information (NCBI). Oxidation and erythrocyte senescence [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10698298 
  1. National Center for Biotechnology Information (NCBI). Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=31845889 
  1. National Center for Biotechnology Information (NCBI). Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917488 
  1. National Center for Biotechnology Information (NCBI). Proteins in the pathway from high red blood cell width distribution to all-cause mortality [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=35065420 
  1. National Center for Biotechnology Information (NCBI). Proteins in the pathway from high red blood cell width distribution to all-cause mortality – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784626 
  1. National Center for Biotechnology Information (NCBI). Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19017793 
  1. National Center for Biotechnology Information (NCBI). Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587583 
  1. National Center for Biotechnology Information (NCBI). Human cytomegalovirus inhibits erythropoietin production [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24722450 
  1. National Center for Biotechnology Information (NCBI). Human Cytomegalovirus Inhibits Erythropoietin Production – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116070 
  1. National Center for Biotechnology Information (NCBI). Near-wall excess of platelets induced by lateral migration of erythrocytes in flowing blood [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8476101 
  1. National Center for Biotechnology Information (NCBI). Concentration profile of blood platelets differs in arterioles and venules [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1566903 
  1. National Center for Biotechnology Information (NCBI). Flow effects on coagulation and thrombosis [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16741150 
  1. National Center for Biotechnology Information (NCBI). The effect of shear rate on platelet interaction with subendothelium exposed to citrated human blood [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7382854 
  1. National Center for Biotechnology Information (NCBI). Finite platelet size could be responsible for platelet margination effect [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22004736 
  1. National Center for Biotechnology Information (NCBI). Finite Platelet Size Could Be Responsible for Platelet Margination Effect – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192962 
  1. National Center for Biotechnology Information (NCBI). Lattice Boltzmann simulation of blood flow in digitized vessel networks [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19343080 
  1. National Center for Biotechnology Information (NCBI). Lattice Boltzmann simulation of blood flow in digitized vessel networks – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390865 
  1. National Center for Biotechnology Information (NCBI). Blood cell interactions and segregation in flow [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18188702 
  1. National Center for Biotechnology Information (NCBI). Blood Cell Interactions and Segregation in Flow – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752714 
  1. National Center for Biotechnology Information (NCBI). <em>In vivo</em> brain imaging with multimodal optical coherence microscopy in a mouse model of thromboembolic photochemical stroke [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32016131 
  1. National Center for Biotechnology Information (NCBI). In vivo brain imaging with multimodal optical coherence microscopy in a mouse model of thromboembolic photochemical stroke – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977401 
  1. National Center for Biotechnology Information (NCBI). In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26554396 
  1. National Center for Biotechnology Information (NCBI). In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692682 
  1. National Center for Biotechnology Information (NCBI). Influence of erythrocyte aggregation on leukocyte margination in postcapillary venules of rat mesentery [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11009430 
  1. National Center for Biotechnology Information (NCBI). The interaction of leukocytes and erythrocytes in capillary and postcapillary vessels [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7360047 
  1. National Center for Biotechnology Information (NCBI). Forces on a wall-bound leukocyte in a small vessel due to red cells in the blood stream [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23062353 
  1. National Center for Biotechnology Information (NCBI). Forces on a Wall-Bound Leukocyte in a Small Vessel Due to Red Cells in the Blood Stream – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471476 
  1. National Center for Biotechnology Information (NCBI). Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8580357 
  1. National Center for Biotechnology Information (NCBI). Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes. [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236447 
  1. National Center for Biotechnology Information (NCBI). Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular injury [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19276082 
  1. National Center for Biotechnology Information (NCBI). Erythrocyte Hemolysis and Hemoglobin Oxidation Promote Ferric 
    Chloride-induced Vascular 
    Injury – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676043 
  1. National Center for Biotechnology Information (NCBI). Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32942605 
  1. National Center for Biotechnology Information (NCBI). Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554753 
  1. National Center for Biotechnology Information (NCBI). Red blood cells mediate the onset of thrombosis in the ferric chloride murine model [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23343833 
  1. National Center for Biotechnology Information (NCBI). Red blood cells mediate the onset of thrombosis in the ferric chloride murine model – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643770 
  1. National Center for Biotechnology Information (NCBI). Sickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in culture [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7635951 
  1. National Center for Biotechnology Information (NCBI). Sickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in culture. [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC185305 
  1. National Center for Biotechnology Information (NCBI). Simultaneous polymerization and adhesion under hypoxia in sickle cell disease [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=30190429 
  1. National Center for Biotechnology Information (NCBI). Simultaneous polymerization and adhesion under hypoxia in sickle cell disease – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156668 
  1. National Center for Biotechnology Information (NCBI). Role of endothelin-1 in hypertension and vascular disease [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11411770 
  1. National Center for Biotechnology Information (NCBI). Monocyte chemoattractant protein 1-mediated migration of mesenchymal stem cells is a source of intimal hyperplasia [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23599443 
  1. National Center for Biotechnology Information (NCBI). The role of shear-induced transforming growth factor-β signaling in the endothelium [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23968981 
  1. National Center for Biotechnology Information (NCBI). The role of shear-induced TGF-β signaling in the endothelium – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129450 
  1. National Center for Biotechnology Information (NCBI). Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32478094 
  1. National Center for Biotechnology Information (NCBI). Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232582 
  1. National Center for Biotechnology Information (NCBI). Assessment of the flow velocity of blood cells in a microfluidic device using joint spectral and time domain optical coherence tomography [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24104312 
  1. National Center for Biotechnology Information (NCBI). Measurement of fluid-flow-velocity profile in turbid media by the use of optical Doppler tomography [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18250655 
  1. National Center for Biotechnology Information (NCBI). Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21946257 
  1. National Center for Biotechnology Information (NCBI). Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target – PMC [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195466 
  1. National Center for Biotechnology Information (NCBI). Allogenic immune response promotes the accumulation of host-derived smooth muscle cells in transplant arteriosclerosis [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15639493 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sharan%20Ananthaseshan 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Krzysztof%20Bojakowski 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Mariusz%20Sacharczuk 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Piotr%20Poznanski 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dominik%20S.%20Skiba 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Lisa%20Prahl%20Wittberg 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jordan%20McKenzie 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anna%20Szkulmowska 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Niclas%20Berg 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Piotr%20Andziak 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hanna%20Menkens 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Maciej%20Wojtkowski 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dorota%20Religa 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Fredrik%20Lundell 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Tomasz%20Guzik 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Zbigniew%20Gaciong 
  1. National Center for Biotechnology Information (NCBI). Search Page [Internet]. [cited 2024 Feb 13]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Piotr%20Religa 

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

MPV Blood Test: Understanding Its Importance and Results

Key Highlights: 

Introduction 

Platelets are the cells in your blood that help in clotting and repairing wounds.  Well, it is necessary to check their health. That’s where the Mean Platelet Volume (MPV) blood test comes into picture. 

In this article, we’ll explore the world of MPV blood tests. We’ll learn what MPV is, how to get ready for the test, analyze the results, and see what happens when the levels are not right. Lastly, we will answer some questions associated with this topic.  

Understanding MPV Blood Test 

In this section, we will try to understand MPV and its role in maintaining our health. 

What is MPV? 

The Mean Platelet Volume (MPV) is a laboratory finding. It measures the average size of platelets present in your blood. These small, colourless cell fragments are crucial for clotting, wound  repair, and fending off infection. They take birth in the bone marrow and then enter the bloodstream. The MPV test gives us the information regarding any abnormality in platelet size. This helps us to detect any issue that may be affecting these cells. 

Importance of MPV Test 

The following are the reasons why the MPV test is done. 

Did you know?

  • MPV tests are commonly used to evaluate platelet function and production. source: medlineplus.gov
  • High MPV (mean platelet volume) may indicate platelet dysfunction or bone marrow disorders. source: medlineplus.gov
  • MPV can be influenced by factors such as age, sex, smoking, and hormonal changes. source: PMC
  • MPV levels may decrease during an acute exacerbation of COPD. source: PMC
  • A cutoff value of less than 8.5fl for MPV has a sensitivity of 92% and specificity of 100% in predicting SLE. source: PMC

MPV Blood Test Process 

The procedure involved in conducting the MPV test is quite simple and is explained in the section below.  

How to Prepare for an MPV Test? 

For an MPV blood test, you don’t need to do anything special. Have a discussion with your doctor in case they advise any other test along with MPV that might require any special preparation like fasting.  Also, you need to disclose your current health conditions, family history, and the drugs and supplements you may be currently on, as they may influence the results of the test.  

What to Expect During an MPV Test? 

The MPV blood test is easy and quick. A phlebotomist takes blood from your arm vein with a needle, while maintaining hygiene. They save the sample in a test tube. Once done, remove the needle and apply a bandage on your arm. The entire process is over in a few minutes with maybe slight discomfort or bruising at the site of needle puncture. 

After the test, they send the blood sample to a laboratory where they check your MPV. Once the laboratory report is ready, your healthcare provider shares it with you. It’s important to discuss the results with them. This will give you a clear picture of your overall health. 

Causes and Implications of Abnormal MPV Results 

Your MPV blood test results can show high or low MPV.  The causes and possible issues due to abnormal MPV are discussed below. 

1. Causes of High MPV 

If your MPV result shows higher than the normal range (more than 12 femtoliters), it might be due to the following.  

Some types of cancer can lead to an increase in platelet size, causing a rise in MPV. But don’t worry as high MPV doesn’t always mean you have cancer. If there is a history of cancer in your family or other risk factors, further testing may be suggested by your doctor. 

Apart from cancer, many other factors can make your MPV  increase. The potential causes are as follows.  

2. Causes of Low MPV 

On the flip side, a low MPV (less than 8 femtoliters) hints that your platelets are mostly old. This is because the production of new platelets in your bone marrow has slowed down. Some common causes of low MPV are as follows. 

Implications of High and Low MPV Results 

 High MPV can lead to blood clot formation. This is because larger platelets are more active. Increased blood clots bring risks such as stroke or deep vein thrombosis (DVT). A low MPV might mean more bleeding or bruising. This is because smaller, older platelets may not work as well. 

Remember high or low MPV levels alone cannot decide anything. Your healthcare provider will use all factors including your past health and other test results to find out what’s causing the abnormal MPV levels. 

Certain studies indicate that MPV may be higher in COVID-19-positive people than in COVID-19-negative people. However, more research is needed to completely understand the association between the results of an MPV blood test and the severity of COVID-19 infection.

Dr. Siddharth Gupta, B.A.M.S, M.D

Thrombocytopenia and MPV 

Thrombocytopenia is when you have a low platelet count.  

What is Thrombocytopenia? 

Thrombocytopenia happens when your blood has fewer platelets than normal. Since platelets help in clotting, a low count of platelets can cause excess bleeding or easy bruising. 

How is Thrombocytopenia diagnosed? 

To find out if you have thrombocytopenia, doctors conduct a complete blood count (CBC) test. It includes a platelet count and MPV check. If results show thrombocytopenia, more tests may be done to find the root cause. These may include a bone marrow biopsy or other blood tests. 

Management options for Thrombocytopenia 

The management for thrombocytopenia depends on how severe it is, and its causes.  

Doctors may give medicines to raise platelet production or they may give medicine to slow down the immune system if that’s causing thrombocytopenia. Some common medicines used include corticosteroids or immunoglobulins. 

Those with thrombocytopenia should be careful to avoid injuries and bleeding risk. So, it’s important to watch your physical activities, take care with medicines that can make bleeding worse (for example,  blood thinners or NSAIDs), and live a healthy life to boost overall wellness. 

Research has indicated that stress, both emotional and physical, might have an impact on platelet count. Heavy exercise for an extended period of time can raise MPV. Higher-than-normal MPV is possible in people with panic disorders.

Dr. Rajeev Singh, BAMS

Preparing for an Appointment with a Healthcare Provider 

What to Expect During a Consultation? 

In your appointment, your healthcare provider will go over your past health, current symptoms, and test results. They might order more testing if needed. You should get ready to discuss any concerns, answer questions about your lifestyle, medicines you are currently taking, and about your family medical history. 

Questions to Ask Your Healthcare Provider? 

It’s a good plan to prepare a list of questions for your healthcare provider. These could the following.  

Also Read: CRP Test Report: Interpreting Results and Their Medical Implication

Conclusion 

Getting to know your MPV blood test results is key for maintaining health. This article gives a complete and easy-to-understand guide to help you understand MPV tests, their weightage, and what it means when results are not normal. 

While MPV can hint at health issues, it’s always important to consult with a healthcare expert. They will help put the results in context and may order more test.  

Frequently Asked Questions (FAQs) 

What does it mean when your MPV is high? 

If your MPV is high, it suggests that your platelets are larger than normal. This might be due to many reasons such as cancer, recovering from injuries, heart disease, and more. Your healthcare provider will consider all factors to find out the real reason for the high MPV. 

What does MPV mean in a blood test when it is low? 

A low MPV suggests that most of your platelets are old. This hints that your bone marrow production of new platelets has reduced. The reason could be bone marrow failure, lupus, chemotherapy, hypothyroidism, iron deficiency anaemia, or HIV/AIDS among others. 

What is a normal MPV level for a woman? 

For women, usual MPV levels are between 8-12 femtoliters. But always consult a healthcare expert to correctly understand your MPV result and what it means for your health. 

What cancers cause low MPV? 

Some cancers that hit the bone marrow, such as leukaemia or lymphoma, might cause low MPV. They disrupt the normal process of producing platelets. Remember only measuring MPV can’t tell for sure if it’s cancer. An in-depth examination by a healthcare expert is needed. 

References: 

  1. National Center for Biotechnology Information (NCBI). Thrombocytopenia [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542208 
  1. National Center for Biotechnology Information (NCBI). Platelet function and ageing – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935731 
  1. National Center for Biotechnology Information (NCBI). Relation between indices of end-organ damage and mean platelet volume in hypertensive patients [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/22576288 
  1. National Center for Biotechnology Information (NCBI). Mean platelet volume and vitamin D level [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24624344 
  1. National Center for Biotechnology Information (NCBI). The relationship between mean platelet volume and thrombosis recurrence in patients diagnosed with antiphospholipid syndrome [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24671503 
  1. National Center for Biotechnology Information (NCBI). Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/21330610 
  1. National Center for Biotechnology Information (NCBI). Usefulness of mean platelet volume for predicting stroke risk in atrial fibrillation patients [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23080368 

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

PDW Blood Test: Understanding Its Purpose and Results

Key Highlights: 

Introduction 

The PDW blood test is a medical test that checks for size differences in blood platelets. The main function of platelets includes clotting and ensuring smooth blood flow in the body.  

In this article, we will cover the basics of a PDW blood test. We’ll discuss about why it’s done, how it’s done, and what the results mean. We will also touch on the connection between PDW, and blood disorders tied to platelets. Lastly, we’ll share ways to get ready for a doctor’s visit for a PDW test. 

Did you know?

Overview of PDW Blood Test 

The role of a PDW (platelet distribution width) blood test is to assess how well a person’s platelets are working whose main function is to create clots and aid in wound repair and stop blood loss. 

What is PDW? 

PDW test measures the size differences in platelets in a person’s blood. High PDW means that there is a range of platelet sizes, and low PDW suggests more similar sized platelets. Knowing these variations helps doctors understand how a person’s platelets are functioning. 

Importance of PDW Blood Test 

The purpose of doing a PDW blood test is as follows.  

Examining how well platelets work helps decide if a person can form blood clots and maintain smooth blood flow. Abnormal platelet activity can hint at health problems that might need further investigation and management.  

A PDW blood test is useful for spotting blood disorders. For example, it sheds light on platelet distribution and activity. This means we may spot issues such as thrombocytopenia (low platelet count) or thrombocytosis (high platelet count). 

How is the PDW Blood Test Performed? 

A PDW blood test needs a blood sample from a vein in your arm or hand. Below we have described how to get ready for the test and what happens during the process.  

Preparing for the Test 

Typically, there are no unique preparations needed for a PDW blood test. But, if you’re also doing other tests on the same day, your healthcare provider may suggest some things. Always let your provider know about any drugs, vitamins, supplements, or herbal products you’re taking. This avoids unexpected impact on test results.  

The Blood Test Procedure 

During the test, a medic places a small needle into a vein in your arm or hand to take blood. Once they get the sample, it’s sent to a laboratory for study. Though the test is quick and mostly painless, some people might feel dizzy or sick. Deep, slow breaths help lessen these feelings. Also, some people may feel slight pain or see bruises where the needle went in. 

Understanding PDW Blood Test Results 

1. Normal PDW Levels 

Normal PDW levels fall between 8 to 12 femtoliters.  This indicates that your platelets are at peak performance and no medical action is needed. 

2. Low PDW Levels 

Low PDW levels (below 8 femtoliters) could mean a majority of your platelets are old or your bone marrow could be making fewer platelets than usual. 

Low PDW could be due to bone marrow failure, lupus, some medications such as chemotherapeutic agents, hypothyroidism, lack of iron, or HIV/AIDS. 

With a low PDW level, your blood may have trouble clotting. The risk of heavy bleeding is higher. You might then need more tests to know the cause and work out a management plan with your doctor. 

3. High PDW Levels 

High PDW levels (above 12 femtoliters) show higher levels of young platelets in the blood.  

Elevated PDW levels could be due to a recent wound or surgery, blood loss, or too much alcohol/vitamin B12  deficiency. Chronic health problems, infections, or even birth control pills use may also affect PDW levels. 

High PDW levels  are linked to an increased risk of forming blood clots. Clots in the arms or legs can be risky if they break loose and travel to other body parts clogging the blood supply to those parts. 

Researchers have found that in pregnancy, simple platelet indicators, such as MPV and PDW, rise in response to platelet activation. Given that PDW might not rise during a simple tissue injury, it is a more precise indicator of platelet activation.

Dr. Siddharth Gupta, B.A.M.S, M.D

Platelet-Related Blood Disorders 

With PDW blood tests, doctors can check for blood disorders tied to platelets. Two common types include thrombocytopenia (low platelet count) and essential thrombocythaemia (high platelet count). 

Thrombocytopenia (Low Platelet Count) 

Thrombocytopenia means you have too few platelets in your blood, which raises the risk of bleeding and bruising. Likely causes include problems with the immune system, some medications, and inherited diseases. Doctors can diagnose it through blood tests, physical exams, and after looking at your medical history. 

Essential Thrombocythaemia (High Platelet Count) 

In essential thrombocythaemia, the bone marrow makes too many platelets. This over-production could be due to gene changes or conditions like cancer. With too many platelets, your risk of forming blood clots increases. This could lead to serious issues like strokes or heart attacks. 

Diagnosis and  Management 

After finding a blood disorder through PDW blood tests or other ways, it’s time to look at management choices. These help control symptoms and avoid likely issues. 

Diagnosing Blood Disorders 

Diagnosing blood disorders often involves several steps. It starts with looking at your medical past, physical examination findings, and laboratory test results that matter. Depending on the suspected disease, you may need more blood or imaging tests. 

A typical way to diagnose blood disorders might include the following steps.  

  1. Looking into your full medical past. 
  2. Doing a physical check-up. 
  3. Running laboratory tests, imaging tests, or both. 
  4. Refer you to a specialist if needed. 
  5. Finding a diagnosis from the information collected. 

Doctors may recommend extra blood tests. These tests could be coagulation tests, complete blood count (CBC), or specialized tests like peripheral blood smear or quantitative immunoglobulins. 

Management Options 

The type of blood disorder, how severe it is, and its causes shape the management choices. Possible options could include the ones below. 

A doctor may give drugs to boost platelet count,  suppress the immune system, or improve overall platelet work. 

People with very low platelets or a high risk of bleeding might need blood or platelet transfusions. These replace lost platelets and bring clotting back to normal. 

In some cases, changing your lifestyle or home remedies may help improve overall blood health. Such changes could include eating a balanced diet full of vitamins and minerals, doing physical activities, or avoiding some drugs known to affect platelet function. 

A recent study indicated that patients with heart failure had a poorer prognosis when their platelet distribution width (PDW) was high.

Dr. Rajeev Singh, BAMS

Complications of Platelet Disorders 

Platelet disorders may bring forth different complications. These depend on the person and the exact disorder.  

Hemorrhages or Clotting Issues 

As described above the first concern with platelet issues is the high chance of uncontrolled bleeding (hemorrhages) or risky blood clots forming. These problems can be life-threatening and may need urgent help. 

Enlarged Spleens 

The main function of the spleen is to filter out unwanted substances from the blood and help fight disease. Some diseases or medical issues can make the spleen grow larger, which can reduce platelet circulation. It may also raise the risk of other health issues. 

Preparing for Your Doctor’s Appointment 

If your PDW blood test results are not normal, or you have symptoms that hint at a bleeding or clotting issue, it’s vital to book an appointment with your healthcare provider.  

What to Bring? 

Here’s what to take to your doctor’s visit. 

Questions to Ask? 

Try to ask these questions during your visit.  

Also Read: How To Increase Platelet Count Naturally

Conclusion 

Knowing why PDW blood tests are done and what their results mean provides information on how a person’s platelets are working and the overall health of their blood. Noticing abnormal PDW levels is the key to finding possible blood disorders, and  their managing options.  

Frequently Asked Questions  (FAQs ) 

What factors can affect PDW test results? 

PDW test results can be affected by some drugs, temporary health issues, and age. Also, factors like low or high altitude, smoking, and high glucose levels can change PDW test results. 

What is the difference between PDW and MPV? 

PDW checks for size differences in platelets, while MPV tells the average platelet size in a blood sample. While both give vital information on how platelets are working, they show different sides of blood health. 

How important is a high or low PDW level, and under what circumstances should someone be concerned? 

High or low PDW levels alone may not mean much. But if these levels are not normal over time, or you have other symptoms, they could hint at a basic health issue that needs more tests and potential therapy. Talk to a healthcare provider if your PDW test results or symptoms tied to a platelet-related disorder worry you. 

Are there any foods or lifestyle changes that can help to normalize PDW levels? 

Eating a balanced diet full of vitamins, minerals, and anti-inflammation items may boost overall blood health. Regular physical activities, reducing or stopping alcohol, and tobacco use may also help make blood cells healthier. 

Are there any risks or side effects linked to PDW blood tests? 

Key risks tied to PDW blood tests include slight pain or bruises at the needle site, and brief feelings of dizziness or sickness in some people. But, these risks are few and don’t last long. 

References: 

  1. National Center for Biotechnology Information (NCBI). Thrombocytopenia [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542208 
  1. National Center for Biotechnology Information (NCBI). Platelet function and ageing – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935731 

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

2

Red Blood Cells: Exploring Their Function and Importance in Health

Key Highlights: 

Introduction 

Red blood cells (RBCs) are special cells that carry oxygen. They go from the lungs to all parts of our body. RBCs owe their oxygen-carrying capacity to haemoglobin, an iron-rich protein. This protein grabs oxygen and takes it around the body via the bloodstream. But they don’t just carry oxygen. They also help remove waste products, like carbon dioxide, from body tissues. Keeping up the right count of RBCs matters a lot for well-being. Without RBCs, our cells would lack the oxygen they need to survive. On top of that, carbon dioxide would rise inside our bodies which is deleterious to the body. In this blog, we’re going to cover all about how they’re formed, how they’re structured and why having the right count matters.  

Did you know?

Formation and Structure of Red Blood Cells 

Haemopoiesis: The process of red blood cell formation 

Creating red blood cells, a process also known as erythropoiesis or haemopoiesis, is complex. It happens in different steps involving various cell types. The main site where this happens is the bone marrow. This is where stem cells live. These are  cells that can turn into any kind of cell. 

Bone marrow, a soft, spongy tissue in our bones, produces blood cells. It forms red and white blood cells, as well as platelets. At the heart of the process are the haematopoietic stem cells (HSCs). These can morph into any type of blood cell.  

The process starts when the HSCs divide and evolve into cells named proerythroblasts. Proerythroblasts then turn into basophilic erythroblasts, which then change to polychromatic erythroblasts. The cells start to make haemoglobin at this stage. They keep growing and change into orthochromatic erythroblasts. These cells lose their nucleus and turn into reticulocytes. Then, these reticulocytes are let into the bloodstream to grow up into full-fledged red blood cells. Below is a table that enumerates the various stages of erythropoiesis and their description. 

Stages of erythropoiesis  Description 
Haematopoietic stem cells (HSCs) An undifferentiated cell that can morph into any blood cell  
Proerythroblast RBC precursor 
Basophilic erythroblast The stage where the synthesis of haemoglobin begins  
Polychromatic erythroblast  Continuation of the maturation process. 
Orthochromatic erythroblast  Loses its nucleus  
Reticulocyte  Immature cells that are released into the bloodstream. 
Mature red blood cell/ Erythrocyte  Fully functional oxygen-carrying cells. 

Structure and components of red blood cells 

Red blood cells (RCBs) are unique with following key features. 

One of their key traits is their biconcave shape. It’s like a flattened donut, but thinner in the middle. This shape gives them a larger surface area that helps in gas exchange, as well as the flexibility to go through tight  spaces. 

At the heart of how RBCs work is the protein haemoglobin. It enables these cells to carry oxygen across our bodies. Haemoglobin binds to oxygen molecules, which gives red blood cells their distinct red colour. Plus, it aids in removing carbon dioxide from body tissues and getting it back to the lungs to breathe out. 

Due to the lack of a central membrane (nucleus), red blood cells have a short lifespan. A red blood cell can only live for 120 days on average when it passes through your blood vessels because it exhausts its energy supply. Red blood cells make up about 40% of your blood, which is why your blood appears red.

Dr. Siddharth Gupta, B.A.M.S, M.D

Functions of Red Blood Cells 

1. Oxygen transportation to tissues 

Perhaps, the chief function of RBCs is carrying oxygen. They pick up oxygen from the lungs and move it to tissues across our bodies. Their special shape and the protein haemoglobin allow them to carry large amounts of oxygen. 

2. Carbon dioxide removal from tissues 

Besides supplying oxygen, RBCs aid waste removal too. After they deliver oxygen, haemoglobin binds with carbon dioxide. This waste product is a result of cell metabolism. RBCs then take these waste molecules back to the lungs, where they are exhaled. 

3. Role in maintaining acid-base balance 

RBCs also help maintain the body’s pH levels stable. Carbon dioxide can form carbonic acid when it’s dissolved in blood. This can cause an acidic environment. By taking carbon dioxide out of the body, RBCs can keep the body’s pH within a healthy range. 

Red Blood Cell Count and Its Significance 

The RBC count is a measure of the number of red blood cells in our blood. The normal range can differ based on the person’s age and  gender.  

Numerous factors can affect the RBC count. These include age,  gender, diet, the air we breathe, and medical  status. Even some drugs can impact RBC production. 

Symptoms and Causes of Abnormal RBC Count 

Having the right RBC count is key for our health. If we have too few or too many, it can cause health issues. 

1. Low RBC count (Anaemia) 

Anaemia is when we have low levels of RBCs or haemoglobin. This results in less oxygen-carrying capacity in the blood. There are several reasons this can happen which are as follows.  

2. Nutritional deficiency 

Low levels of iron, vitamin B12, or folic acid can affect RBC production, leading to anaemia. Eating a balanced diet full of these key nutrients can help stop anaemia due to nutrient lack. 

3. Bone marrow failure 

Diseases like aplastic anaemia or some cancers can disrupt bone marrow function and hinder RBC production. 

4. Hemolysis 

Some autoimmune diseases or genetic disorders can cause the body to get rid of RBCs quicker than it can create new ones, thus causing anaemia. 

5. Chronic conditions 

Chronic illnesses such as kidney disease or inflammatory conditions like arthritis can derail RBC production, leading to long-term anaemia. 

High RBC count (Polycythaemia) 

Having too many red blood cells is called polycythaemia. This leads to thicker blood, increasing the chance of forming clots. Several factors can cause high RBC count which are as follows. 

Primary erythrocytosis means there’s a problem with bone marrow cell growth. This results in too many RBCs being made. Polycythaemia vera, a genetic mutation, is an example of primary polycythaemia. 

Outside factors such as lung diseases, high altitudes, and dehydration can trigger secondary erythrocytosis, a condition where the RBC count rises. 

Some medications, like anabolic steroids or erythropoietin injections, can artificially increase the RBC count. 

Red Blood Cells and Health 

Red blood cells and blood cancers 

Blood cancers like leukaemia and myeloma can disrupt RBC formation. They stop the body from being able to make healthy blood cells. This can cause abnormal RBC counts, leading to serious health issues. 

Impact of lifestyle and dietary factors on red blood cell health 

Genes and medical problems can play a big role in RBC health. But so does lifestyle, diet, and daily habits. Living a healthy life and eating a balanced diet may support blood cell health. 

Also Read: Cherry Tomatoes: Unveiling the Nutritional Benefits and Culinary Uses

Diagnosis and Management of Abnormal Red Blood Cell Count 

1. Diagnosing low or high RBC count 

If you are feeling symptoms tied to abnormal RBC counts, discuss with your healthcare provider. They might conduct a blood test called a complete blood count (CBC) to check the number of different blood cells. This test can help figure out if management is needed. 

2. Management options for abnormal RBC count 

There are different management options depending on the root cause of the RBC count issue. 

3. Management for low RBC count (Anaemia) 

If you have anaemia, the best option depends on the exact cause. 

If nutrient lack is causing anaemia, your healthcare provider may suggest taking supplements of iron, vitamin B12, or folic acid. Don’t start supplements on your own always convey your symptoms to your doctor first following which they will conduct tests and based on the results prescribe supplements.  

Your doctor may prescribe some medicines. These may increase RBC production or manage root conditions, like autoimmune diseases or kidney issues. 

4. Management for high RBC count (Polycythaemia) 

If you have polycythaemia, there are some potential options which are as follows.  

A phlebotomy is a procedure that takes a small amount of blood out of the body. This helps to lower the RBC count and reduces the risk of blood clots. 

Your doctor may give you certain medications to help bring down your RBC count and avoid clot formation. 

Making changes like quitting smoking, drinking enough water, and exercising often may aid in managing a high RBC count. 

Conclusion 

Healthy red blood cells are vital for overall health as they handle critical jobs like carrying oxygen, removing carbon dioxide, and keeping pH balance in check. Knowing how RBCs form and what affects their count allows everyone to understand why it’s essential to manage them effectively. 

RBC count that’s too high or too low can lead to various health problems. By adopting a nourishing diet, getting regular exercise, and implementing positive lifestyle adaptations, you may make a significant impact on RBC health. This ensures efficient oxygen delivery and waste removal throughout the body. Early detection and management of abnormal RBC counts is crucial to avoid serious health outcomes. Consult with your healthcare provider if you’re concerned about your RBC count. They can guide you in managing it best. 

Frequently Asked Questions (FAQs) 

Is a low RBC count and anaemia the same thing? 

No, they’re not. Anaemia happens when you have a low RBC count or the haemoglobin is low. This affects how much oxygen the blood can carry. Having a low RBC count is just one factor that can bring about anaemia. 

What are the most common causes of anaemia? 

The key causes of anaemia tend to be reasons like nutrient lack (like iron, vitamin B12, or folic acid), blood loss, bone marrow failure, and certain chronic health problems. 

How can I increase my red blood cell count naturally? 

You may naturally increase your RBC count by eating a balanced diet full of key nutrients. Regular exercise and embracing healthy lifestyle habits that may also work. 

What level of low RBC count is concerning? 

A low RBC count becomes a concern when it’s lower than the normal range of 4.7–6.1 million cells/µL for adult males or 4.2–5.4 million cells/µL for adult females. However, the exact level that causes worry can differ based on factors like age, gender, or overall health. 

When should I contact a doctor regarding my red blood cell count? 

If you’re having symptoms tied to abnormal RBC count, such as fatigue, breathing troubles, feeling dizzy, or heart fluttering, it’s key that you see your healthcare provider. They can do tests to figure out what’s happening and propose the best management options if needed. 

References: 

  1. National Center for Biotechnology Information (NCBI). Secondary Polycythemia [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562233 
  1. American Cancer Society. Low Red Blood Cell Counts (Anemia) [Internet]. [cited 2024 Feb 13]. Available from: https://www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/low-blood-counts/anemia.html 
  1. National Center for Biotechnology Information (NCBI). Polycythemia [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK526081 
  1. National Health Service (NHS). Iron deficiency anaemia [Internet]. [cited 2024 Feb 13]. Available from: https://www.nhs.uk/conditions/iron-deficiency-anaemia 
  1. World Health Organization (WHO). Anaemia [Internet]. [cited 2024 Feb 13]. Available from: https://www.who.int/health-topics/anaemia#tab=tab_1 
  1. National Center for Biotechnology Information (NCBI). Megaloblastic Anemia [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537254 
  1. PubMed. Copper deficiency anemia: review article [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/29959467 
  1. American Heart Association. What Exercise Is Right for Me? [Internet]. [cited 2024 Feb 13]. Available from: https://www.heart.org/en/healthy-living/go-red-get-fit/what-exercise-is-right-for-me 
  1. National Health Service (NHS). Red blood cell count [Internet]. [cited 2024 Feb 13]. Available from: https://www.nhs.uk/conditions/red-blood-count 
  1. World Health Organization (WHO). Anaemia [Internet]. [cited 2024 Feb 13]. Available from: https://www.who.int/health-topics/anaemia 
  1. National Health Service (NHS). Erythrocytosis [Internet]. [cited 2024 Feb 13]. Available from: https://www.nhs.uk/conditions/polycythaemia 

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

1

RDW Blood Test: Interpreting Results and Understanding its Importance

Key Highlights: 

Introduction 

Red blood cell distribution width (RDW) is an important factor when it comes to understanding the health of your blood cells. An indicator of the variations in the size and volume of red blood cells, RDW plays a crucial role in diagnosing and differentiating various health conditions, including anaemia. In this article, we will discuss the purpose of the RDW blood test, how it is conducted, and how the results are interpreted. We will also delve into the significance of RDW in monitoring therapy progress, as well as the factors that may affect RDW values. 

Did you know?

What is the RDW Blood Test? 

Definition and purpose 

Red cell distribution width (RDW) is a crucial measure in blood tests. It shows how much the size and volume of red blood cells differ from each other. The job of these cells is to transport oxygen from the lungs to the different body parts. A non-normal RDW result might mean problems with body functions that affect oxygen flow. However, knowing about extra tools, like mean corpuscular volume (MCV), is key to understanding blood health. 

Analyzing Red Blood Cell Distribution Width 

Red blood cells usually stay at a size of 6 to 8 micrometers across. Higher RDW test results mean the sizes of cells vary more. In short, the higher the RDW results, the more diverse the sizes of red blood cells. It’s key to use RDW results with other blood tests, like the MCV, for a more accurate diagnosis. 

Relation with other blood tests 

RDW tests often go alongside a complete blood count (CBC). This test looks at the types,  numbers, and traits of your blood cells. Included are red and white blood cells and platelets, haemoglobin levels, etc.  

Why is the RDW Test Done? 

Differentiating various anaemia types 

The main aim of RDW blood tests is to diagnose anaemia and its cause. The types of anaemia that are linked to different RDW results include iron lack anaemia, anaemia caused by a lack of B12 or folate, and others. Doctors can accurately diagnose the type of anaemia using the RDW test. This information is essential for making a good management plan. 

Diagnosing various health conditions 

Aside from anaemia, the RDW test can also point out the presence of other health problems, such as thalassaemia, diabetes, heart disease, liver disease, and cancer. Early spotting of these health problems means an early start to effective  management. 

Monitoring therapy progress 

RDW tests help in tracking the progress of therapies used for different health problems. For example, a falling RDW after starting anaemia management might show that the therapy is working and that all the red blood cells are returning to normal size. 

How to Prepare for an RDW Test? 

Pre-test preparations 

An RDW blood test doesn’t need much preparation. However, if your healthcare provider adds other tests to the RDW in a complete blood count, you might need to fast or follow special instructions. 

Doctor’s instructions 

It’s key to follow any unique instructions given by your healthcare provider before an RDW test. Be sure to tell your doctor about any medications, supplements, or vitamins you’re taking. This information could impact the test results. 

Depending on the results of your test, your doctor will design a treatment plan to increase the amount of oxygen your red blood cells can carry in case you have a chronic blood disorder, such as anaemia. Your provider may suggest iron supplements, medicines, and/or dietary changes based on your specific condition.

Dr. Siddharth Gupta, B.A.M.S, M.D

Understanding RDW Test Results 

1. High RDW results 

High RDW results might point to an underlying health problem, such as a lack of iron, folate, or B12. High RDW can also be linked to macrocytic anaemia, where the body does not make enough normal red blood cells. The leftover cells then grow larger than average. Microcytic anaemia, where red blood cells are smaller than normal, can also raise RDW. 

A high RDW result could mean a raised risk of health issues. This includes heart disease, liver problems, and some cancers. A comprehensive look at RDW and other blood tests, like MCV, is needed to work out the best course of action. 

2. Normal RDW results 

Normal RDW results mean the red blood cells are typically the same in size and shape. However, even if the RDW results are normal, there could still be an underlying health concern. That’s why healthcare providers must consider other blood tests during a check-up before confirming any kind of diagnosis. 

To keep RDW healthy, focus on a well-balanced diet packed with essential nutrients, regular workouts, and enough sleep, these may help.  

3. Low RDW results 

No exact blood disorders is linked to a low RDW result. Yet, a low RDW shows that red blood cells are fairly the same in size and shape. This is often viewed as ideal for overall health. 

A low RDW result doesn’t come with clear risks or worries. A consistently low RDW might mean overall good health, as long as there are no other symptoms or health issues. 

Many studies have demonstrated a correlation between the baseline RDW value and long-term adverse events in both acute and chronic conditions, including peripheral artery disease, acute myocardial infarctions (MI), heart failures, stable angina, stroke, and angina.

Dr. Rajeev Singh, BAMS

Factors Affecting RDW Values 

Age 

As we get older, the size, shape, and spread of red blood cells may alter. This may lead to a rise in RDW values. 

Lifestyle 

Lifestyle choices, like smoking too much, drinking alcohol, not exercising, and eating badly, might raise RDW values. 

Underlying medical conditions 

Several health issues, like long-term liver disease, kidney disease, heart disease, and inflammatory/autoimmune diseases, can affect RDW values.  

How to Lower a High RDW? 

Dietary changes 

Adding a balanced diet full of essential nutrients especially iron, vitamin B12, and folate may counter any deficiencies causing a high RDW. 

Maintaining a healthy lifestyle 

Quitting smoking, lessening alcohol intake, getting regular exercise, and getting enough sleep may all help lower a raised RDW.  

Medical interventions 

If there are any underlying health problems, they should be managed with the right medical management, as advised by healthcare providers. This may aid in controlling RDW values and keeping overall health in check. 

Studies have shown that overall cancer mortality might be correlated with elevated RDW. RDW may be able to somewhat forecast cancer patients’ mortality risk.

Dr. Smita barode, B.A.M.S, M.S.

RDW and Other Blood Tests 

The other tests that can be combined with the RDW test to give more insight are as follows.  

Other Blood Tests Importance 
Mean Corpuscular Volume Helps differentiate between types of anaemia 
Red Blood Cell Count Shows the quantity of red blood cells 
Other Indices in CBC Gives insights into overall health 

Conclusion 

The RDW blood test is a key tool in examining the health of your red blood cells and diagnosing anaemia and other health issues. By understanding your RDW results and working with a healthcare provider, you can deal with any underlying health issues and keep healthy. Always remember, the RDW test is just one tool among many used to check overall health.  

Frequently Asked Questions (FAQs) 

What does it mean if RDW is high? 

A high RDW might mean there’s an underlying issue including a lack of nutrients or various health problems like anaemia, autoimmune conditions, and liver or kidney disease. Make sure you discuss your RDW results with your healthcare provider to find the main cause and outline the right management plan. 

What does it mean if RDW is low? 

A low RDW means that your red blood cells are pretty much the same in size and shape. This is often considered ideal for optimal health. This indicates no known blood problems are affecting your RDW test results. 

Does high RDW cause fatigue? 

While high RDW does not directly bring about fatigue, it could be due to anaemia or another health problem that leads to fatigue. If you have high RDW and feel tired, discuss your results and symptoms with your healthcare provider to find the main problem. 

What cancers cause high RDW? 

Certain cancers could lead to high RDW, including blood cancers like leukaemia, and lung and colon cancer. A raised RDW may also indicate a less favourable outcome for cancer patients. However,  diagnosing cancer with just RDW alone is not possible. Extra tests and studies are needed for a firmed cancer diagnosis. 

References: 

  1. PubMed. Poikilocytosis [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/32965812 
  1. National Center for Biotechnology Information (NCBI). The role of red blood cell distribution width (RDW) in cardiovascular risk assessment: useful or hype? – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861793 
  1. National Center for Biotechnology Information (NCBI). Macrocytic Anemia [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459295 
  1. PubMed. Red blood cell distribution width is increased in patients with psoriasis vulgaris: A retrospective study on 261 patients [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/25819386 
  1. PubMed. Baseline Red Blood Cell Distribution Width Correlates with Disease Activity and Therapeutic Outcomes in Patients with Systemic Lupus Erythematosus, Irrespective of Anemia Status [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/28164513 
  1. PubMed. Clinical Significance of Red Blood Cell Distribution Width and Inflammatory Factors for the Disease Activity in Rheumatoid Arthritis [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/28164544 
  1. PubMed. The effects of blood transfusion on red blood cell distribution width in critically ill patients: a pilot study [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/29770452 
  1. PubMed. The effect of smoking on chronic inflammation, immune function and blood cell composition [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/33173057 
  1. National Center for Biotechnology Information (NCBI). Association between alcohol-induced erythrocyte membrane alterations and hemolysis in chronic alcoholics – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281527 
  1. PubMed. Sleep duration and sleep disorder with red blood cell distribution width [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/26018095 
  1. PubMed. Relationships between sedentary behaviour, physical activity levels and red blood cell distribution width in children and adolescents [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/29744311 
  1. PubMed. The association between muscle strengthening activities and red blood cell distribution width among a national sample of U.S. adults [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/25602910 
  1. PubMed. The relationship between red cell distribution width and all-cause and cause-specific mortality in a general population [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/31700048 

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

MCV Blood Test: Decoding its Significance in Your Health Report

Key Highlights: 

Introduction 

Managing your overall health requires an understanding of your blood test results. The MCV blood test is a key part of this. In this article, we will delve into the value of MCV blood test. We will take you through its role in making sense of your health report. 

 We will  also discuss the MCV blood test. What it measures, why it matters. We’ll look at how the test works, what normal ranges look like, and which health issues linked to high or low MCV values. Lastly, we will answer some frequently asked questions regarding this topic.  

What is MCV (Mean Corpuscular Volume)? 

Healthcare providers study your red blood cells. They check the average size or volume of these cells using the MCV. The MCV blood test is done to find out what type of anaemia a person might have. Detecting the exact type of anaemia is key as it offers hints to the deep-rooted cause of the issue. This allows for a direct and pinpointed course of  management. 

Did you know?

  • Factors such as diet, activity level, and medications can affect MCV test results. source: MedlinePlus
  • High MCV is associated with increased all-cause mortality and cancer mortality in non-anemic individuals. source: NCBI
  • MCV levels can be affected by a menstrual period. source: medlineplus.gov


The MCV Blood Test Process 

In this section, we will discuss the steps involved in the testing process. 

What happens during an MCV-level blood test? 

For an MCV blood test, a small blood sample is all that’s needed. It’s usually drawn from the vein in the arm. There’s no need to prepare specially for the test. However, let’s go through the order of the process, potential risks, and how to decipher the test results. 

1. Procedure 

Getting an MCV blood test is easy and fast. A laboratory technician or phlebotomist takes a small blood sample from you. A needle goes into a vein in your arm for this. The sample then heads to a laboratory. Here, it’s  studied, and the results are put out. 

2. Risks 

The MCV blood test is accompanied with very little discomfort or risk. You might feel a small tingle when the needle goes in. Blood drawing can have side effects like bleeding, blue patches, infection, or feeling dizzy, but when the procedure is followed correctly, and hygiene is maintained throughout these side effects rarely occur. Even if bruising, bleeding, or dizziness occurs it is mild and lasts only a short time. 

3. Interpretation of results 

Healthcare providers review the data from the MCV blood test. They check it alongside other tests. These include those in the complete blood count (CBC). This helps them detect any odd results, say, microcytic or macrocytic anaemia. These can signal certain health issues that need to be dealt with. 

Normal Ranges and Variations 

MCV ranges might differ based on age, gender, or group of people. The common levels for men, women, and children are not the same but vary slightly. However, the range for all groups is generally between 80 and 100 femtoliters (fL). 

1. What is a normal MCV level? 

A typical MCV level for an adult is 80–100 fL. Remember that these average values can change subject to age and  gender. For kids aged 6-12 years, the MCV is roughly 86 fL.  

Offered values can differ from one laboratory to another. So, discuss with your healthcare provider if your MCV results increase or decrease below this range. 

2. Significance of age and gender 

Different ages and genders have different MCV levels. This is due to differences in red blood cell production and renewal. Men usually have higher MCV levels than women. Younger people might have lower MCV compared to older  people. Knowing these changes helps healthcare providers read your MCV test results. 

3. Low MCV level 

A low MCV level means your red blood cells are smaller than they should be. This means you might have microcytic anaemia. The causes and effects of this could vary. Common health conditions related to low MCV levels include iron lack anaemia and thalassaemia. 

4. High MCV level 

A high MCV level tells us that your red blood cells are bigger than they should be. This signals macrocytic anaemia. Dietary deficiency or weak immunity could be behind this kind of anaemia. 

A Von Willebrand Factor and/or thyroid panel may be prescribed by the doctor if the patient is a menstruating woman with an MCV under 80 to ascertain the underlying cause of menorrhagia and to obtain a complete menstrual history.

Dr. Siddharth Gupta, B.A.M.S, M.D

Association with Medical Conditions 

Abnormal MCV levels can hint at specific health conditions. But it’s key to know that these test results don’t mean a sure diagnosis. Instead, your healthcare provider will weigh them with your medical background and other tests to find the right diagnosis. 

Because high MCV is linked at times to some cancers, like myelodysplastic syndromes. But there are other, more common causes for high MCV, like dietary deficiencies, liver disease, and certain medicines. It’s key to remember that a high MCV doesn’t mean you have cancer; more investigations and examinations are needed to confirm or rule out cancer. 

Low or high MCV levels can signal different types of anaemia. Microcytic anaemia has low MCV because of smaller red blood cells. Macrocytic anaemia features high MCV because of larger red blood cells. Both kinds of anaemia need correct diagnosis and management.  

MCV testing can also offer valuable inputs for other health conditions or therapy progress. MCV may help predict what’s in store for kidney diseases. It may help predict death rates in esophageal and colorectal cancer. It may help assess how well older adults think and recall. So, while MCV testing is often linked to anaemia, it offers vital details about your overall health. It can guide possible medical management. 

Several factors could cause high MCV levels. These include the use of certain medicines, drinking alcohol, lack of vitamins, and liver disease. Knowing what’s driving high MCV helps your healthcare provider decide the right management plan. It’ll focus on addressing your specific health issues. 

How is a High MCV Managed? 

Just a high MCV without any symptoms often doesn’t need any management. But if high MCV is causing symptoms or concerns, managing the root cause may help. Below we have described what may be done to manage it.  

Limitations of MCV Blood Tests 

MCV blood tests are handy tools in diagnosis, but they have their limits. Many factors can affect MCV results and introduce errors. Some examples are as follows.  

Despite these limitations, MCV blood tests stay vital in managing your overall health and screening for potential conditions. 

Related Tests and Measures 

MCV blood tests are often studied alongside other red blood cell measures. They help offer a more detailed picture of your blood cell health. Some examples of linked tests and measures are as follows.  

When to Contact a Doctor? 

If you sense symptoms linked to abnormal MCV levels such as feeling tired, weak, your skin getting pale, or feeling dizzy, it is key to consult your healthcare provider. Regular checks and blood tests, including MCV  test, can help detect, and monitor possible health threats before they  progress. 

Conclusion 

MCV blood tests play a vital role in figuring out your red blood cell health and triggering healthcare conditions tied to abnormal levels. Knowledge of MCV values and their impact will get you ready to manage your overall health. It’ll set you on the path to a long, healthy life. 

Remember, always to talk to your healthcare provider if you are worried about your MCV levels or any other aspect of your health. 

Frequently Asked Questions (FAQs) 

What does a high MCV level in a blood test mean? 

A high MCV level might mean macrocytic anaemia. Here, red blood cells are bigger than normal. Major causes of macrocytic anaemia include lack of vitamin B12 and folate, liver disease, and certain drugs. 

What does a low MCV level in a blood test indicate? 

A low MCV level signals microcytic anaemia. Here, red blood cells are smaller than normal. Iron-deficient anaemia and thalassaemia are common causes of a low MCV. 

How do doctors use an MCV blood test to diagnose health conditions? 

Doctors use MCV blood tests as part of a whole blood count (CBC) to review the size and volume of red blood cells. This helps them detect cases of anaemia. This can hint at hidden health issues like lack of vitamins or thalassaemia. 

Can MCV levels be affected by diet and lifestyle choices? 

Yes, diet and lifestyle choices may help maintain normal MCV levels. For instance, heavy drinking, poor diet, and certain drugs can push MCV levels up high. 

What is the relationship between MCV and red blood cell indices? 

MCV is one of the red blood cell  indices. This also includes mean corpuscular hemoglobin concentration (MCHC) and mean corpuscular hemoglobin (MCH). These figures are used to review red blood cell health and diagnose anaemia types. 

References: 

  1. National Center for Biotechnology Information (NCBI). Mean Corpuscular Volume [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545275 
  1. National Center for Biotechnology Information (NCBI). The effect of smoking on chronic inflammation, immune function and blood cell composition – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655856 
  1. National Center for Biotechnology Information (NCBI). Macrocytosis [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560908 
  1. Centers for Disease Control and Prevention (CDC). What is Thalassemia? [Internet]. [cited 2024 Feb 13]. Available from: https://www.cdc.gov/ncbddd/thalassemia/facts.html 
  1. National Center for Biotechnology Information (NCBI). Autoimmune gastritis – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065578 
  1. National Center for Biotechnology Information (NCBI). 3Best practice in phlebotomy and blood collection [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK138496 
  1. American Cancer Society. Key Statistics for Myelodysplastic Syndromes [Internet]. [cited 2024 Feb 13]. Available from: https://www.cancer.org/cancer/myelodysplastic-syndrome/about/key-statistics.html 
  1. American Cancer Society. What Are Myelodysplastic Syndromes? [Internet]. [cited 2024 Feb 13]. Available from: https://www.cancer.org/cancer/myelodysplastic-syndrome/about/what-is-mds.html 
  1. National Center for Biotechnology Information (NCBI). Clinical Significance of Mean Corpuscular Volume in Patients With Locally Advanced Esophageal Squamous Cell Carcinoma – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463929 
  1. PubMed. The mean corpuscular volume as a prognostic factor for colorectal cancer [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/28795308 
  1. PubMed. Mean corpuscular volume levels and all-cause and liver cancer mortality [Internet]. [cited 2024 Feb 13]. Available from: https://pubmed.ncbi.nlm.nih.gov/26630695 
  1. National Center for Biotechnology Information (NCBI). Clinical significance of mean corpuscular volume as a prognostic indicator of radiotherapy for locally advanced lung cancer: a retrospective cohort study – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840020 
  1. National Center for Biotechnology Information (NCBI). Diagnosis and treatment of macrocytic anemias in adults [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689413 
  1. National Center for Biotechnology Information (NCBI). Machine learning-based improvement of MDS-CBC score brings platelets into the limelight to optimize smear review in the hematology laboratory – PMC [Internet]. [cited 2024 Feb 13]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9464379 

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

Fenugreek for Hair Growth: Reviewed and Confirmed by Effective Studies

Key Highlights: 

Introduction 

Hair, being one of the essential aspects of an individual’s appearance, plays a significant role in boosting one’s self-esteem and confidence. Maintaining the health of our hair is crucial, but daily exposure to environmental stressors, unhealthy lifestyles, and genetic factors can often lead to various hair problems, including hair loss. There are several natural remedies proposed to promote hair growth and improve overall hair health. One such herb is fenugreek which is believed in many cultures as an effective ingredient to deal with hair problems. 

This article aims to explore fenugreek benefits on hair growth, supported by scientific studies and traditional applications. We will delve into the nutritional composition of fenugreek and its impact on possibly reducing hair loss and promoting hair regrowth. We will also provide insights on the effective use of fenugreek seeds in hair care routines and potential risks that must be taken into consideration while using it. Lastly, we will guide you through a holistic approach to maintaining the general health of your hair while using fenugreek. 

Did you know?

  • Fenugreek may help lower blood sugar levels in people with diabetes. Source: NCCIH
  • Fenugreek may have potential benefits for sexual health and libido.Source: NCCIH
  • Fenugreek has been used worldwide as a galactogogue to increase milk supply. source: NCCIH
  • High dosages of fenugreek may cause lowering of cholesterol and blood sugar. source: NCCIH

What is Fenugreek? 

Fenugreek, scientifically known as Trigonella foenum-graecum, is a versatile herb native to the Mediterranean region and South Asia. It has been used for centuries in traditional medicine and culinary practices. Fenugreek seeds are rich in essential nutrients, including proteins, vitamins, minerals, and antioxidants. These seeds also contain compounds such as flavonoids, alkaloids, and saponins, which contribute to their potential benefit to hair health. 

Origin and Uses 

Fenugreek is a herb native to Southern Europe, the Mediterranean, and Western Asia. It looks similar to clover and has seeds that taste and smell like maple syrup. Many cultures use fenugreek in medicine and cooking. In Asian, Southern European, and North African traditions, it’s been used to manage diabetes and help with breastfeeding. In Ayurvedic and Chinese medicine, fenugreek has been used to boost digestion and induce labour. It’s also been used to improve overall health and metabolism. 

Today under alternative medical sciences, fenugreek is still used by some as a dietary supplement for menstrual cramps, diabetes, and promoting milk production for breastfeeding. 

Nutritional Composition 

The nutritional composition of fenugreek seeds includes the following. 

These nutrients provide the foundation for fenugreek’s potential benefits in hair growth and overall health. 

Traditional Applications in Hair Care 

Fenugreek has been traditionally used in various hair care applications, which are described below.  

Fenugreek and Hair Growth 

Scientific Evidence 

1. Role in Stimulating Hair Follicles 

Fenugreek seeds are said to stimulate hair growth by nourishing the hair follicles and increasing blood circulation to the scalp. The proteins present in fenugreek seeds are supposed to strengthen the hair shaft, reducing hair fall and promoting the growth of new, healthy strands. 

2. Fenugreek as a Natural DHT Blocker 

The proposed mechanism by which it may work is the fact that the various plant compounds in fenugreek may interact with a chemical in the body known as dihydrotestosterone (DHT). If DHT attaches itself to your hair follicles, the result, sooner or later, would be hair loss. Fenugreek may slow down the ability of DHT to attach to your hair follicles. 

A small study involving 53 people found that a 300 mg daily oral dose of fenugreek seed extract over six months led to improvements in hair volume and thickness for more than 80% of the participants compared to those given a placebo. 

3. Reducing Hair Loss 

Fenugreek seeds contain hormone-regulating compounds that may help in reducing hair loss caused by hormonal imbalances. Additionally, the seeds have antimicrobial properties that may help protect the scalp from infections, reducing the risk of hair loss due to scalp conditions. 

4. Reviving Damaged Hair 

Fenugreek seeds possess conditioning properties that help in reducing dryness and frizz. Regular use of fenugreek seeds as a hair mask or rinse may make your hair soft, smooth, and manageable. They also provide hydration to the scalp, reducing flakiness and itching. 

5. Dandruff Control 

The antifungal and antibacterial properties of fenugreek seeds may be responsible for anti-dandruff effects. Regular application of fenugreek seed paste or oil may help reduce scalp inflammation, itching, and flaking associated with dandruff. 

6. Scalp Health and Inflammation Reduction 

Fenugreek’s anti-inflammatory properties may help reduce scalp inflammation and alleviate itchy, red, or irritated skin. This may aid in improving overall scalp health and promote healthy hair growth. 

There are medical conditions also that may affect your hair and scalp, causing scalp issues and hair loss. If you are unsure, it is best to consult a dermatologist before initiating any home remedy.  

For most people, fenugreek seeds are safe. However, in my opinion, one should avoid them before the 37th week of pregnancy as they may cause early labour. If you have a peanut or chickpea allergy, you are advised to stay away from fenugreek.

Dr. Siddharth Gupta, B.A.M.S, M.D

How to Use Fenugreek? 

Fenugreek can be incorporated into your hair care routine in multiple ways, which are described below.  

1. Raw Seeds 

You can use raw fenugreek seeds as a natural hair mask or hair oil. Simply grind the seeds, create a paste, and apply it to your hair and scalp. Leave the paste on for a few minutes before rinsing it off. 

2. Powder and Paste 

Fenugreek powder can be used as a hair mask or mixed with other ingredients, such as yogurt, honey, or oils, to create a nourishing paste. Apply the paste to your scalp and hair, focusing on the roots, and leave it on for about 30 minutes before rinsing thoroughly with lukewarm water. 

3. Fenugreek Oil 

You can make your own fenugreek oil by heating fenugreek seeds with a carrier oil, such as coconut or olive oil. Let the seeds infuse the oil for a few minutes, then strain the oil and store it in a clean container. Massage the fenugreek seed oil onto your scalp and hair, leave it on for an hour or overnight, and shampoo as usual. 

4. Supplements 

Fenugreek supplements are available in the form of capsules, powders, and extracts, making it easy to incorporate this natural remedy into your daily routine. Consult with your healthcare provider before starting fenugreek supplementation, as it may interact with certain medications. 

5. Topical Applications 

Fenugreek can be applied topically to your hair and scalp in the form of hair masks, hair rinses, shampoos, and conditioners. 

Ad* You May Also Explore: Pharmeasy Vitamin E Capsules

Consumption Methods 

Fenugreek can be consumed in various forms to incorporate its benefits internally, which are described below.  

Risks of Using Fenugreek 

While fenugreek is generally considered safe for most individuals, there are some possible side effects and risks associated with its use, which are as follows.  

1. Possible Side Effects 

Overconsumption of fenugreek may cause the following.  

 
Moderate your fenugreek intake and monitor your body’s reaction to ensure a safe experience. 

2. Allergic Reactions 

Like any other herb, people allergic to legumes, peanuts, chickpeas, or related plants might be sensitive to fenugreek, causing inflammation, itchiness, or redness on the skin. If you notice any unusual reactions after consuming or applying fenugreek, discontinue its use and consult your healthcare provider. 

3. Medication Interactions 

Fenugreek might interfere with certain medications, including those used to control diabetes, blood clotting, thyroid disorders, and high cholesterol levels. Consult with your doctor before taking fenugreek orally if you are on any medication. 

4. Dosage Considerations 

When consuming fenugreek, it is crucial to adhere to the recommended dosages. A high dose of fenugreek may cause a sudden drop in blood sugar and may have hepatotoxic effects. Pregnant women should avoid fenugreek supplementation, as it may increase the risk of birth defects. 

Other Ways to Promote Hair Growth 

A holistic approach to hair growth addresses not only the application of topical remedies and supplements for hair health but also considers various factors that can influence hair growth. 

1. Nutrition 

Consume a balanced diet rich in hair-friendly nutrients, such as protein, iron, zinc, vitamins, and healthy fats. Ensure that you are getting enough essential amino acids, vitamins, and minerals through your diet to support optimal hair growth. Focus on a variety of whole foods, such as green leafy vegetables, lean protein sources, dairy products, and healthy fats. 

2. Stress Management 

Stress is known to affect hair growth negatively. Try incorporating stress management techniques such as breathwork, meditation, yoga, or exercise into your daily routine to help reduce stress and support better hair health. 

3. Lifestyle Modifications 

Certain lifestyle choices, such as smoking, excessive alcohol consumption, and poor sleep hygiene, can adversely impact hair health. Make a conscious effort to adopt healthier habits and prioritize restorative sleep to support your hair growth journey. 

4. Hair Care Routine and Products 

Choose hair care products suited for your hair type and avoid harsh chemicals, sulfates, parabens, and silicones. Adopt a gentle haircare routine, including regular scalp massages to stimulate blood circulation and promote hair growth. 

5. Genetic Factors  

Genetic factors play a significant role in hair loss and hair growth patterns. If you suspect a hereditary pattern of hair loss, consult your healthcare provider to discuss suitable options. 

Conclusion 

Fenugreek seeds offer remarkable benefits in hair growth and hair health, supported by scientific research and traditional practices. Incorporating fenugreek seeds into your hair care routine may help reduce hair loss, stimulate hair growth, address dandruff, scalp inflammation, and reviving damaged hair. 

While using fenugreek may be beneficial, it’s essential to consider possible side effects, allergies, and medication interactions. Utilizing a holistic approach that encompasses proper nutrition, stress management, lifestyle modifications, and appropriate hair care products is crucial for promoting healthy hair growth. 

Frequently Asked Questions (FAQs) 

Can you use fenugreek on hair every day? 

It is not necessary to use fenugreek on your hair every day. Applying it 2-3 times a week as part of a hair mask or oil massage may provide sufficient benefits. Daily use may risk increasing Pitta dosha levels on your scalp. 

How much fenugreek should you take for hair growth? 

There is no specific recommended amount of fenugreek for hair growth, as it may vary based on individual experiences and conditions. However, some studies suggest that a daily oral dose of 300 mg of fenugreek seed extract may significantly improve hair growth and thickness. Always consult your doctor before deciding to consume fenugreek. 

How long should you leave in a fenugreek mask? 

Typically, you can leave a fenugreek mask on your hair for about 30-45 minutes before rinsing it off with warm water. If you have severely dry hair and dandruff issues, you may leave the mask overnight and wash it off the next morning. 

Is drinking fenugreek water good for hair? 

Apart from providing essential nutrients for hair growth, fenugreek water is said to help flush out toxins from your body, improving digestion and bowel movement. As a result, fenugreek contributes to maintaining the harmony of your Ayurvedic doshas in the body, which in turn, is said to promote voluminous hair growth and avoid dryness and dandruff issues. 

How long does it take for fenugreek to grow hair? 

Studies suggest that significant improvements in hair growth can be observed after using fenugreek consistently for 3-4 months. However, the duration to achieve desired results may vary among individuals, depending on their unique hair needs and conditions. You may try fenugreek, after using it if you feel there isn’t much improvement then there may be some other reason for hair loss, and it is better to consult a dermatologist. Also, if you want to consume fenugreek then before doing so always discuss it with your doctor first.  

References: 

  1. National Center for Biotechnology Information (NCBI). Anti-inflammatory activity of fenugreek ( Trigonella foenum-graecum Linn) seed petroleum ether extract [Internet]. [cited 2024 Jan 10]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980935 
  1. PubMed. A Review on Ethnobotanical and Therapeutic Uses of Fenugreek (Trigonella foenum-graceum L) [Internet]. [cited 2024 Jan 10]. Available from: https://pubmed.ncbi.nlm.nih.gov/25922446 
  1. PubMed. Effect of Fenugreek Use on Fasting Blood Glucose, Glycosylated Hemoglobin, Body Mass Index, Waist Circumference, Blood Pressure and Quality of Life in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trials [Internet]. [cited 2024 Jan 10]. Available from: https://pubmed.ncbi.nlm.nih.gov/34466512 
  1. National Center for Biotechnology Information (NCBI). A small plant with big benefits: Fenugreek (Trigonella foenum-graecum Linn.) for disease prevention and health promotion [Internet]. [cited 2024 Jan 10]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/28266134 
  1. National Center for Biotechnology Information (NCBI). Seborrheic Dermatitis and Dandruff: A Comprehensive Review [Internet]. [cited 2024 Jan 10]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27148560 
  1. National Center for Biotechnology Information (NCBI). Antioxidant and hemolytic activities, and effects in rat cutaneous wound healing of a novel polysaccharide from fenugreek (Trigonella foenum-graecum) seeds [Internet]. [cited 2024 Jan 10]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27914964 
  1. National Center for Biotechnology Information (NCBI). Formulation and characterization of a cream containing extract of fenugreek seeds [Internet]. [cited 2024 Jan 10]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/20369794 
  1. National Center for Biotechnology Information (NCBI). Diet and hair loss: effects of nutrient deficiency and supplement use [Internet]. [cited 2024 Jan 10]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/28243487 
  1. National Center for Biotechnology Information (NCBI). Stress and the Hair Growth Cycle: Cortisol-Induced Hair Growth Disruption [Internet]. [cited 2024 Jan 10]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27538002 
  1. National Center for Biotechnology Information (NCBI). Free radicals, antioxidants and functional foods: Impact on human health [Internet]. [cited 2024 Jan 10]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/22228951 
  1. National Center for Biotechnology Information (NCBI). Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond? [Internet]. [cited 2024 Jan 10]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/28685843 
  1. PubMed. Fenugreek [Internet]. [cited 2024 Jan 10]. Available from: https://pubmed.ncbi.nlm.nih.gov/30000838 
  1. National Center for Biotechnology Information (NCBI). A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases [Internet]. [cited 2024 Jan 10]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878086 

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

Links and product recommendations in the information provided here are advertisements of third-party products available on the website. PharmEasy does not make any representation on the accuracy or suitability of such products/services. Advertisements do not influence the editorial decisions or content. The information in this blog is subject to change without notice. The authors and administrators reserve the right to modify, add, or remove content without notification. It is your responsibility to review this disclaimer regularly for any changes.

5
Next Page »« Previous Page