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What Causes Low Blood Sugar In a Non-diabetic: Research-Based Analysis

By Dr. Nayana Shetty +2 more

Key Highlights: 

  • Definition and types of Hypoglycaemia (low blood sugar). 
  • Various causes of low blood sugar without diabetes 
  • Common symptoms of hypoglycaemia. 
  • Diagnosis and management options that are available. 
  • Complications and long-term effects of repeated hypoglycaemia episodes. 
  • Strategies to reduce the risk of hypoglycaemia in non-diabetic individuals. 

Introduction 

Low blood sugar can be a problem even if an individual is not a diabetic patient. This article offers a detailed glance at the potential causes, symptoms, diagnosis, and management options of this condition. We’ll also delve into its complications and how to avoid them. Lastly, we will answer some frequently asked questions regarding this topic.

what causes low blood sugar without diabetes

Did you know?

  • Hypoglycemia can also occur in people without diabetes due to conditions such as liver disease, kidney disease, and hormone deficiencies. source: medlineplus.gov
  • For people without diabetes, hypoglycemia is typically a blood glucose level lower than 55 mg/dL. source: medlineplus.gov
  • Hypoglycemia can occur in non-diabetic individuals due to various causes such as insulinoma, alcohol consumption, liver or renal failure, and medication use. source: NCBI
  • Treatment of non-diabetic hypoglycemia depends on the underlying cause. It may involve discontinuing medications that cause hypoglycemia, dietary modifications, surgical resection of insulinomas, or hormone replacement therapy for hormone deficiencies. source: NCBI
  • Hypoglycemia can lead to various complications if left untreated, including anxiety, seizures, confusion, coma, cardiac arrhythmias, multi-organ failure, and even death. source: NCBI

Low Blood Sugar (Hypoglycaemia): Definition and Types 

What is hypoglycaemia? 

In simple terms, hypoglycaemia is when your blood sugar level dips below normal. Sugar, or glucose, fuels our bodies. When the fuel gauge hits ‘low’, it spells trouble. The effects can be slight to severe and may even threaten your life in some cases. 

  • Blood sugar ranges and levels 

Knowing your blood sugar range is key for spotting hypoglycaemia. When blood sugar drops below 70 mg/dL or 3.9 mmol/L, it’s often labeled as hypoglycaemia. Remember though, these numbers aren’t set in stone for everyone. Make sure to follow your healthcare provider’s guidance. 

Types of hypoglycaemia 

Hypoglycaemia can be split broadly into two groupings which are reactive and nonreactive. There’s another type called dumping syndrome. These are discussed below.  

  • Reactive hypoglycaemia 

Reactive hypoglycaemia happens a few hours after you eat. The reason is  an insulin surge. This is often a red flag for early-stage diabetes. 

  • Nonreactive hypoglycaemia 

Also known as fasting hypoglycaemia, it isn’t tied to your meals. It could be due to an underlying illness. Some other triggers could be medications, alcohol, or a hormone imbalance. 

  • Dumping syndrome 

This happens due to surgeries disrupting your stomach’s regular functions. You can get this from gastric bypass surgery or GERD surgery. It causes sudden changes in blood sugar after loading up on carbohydrates. 

In my opinion, regular meal consumption may help you avoid blood sugar dips at night. Eating may be especially beneficial when consuming alcohol. Eat something before going to bed if you believe you might experience low blood sugar during the night.

Dr. Siddharth Gupta, MD

Causes of Low Blood Sugar Without Diabetes 

As we’ve mentioned before, even non-diabetics can face bouts of low blood sugar. Below we will discuss why this happens. We’ll also discuss how blood sugar regulation plays out within the body. 

Blood sugar regulation in the body 

Controlling blood sugar isn’t a linear task. It’s complex, involving various hormones, body parts, and systems. At its heart lie two crucial hormones which are insulin and glucagon.  

  • The role of insulin and glucagon 

Insulin, made by the pancreas, enables glucose to enter cells for energy. In contrast, glucagon is released when blood sugar falls. It prompts the liver to break down stored glycogen and release glucose into the bloodstream. A disruption in the making of these hormones or their workings can lead to hypoglycaemia. 

Possible non-diabetic causes of low blood sugar 

 Causes of low blood sugar in non-diabetics are as follows.  

Fasting hypoglycaemia 

Fasting hypoglycaemia happens when blood sugar falls in non-eating periods. This includes sleep or long breaks between meals. Often, this type is linked to an existing health issue. It could also be triggered by heavy drinking or certain drugs, some of which are described below. 

  • Medications 

Some medications can trigger hypoglycaemia in non-diabetics. These  are as follows. 

  1. Quinine, a medication for malaria 
  2. Some antibiotics 
  3. Some pneumonia medications 
  • Excessive alcohol consumption 

Alcohol can interfere with blood sugar control. It does so by hampering the liver’s work to release glucose. This can lead to hypoglycaemia. 

  • Critical illness 

Serious infections, liver issues like hepatitis or cirrhosis, kidney problems, and advanced heart disease can  affect blood sugar control. This could cause hypoglycaemia. 

  • Hormonal deficiencies 

Certain hormonal imbalances, such as issues with the adrenal or pituitary gland, can cause low blood sugar. These hormones help control glucose production or metabolism. 

  • Insulin-producing tumours 

Insulin-producing tumours (insulinomas) though rare can cause hypoglycaemia. They are located in the pancreas and cause a lot of insulin to be released, leading to hypoglycaemia. Other tumours too can produce substances that act like insulin, which results in low blood sugar. 

Reactive hypoglycaemia  

The causes are listed below.  

  • Gastric surgery 

 Gastric surgery like bypass surgery or surgery for GERD can cause reactive hypoglycaemia. This is due to quick changes in blood sugar levels post meals loaded with carbohydrates. Also, separately known as dumping syndrome.  

  • Pre-diabetes 

Reactive hypoglycaemia can warn about pre-diabetes. This is when blood sugar levels rise, though not enough for a diabetes diagnosis. 

  • Rarer medical conditions 

At times, very rare health issues that affect hormone production can cause reactive hypoglycaemia. Also, any issues with storing and releasing glucose can cause this problem. 

In my experience, you might need to check your blood sugar multiple times a day for several days if you doctor thinks you may have low blood sugar. Further testing, such as imaging studies to establish if a tumour is the source of the low blood sugar episodes, will be necessary to identify the underlying cause of the hypoglycemia.

Dr. Rajeev Singh, BAMS

Symptoms of Low Blood Sugar in non-diabetics  

Low blood sugar symptoms in non-diabetics can show up in physical and cognitive ways. It’s important to know what these symptoms are so you can act fast. 

Physical symptoms 

The physical signs that show up when a non-diabetic has low blood sugar are as follows. 

  • Pale skin 
  • Shakiness or tremors 
  • Sweating 
  • Feeling weak or tired 
  • A fast-paced heartbeat 
  • Feeling hungry or nauseous 

These signs usually show up first and can range from mild to medium in intensity. 

Cognitive symptoms 

Low blood sugar can also affect the brain,  resulting in the following.  

  • Trouble focusing 
  • Feeling dizzy or light-headed 
  • Getting confused 
  • Issues with deciding or solving problems 
  • Slurred speech or trouble talking 
  • Blurred sight or tunnel vision 

These cognitive issues can worsen if blood sugar keeps dropping. This can even lead to fainting, seizures, or coma. 

Hypoglycaemia unawareness 

What is hypoglycaemia unawareness? 

This is when you have no idea your blood sugar level has dropped too low. The early warning signs like shakiness, hunger, or sweating don’t show up. This unawareness increases the odds of hypoglycaemia, as people don’t realize their blood sugar levels are dangerously low and fail to get treated in time. 

Risk factors for developing hypoglycaemia unawareness 

Several factors increase the risk of hypoglycaemia unawareness. These are as follows. 

  • Frequent past episodes of low blood sugar 
  • Having diabetes for a long time 
  • Trying to tightly control blood sugar 
  • Some medications that suppress early warning signs 
  • Old age 

People with hypoglycaemia unawareness must be under the careful watch of healthcare professionals. They may also need to adjust their management plans to lessen the risk of serious hypoglycaemia  episodes. 

Diagnosis and Management of Low Blood Sugar in Non-diabetics 

Diagnosing and managing low blood sugar accurately is vital for optimal health and avoiding future problems. Now, let’s discuss the ways to diagnose and manage hypoglycaemia in non-diabetics. 

How is hypoglycaemia diagnosed? 

To spot hypoglycaemia, healthcare professionals first check the person’s medical history, current symptoms, and any risk factors. They may also carry out blood sugar tests to figure out the severity of the issue. In some cases, special diagnostic tests may be needed to identify the root cause of hypoglycaemia. This includes hormonal assays, imaging studies, or genetic testing. 

Blood sugar tests 

Blood sugar tests are a simple, non-invasive way to gauge blood glucose levels. Regular checks can help catch and properly manage hypoglycaemia. 

Medical history evaluation 

When making sense of your medical history, healthcare providers seek clues that will help uncover the cause of an individual’s low blood sugar which are as follows. 

  • Any recent changes in diet or exercise habits. 
  • Ongoing medications or supplements. 
  • Family medical history, including any history of diabetes or other blood sugar-related disorders. 
  • Existence of any other medical conditions that might affect blood sugar regulation. 

Special diagnostic tests 

Depending on the cause of a person’s hypoglycaemia, extra diagnostic tests may be suggested to confirm the diagnosis. These tests are as follows.  

  • Hormonal assays to check the function of the insulin-making cells in the pancreas or other hormone-releasing glands 
  • Imaging studies, like computed tomography (CT) scans, magnetic resonance imaging (MRI), or ultrasound, to see any oddities in the pancreas, liver, or other relevant organs 
  • Genetic testing to spot any inherited conditions that could be causing low blood sugar 

Manangement of hypoglycaemia 

The aim of managing hypoglycaemia is to get blood sugar levels back to normal immediately, and then deal with any root causes or factors to avoid future episodes. 

Immediate  steps 

First-hand steps needed to be taken for hypoglycaemia are as follows.  

  • Consuming quick-acting carbohydrates, like glucose tablets, fruit juice, candy, or regular soda, which can quickly  increase blood sugar levels. 
  • Injecting glucose or taking an oral glucose supplement, if available, as directed by a healthcare provider. 
  • Keeping a close watch on blood sugar levels until they return to the target range. 

Long-term options 

Along with immediate management to boost blood sugar levels, long-term management methods may be needed to tackle the root causes of hypoglycaemia and reduce the risk of future episodes. This might mean: 

  • Changing medication, including adjusting dosages or switching to another type of medication if current medications are causing hypoglycaemia 
  • Tweaking diet to ensure constant eating throughout the day with diets containing carbohydrates, proteins, and healthy fats.
  • Medical interventions for root causes, such as surgery to remove insulin-producing tumours or hormone replacement therapy for hormonal imbalances. 

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Complications of Low Blood Sugar in Non-diabetics 

If unchecked, low blood sugar can lead to short-term and long-term problems. It’s important to be aware of these complications and seek quick treatment if needed. 

Untreated hypoglycaemia 

If hypoglycaemia goes untreated, symptoms can worsen, leading to severe problems which are as follows.

  • Seizures or convulsions 
  • Loss of consciousness or coma 
  • Nerve damage affecting cognitive function, speech, or motor skills 

Long-term complications 

The long-term effects of low blood sugar are as follows.  

  • Impact on overall health over time, such as impaired cognitive function, lesser quality of life, or increased risk for accidents or injuries. 
  • Higher risk of developing diabetes and related health issues, especially if hypoglycaemia is an early sign of pre-diabetes or is caused by insulin-producing tumours. 
     

Avoiding Low Blood Sugar in Non-diabetics 

There are several ways that non-diabetic individuals may try to avoid low blood sugar swings and protect their overall health. 

For non-diabetic individuals 

Here are some steps that may help.  

  • Eat balanced meals and take snacks that steadily give you carbohydrates, proteins, and healthy fats throughout the day. 
  • Keep track of how much sugar and carbohydrates you’re eating to ensure consistent blood sugar levels. 
  • Quit alcohol or at least avoid drinking too much, as this can affect the liver’s ability to release glucose. 
  • Regularly exercise and maintain a healthy weight to support overall metabolic and endocrine health. 

Conclusion 

In conclusion, low blood sugar in non-diabetics is an important yet often overlooked health concern. While hypoglycaemia is typically associated with diabetes, it can affect individuals without diabetes due to various factors such as medications, lifestyle choices, and underlying medical conditions. It is crucial to be aware of the symptoms, causes, diagnosis, and management options for low blood sugar  to avoid  complications and ensure overall well-being. Remember, proper awareness, timely diagnosis, and appropriate management are vital.  

Frequently Asked Questions (FAQ) 

Can you have hypoglycaemia without having diabetes? 

Sure, you can. Although it’s less common. The culprits could include certain medications, lifestyle factors, and certain medical conditions. 

What are the common symptoms of low blood sugar without diabetes? 

People may experience tremors, sweating, feeling hungry, dizzy, and confused. They can have rapid palpitations and trouble focusing as well. 

How is low blood sugar without diabetes diagnosed? 

Healthcare professionals use a combination of medical history checks, symptom assessments, blood sugar tests, and specialized diagnostic tests (if needed) to make the diagnosis. 

Can low blood sugar without diabetes lead to diabetes? 

Sometimes, yes. Low blood sugar in non-diabetics can be an early warning sign of pre- diabetes, or it might indicate the presence of insulin-producing tumours.  

What steps can be taken to prevent low blood sugar without diabetes? 

To avoid low blood sugar if you’re not a diabetic, eat balanced meals and snacks, monitor sugar and carbohydrate intake, drink alcohol in moderation, and keep up regular exercise, and a healthy weight. 

References: 

  1. National Center for Biotechnology Information (NCBI). Treatment of Mild Hypoglycemia [Internet]. [cited 2023 Dec 26]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522892 
  1. National Center for Biotechnology Information (NCBI). Non-Diabetic Hypoglycemia [Internet]. [cited 2023 Dec 26]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK355894 
  1. American Diabetes Association. Hypoglycemia (Low Blood Glucose) [Internet]. [cited 2023 Dec 26]. Available from: https://www.diabetes.org/healthy-living/medication-treatments/blood-glucose-testing-and-control/hypoglycemia 
  1. American Diabetes Association. Diagnosis [Internet]. [cited 2023 Dec 26]. Available from: https://www.diabetes.org/a1c/diagnosis 
  1. PubMed. Hypoglycemia and Cardiovascular Disease: Lessons from Outcome Studies [Internet]. [cited 2023 Dec 26]. Available from: https://pubmed.ncbi.nlm.nih.gov/26468155 
  1. National Center for Biotechnology Information (NCBI). Diabetic Kidney Disease [Internet]. [cited 2023 Dec 26]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718284 
  1. National Center for Biotechnology Information (NCBI). Diabetic Gastroparesis [Internet]. [cited 2023 Dec 26]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430794 
  1. National Center for Biotechnology Information (NCBI). Peripheral Diabetic Neuropathy [Internet]. [cited 2023 Dec 26]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK442009 
  1. American Diabetes Association. Diagnosis [Internet]. [cited 2023 Dec 26]. Available from: http://www.diabetes.org/diabetes-basics/diagnosis 
  1. American Diabetes Association. Hypoglycemia (Low Blood Glucose) [Internet]. [cited 2023 Dec 26]. Available from: http://www.diabetes.org/living-with-diabetes/treatment-and-care/blood-glucose-control/hypoglycemia-low-blood.html 
  1. National Center for Biotechnology Information (NCBI). Practical Approaches to Diagnosing, Treating and Preventing Hypoglycemia in Diabetes [Internet]. [cited 2023 Dec 26]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688990 
  1. National Center for Biotechnology Information (NCBI). Mechanisms of hypoglycemia unawareness and implications in diabetic patients [Internet]. [cited 2023 Dec 26]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499525 
  1. National Center for Biotechnology Information (NCBI). Ocular complications of diabetes mellitus [Internet]. [cited 2023 Dec 26]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317321 
  1. PubMed. Hypoglycemia Among Patients with Type 2 Diabetes: Epidemiology, Risk Factors, and Prevention Strategies [Internet]. [cited 2023 Dec 26]. Available from: https://pubmed.ncbi.nlm.nih.gov/29931579 
  1. National Center for Biotechnology Information (NCBI). Non-Diabetic Hypoglycemia [Internet]. [cited 2023 Dec 26]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK573079 
  1. American Diabetes Association. Hypoglycemia (Low Blood Glucose) [Internet]. [cited 2023 Dec 26]. Available from: https://diabetes.org/healthy-living/medication-treatments/blood-glucose-testing-and-control/hypoglycemia 

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