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Tips to Avoid Breakthrough Seizures: A Comprehensive Guide

By Dr. Nayana Shetty +2 more

Key Highlights: 

  • What is epilepsy and breakthrough seizures? 
  • Identifying symptoms and warning signs. 
  • Knowing when to see a doctor. 
  • Understanding the causes and risk factors of seizures. 
  • Exploring diagnosis,  management, and strategies to reduce the risk of breakthrough seizures. 
  • Discovering the future of seizure risk reduction and management.  

Introduction 

Epilepsy affects lots of people. It is a brain disorder that leads to seizures due to abnormal brain activity. Epilepsy can often be controlled with medicines or other management options. Still, some people may experience breakthrough seizures even after long periods without seizures. 

In this article, we will discuss breakthrough seizures. We will try to understand what they are, how to recognize them, and most crucially, how to avoid them. If you or a loved one has epilepsy, this guide may help you take steps to reduce the risk and impact of breakthrough seizures on daily life. 

tips to prevent breakthrough seizures

Did you know?

  • Taking medicine as prescribed is crucial for stopping seizures and finding the right treatment. source: CDC
  • Self-management of epilepsy includes getting enough sleep, managing stress, and maintaining a healthy diet. source: CDC
  • Traumatic brain injuries are a common cause of epilepsy, emphasizing the importance of preventing such injuries. source: CDC
  • Good hygiene and food preparation practices can prevent an infection called cysticercosis, a common cause of epilepsy worldwide. source: CDC
  • Immunizations can lower the risk of infections that may lead to epilepsy. source: CDC

Understanding epilepsy 

Epilepsy is a brain disorder. It can happen to anyone, regardless of age, gender, race, or ethnicity. Seizures in epilepsy can vary in how often they occur, how long they last, and how intense they are, which can make diagnosis and management difficult. In many cases, the exact cause of epilepsy is unknown. But, it might be due to genetic factors, head injuries, infections, or developmental problems. 

Defining breakthrough seizures 

A seizure is called a “breakthrough seizure” if it happens after a person has been seizure-free for at least a year while on medication. This type of seizure can be caused by various things. It could  happen as a result of not taking enough medication, forgetting to take medication, feeling stressed, not getting enough sleep, or exposure to known triggers for seizures. Breakthrough seizures can have serious effects, like physical injuries or emotional upset. 

Symptoms and warning signs 

The Difference Between Generalized and Breakthrough Seizures 

There are two main types of seizures: generalized and focal. While generalized seizures affect both sides of the brain, focal seizures occur in specific parts of the brain. Breakthrough seizures usually look like the type of seizures a person typically has. But they happen despite therapy and a period of seizure control. 

Identifying the Warning Signs of Seizures 

Knowing what a breakthrough seizure looks like is critical for people with epilepsy. Signs may include the following.  

  • Feeling confused for a short time 
  • Persistent staring 
  • Muscles that are stiff or relaxed 
  • Twitching that you can’t control 
  • Smacking your lips or fluttering your eyes 
  • Losing consciousness or awareness 

Remember, seizure symptoms can greatly vary from person to person.  So, it’s important to know what your seizures typically look like. 

When to See a Doctor? 

Timing of Breakthrough Seizures 

If you have a breakthrough seizure, you should see a doctor right away. If you have a seizure after a year of being seizure-free under therapy, you must visit your healthcare provider as soon as you can. This is important because breakthrough seizures might mean that your management plan needs adjusting. 

Recurrence of Seizures 

You should also seek medical help if you have frequent seizures, even if you had a period of control before. Regular seizures can lead to risks and complications, like physical injuries and emotional upset.  

Causes and Risk Factors 

Exploring the Causes of Seizures 

Often, the exact cause of epilepsy is unknown. Seizures can potentially result from the following.  

  • Genes 
  • Injuries to the head 
  • Infections in the brain 
  • Issues with development 
  • Abnormalities in the brain’s structure 

Common Seizure Triggers 

What triggers a seizure can vary greatly from person to person. Some common triggers are as follows.  

  • Not taking enough medicine or forgetting to take it 
  • Feeling stressed 
  • Not getting enough sleep 
  • Drinking alcohol or withdrawing from it abruptly 
  • Exposure to flashing lights or rapidly moving visual things 

If you have epilepsy, it’s crucial to know what your triggers are and try to stay away from them as much as you can. 

Risk factors for Breakthrough Seizures 

Some factors may increase your risk of having a breakthrough seizure. These are as follows.  

  • Having an infection 
  • Having low blood sugar from not eating enough 
  • Consuming caffeine 
  • Taking certain medications (for example, hormone replacements, antibiotics, or painkillers) 

Knowing and handling these risk factors may lower the odds of you having a breakthrough seizure. 

Complications and Emotional Health Issues 

Physical Complications from Seizures 

Seizures can lead to many different physical complications. These depend on the type and severity of the seizure. Complications may include the following.  

  • Falling and getting hurt due to loss of muscle control or consciousness. 
  • Drowning while swimming or bathing. 
  • Car accidents if a seizure happens while driving. 
  • Injuries caused by convulsive or other sudden movements. 

The Impact of Seizures on Emotional Health 

Living with epilepsy can greatly affect emotional health as well. You may experience the following.  

  • Feeling of  depression 
  • Feelings of anxiousness 
  • Thoughts or actions related to suicide 

These mental health issues might relate not just to the difficulty of managing epilepsy, but also to the social stigma that sometimes comes with the condition. So, people with epilepsy and their loved ones must get support from skilled mental health professionals when needed. 

Diagnosis and Management 

1. Diagnosing Breakthrough Seizures 

To diagnose a breakthrough seizure, the healthcare provider will need a detailed medical history. This includes information about past seizures, recent illnesses, and how well the patient has been taking their medicine. Doctors might also want to talk to family members or others who saw the seizure. 

To find any abnormalities in the brain’s function or structure, doctors may order tests. These can include an EEG, CT scan, MRI scan, or blood tests. 

2. Medications and Therapies 

Once a breakthrough seizure is diagnosed, changes in the management plan may be recommended by your healthcare provider. Changes may include adjusting the dose of existing anti-epileptic medications or trying different anti-epileptic medications. If you have epilepsy, it’s crucial to follow your healthcare provider’s advice on using and dosing medication. Sometimes, breakthrough seizures can mean that the current management plan needs adjustments. 

3. Surgery Options 

For some people with epilepsy that is hard to manage with drugs, surgery could be an option. Common surgical procedures to manage epilepsy are listed below.  

  • Lobectomy: doctors remove a part of the brain where seizures start. 
  • Corpus callosotomy: the connection between the two halves of the brain is cut to stop the spread of seizures. 
  • Multiple subpial transection: doctors cut nerve fibers to disrupt where seizures start. 

The choice to have surgery depends on many factors. These can include the type and severity of seizures, overall health, and any other underlying health issues. 

4. Specialist-Driven Therapies 

If medications or surgery do not work well, there are other management options. These are driven by specialists and  are as follows. 

  • Vagus nerve stimulation (VNS): a small device that sends electrical signals to the brain to reduce seizures. 
  • Deep brain stimulation (DBS): electrodes deliver controlled electrical stimulation to suppress seizure activity. 
  • Responsive neurostimulation (RNS): monitors brain activity and delivers electrical stimulation in response to detected seizure activity. 

5. The Role of Diet 

Changes in diet also play a role in managing epilepsy for some individuals. The ketogenic diet, which is high in fat and low in carbohydrates, is said to help reduce seizures, especially in children. Other dietary approaches, like the modified Atkins diet or the low glycemic index  diet, might also help some people with epilepsy. It’s important to ask your healthcare provider and a dietitian before making big changes to your diet. 

Strategies to Reduce the Risk 

Lifestyle Changes to Reduce Seizure Risk 

There are several lifestyle changes that individuals with epilepsy can make to reduce their risk of breakthrough seizures. These are listed below.  

Sleep Hygiene 

Those with epilepsy need to get enough sleep, as lack of sleep can trigger seizures. Tips to improve sleep quality  are as follows. 

  • Having a regular sleep schedule 
  • Creating a nightly routine 
  • Making your sleeping area comfortable and restful 
  • Limiting screen time before bed 
  • Avoiding stimulants like caffeine and nicotine close to bedtime 

Stress Management 

Stress is a common trigger for seizures, so it’s essential to find ways to control stress. This could include deep breathing, meditation, or progressive muscle relaxation. Also, making time for enjoyable hobbies and activities may help relieve stress. 

Exercise and Physical Activity 

Regular exercise may help overall health and well-being. They may reduce stress and possibly lower the risk of seizures. Try to get at least 150 minutes of moderate-intensity aerobic exercise or 75 minutes of vigorous-intensity aerobic exercise each week. Also, do muscle-strengthening activities on two or more days per week. 

Medication Adherence 

Those with epilepsy must stick to their prescribed medication regimen. This helps control seizures. Always take your medications as directed by your healthcare provider and discuss any concerns or side effects promptly. 

Exploring Complementary Options 

While medications and surgery remain the main options for managing epilepsy, some people may find benefit from complementary therapies such as: 

Music therapy 

Some studies suggest that listening to certain music, like Mozart’s Sonata for Two Pianos in D Major (K448), may reduce the frequency of seizures for some people with epilepsy. 

Yoga and relaxation techniques 

Doing yoga or other relaxation techniques like deep breathing or meditation might help reduce stress levels and lower the risk of seizures. 

Biofeedback 

Biofeedback is a way for individuals to become more aware of and control processes in the body, such as heart rate and muscle tension. Some evidence suggests biofeedback may help lower the frequency of seizures in certain individuals with epilepsy. 

Art therapy 

Doing art therapy may improve self-esteem and overall quality of life for people with epilepsy. This might reduce the frequency of seizures and lessen emotional distress. 

Also Read: Epilepsy Treatment Adherence: Research-Based Guidelines for Effective Management

The Future of Seizure Risk Reduction and Management 

As epilepsy research continues, new technologies and management options are coming up. These have been described below.  

1. Stereotactic Radiosurgery 

This new management option uses highly focused radiation to target and destroy areas of the brain causing seizures. It offers a less invasive alternative to traditional surgical methods. 

2. Thermal Ablation 

Also known as laser interstitial thermal therapy, thermal ablation uses heat to destroy specific brain tissue that causes seizures. It provides a minimally invasive way to manage epilepsy. 

3. External Nerve Stimulation 

Devices like the Monarch eTNS System are being developed to stimulate specific nerves noninvasively to reduce seizures, potentially making therapy less invasive and more flexible for individuals with epilepsy. 

4. Subthreshold Cortical Stimulation 

This potential new therapy provides continuous electrical stimulation of specific areas of the brain to avoid seizures. This could be an alternative for those who are resistant to drugs and are not candidates for more invasive therapy. 

Conclusion 

Epilepsy is a complex disorder of the brain that can affect anyone, no matter their age or background. Despite progress in diagnosis and management, breaking through seizures is still a challenge for many. However, by understanding the causes and risks of these seizures, people with epilepsy can partner with their healthcare providers to develop tailor-made management plans. They may also adopt lifestyle changes to reduce the chance of breakthrough seizures occurring. 

In looking forward, the future of managing epilepsy seems bright. There are numerous novel therapies and technologies under development. As researchers keep learning more about epilepsy, we can hope for even better management options and strategies to reduce the risk. These will improve the lives of those affected by this tough condition. 

Frequently Asked Questions (FAQs) 

How do you prevent breakthrough seizures? 

To avoid breakthrough seizures, take your medicine as prescribed, address lifestyle factors like sleep and stress, and avoid known seizure triggers. Also, work closely with your healthcare provider to monitor and adjust your management plan if needed. 

What triggers a breakthrough seizure? 

Several factors can trigger a breakthrough seizure. They might include not taking enough medication, forgetting doses of your medicine, stressful situations, not getting enough sleep, exposure to quickly changing lights or visual things, and other environmental or physical triggers. 

How do you stop an upcoming seizure? 

While stopping an upcoming seizure might not always be possible, recognizing the early warning signs and taking action, like avoiding known triggers, maintaining good sleep habits, and managing stress through relaxation techniques, may help lower the risk of seizures. 

Can you prevent an oncoming seizure? 

Even though you might not always be able to avoid an oncoming seizure, sticking to your prescribed medication regimen, addressing lifestyle factors like sleep and stress, and avoiding known seizure triggers may help lower the likelihood of seizures and improve overall control of seizures. 

References: 

  1. Centers for Disease Control and Prevention (CDC). Epilepsy Fast Facts [Internet]. [cited 2024 Mar 8]. Available from: https://www.cdc.gov/epilepsy/about/fast-facts.htm 
  1. Centers for Disease Control and Prevention (CDC). Types of Seizures [Internet]. [cited 2024 Mar 8]. Available from: https://www.cdc.gov/epilepsy/about/types-of-seizures.htm 
  1. Centers for Disease Control and Prevention (CDC). Spotlight on Seizures [Internet]. [cited 2024 Mar 8]. Available from: https://www.cdc.gov/epilepsy/communications/features/seizures.htm 
  1. National Center for Biotechnology Information (NCBI). Breakthrough seizures—Further analysis of the Standard versus New Antiepileptic Drugs (SANAD) study – PMC [Internet]. [cited 2024 Mar 8]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739445 
  1. World Health Organization (WHO). Epilepsy [Internet]. [cited 2024 Mar 8]. Available from: https://www.who.int/news-room/fact-sheets/detail/epilepsy 
  1. Centers for Disease Control and Prevention (CDC). Epilepsy Program Home Page [Internet]. [cited 2024 Mar 8]. Available from: https://www.cdc.gov/epilepsy/index.html 
  1. National Health Service (NHS). Symptoms – Epilepsy [Internet]. [cited 2024 Mar 8]. Available from: https://www.nhs.uk/conditions/epilepsy/symptoms 
  1. Centers for Disease Control and Prevention (CDC). Frequently Asked Questions About Epilepsy [Internet]. [cited 2024 Mar 8]. Available from: https://www.cdc.gov/epilepsy/about/faq.htm 
  1. Centers for Disease Control and Prevention (CDC). Seizure First Aid [Internet]. [cited 2024 Mar 8]. Available from: https://www.cdc.gov/epilepsy/about/first-aid.htm 
  1. National Center for Biotechnology Information (NCBI). Epilepsy in adults: Treatment with medication [Internet]. [cited 2024 Mar 8]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK343318 
  1. National Center for Biotechnology Information (NCBI). Phenobarbital [Internet]. [cited 2024 Mar 8]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532277 

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