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Cat’s Claw: Benefits, Uses, Side Effects & More! 

By Dr Rajeev Singh +2 more

Key Highlights: 

  • Cat’s claw is a woody vine native to South and Central America. 
  • Has a long history of traditional use for various health problems like arthritis, inflammation, and infections. 
  • Research suggests potential immune-boosting, anti-inflammatory, anticancer properties, and more. 
  • Dosage varies depending on form and purpose; consult with a healthcare professional before taking it. 
  • Some possible side effects and interactions with medications; caution is needed during pregnancy and certain health conditions. 

Introduction 

Cat’s claw, or Uncaria tomentosa, is a special plant hailing from the Amazon and other warm parts of South and Central America. It is named after its thorny hooks that look like a cat’s claw. This plant, known for its possible health benefits, has been around for hundreds of years. People in these areas often turned to the root and bark of the cat’s claw plant for health needs. 

In this article, we will delve into possible health benefits that cat’s claw may offer, according to science. We’ll also touch on some untrue health claims, safe dosages, and side effects. Lastly, we will answer some frequently asked questions regarding this topic.  

cat's claw benefits

Did you know?

  • The usual doses of cat’s claw vary by preparation, from 30 to 300 mg of extract once daily. source: NCBI 
  • Cat’s claw is widely used and claimed to have anti-inflammatory and analgesic effects. source: NCBI 
  • Cat’s claw extracts have immune modulatory, antiviral, and antimutagenic activities. source: NCBI 
  • Cat’s claw extracts contain oxindole alkaloids, indole alkaloidal glucosides, quinovic acid glycosides, tannins, polyphenols, catechins, and beta-sitosterol. source: NCBI 
  • Small controlled trials have suggested a beneficial effect of cat’s claw on pain in chronic rheumatoid and osteoarthritis. source: NCBI

What is Cat’s Claw? 

Plant Description 

Cat’s claw is a prickly, solid vine that can stretch as far as 100 feet. It mainly grows in the Amazon rainforest but also calls other warm parts of South and Central America home. The plant is named after its bent, claw-like thorns. 

Scientific Family and Botany 

The cat’s claw belongs to the Rubiaceae family. Two common types used for health purposes are Uncaria tomentosa and Uncaria guianensis. The former is commonly used in the US, while the latter is favored in Europe.      

Traditional uses and history 

Many South American societies have used cat’s claw to  manage health issues such as arthritis, stomach ulcers, swelling, dysentery, and fevers. It also served as a form of birth control. 

Active compounds in Cat’s Claw 

Several constituents in cat’s claw offer health benefits. These cover plant chemicals that aid in curbing inflammation, such as tannins and sterols, and those that fight viruses, for example, quinovic acid glycosides. 

Potential Health Benefits of Cat’s Claw 

1. Supporting Immune System  

Antiviral and Antibacterial Properties 

Early studies hint at the antiviral and antibacterial properties of cat’s claw. It might kill cancer cells in test tubes, though more research is needed to establish this. 

In Vitro and Animal Studies 

In vitro and animal studies suggest that cat’s claw may help stimulate the immune system, relax muscles, dilate blood vessels, and act as a diuretic (aiding the body in getting rid of excess water). 

Clinical Data on Immune System Enhancement 

Not many clinical studies support the immune-boosting potential of cat’s claw. However, one trial discovered that 700 mg of cat’s claw extract taken daily for two months increased white blood cell count. This is crucial in fighting off infections. To confirm that cat’s claw is an effective immune booster, we need more extensive studies. 

2. Anti-Inflammatory Effects 

Osteoarthritis Relief 

Research implies that cat’s claw may provide some respite from the pain caused by osteoarthritis. One study showed that 100 mg of its extract taken daily for 4 weeks lessened pain during physical movement without severe side effects. 

Rheumatoid Arthritis Relief 

Another study discovered that people with rheumatoid arthritis who took 60 mg of cat’s claw extract daily alongside their usual medicines experienced fewer painful and inflammed joints. This is as compared to those only taking the medications. 

Mechanism of Action 

The anti-inflammatory effects of cat’s claw are believed to be due to its antioxidant properties. These help in neutralising free radicals and reducing inflammation in the body. 

Clinical Studies on Anti-Inflammatory Properties 

Clinical studies on the anti-inflammatory properties of cat’s claw are not abundant. But, available evidence suggests that it might help with swelling and affiliated pain in some cases, specifically in osteoarthritis and rheumatoid arthritis. 

3. Anticancer Properties 

Lowering Tumor Risk or Slowing Tumor Growth 

Early laboratory studies indicate that a cat’s claw might avoid or slow down tumour growth. However, more research is needed to see if humans would experience the same effects. 

Animal and in Vitro Data 

A number of animal and in vitro studies indicate that cat’s claw extracts may have anticancer effects. These include inhibiting cancer cell growth and causing the death of cancer cells. 

Clinical Data on Cancer Risk Reduction and Management 

While the clinical data on anticancer properties of cat’s claw is thin, one study found that 100 mg of cat’s claw extract taken three times every day alongside cancer therapy may boost the quality of life for those with advanced solid tumours. 

4. Cardiovascular Effects 

In Vitro and Animal Research 

In vitro and animal research state that a cat’s claw might have cardiovascular benefits. These include better relaxation of blood vessels, diuretic effects, and improved blood flow. 

Clinical Studies on Heart Health 

Despite positive early results, clinical studies on the benefits on heart health of cat’s claw are lacking. More research is needed to affirm its impact on the human heart.  

5. Central Nervous System (CNS) Effects 

Alzheimer’s Disease and Cognitive Function 

Some new research implies that cat’s claw may provide benefits for Alzheimer’s disease and cognitive function. In vitro trials found possible protective effects against damage and decline of nerves. 

Animal and in Vitro Data 

Animal and in vitro studies hold promise for cat’s claw’s potential in enhancing cognitive function. This may be due to its impact on brain cells and brain chemical pathways. 

Clinical Studies on CNS Effects 

We only have limited clinical data on the effects of cat’s claw on the central nervous system (CNS).  However, this remains an exciting area for more research in the future. 

6. Denture Stomatitis Relief 

Clinical Data on Stomatitis Management 

In a small trial that was  randomised, a 2% cat’s claw gel showed similar results to a prescription antifungal gel in reducing denture stomatitis symptoms. This condition is a mouth and gum inflammation due to yeast overgrowth, typically affecting those who wear dentures. More research is required.  

7. Effects on female hormones 

Animal Data on Estrogenic Effects 

Animal studies imply that cat’s claw might have estrogenic effects. Meaning, it could interact with or act like the body’s estrogen hormone. 

Clinical Studies on Hormone Therapy 

Clinical studies on the effect of cat’s claw on female hormone balance and hormone management aren’t many. However, they call for more research to weigh the possible benefits and risks accurately. 

Unfounded Health Claims 

While many potential benefits of cat’s claw have been explored, it is essential to note that there are numerous unfounded claims regarding the plant’s effectiveness in managing various health conditions. These claims lack sufficient scientific evidence, and reliance on cat’s claw without medical consultation may lead to improper management of underlying health issues. 

Always consult with your healthcare professional before using any dietary supplement, including cat’s claw, to ensure it is safe and appropriate for your specific health needs. 

Dosage and How to Take Cat’s Claw?  

1. Available Forms of Cat’s Claw 

You can get cat’s claw in many forms like liquid extracts, capsules, powders, and teas. The form you pick will depend on your preference, the dosage you want, and the specific health issue you’re tackling. 

2. Recommended Dosage for Adults 

Sadly, there are no clinical trials to support the right dosage suggestions for cat’s claw. That said, there are some general guidelines to follow which are as follows.  

  • For root bark: 1 gram taken 2 to 3 times daily. 
  • For standardised root and bark extracts: 20 to 30 mg daily. 
  • For capsules: 300 to 500 mg daily, divided into 2 to 3 separate doses. 

Your healthcare professional can give personal dosage advice tailored to your needs and health conditions. Always consult them beforehand. 

3. Factors influencing dosage recommendations 

Several factors can affect the suggested dosage for cat’s claw. These include the specific health issue you’re addressing, the intensity of symptoms, personal biological differences, and potential interactions with other medicines or supplements. 

Remember, natural products like cat’s claw can differ hugely in quality and potency. Always go for a trusted supplier and discuss your options with a healthcare professional. 

Safety and Side Effects of Cat’s Claw 

1. Common Side Effects 

While cat’s claw is usually safe for short-term use, some people have reported side effects. They include: 

  • Headache 
  • Dizziness 
  • Vomiting 
  • Stomach pain 
  • Diarrhoea 

It’s crucial to watch your body’s response to the cat’s claw and discuss with your healthcare professional if you experience any bizarre or intense side effects. 

2. Contraindications 

People with the following  health conditions should be careful when thinking of using cat’s claw: 

  • Autoimmune diseases (e.g., multiple sclerosis, lupus) 
  • Blood disorders 
  • Leukaemia 
  • Kidney or liver diseases 
  • Low blood pressure 

3. Pregnancy and Lactation Considerations 

There are no safety data on using cat’s claw during pregnancy and lactation. It’s generally advised to stay away from cat’s claw during this time. Always check with your healthcare professional before using any supplements. 

Drug and Supplement Interactions 

Cat’s claw could interact with several medications which are as follows.  

  • Drugs altered by the liver (Cytochrome P450 3A4(CYP3A4) substrates), such as lovastatin, ketoconazole, and many others. 
  • High blood pressure medicines (antihypertensive drugs) 
  • Calcium channel blockers 
  • HIV/AIDS drugs (protease inhibitors) 
  • Immunosuppressants 
  • Blood thinners (anticoagulant/antiplatelet medications) 

If you are taking any medicines or have a medical issue, always consult your healthcare  professional before starting cat’s claw. 

Also Read: Chaga Benefits: An In-Depth Look at the Mushroom’s Health Potential

Conclusion 

 In conclusion, cat’s claw is an intriguing plant with a deep past in South and Central America. Its possible health benefits span wide, with immune support, anti-inflammatory effects, and possible anticancer properties. Even though more extensive clinical trials are needed to confirm these benefits, early findings suggest that cat’s claw may be a useful addition to a healthy lifestyle for some people. 

Always check with your healthcare professional before you try any new supplements or medications. Be aware of potential side effects and interactions as well. 

Frequently Asked Questions (FAQs) 

What is cat’s claw supplement good for? 

Cat’s claw has been traditionally used for issues like arthritis, inflammation, and infections. According to some research, it might benefit the immune system. It may also have potential anti-inflammatory and anticancer effects. 

What are the side effects of taking cat’s claw? 

Possible side effects of taking cat’s claw include headache, dizziness, vomiting, stomach discomfort, and diarrhoea. Always keep an eye on your body’s reaction and discuss with your healthcare professional if any strange or harsh side effects arise. 

Can you take cat’s claw every day? 

Generally, taking cat’s claw in suggested dosages every day for short periods is considered safe. As always, follow your healthcare professional’s advice based on your specific health needs and worries. 

What does a cat’s claw do for the brain? 

Early research shows promising signs for protective effects on nerve cells and brain chemical pathways. This suggests that it may have some benefits for cognitive function and possibly even Alzheimer’s disease. More clinical research is needed to prove these effects. 

References: 

  1. National Center for Biotechnology Information (NCBI). Pharmacology and therapeutic uses of cat’s claw [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/19451609 
  1. National Center for Biotechnology Information (NCBI). Morphoanatomical studies of Uncaria tomentosa and Uncaria guianensis bark and leaves [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15070175 
  1. National Center for Biotechnology Information (NCBI). Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100 [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11515716 
  1. National Center for Biotechnology Information (NCBI). Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/10687868 
  1. National Center for Biotechnology Information (NCBI). Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae) [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12065162 
  1. National Center for Biotechnology Information (NCBI). Cat’s claw: an Amazonian vine decreases inflammation in osteoarthritis [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/17210508 
  1. National Center for Biotechnology Information (NCBI). Epidemiology of Osteoarthritis – PMC [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920533 
  1. National Center for Biotechnology Information (NCBI). Efficacy and safety of freeze-dried cat’s claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11603848 
  1. National Center for Biotechnology Information (NCBI). Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351] [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/17974032 
  1. National Center for Biotechnology Information (NCBI). Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: A randomized controlled trial [ISRCTN38432711] – PMC [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1276811 
  1. National Center for Biotechnology Information (NCBI). Current nutraceuticals in the management of osteoarthritis: a review [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/22850529 
  1. National Center for Biotechnology Information (NCBI). Prevalence of rheumatoid arthritis in the United States adult population in healthcare claims databases, 2004-2014 [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/28455559 
  1. National Center for Biotechnology Information (NCBI). Randomized double-blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria tomentosa for the management of rheumatoid arthritis [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11950006 
  1. National Center for Biotechnology Information (NCBI). An active ingredient of Cat’s Claw water extracts identification and efficacy of quinic acid [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15619581 
  1. National Center for Biotechnology Information (NCBI). Anti-inflammatory and antioxidant activities of cat’s claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/12120814 
  1. National Center for Biotechnology Information (NCBI). Acute renal failure caused by ‘cat’s claw’ herbal remedy in a patient with systemic lupus erythematosus [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/9375835 
  1. National Center for Biotechnology Information (NCBI). Silicate nephrolithiasis after ingestion of supplements containing silica dioxide [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/19100669 
  1. National Center for Biotechnology Information (NCBI). Integrating complementary medicine into cardiovascular medicine. A report of the American College of Cardiology Foundation Task Force on Clinical Professional Consensus Documents (Writing Committee to Develop an Professional Consensus Document on Complementary and Integrative Medicine) [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15992662 
  1. National Center for Biotechnology Information (NCBI). Alternative medicine remedies might stimulate viability of leukemic cells [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16047362 
  1. National Center for Biotechnology Information (NCBI). Role of natural herbs in the management of hypertension – PMC [Internet]. [cited 2024 Jun 20]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210006 

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

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