Medohar Guggulu: Uses, Benefits, Side Effects & More
By Dr. Raghuveer +2 more
Medically reviewed by Dr. Raghuveer
Last updated: Dec 18, 2025 Published on: Dec 18, 2025
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By Dr. Raghuveer +2 more
Table of Contents
Medohar Guggulu, a classic ayurvedic formulation, is based on the traditional use of guggul (an oleogum resin) that is obtained from the Commiphora mukul tree1,2.
Medohara in Sanskrit means ‘fat-eliminating’ and in Ayurveda, Medohar Guggulu has been used to manage a wide range of metabolic and inflammatory conditions1,3. Modern research identifies guggulsterone as one of the major bioactive constituents of guggul, which supports the growing relevance of guggul-based formulations in contemporary health care2.
And with increasing interest in plant-based and mechanism-driven therapies, Medohar Guggulu remains a well-known classical formulation that continues to be explored for its potential benefits, active constituents, and mechanisms of action. Therefore, through this article, we aim to explore scientifically backed evidence for Medohar Guggulu uses, benefits, side effects, and more.
Medohar Guggulu is a traditional Ayurvedic formulation that contains Shuddha Guggulu (purified Guggulu) as its base, which is combined with other synergistic herbs. These may include
1. Sunthi (dry ginger)
2. Pippali (long pepper)
3. Marich (black pepper)
4. Chitraka (leadwort)
5. Haritaki (chebulic myrobalan)
6. Vibhitaki (beleric myrobalan)
7. Amalaki (Indian gooseberry)
8. Musta (nutgrass)
9. Vaividanga (embelia).
This herbal blend containing guggul is traditionally crafted to support balanced metabolism and healthy fat processing in the body4.
According to Ayurveda principles, descriptions and traditional beliefs, Medohara Guggulu acts through several mechanisms4:
Through these combined traditional actions, Medohara Guggulu is used in Ayurveda to support metabolic balance and healthy processing of lipids. However, clinical evidence confirming these effects and benefits is still limited.
Although Medohara Guggulu is primarily valued for its metabolic and lipid-modulating actions, an understanding of the nutritional and techno-functional properties of its key constituent, which is guggul (Commiphora mukul gum), will help provide insight into its broader relevance as a functional ingredient.
A recent analytical study investigating the nutritional profile of C. mukul gum powder reported the following5:
| Parameter | Value |
| Moisture | 2.07% |
| Fat | 17.43% |
| Protein | 9.77% |
| Ash (mineral content) | 6.73% |
According to this study, the gum exhibits a bulk density of 0.63 g/cm³, which indicates good compressibility and ease of incorporation into various formulations. It also possesses notable phytochemical richness, containing 6.91 mg GAE/g of total phenolics and 1.68 mg QE/g of total flavonoids, both contributing to its antioxidant potential.
Together, these characteristics position C. mukul gum as a nutritionally valuable and bioactive component, reinforcing Medohara Guggulu’s uses in obesity and metabolic disorders.
Medohar Guggul demonstrates several key advantages for metabolic and systemic well-being by combining traditional Ayurvedic principles with modern biochemical insights. Common Medohar Guggulu benefits include:
Medohar Guggulu helps improve digestion, boost metabolism, break down fat, and improve insulin function4,6. In a study on 58 obese adults, those taking Medohar Guggul with diet and exercise lost more weight than those on lifestyle changes alone, especially people weighing over 90 kg7. This suggests it may enhance weight reduction efforts in heavier individuals.
Medohar Guggulu shows anti-inflammatory properties which may help ease joint discomfort in osteoarthritis patients. A study showed that guggul extract may facilitate improvement in osteoarthritis of the knee by reducing knee pain, stiffness and enhancing mobility8.
Guggulsterone, the active compound in guggul, may help lower cholesterol. It does so by improving how the liver removes cholesterol and by reducing inflammation1. This supports healthier lipid levels and overall cardiovascular wellness.
Guggulipid has shown benefits in reducing nerve-related pain in animal studies by easing burning sensations and sensitivity9. These effects may be due to guggulipid’s action on nerve inflammation. This suggests it could help support the management of neuropathic pain.
Guggul (guggulsterone) may help support diabetes management. It helps to reduce high blood glucose levels by improving glucose tolerance and supporting better insulin function, suggesting it’s potential as adjunct in diabetes management10.
Due to the presence of bioactive compounds like phenolics and flavonoids, Guggul may help regulate inflammatory mediators and support immune health. This helps to balance the body’s immune response11.
Guggulsterone may help support healthy thyroid function. It can increase thyroid hormone activity and boost metabolic processes (as seen in animal models)12. This points towards its potential support to manage hypothyroid symptoms
Lab studies indicate that guggulsterone may slow the growth of cancer cells and help harmful cells self-destruct13. While more human research is needed, early evidence suggests guggulsterone may have protective, anti-tumour benefits.
While initial studies have shown positive results, more high-quality human research is needed to confirm the above-mentioned Medohar Guggulu benefits.
Note: Medohar Guggulu is an Ayurvedic formulation that may offer supportive health benefits, but it should never replace modern medical treatment for conditions like cancer, nerve disorders, diabetes, or heart disease.
Medohar Guggulu is traditionally taken in tablet or powder (churna) form, usually under the guidance of an Ayurvedic physician. The general approach focuses on supporting digestion, fat metabolism, and overall balance of Kapha and Vata.
Below mentioned are typical usage guidelines (general Ayurvedic practice):
As per Ayurvedic practice, certain foods and habits are said to support Medohar Guggulu’s benefits. These include4:
While Medohar Guggulu is generally well-tolerated when taken in recommended doses, modern clinical and toxicological studies show that some individuals may experience mild to moderate side effects. Possible Medohar Guggulu side effects include:
The most common side effects reported include stomach upset, loose stools, belching, and hiccups. These were noted in human studies of guggul resin and extracts and not directly with Medohar Guggulu14.
Higher doses may occasionally cause skin reactions such as redness or itching in some individuals14,15.
Hepatotoxicity has been documented in case reports following use of concentrated guggul extracts14,16. While uncommon, liver-related adverse events have been described and should prompt immediate medical review.
Animal studies show that guggul might stimulate thyroid hormone activity11,14. This may cause adverse symptoms in sensitive individuals.
Like with any natural product, if you consider including Medohar Guggulu in your routine diet, the following should be kept in mind:
Guggul and its active compound, guggulsterone, influence liver enzymes, cholesterol pathways, and hormone receptors. And because of this, Medohar Guggulu may interact with some modern medicines. Possible drug interactions include:
Always consult a qualified doctor before starting Medohar Guggulu, especially if you have any medical conditions or are on medication.
Usually, 1-2 tablets per day after meals, often used for 6 to 12 weeks may be suggested, but the recommendation varies depending on the individual’s condition and the doctor’s advice4,7.
Also note that commercially available Medohar Guggulu tablets differ significantly in potency due to varying formulation, purification methods, and resin content. So, Medohar Guggulu dosage can vary depending on your needs and also the brand used.
Important: Since Medohar Guggul has metabolic and digestive effects, dosage should be personalised. Always consult a qualified Ayurvedic practitioner to know the right dosage based on your overall health and needs.
Also Read: Guggul: Uses, Benefits, Side Effects and More!
Medohar Guggulu is an Ayurvedic formulation enriched with the therapeutic benefits of guggul and other metabolism-supporting herbs. Both classical Ayurvedic texts and modern scientific research highlight its helpful role in supporting healthy weight management, improving metabolism, regulating lipids, promoting joint comfort, and enhancing overall systemic wellness. Research on guggulsterone (the active compound in Commiphora mukul) further reinforces its pharmacological value due to its antioxidant, anti-inflammatory, and cholesterol-balancing properties.
However, its effectiveness and safety depend greatly on product quality and correct dosing. More well-designed, long-term clinical studies are needed, and Medohar Guggulu should be used only as a supportive measure and not as a substitute for modern medical treatment.
When taken responsibly, along with a balanced lifestyle, a wholesome diet, and proper medical guidance, Medohar Guggulu has the potential to provide meaningful support for metabolic health and overall well-being.
Also Read: Kanchanar Guggulu: Benefits, Side Effects, Precautions & More!
Weight reduction varies from person to person. In a small clinical trial, people who used Medohar Guggulu along with diet and walking showed slightly more weight reduction, especially those above 90 kg, who were all able to reduce some weight6. However, Medohar Guggulu cannot cause major weight loss on its own; it works best as a supportive aid when combined with a healthy diet and regular exercise.
Medohar Guggulu is generally taken after meals with warm water, as this helps digestion and enhances its metabolic effect4. However, dosing may vary by brand and practitioner, so it is best to follow your doctor’s/manufacturer’s instructions.
To use Medohar Guggulu effectively, it should be combined with a balanced lifestyle. Most brands recommend taking 1 to 2 tablets, once or twice daily after meals, depending on the tablet strength and guggulsterone content. For best results, you may pair it with a light diet, regular physical activity, warm water intake, and controlled meal timings4. The formulation works by improving digestion, boosting metabolism, and helping the body burn excess fat more efficiently, but it is not a standalone weight-loss treatment. Always consult an Ayurvedic doctor (especially if you have existing medical conditions or take other medications) to determine the correct dose and suitability for your body type.
Yes, it is generally safe for prolonged use if consumed as and when recommended by a certified ayurvedic practitioner. Although, it’s ideal to consult the specialist at regular interval in between to monitor progress.
Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.
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