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How to Decrease Melanin in Skin

By Dr. Raina N. Nahar +2 more

Join Health Talk by PharmEasy on WhatsApp

Introduction

All individuals are unique in their appearance, particularly in features such as skin tone, hair colour, etc. Have you ever wondered why this happens? This is because of the variations in a pigment called melanin. Melanin defines the colour of our skin which varies from person to person. The peculiarity of this pigment is that its production increases once the skin is exposed to the sun light1.

The skin pigmentation on sun exposure is actually a defensive mechanism of our body to protect it from harmful UV rays1. But there are conditions where melanin production increases beyond the need and people start feeling low on it. This article may help you understand why this happens and how to reduce melanin in skin to manage this condition.

melanin

What is Melanin?

Melanin is a natural pigment which gives colour to the different parts of our body, such as skin, hair, eyes, etc. There are two types of melanin, eumelanin and pheomelanin1,2.

  • Eumelanin: This form of melanin synthesizes dark brown to black pigments. It protects our body from harmful UV rays by effectively absorbing and neutralising them2. By absorbing the sunlight, it also keeps the body cool and regulates temperature. People with darker skin tones will have higher amounts of eumelanin1.
  • Pheomelanin: This is a type of melanin which produces red or yellow pigments1,2. Unlike eumelanin, it does not effectively absorb UV rays, but it can keep the body cool and regulate temperature by reflecting away the heat from the body, especially during the sunny days. It is seen in higher amount in people with lighter skin tone1.

Melanin is produced by melanocytes, which are the specialised pigment-producing cells found in the epidermis (outermost layer of the skin)1,2. Melanocytes produce melanin from an amino acid called tyrosine, through a multi-step process, by using a key enzyme called tyrosinase. This melanin which is produced is then enclosed in a membrane bound organelle called melanosome. These melanosomes are then actively moved to nearby keratinocytes, which are the main cells of the epidermis2.


As mentioned earlier, melanin normally increases once your body comes in contact with the UV rays. These UV rays penetrate the skin and trigger the melanocytes to produce more melanin, leaving your skin darker or tanned1. Other factors which increase melanin production are discussed in the next section.

Causes of Excess Melanin Production

Hyperpigmentation, a result of excess melanin production, can be caused by several factors. Understanding these factors may help you in knowing how to decrease melanin in skin. Following are some common factors among them.

melanin
  • Genetic Factor: The production of melanin in your body is under the control of genes. These genes determine the number of melanocytes produced in your body. It can also predict how strongly the melanocytes get stimulated by sunlight, making some people prone to hyperpigmentation. 
  • Sun Exposure: UV rays from the sun stimulates the melanocytes to increase the production of melanin to protect your body from DNA damage. Prolonged or repeated exposure to sunlight makes you prone to hyperpigmentation2.
  • Hormonal Changes: Changes in hormones such as oestrogen, progesterone, and melanocyte-stimulating hormone (MSH) during pregnancy, puberty, menopause, or while using contraceptive pills can stimulate melanocytes. These hormones may cause variations in the level of melanin, inducing hyperpigmentation such as melasma3
  • Certain Medications: Certain medications such as antibiotics, birth control pills, etc., can stimulate the production of melanin. This intensifies the skin pigmentation, causing drug-induced hyperpigmentation1
  • Inflammation or Skin Injury: Inflammations resulting from chemical exposure, burns, psoriasis, and acne can stimulate melanocytes to produce more melanin while on healing. This melanin can leave the skin discoloured and dark, causing post-inflammatory hyperpigmentation (PIH)1.
  • Ageing: Ageing causes the decrease in number of melanocytes in the body1,3. The remaining melanocytes become more active and prominent, causing an uneven skin tone. This produces pigmented spots called age-spots particularly in areas exposed to sun, which is age-related hyperpigmentation4
  • Medical Conditions: Conditions such as Addison’s disease (adrenal hormones insufficiency), thyroid, and diabetes can increase the production of MSH; this can stimulate melanocytes to darken the skin and mucous membrane, resulting in hyperpigmentation3,5

Home Remedies to Reduce Melanin

Before seeking medical attention, trying some home care tips may be effective for some common pigmentation issues. Here are some simple home care tips that you can follow for melanin reduction. 

1. Green Tea

green tea

Green tea is rich in polyphenols and catechins, which have anti-inflammatory and antioxidant properties. These compounds, particularly polyphenols, have been found to reduce DNA damage, oxidative stress, skin ageing and excess melanin production caused by UV exposure6. Therefore, applying green tea extract or drinking green tea might help calm your skin and reduce melanin production. 

2. Aloe Vera

aloe vera

Aloe vera is a plant which is extensively adopted in many skincare products and in dermatology. It is well known for its medicinal properties. Its anti-inflammatory and antioxidant properties might help soothe the skin and reduce inflammation due to skin conditions such as acne, eczema, and rosacea1,7. It also has a compound called aloin, which is said to have skin-lightening properties. Hence, applying aloe vera might help in depigmenting your skin by reducing melanin1.

3. Turmeric

turmeric

Turmeric is a traditional plant which is known for its potential uses. It contains curcumin, a compound with anti-inflammatory and antioxidant properties. This compound has been found to lower skin inflammation caused by conditions such as psoriasis and eczema. Another compound called curcuminoid has been found to have exfoliating effects, which helps in removing dead skin cells and reducing hyperpigmentation. Both these compounds work by reducing the formation of the MSH hormone to minimise hyperpigmentation1. Hence, using turmeric might help in lightening your skin by reducing melanin. 


4. Tomato

tomatoes

Tomato is a vegetable widely used in household kitchens. It has a compound called lycopene, which is a natural antioxidant. It may help protect the skin from sun damage by fighting harmful molecules caused by UV rays. It is also known to reduce skin redness and improve skin appearance by reducing pigmentation and early ageing8. Hence applying tomato might improve your skin by reducing pigmentation. 

5. Argan Oil

Argan oil is a natural extract, which is rich in antioxidants and fatty acids. These components in argon oil might help reduce inflammation and promote skin brightening. Its anti-inflammatory property might also be helpful in improving skin conditions such as acne, eczema, and rosacea, by reducing inflammation9. Hence, applying argon oil might help you manage skin darkening and inflammation. 

6. Liquorice Root

Liquorice Root

Liquorice root extract is known to have several medicinal properties, especially its benefits for skin health. Its antioxidant and anti-inflammatory properties might reduce inflammation and improve skin texture by reducing pigmentation. It’s may also be affective in managing or reducing the severity of skin conditions such as rosacea and acne1. Hence, applying liquorice roots extract might improve your skin from hyperpigmentation’s such as melasma and manage other skin-related diseases. 

  • General recommendation: Limiting sun exposure is the most effective thing you can do to reduce the production of melanin in your body. Stay indoors between 10 am and 4 pm. If you are going out, do apply a sunscreen having an SPF 30 or higher grade, wear sunglasses and other necessary items which might be useful in covering your body from direct sun light10

Although home remedies may be helpful in reducing melanin, consistency is key to see results. When using any new product for the first time, it is always advisable to do a patch test before using to avoid risk of any allergies. 

Medical Treatment to Reduce Melanin 

There are several medical options available to decrease melanin in skin and manage hyperpigmentation. Following are some among them: 

1. Topical Depigmenting Agents

Topical creams are the most common method for managing hyperpigmentation. These creams contain depigmenting agents like hydroquinone, azelaic acid, kojic acid, niacinamide, or arbutin. Most of these agents work by inhibiting the production of the tyrosinase enzyme, which is essential for producing melanin. Hence, using topical creams which contain these agents might help in lightening your skin by reducing the production of melanin1.

2. Topical Retinoids

Topical retinoids include retinoic acid, retinol, retinaldehyde, tazarotene, and adapalene. They may help improve the skin by shedding old, damaged, and highly pigmented cells, and by reducing the transfer of melanin. They are mainly applied to manage uneven skin pigmentation caused by sun damage, melasma, and PIH. Combining them with other depigmenting agents like hydroquinone or azelaic acid might give you more effective results11

3. Chemical Peels 

Chemical peels involve the application of compounds like salicylic acid, lactic acid, or glycolic acid. They work by exfoliating the top layer of the skin which contains excess melanin1,3. This might diminish the dark patches and promote the growth of new cells. Performing chemical peeling under an expert’s supervision might also help in managing psoriasis, warts, keratoses, and acne, along with reducing hyperpigmentation1.

4. Laser and Light-Based Therapies

Laser and light-based therapies are the modern methods for managing or reducing hyper pigmentation. They work by directly targeting the melanin, both over and under the skin surface, without causing any irritation. Hence, you might adopt these therapies to manage age spots and sun damage. Lasers in combination with light energy and intense pulsed light may also be helpful to reduce stubborn pigmentations1.

5. Oral Medications and Supplements 

Oral medications involve compounds such as tranexamic acid. These medicines are known to reduce skin pigmentation by controlling the activity of the enzyme tyrosinase, which plays a key role in melanin production. Hence, taking oral medications under an expert’s supervision maybe helpful in managing skin conditions such as melasma, acne, PIH, and rosacea1,12

6. Combination Therapy 

Combination therapy may include topical depigmenting agents, retinoids, chemical peels, and strict sun protection. It is known to improve many pigmentation disorders better than a single approach. This approach enhances effectiveness while lowering the chances of side effects or the pigmentation recurrence13.

Although these medical approaches may be helpful in managing hyperpigmentation, it should only be performed or taken under the guidance of an expert doctor or dermatologist for safety and better results. 

Foods that Help to Reduce Melanin in Skin

Certain foods may help support healthy skin and may reduce excess melanin and pigmentation. Following are some melanin reducing foods that you can go for. 

1. Foods Rich in Vitamin C

vitamin c

Vitamin C is a strong antioxidant. It reduces the production of tyrosinase enzyme, which is essential for the synthesis of melanin. Hence, consuming Vitamin-C-rich foods might help you in reducing melanin and managing hyperpigmentation. It also promotes collagen synthesis, supporting overall skin health. Examples include citrus fruits such as lemon and orange, kiwi fruit, guava, and strawberries14

2. Foods Rich in Vitamin E

vitamin e

Vitamin E is a vital fat-soluble antioxidant which is produced by plants. It may help reduce pigmentation by protecting melanocytes from damage, increasing glutathione levels, and reducing the activity of the tyrosinase enzyme. Therefore, consuming foods rich in Vitamin E might help your body to reduce melanin production and manage hyperpigmentation. Examples include nuts (almond, hazelnuts, etc), whole grains, spinach, olive oil, and sunflower oil15

3. Foods Rich in Polyphenol

Polyphenol

Polyphenol is a compound with antioxidant and anti-inflammatory properties. It helps protect skin from DNA damage and oxidative stress and lowers the production of excess melanin due to UV exposure. Hence, taking foods rich in polyphenols might improve your skin by reducing pigmentation and skin damage. Examples include oranges, mangoes, passion fruits, grapes, almonds, green tea, coffee, etc6,16

4. Foods Rich in Zinc

zinc

Zinc is an essential micronutrient. It may be helpful to manage several dermatological conditions such as infections, inflammatory diseases, etc. It helps manage pigmentation by regulating the melanocyte activity. There, intake of zinc-rich foods might keep your skin healthy and help you in improving hyperpigmentation’s such as melasma. Zinc rich foods are mostly animal-based, such as fish, oysters, eggs, meat, etc17

5. Foods Rich in Antioxidants

antioxidants

Antioxidants are the compounds found in several foods. They combat harmful free radicals in the body. They also lower the melanin level by regulating the tyrosinase enzyme which is important for melanin synthesis. Hence, consuming foods rich in antioxidants might help you in maintaining a lightened skin1. Some antioxidant-rich foods are mangoes, pumpkins, lean meat, grapes, berries, leafy vegetables, potatoes, tomatoes, avocados, etc18

6. Foods Rich in Vitamin A

vitamin a

Vitamin A is an important micronutrient. It plays a key role in skin health by daily replacement of dead skin cells. This might remove the cells which have excess melanin, thereby reducing the chances of hyperpigmentation. Therefore, vitamin-A-rich food intake might help you in managing melanin levels in your body. Here are a few examples of Vitamin-A-rich foods: leafy vegetables (amaranth, spinach, and chard), carrots, pumpkins, eggs, milk, liver, etc19.

While these nutrients have shown depigmentation effect on skin in initial studies, further large-scale human trials are needed for confirmation of these effects of specific food items. It is ideal to discuss with your doctor before incorporating anything new to your routine diet, especially if you have any medical conditions. 

Can Melanin be Reduced Permanently?

As described earlier, melanin is a pigment that gives colour to different parts of the human body and is produced by melanocytes through a process called melanogenesis1,2. As melanin production is mainly determined by genetics1, it is not possible to permanently reduce or eliminate melanin from your skin. We discussed different ways by which melanin production can be reduced or diminished. But all these are meant to give only temporary results. This is because most of these work by inhibiting or reducing tyrosinase enzyme, which is crucial for melanin production1,14. And once you stop these methods, the body starts producing the enzymes and melanocytes depending on the genetic factor. So, the only thing you can do is to manage the level of pigmentation through various safe methods but not permanently reduce it.  

Also, it’s important to note that the FDA suggests not to use any over the counter medications for skin lightening, as these may cause permanent damage to skin like ochronosis (skin discolouration)20. This might also interfere with the skin’s natural protective mechanism. Melanin is important for your skin to mask it from harmful UV rays, which can cause several skin disorders1,2. Therefore, stay away from unwanted and unsafe approaches and try natural ways or seek a dermatologist’s help to reduce your pigmentation problems. 

When to Consult a Doctor?

Certain changes in your skin might be an indication of any underlying issues. It is important to note such changes and seek medical attention. Following are some warning signs that you must not ignore. 

  • Alterations in the size or colour of a mole, birthmark, or other dark spots 
  • Unexpected scaling, fluid release, or bleeding from the skin 
  • Sudden itching, soreness, or pain from a spot on skin21 
  • Sudden changes in the colour of skin 
  • Prolonged unexpected darkening or lightening of the skin
  • Sore or lesion that changes colour, size, or shape22 
  • Lesions with uneven, irregular borders and varied colour23 

Conclusion

Melanin is a pigment which gives colour to your skin. Excess melanin causes hyperpigmentation issues. To manage it, you may try home care tips, or medical approaches under an expert’s guidance. You can also prioritise foods that help to manage hyperpigmentation. But never ignore if you notice any sudden changes in your skin colour or texture they might be warning signs of any underlying conditions, hence seek immediate medical attention. 

Also Read: Is Glycerine Good for Skin?

Frequently Asked Questions (FAQs)

Can vitamin C reduce melanin?

Yes, Vitamin C, which is a substance naturally found in fruits is known to reduce melanin, by inhibiting the production of the tyrosinase enzyme, which is essential for producing melanin14.

Which drink reduces melanin fast?

To reduce melanin, the best drinks you may choose are green tea and vitamin C- rich fruit juices6,14 like lemonade, orange juice, strawberry smoothie, although further research is needed to confirm their depigmentation effects.

What causes high melanin levels?

High melanin levels in the body can result from several factors, including genetics, certain medications, prolonged sun exposure, ageing, hormonal changes during pregnancy or menopause, the use of oral contraceptive pills, and underlying health conditions such as Addison’s disease, diabetes, or thyroid1,5.

What foods should I avoid for melanin?

To reduce hyperpigmentation and improve skin health, it is best to limit excessive sugar, highly processed foods, and foods with a high glycaemic index, as they can worsen inflammation and pigmentation. Also avoid excessive alcohol, baked or junk foods and tobacco24.

What deficiency causes skin darkening?

The deficiency of vitamin B12 is found to cause the skin darkening. However, it is a reversible type of skin darkening; taking vitamin B12 supplements or eating vitamin B12-rich foods might help reduce or manage this condition25.

References

  1. Thawabteh AM, Jibreen A, Karaman D, Thawabteh A, Karaman R. Skin Pigmentation Types, Causes and Treatment: A Review. Molecules [Internet]. 2023 Jun 18;28(12):4839. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10304091/ 
  2. Schlessinger DI, Schlessinger J, Anoruo M. Biochemistry, Melanin [Internet]. NIH. StatPearls Publishing; 2025. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459156/ 
  3. Basit H, Godse KV, Al Aboud AM. Melasma [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459271/ 
  4. Aging Changes in Skin [Internet]. MedlinePlus. 2024. Available from: https://medlineplus.gov/ency/article/004014.htm 
  5. Verma D, Sarkar R, Mendiratta V, Srivastava A. Addisonian Pigmentation – the Great Mimicker: A Review. Indian Journal of Dermatology [Internet]. 2024 Oct;69(5):422. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11623411/ 
  6. Fukushima Y, Takahashi Y, Kishimoto Y, Taguchi C, Suzuki N, Yokoyama M, et al. Consumption of Polyphenols in Coffee and Green Tea Alleviates Skin Photoaging in Healthy Japanese Women. Clinical, Cosmetic and Investigational Dermatology [Internet]. 2020 Feb;13:165–72. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7020926/ 
  7. Surjushe A, Vasani R, Saple D. Aloe vera: A Short Review. Indian Journal of Dermatology [Internet]. 2008;53(4):163–6. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763764/ 
  8. Zhang X, Zhou Q, Qi Y, Chen X, Deng J, Zhang Y, et al. The Effect of Tomato and Lycopene on Clinical Characteristics and Molecular Markers of UV-induced Skin deterioration: A Systematic Review and meta-analysis of Intervention Trials. Critical Reviews in Food Science and Nutrition [Internet]. 2023 Jan 6;64(18):6198–6127. Available from: https://pubmed.ncbi.nlm.nih.gov/36606553/ 
  9. Goik U., Goik T., Załęska I. The properties and application of argan oil in cosmetology. Eur. J. Lipid Sci. Technol. 2019;121:1800313–1800342. Available from: https://www.researchgate.net/publication/330719519_The_Properties_and_Application_of_Argan_Oil_in_Cosmetology
  10. Tanning [Internet]. MedlinePlus. 2017. Available from: https://medlineplus.gov/tanning.html 
  11. Ortonne JP. Retinoid Therapy of Pigmentary Disorders. Dermatologic Therapy [Internet]. 2006 Sep;19(5):280–8. Available from: https://pubmed.ncbi.nlm.nih.gov/17014483/ 
  12. Gaćina K. The Use of Tranexamic Acid in Dermatology. Acta Clinica Croatica [Internet]. 2023 Aug;62(2):368–72. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10969640/ 
  13. Wolfgang Philipp-Dormston. Melasma: a Step-by-Step Approach Towards a Multimodal Combination Therapy. Clinical, Cosmetic and Investigational Dermatology [Internet]. 2024 May 1;17(22):1203–16. Available from: https://pubmed.ncbi.nlm.nih.gov/38800358/ 
  14. Sanadi RM, Deshmukh RS, Kale AD, Antony VV, Sheikh S. Vitamin C as a Probable Inhibitor of Tyrosinase (Tyr) and tyrosinase-related protein-1 (TRP-1) in Human gingiva: an Analytical Study. Journal of Oral and Maxillofacial Pathology [Internet]. 2025 Apr;29(2):281–5. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC12283051/ 
  15. Keen MA, Hassan I. Vitamin E in Dermatology. Indian Dermatology Online Journal [Internet]. 2016 Aug;7(4):311-315. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976416/ 
  16. Fam VW, Charoenwoodhipong P, Sivamani RK, Holt RR, Keen CL, Hackman RM. Plant-Based Foods for Skin Health: A Narrative Review. Journal of the Academy of Nutrition and Dietetics [Internet]. 2022 Mar;122(3):614–29. Available from: https://www.sciencedirect.com/science/article/pii/S2212267221014337 
  17. Gupta M, Mahajan VK, Mehta KS, Chauhan PS. Zinc Therapy in Dermatology: A Review. Dermatology Research and Practice [Internet]. 2014; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120804/ 
  18. Antioxidants [Internet]. Better Health Channel. 2022. Available from: https://www.betterhealth.vic.gov.au/health/healthyliving/antioxidants 
  19. Gilbert C. What Is Vitamin a and Why Do We Need it? Community Eye Health [Internet]. 2024;26(84):65. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3936685/ 
  20. FDA Works to Protect Consumers from Potentially Harmful OTC Skin Lightening Products. FDA [Internet]. 2022 May 10; Available from: https://www.fda.gov/drugs/drug-safety-and-availability/fda-works-protect-consumers-potentially-harmful-otc-skin-lightening-products 
  21. The Risks of Tanning [Internet]. U.S. Food and Drug Administration. 2023. Available from: https://www.fda.gov/radiation-emitting-products/tanning/risks-tanning 
  22. Abnormally Dark or Light skin. MedlinePLus. 2025. Available from: https://medlineplus.gov/ency/article/003242.htm 
  23. Heistein J, Acharya U. Malignant Melanoma [Internet]. StatPearls Publishing; Available from: https://www.ncbi.nlm.nih.gov/books/NBK470409/ 
  24. Cao C, Xiao Z, Wu Y, Ge C. Diet and Skin Aging—From the Perspective of Food Nutrition. Nutrients [Internet]. 2020 Mar 24;12(3):870. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146365/ 
  25. El-Shafie K, Samir N, Lakhtakia R, Davidson R, Al-Waili A, Al-Mamary M, et al. Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis. Sultan Qaboos University Medical Journal [Internet].2015;15(3):e420-423. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4554280/

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

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