What Causes Low Creatinine
By Dr. Shubham Pandey +2 more
Medically reviewed by Dr. Shubham Pandey
Last updated: Aug 14, 2025 Published on: Nov 6, 2023
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By Dr. Shubham Pandey +2 more
Table of Contents
Creatinine is a metabolic waste product naturally produced in the body and is commonly used as an indicator of muscle function. Understanding creatinine and the factors that may lead to low levels is important for maintaining overall health1.
The body uses creatine as a source of energy, particularly within skeletal muscles2. Creatinine is the waste product formed when creatine is broken down during this process1,3.
Our skeletal muscles create creatinine after metabolising creatine phosphate. The primary function of creatinine is to be filtered out from the blood by the kidneys, after which it is excreted from the body in the urine. This process helps to maintain a consistent level of creatinine in the blood4.
Several factors influence the level of creatinine in the blood. These include, age, gender, muscle mass, and ethnic background4. The common range for adult men is 0.74 to 1.3 mg/dL and for adult women, 0.4 to 1.0 mg/dL5. These values may change from person to person, depending on the laboratory conducting the test and the individual’s body composition.
A variety of factors may contribute to low creatinine levels. These can include reduced muscle mass, liver conditions, dietary factors, certain medical conditions, and pregnancy.
Reduced skeletal muscle mass may lead to lower creatinine levels, as creatinine is a by-product of the breakdown of skeletal muscle tissue.
Liver conditions, such as liver disease or liver failure, may affect the production of creatine. This can subsequently lead to reduced creatinine levels6.
Diet can also influence creatinine levels. A diet low in protein, as well as vegetarian or vegan diets, may be associated with lower creatinine levels.
Pregnant women may experience lower creatinine levels during pregnancy. This occurs due to an increased blood flow to the kidneys and typically returns to normal after childbirth8.
Certain medical conditions may also cause low creatinine levels. These include muscular dystrophy, hyperthyroidism, and anaemia2.
Several factors may contribute to lower creatinine levels, which can cause your estimated glomerular filtration rate (eGFR) to appear higher than it truly is. These factors include following a vegetarian or vegan diet, having low muscle mass, pregnancy, a history of muscular atrophy or amputation, and severe liver cirrhosis. It is essential to consult your healthcare provider if you have any questions about interpreting your eGFR or serum creatinine results1.
Dr. Rajeev Singh, BAMS
The symptoms and signs vary depending on the underlying cause of the low creatinine level.
Symptoms of low creatinine levels can be difficult to identify and may include9:
It is essential to undergo a comprehensive medical evaluation. Discuss any symptoms you are experiencing with your healthcare provider, who will review your full medical history and arrange any necessary laboratory tests.
Studies3 suggest that since the liver produces creatine, decreased liver function may result in a decrease in the body’s production of creatinine. Overall liver functioning can be affected by liver disease and liver failure caused by various medical conditions.
Dr. Siddharth Gupta, B.A.M.S, M.D (Ayu)
Low creatinine levels can be detected through blood and urine tests, a physical examination, and a thorough review of your medical history. These assessments will be conducted by your healthcare provider.
Your healthcare provider will also review your medical history, including any chronic conditions, medication use, and family history of kidney disease. Alongside a physical examination, this helps to determine the possible causes of low creatinine levels.
Your healthcare provider may recommend blood and urine tests to assess how well your kidneys are functioning.
Your healthcare provider will recommend appropriate treatment options if a cause for your low creatinine levels is identified. Managing this condition may involve addressing underlying health issues, modifying medications, and making lifestyle adjustments.
The management of low creatinine levels depends on the underlying cause.
Modifying your daily habits may help to improve your creatinine levels.
Cigarette smoking has several negative effects on the body, including a significantly increased risk of chronic kidney disease. Research suggests that quitting smoking may help reduce the risk of kidney-related issues, which could otherwise contribute to fluctuations in creatinine levels16.
Dr. Smita Barode, B.A.M.S, M.S.
To help prevent low creatinine levels, you may consider adopting the following measures:
Ensuring a balanced diet, one that includes a variety of protein sources and an appropriate intake of calories may help support healthy creatinine levels2.
Making sure that you eat a balanced diet, including using different sources of proteins and taking in the right amount of calories, may help keep normal creatinine levels14.
Maintaining proper hydration supports kidney function, which in turn may help to keep creatinine levels within the normal range15.
Engaging in regular physical activity and exercises that support the maintenance or development of muscle mass may help in sustaining normal creatinine levels12.
Low creatinine levels can arise from various underlying causes and may pose certain health risks. The implications largely depend on the specific reason behind the decrease. Early identification of the cause significantly improves the chances of effectively managing the condition and maintaining healthy creatinine levels.
Low creatinine levels result from various factors, including reduced muscle mass, liver conditions, dietary habits, and pregnancy. Symptoms can differ depending on the underlying cause. Diagnosis typically involves blood and urine tests, along with a thorough review of the individual’s overall health. By identifying the root cause, healthcare professionals can develop personalised management plans tailored to the patient’s specific needs.
Low creatinine levels may indicate muscle loss, liver problems, poor nutrition, or increased elimination during pregnancy. Proper management begins with identifying the underlying cause.
Low creatinine levels may indicate a range of health issues, from milder concerns such as inadequate nutrition to more serious conditions like liver disease or muscle disorders. It is important to consult a healthcare provider if you have concerns about your creatinine levels.
To naturally increase creatinine levels, you may consider incorporating more protein into your diet, engaging in regular exercise to maintain or build muscle mass, and ensuring adequate hydration.
Yes, older adults, individuals with muscle disorders, those experiencing liver problems, people with inadequate nutrition, and expectant mothers may be at a higher risk of low creatinine levels.
If you notice that your creatinine levels frequently exceed the normal range, or if you experience symptoms associated with low creatinine levels, such as muscle weakness or persistent fatigue, it is important to consult a healthcare professional. They can conduct a thorough evaluation and recommend appropriate management options.
To support healthy creatinine levels, it is advisable to include protein-rich foods such as meat, fish, and dairy products in your diet, alongside maintaining proper hydration. However, it is important to consult a healthcare professional for personalised guidance and to exclude any underlying medical conditions.
Low creatinine levels can indicate potential kidney issues, muscle loss, or pregnancy. However, context is crucial as it may be normal for pregnant women. Always consult a healthcare professional for accurate interpretation.
Low creatinine levels can indicate reduced muscle mass, malnutrition, or potential kidney dysfunction. It’s essential to consult a healthcare provider for proper evaluation and diagnosis to determine the underlying cause and appropriate management.
Low creatinine levels can sometimes indicate kidney disease, particularly if accompanied by other symptoms like fatigue or swelling. However, it is essential to consult a healthcare provider for proper diagnosis and treatment.
Yes, low creatinine levels are considered normal during pregnancy due to the increase in blood volume and changes in kidney function. However, it’s essential for expecting mothers to consult their healthcare provider for proper monitoring and guidance.
Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.
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