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What Happens When Your Potassium Levels Are Too High 

By Dr. Vishesh Bharucha +2 more

Introduction

Potassium is the most abundant positively charged ion (cation) inside your cells1. It plays a crucial role in maintaining normal cell function2. This is especially important in tissues like the heart, nerves, and muscles, where potassium and sodium primarily regulate the resting membrane potential and action potentials that control nerve impulses and muscle contractions1,2.  

Usually, a slight increase in potassium does not cause any noticeable symptoms. Even at a moderately high level, some patients may only have subtle electrocardiogram (ECG) changes. However, significantly high potassium level can be dangerous. It can disrupt the heart’s rhythm, potentially leading to life-threatening arrhythmias, as well as causing muscle weakness or even paralysis2.  

Therefore, understanding the reasons for high potassium is essential for addressing this potentially serious condition. In this article, we will explore the causes, symptoms, diagnosis, treatment, and management of elevated potassium levels, helping you understand how to recognise and manage this condition. 

What Is Potassium and Why Is It Important?

Potassium is a type of mineral and electrolyte that our body needs to function properly2. It’s found naturally in many foods, especially fruits and vegetables like bananas, oranges, spinach, and potatoes3

Majority of potassium in our body is stored inside cells, particularly in muscles (around 98%). The remaining potassium (2%) lies in bones, and important organs like the liver, lungs, and brain. Only a small amount is found outside the cells, where it plays a critical role in keeping the cells healthy and maintaining their proper function3. Potassium helps regulate the body’s fluid balance, supports normal nerve signals, and ensures that muscles, including that of the heart, contract properly. It also helps maintain healthy blood pressure2,3.  

What Is Considered a High Potassium Level?

Potassium levels in the blood are carefully regulated because they play a vital role in maintaining the normal electrical activity of cells, especially in the heart, muscles, and nerves.  

  • Normal Range: In healthy individuals, the normal range of potassium in the blood (serum or plasma) is between 3.5 and 5.0 mmol/L1
  • High Levels: When potassium levels rise above this range, typically above 5.0 to 5.5 mmol/L, it is considered hyperkalaemia, or high potassium2.  

You may be wondering, what is the main cause of high potassium? This will be discussed in the next section.  

What Causes High Potassium?

High potassium levels in the blood can occur when your body either retains too much potassium or releases too much of it from the cells into the bloodstream2. Normally, the kidneys work to keep potassium levels in balance, but several factors can interfere with this process1. Common high potassium levels causes include: 

  • Kidney Problems: Since the kidneys are responsible for removing excess potassium, any condition that reduces kidney function, like chronic kidney disease, can lead to potassium buildup in the blood2
  • Certain Medications: Some drugs can affect how the kidneys handle potassium, including Angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), potassium-sparing diuretics, and some nonsteroidal anti-inflammatory drugs (NSAIDs)4
  • Excess Potassium Intake: Although excess potassium intake rarely causes hyperkalaemia in healthy individuals, it can raise potassium levels when kidney function is impaired or other risk factors are present2
  • Tissue Damage: When cells are damaged, such as in rhabdomyolysis (breakdown of muscle cells), haemolysis (breakdown of blood cells), tumour lysis syndrome (breakdown of tumour cells), potassium can leak out of the cells and into the bloodstream causing a surge2,5
  • Diabetes: Unregulated or poorly controlled diabetes can cause an extracellular shift of potassium (from inside the cells into the bloodstream) even if total body potassium levels are normal or low. This shift, often due to insulin deficiency or acidosis, may lead to a spike in blood potassium levels (hyperkalaemia)4,6
  • Adrenal Disorders: Conditions such as Addison’s disease (adrenal insufficiency) can lead to reduced levels of aldosterone (hormones that help control potassium balance)5. This deficiency consequently impairs renal potassium excretion leading to hyperkalaemia. 

Now that you are aware of the causes, you may be worried about what if potassium is high and how it could affect your health. Let’s move to the next sections to understand this better. 

Symptoms of High Potassium

High potassium symptoms often develop gradually but may be absent in mild cases; however, sudden severe elevations can cause rapid symptoms2. These can range from mild to severe and may include: 

  • Muscle weakness or fatigue2 
  • Tingling or burning sensation4 
  • Irregular heartbeat (arrhythmia)4 
  • Heart palpitations5 
  • Muscle paralysis (in extreme cases)4 

Since some symptoms of hyperkalaemia can be subtle or mistaken for other conditions, it’s important to get medical attention if you’re at risk or experiencing any unusual signs, especially if you have a known kidney condition or are on medications that affect potassium levels. 

Complications of Untreated High Potassium Levels

If high potassium levels are not identified and addressed in time, they might lead to serious complications4. Since potassium plays a vital role in nerve and muscle function, especially in the heart, excess potassium can disrupt normal body processes in dangerous ways. Key complications include: 

  • Worsening of underlying conditions4 
  • Muscle paralysis5 
  • Life-threatening heart arrhythmias4 
  • Cardiac arrest7 

Thus, it’s important to diagnose hyperkalaemia promptly and avoid complications, which may even become life-threatening. 

How Is It Diagnosed?

Diagnosing high potassium in body usually begins with a review of your symptoms, medical history, and medications, especially if you have kidney disease or are taking drugs that affect potassium levels. After initial examination, routine tests are performed. Key diagnostic tests include: 

1. Blood Tests 

The most common and reliable way to diagnose hyperkalaemia is through a serum potassium test6. It is important to get tested at a reputable laboratory because proper blood sample handling is crucial. This is because haemolysis (damage to blood cells) during sample collection or processing can falsely elevate potassium levels, a phenomenon known as pseudohyperkalemia. 

2. Urine Potassium Test 

Measuring the amount of potassium in your urine can help doctors determine whether your body is excreting potassium properly. Tests such as the urine potassium-to-creatinine ratio or a 24-hour urine potassium collection are especially useful in distinguishing whether hyperkalaemia is caused by kidney or non-kidney related factors

3. Electrocardiogram (ECG or EKG) 

Since high potassium can affect heart function, your doctor may perform an ECG to check for changes in your heart rhythm2

4. Kidney Function Tests 

Since the kidneys are responsible for filtering out excess potassium, tests such as serum creatinine and blood urea nitrogen (BUN) may be done to assess kidney health and determine whether kidney problems are contributing to high potassium9

5. Additional Investigations 

Depending on your symptoms and health history, your doctor may also order tests for adrenal function, blood sugar levels, or acid-base balance, particularly if conditions like diabetes or adrenal disorders are suspected2

Early diagnosis is key to avoiding complications. If you’re at risk due to kidney issues, medications, or chronic illnesses, regular blood tests, such as the Potassium (K+) Test, can help monitor your potassium levels and identify problems early on. 

How to Manage High Potassium Levels  

The severity of the problem and its cause will determine how high potassium levels are addressed.  The intention is to deal with the root cause, protect the heart, and quickly bring potassium levels down to a safe range. Your doctor might recommend the following methods to accomplish this: 

1. Dietary Changes 

Limiting high-potassium foods, such as bananas, oranges, potatoes, tomatoes, and spinach, may be recommended, especially for individuals with kidney problems2

2. Adjusting Medications 

If a medication or supplement is contributing to high potassium levels, your doctor may adjust the dose or switch to an alternative. Common contributors to hyperkalaemia include potassium-sparing diuretics, NSAIDs, ACE inhibitors, ARBs, certain beta blockers, and potassium supplements2,4

3. Potassium Removal 

To remove excess potassium from the body, doctors may use: 

  • Diuretic medication (Water Pills): These increase urine output and help the kidneys eliminate potassium from the body2

Note: Loop and thiazide diuretics promote potassium excretion and can help lower potassium levels, whereas potassium-sparing diuretics may worsen hyperkalaemia. 

  • Gastrointestinal cation exchangers: These bind potassium in the intestines so it can be removed from the body through the stool2
  • Dialysis: In patients with kidney failure or when other options don’t work fast enough, dialysis may be needed to physically remove potassium from the blood10

4. Emergency Treatment (for Severe Hyperkalaemia) 

If potassium levels are dangerously high or if there are signs of heart involvement, emergency addressal is needed. This may include: 

  • Calcium Gluconate: Given intravenously to protect the heart by stabilising its electrical activity10. However, it is important to note that these do not lower potassium levels. 
  • Insulin with Glucose: Rapidly shifts potassium from the blood into the cells, lowering blood levels quickly. Glucose is given to avoid low blood sugar2
  • Beta-2 Agonists: These medications, often used for asthma, can also help shift potassium into cells10. However, these may be less reliable when used alone. 
  • Sodium Bicarbonate: Mainly useful if metabolic acidosis (low blood pH) is present, as it can help shift potassium intracellularly by correcting blood pH2

5. Addressing Underlying Conditions 

Finally, managing the root cause, like improving blood sugar control in diabetes or addressing adrenal gland issues, is essential to avoid hyperkalaemia from recurring. 

How to Prevent High Potassium Levels  

Avoiding high potassium levels involves a combination of lifestyle choices, regular monitoring, and medical management, especially for those at higher risk, such as people with kidney disease, diabetes, or those taking certain medications. Here are some effective ways to avoid potassium buildup: 

1. Monitor Potassium Intake 

While potassium is essential for health, people at risk of hyperkalaemia may need to limit foods that are high in potassium. This includes2,11

  • Bananas, oranges, avocados 
  • Potatoes, tomatoes, spinach 
  • Beans, nuts, and dried fruits 

Your doctor or a dietitian can help create a meal plan if needed. 

2. Follow Medication Guidelines Carefully 

Some medications can raise potassium levels. If you’re taking drugs like ACE inhibitors, ARBs, potassium-sparing diuretics, or potassium supplements, it’s important to take them exactly as prescribed6. Never adjust or stop medications without consulting your doctor. 

3. Avoid Salt Substitutes with Potassium 

Nowadays, many salt alternatives are available in the market that swap potassium chloride for sodium. While this may be healthy for some people, it can be dangerous for those at risk of hyperkalaemia4. Always check labels and consult your doctor before using salt alternatives. 

4. Stay Hydrated 

Drinking enough fluids, like water, helps support kidney function. This, in turn, helps your body naturally excrete excess potassium2. However, in patients with advanced kidney disease or heart failure, fluid intake may need to be restricted to prevent fluid overload, so hydration advice should be individualised by a healthcare professional. 

5. Regular Blood Tests 

Routine blood tests to check potassium levels are especially important if you have kidney disease, heart failure, or diabetes, or if you’re on medications that affect potassium balance. Early detection helps avoid serious complications. 

6. Manage Chronic Conditions 

Keeping conditions like diabetes, high blood pressure, and kidney disease under control reduces the risk of potassium imbalances. This may involve certain lifestyle changes or medications/supplements. Make sure to have regular follow ups with your doctor to address any underlying issues. 

When to See a Doctor  

It’s important to seek medical attention if you suspect the effects of high potassium, especially if you have a condition that puts you at risk.  

You should see a doctor if you experience2,4

  • Unexplained muscle weakness or fatigue 
  • Tingling, numbness, or unusual sensations 
  • Irregular heartbeat, palpitations, or chest pain 

Additionally, consult your doctor if: 

  • You have kidney disease, diabetes, or heart failure, and start noticing unusual symptoms 
  • You’re taking medications that affect potassium levels, and notice new or worsening symptoms 
  • You’ve received abnormal blood test results showing elevated potassium 
  • You’re unsure whether your diet or supplements may be affecting your potassium levels 

Conclusion  

It’s critical to understand the significance of potassium balance for safeguarding general health, particularly for the optimal functioning of your heart, muscles, and nerve cells. While potassium is an essential nutrient, its excessive levels or hyperkalaemia can be harmful. These occur more commonly in individuals with kidney disease or taking certain medications which affect potassium excretion.  

Symptoms of hyperkalaemia often develop late and may be nonspecific or even absent initially. Therefore, early detection of high potassium levels mainly relies on regular blood tests for individuals at risk, rather than symptom recognition alone. Taking proactive steps, such as managing chronic conditions, following medical advice, and monitoring potassium levels, can help control hyperkalaemia. With proper awareness and care, it is entirely possible to maintain healthy potassium levels and avoid potentially dangerous complications from imbalance. 

Frequently Asked Questions (FAQs)

Can I feel normal and still have high potassium? 

Yes, mildly elevated potassium levels often have no symptoms2.This is why regular blood tests are important for people at risk. As potassium levels rise, symptoms like fatigue, muscle weakness, or irregular heartbeat may appear. 

Is it safe to take multivitamins or supplements with potassium? 

Many multivitamins contain small amounts of potassium, but potassium supplements should only be taken if prescribed4. People with kidney disease or on potassium-affecting medications should avoid over-the-counter potassium supplements unless approved by their doctor. 

Can stress affect potassium levels? 

While stress doesn’t directly raise potassium levels, physical stress (such as illness, injury, or surgery) can impact hormonal balance and kidney function, potentially contributing to shifts in potassium levels, especially in people with underlying conditions2,6

Is high potassium always a sign of a serious health problem? 

No, not always. Sometimes, a false high reading can occur due to how the blood sample was handled (e.g., if red blood cells rupture during collection, which is called pseudohyperkalaemia)2. Your doctor could repeat the blood test to make sure whether your potassium levels are abnormally high. 

References  

  1. Sevamontree C, Jintajirapan S, Phakdeekitcharoen P, Phakdeekitcharoen B. The Prevalence and Risk Factors of Hyperkalaemia in the Outpatient Setting. Int J Nephrol. 2024 Jan 22;2024:5694131. Available from: https://pmc.ncbi.nlm.nih.gov/articles/pmid/38292832/ 
  1. Simon LV, Hashmi MF, Farrell MW. Hyperkalaemia [Internet]. StatPearls Publishing; 2025 Jan; [updated 2023 Sep 4; cited 2025 May 21]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470284/ 
  1. D’Elia L. Potassium Intake and Human Health. Nutrients. 2024 Mar 14;16(6):833. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10973985/ 
  1. National Institutes of Health, Office of Dietary Supplements. Potassium – Health Professional Fact Sheet [Internet]. National Institutes of Health; [updated 2023 Mar 24; cited 2025 May 21]. Available from: https://ods.od.nih.gov/factsheets/Potassium-HealthProfessional/ 
  1. Dépret F, Peacock WF, Liu KD, Rafique Z, Rossignol P, Legrand M. Management of hyperkalaemia in the acutely ill patient. Ann Intensive Care. 2019 Feb 28;9(1):32. Available from: https://pmc.ncbi.nlm.nih.gov/articles/pmid/30820692/ 
  1. Viera AJ, Wouk N. Potassium Disorders: Hypokalemia and Hyperkalaemia. Am Fam Physician. 2015 Sep 15;92(6):487-95. Available from: https://www.aafp.org/link_out?pmid=26371733 
  1. Montford JR, Linas S. How Dangerous Is Hyperkalaemia? J Am Soc Nephrol. 2017 Nov;28(11):3155-3165. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5661285/ 
  1. Mente A, Irvine EJ, Honey RJ, Logan AG. Urinary potassium is a clinically useful test to detect a poor quality diet. J Nutr. 2009 Apr;139(4):743-9. Available from: https://pubmed.ncbi.nlm.nih.gov/19211830/ 
  1. Gounden V, Bhatt H, Jialal I. Renal function tests [Internet]. StatPearls Publishing; 2025 Jan; [updated 2024 Jul 27; cited 2025 May 21]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507821/ 
  1. Sterns RH, Grieff M, Bernstein PL. Treatment of hyperkalaemia: something old, something new. Kidney Int. 2016 Mar;89(3):546-54. Available from: https://pubmed.ncbi.nlm.nih.gov/26880451/ 
  1. Weinstein J, Girard LP, Lepage S, McKelvie RS, Tennankore K. Prevention and management of hyperkalaemia in patients treated with renin-angiotensin-aldosterone system inhibitors. CMAJ. 2021 Dec 6;193(48):E1836-E1841. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8648362/ 

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

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