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Sesame Seeds: Benefits, Uses, Side Effects and More!

By Dr Smita Barode +2 more

Introduction

Sesame (Sesamum indicum), often known as Til, is a flowering plant in the Sesamum genus. It is farmed for its edible seeds, which are produced in pods, and has become widely naturalized in tropical locations around the world. In 201823, the top producers were Sudan, Myanmar, and India. The cultivated type, S. indicum, is from India.

Sesame seeds may be small, but they pack a powerful punch when it comes to nutrition and health benefits. These tiny, oil-rich seeds have been a staple in cuisines and traditional medicine for centuries. Whether sprinkled on salads, blended into tahini, or used as a topping for bread, sesame seeds offer a unique combination of flavor and wellness. Sesame oil is most widely utilized in bakeries. The oil content of sesame is among the greatest of any seed. It is a common component in cuisines across the world because of its rich, nutty flavour. 

Sesame Seeds

Nutritional Value of Sesame Seeds

Protein, vitamin B1, dietary fiber, phosphorus, iron, magnesium, calcium, manganese, copper, and zinc are all abundant in sesame seeds. Here are the nutritional components of sesame seeds per 100 grams3.

  • Total Fat: 50 g
  • Saturated Fat: 7 g
  • Copper: 2.29 mg
  • Total Carbohydrate: 23 g
  • Dietary Fibre: 12 g
  • Calcium: 1450 mg
  • Protein: 18 g
  • Sodium: 11 mg
  • Potassium: 468 mg
  • Iron: 9.3 mg
  • Zinc: 12.20 mg
  • Magnesium: 87% (of daily value)
  • Vitamin B6: 40% (of daily value)

Studies have revealed that sesame seeds are not only packed with nutrients but also have an impressive composition. They contain approximately 21.9% protein and 61.7% fat17, making them a great source of these essential macronutrients. No wonder they have earned the reputation of being an ‘all-purpose nutrient bank’ and even the illustrious title of the ‘crown of eight grains.’

Dr. Rajeev Singh, BAMS

Properties of Sesame Seeds

It is widely utilized for medicinal applications due to the presence of some unique phytochemicals. It may have following properties2

  • It may show blood sugar-lowering activity  
  • It might have lipid-lowering activity    
  • It may show anti-cancer properties  
  • It may have blood pressure-lowering activity  
  • It might have liver-protective activity  
  • It may have anti-inflammatory properties    
  • It may have antimicrobial activity
  • It might show antioxidant activity

Potential Uses of Sesame Seeds

It is a powerful energy source. Its seeds may be utilized for their various health-promoting properties, while its seed coat, a byproduct of sesame and a valuable source of fibers, may be a source for animal feedstuff2. Sesame seeds provide a wide range of health benefits, which are detailed below:

1. Potential Uses of Sesame Seeds for Hair Health

Plant polyphenols found in sesame seeds can aid hair health. Because of the vitamins and minerals in sesame seed oil, it is frequently massaged into the scalp, which may help with premature greying and hair growth2. The amino acids and antioxidants in sesame seed oil may also help dull hair regain its lustre. It can also be used to hydrate a dry scalp and prevent hair from the harmful effects of the sun and pollutants20. However, more research is required to prove such effects of sesame seeds.

2. Potential Uses of  Sesame Seeds for Heart Functioning

Natural oil-soluble plant lignans found in sesame seeds may aid in the treatment of hypertension5. Furthermore, magnesium has long been recognised as a vasodilator (a substance that lowers blood pressure). Thus, it may have some effect on your heart health. However, it is advisable to consult a doctor for heart-related issues.

Did you know that sesame seeds, along with nuts and legumes, are not just delicious additions to your meals but also fantastic sources of phytosterols1? These magical compounds might have the power to maximize cholesterol reduction in your body.

Dr. Siddharth Gupta, B.A.M.S, M.D (Ayu)

3. Potential Uses of Sesame Seeds for Constipation

Sesame seeds have a higher content of fibre that may be beneficial for good digestion. It may also help with symptoms like constipation6 and diarrhoea while also protecting the colon and lowering the risk of gastrointestinal disorders. You must consult a doctor for its benefits for digestion.

4. Potential Uses of Sesame Seeds for Diabetes

Sesame seeds may be useful in managing diabetes. It may have an effect on blood glucose levels and reduce or delay the absorption of glucose in the body7. However, serious conditions like diabetes must be diagnosed and treated by a doctor. Therefore, kindly consult a doctor and do not self-medicate.

Also Read: Diet Tips for Gestational Diabetes

5. Potential Uses of Sesame Seeds for Arthritis

Anti-arthritic, anti-inflammatory, and antioxidant effects of sesame seeds and sesame seed oil are owing to sesamol, a bioactive substance found in sesame seeds. It might be responsible for preventing pro-inflammatory chemical synthesis.

It may also lower the number of reactive oxygen species produced. Sesame seeds or seed oil may help to reduce the pain and inflammation associated with arthritis because of their qualities8, 9.  Pain and inflammation may be reduced by massaging joints with sesame seed oil11. However, since insufficient studies are available, for conditions of bones, it is important to consult your medical practitioner for advice, as the herb may have different effects on individuals.

6. Potential Uses of Sesame Seeds for Oral Health

The effects of sesame seeds on dental health may be perhaps the most apparent. Sesame seed oil pulling may have antibacterial and astringent effects on many aspects of dental health.

It may also be linked to lowering the presence of Streptococcus bacteria, a common bacterium that can cause problems in the mouth. Oil pulling with sesame oil can help reduce dental plaque as well as improve gum health10. You must consult a qualified dentist for proper advice and guidance.

7. Potential Uses of Sesame Seeds for Alzheimer’s Disease

Sesame seeds can aid in the treatment of Alzheimer’s disease. They might have anti-inflammatory and antioxidant properties. Sesame seeds may reduce the formation of pro-inflammatory molecules that may be linked to Alzheimer’s disease. Furthermore, they might manage Alzheimer’s disease by inhibiting the damage induced by reactive oxygen species to brain cells 12, 13. You must always consult a qualified professional for diagnosis and treatment.

8. Potential Uses of Sesame Seeds for Anaemia

Sesame seeds aid in the treatment of anaemia14. Iron is abundant in sesame seeds. They help in the production of haemoglobin, hematocrit, and red blood cells in the body. This effect of sesame seeds will need further studies to provide scientific evidence.

9. Potential Uses of Sesame Seeds for Anxiety

Due to its anxiolytic impact, sesame seeds can be beneficial in the treatment of anxiety. They might also have antioxidant capabilities, which aid in the elimination of free radicals and the reduction of stress-related anxiety15. You must consult a doctor and consume any herb only under their supervision.

10. Potential Uses of Sesame Seeds for Skincare 

Zinc is an important component of sesame seeds. Zinc is a necessary component in the synthesis of collagen, which helps strengthen muscle tissue, hair, and skin. Thus, consuming sesame seeds can help improve the health of hair and skin. 

Due to the presence of antioxidants, sesame seed oil is helpful to the skin, and applying it to the face overnight softens and tightens the skin4. Because of its antibacterial and antifungal characteristics, it improves wound healing.  

They prevent wound infection while also boosting wound healing. They fight common skin diseases with antibacterial and antifungal properties. They are also beneficial for wound healing because they help promote collagen production and cell proliferation16.  

Though studies show the benefits of sesame seeds against various disease conditions, these studies are insufficient, and there is a need for further studies to establish the true extent of the benefits of sesame seeds on human health.  

Not only are sesame seeds a great source of protein, but the protein they contain is also complete. In fact, the ratio of essential amino acid content in sesame protein is remarkably similar to that of the human body. This means that sesame seeds may provide us with all the essential amino acids our bodies need for optimal health17.

Dr. Smita Barode, B.A.M.S, M.S.

How to Use Sesame Seeds?

Sesame seeds are available in six different forms: 

  • Sesame seeds 
  • Sesame milk 
  • Sesame seed oil 
  • Sesame seed capsule 
  • Sesame seed powder 
  • Sesame seed paste 

You must consult a qualified doctor before taking sesame seeds or any herbal supplements. Do not discontinue or replace an ongoing treatment of modern medicine with an ayurvedic/herbal preparation without consulting a qualified doctor.  

The historical text ‘Shennong Ben Cao Jing’ provides insights into the traditional medicinal uses of sesame seeds. According to this ancient document, sesame seeds were believed to have therapeutic properties, possibly in taking care of injuries, nourishing internal organs, boosting energy, promoting muscle growth, and replenishing the bone marrow.

Dr. Anuja Bodhare, B.A.M.S, M.D (Ayu)

Side Effects of Sesame Seeds

The majority of studies have determined that sesame seeds are safe to eat and have no negative effects17. Excessive sesame seeds can result in some of the adverse effects described below. 

  • If sesame seeds are not consumed in moderation, they might cause blood glucose levels to drop below normal. 
  • Excessive consumption of sesame seeds can drop blood pressure to dangerously low levels. 
  • Fibre from sesame seeds can form a layer over the appendix, causing bloating and pain.  
  • Because sesame seed allergy is a prevalent type of allergy, it is recommended that you consult a doctor before including sesame-based items in your daily diet. 
  • Sesame seeds have a detrimental effect if ingested in large quantities, as more of them are stored in the stomach without being digested, perhaps leading to weight gain. 
  • Sesame seeds should be used with caution, and persons with gout should avoid them entirely, as sesame seeds contain oxalates, a natural substance that contributes to the aggravation of gout symptoms. 

It’s amazing how adding ground sesame seeds to salads can enhance the absorption of fat-soluble phytonutrients found in greens. Not only that, but sesame seeds also contain lignans, which are compounds known for their potential anti-cancer properties. These lignans may play a role in reducing the occurrence of breast cancer22.

Dr. Ashok Pal, B.A.M.S.

Precautions to Be Taken with Sesame Seeds

Before consuming sesame seeds, seek medical counsel if you have one or more of these conditions. 

  • In some people, sesame seeds or oil might trigger allergic responses (contact dermatitis). If you have an allergic response after eating sesame seeds, you should see a doctor18, 19

Interactions with Other Drugs

It is critical to remember that none of these medications should be used with sesame seeds. 

  • Anti-Diabetes Drugs: Sesame helps in lowering blood sugar levels. Blood sugar is also controlled using diabetes medicines. Taking sesame with diabetes drugs may cause blood sugar levels to drop dangerously low.
  • Antihypertensive Drugs: Sesame can help decrease blood pressure. When taking sesame with blood pressure medications, the effects of the medications may be amplified, lowering blood pressure too much.  

Frequently Asked Questions (FAQs)

How to eat sesame seeds? 

Raw sesame seeds are a delicious snack (hulled or unhulled). You can toast and bake them as well. 

How many sesame seeds should I eat daily? 

Consume one tablespoon of raw or roasted sesame seeds every day, or season salads with sesame seeds to taste.

Does sesame seeds affect pregnancy? 

Sesame seeds cause the fertilised ovum to be ejected by stimulating the uterine muscles. Sesame seeds should be avoided by all pregnant women throughout the first three to four months of pregnancy, according to experts. 

How to use sesame seeds? 

Sesame seeds can be sprinkled in salads, stir-fries, and soups. Sesame seeds can be toasted to make them crunchier and to enhance their flavour. Sesame seeds can be toasted by spreading them out on a baking dish and roasting them at 350°F for 5-10 minutes.

How to store sesame seeds? 

Keep sesame seeds in an airtight container in a cool and dry place. 

How to make sesame oil at home? 

To make sesame oil at home, toast the seeds until golden brown, then combine them with your favourite cooking oil and blend until smooth. The sesame oil develops on top of the components at this point. Refrigerate sesame oil for up to two years so you can use it in a variety of dishes. 

Sesame seeds, are they gluten-free? 

Yes, Sesame seeds, both black and white, are gluten-free. 

Can sesame seeds cause acne? 

No, Sesame oil, on the other hand, aids in the regulation of excess oils and has a healing impact on the skin.

Can you freeze sesame seeds? 

Yes, sesame seeds can be frozen. Sesame seeds have a storage life of 6-8 months at room temperature and up to a year if refrigerated. 

References

  1. Phillips KM, Ruggio DM, Ashraf-Khorassani M. Phytosterol composition of nuts and seeds commonly consumed in the United States. Journal of Agricultural and Food Chemistry. 2005 [cited 2025 Apr 8]. Available from: https://pubmed.ncbi.nlm.nih.gov/16302759/ 
  2. Anilakumar R, Pal A, Khanum F et al. Nutritional, medicinal and industrial uses of Sesame (S. indicum L.) seeds-an overview. Agric Conspec Sci.2010;75(4):159-168. Available from: https://hrcak.srce.hr/file/98744 
  3. USDA FoodData Central. Seeds, sesame seeds, whole, dried – Nutrients – SR Legacy. USDA FoodData Central. [cited 2025 Apr 8]. Available from: https://fdc.nal.usda.gov/food-details/170150/nutrients 
  4. Pathak N, Rai AK, Kumari R, Bhat KV. Value addition in sesame: A perspective on bioactive components for enhancing utility and profitability. Pharmacog Rev. 2014 Jul;8(16):147. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127822/
  5. Peterson J, Dwyer J, Adlercreutz H, Scalbert A, Jacques P, McCullough ML. Dietary lignans: physiology and potential for cardiovascular disease risk reduction. Nutr Rev. 2010; 68(10): 571-603. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951311/
  6. Bamigboye AY, Okafor AC, Adepoju OT. Proximate and mineral composition of whole and dehulled Nigerian Sesame seed. Afr J Food Sci Technol. 2010;1(3):71-75. Available from: https://www.interesjournals.org/articles/proximate-and-mineral-composition-of-whole-anddehulled-nigerian-sesame-seed.pdf
  7. Ramesh B, Saravanan R, Pugalendi K V. Influence of Sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats. J Med Food.2005;8(3). Available from: https://pubmed.ncbi.nlm.nih.gov/16176150/
  8. Hemshekhar M, Mohan Thushara R, Jnaneshwari S et al. Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status. Eur J Nutr.2013; 52(7): 1787-1799. Available from: https://www.researchgate.net/publication/233995394_Attenuation_of_adjuvant-induced_arthritis_by_dietary_sesamol_via_modulation_of_inflammatory_mediators_extracellular_matrix_degrading_enzymes_and_antioxidant_status
  9. Yadav NV, Sadashivaiah, Ramaiyan B et al. Sesame oil and rice bran oil ameliorates adjuvant-induced arthritis in rats: distinguishing the role of minor components and fatty acids. Lipids.2016; 51(12): 1385-1395. Available from: https://pubmed.ncbi.nlm.nih.gov/27747452/
  10. Asokan S, Emmadi P, Chamundeswari R. Effect of oil pulling on plaque induced gingivitis: A randomized, controlled, triple-blind study. Indian Journal of Dental Research. 2009; 20(1): 47. Available from: https://pubmed.ncbi.nlm.nih.gov/19336860/
  11. Shamloo MBB, Nasiri M, Dabirian A, Bakhtiyari A, Mojab F, Majd HA. The effects of topical sesame (Sesamum indicum) oil on pain severity and amount of received non-steroid anti-inflammatory drugs in patients with upper or lower extremities trauma. Anesthesiology and Pain Medicine. 2015 [cited 2025 Apr 8]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4493737/ 
  12. Kanu PJ, Bahsoon JZ, Kanu JB et al. Nutraceutical importance of Sesame seed and oil: a review of the contribution of their lignans. Sierra Leone J Biomed Res.2010; 2(1): 4-16. Available from: https://www.ajol.info/index.php/sljbr/article/view/56583
  13. Lee SY, Son DJ, Lee YK et al. Inhibitory effect of sesaminol glucosides on lipopolysaccharide-induced NF-κB activation and target gene expression in cultured rat astrocytes. Neurosci Res.2006; 56(2): 204-212. Available from: https://pubmed.ncbi.nlm.nih.gov/16842873/
  14. Soltan SSA. The protective effect of soybean, Sesame, lentils, pumpkin seeds and molasses on iron deficiency anemia in rats. World Appl Sci J. 2013; 23(6): 795-807. Available from: http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.388.2602&rep=rep1&type=pdf 
  15. Kumar A, Kaur G, Kalonia H et al. Evaluation of sesamol and buspirone in stress induced anxiety in mice. Indian J Pharmacol.2013; 45(1):49-53. Available from: https://pubmed.ncbi.nlm.nih.gov/23543858/
  16. Kiran K, Asad M. Wound healing activity of S. indicum L seed and oil in rats. Indian J Exp Biol.2008;46(11):777-782. https://nopr.niscair.res.in/bitstream/123456789/4648/1/IJEB%2046(11)%20777-782.pdf
  17. Wei P, Zhao F, Wang Z, Wang Q, Chai X, Hou G, et al. Sesame (Sesamum indicum L.): A comprehensive review of nutritional value, phytochemical composition, health benefits, development of food, and industrial applications. Nutrients. 2022 [cited 2025 Apr 8]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC9573514/
  18. Neering H, Vitányi BE, Malten KE. Allergens in Sesame oil contact dermatitis. Acta Dermato-venereologica.1975;55(1):31-34. Available from: https://pubmed.ncbi.nlm.nih.gov/46670/
  19. Kubo Y, Nonaka S, Yoshida H. Contact sensitivity to unsaponifiable substances in Sesame oil. Contact Dermatitis.1986;15(4):215-217. Available from: https://pubmed.ncbi.nlm.nih.gov/2948757/
  20. Mysore V, Arghya A. Hair oils. International Journal of Trichology. 2022 [cited 2025 Apr 8]. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC9231528/ 
  21. Obiajunwa EI, Adebiyi FM, Omode PE. Determination of essential minerals and trace elements in Nigerian Sesame seeds, using TXRF technique. Pakistan J Nutr.2005;4(6):393-395. Available from: https://docsdrive.com/pdfs/ansinet/pjn/2005/393-395.pdf
  22. Wu MS, Aquino LBB, Barbaza MYU, Hsieh CL, De Castro-Cruz KA, Yang LL, et al. Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review. Molecules [Internet]. 2019 Dec 4;24(24):4426. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6943436/ 
  23. Sesamum indicum L. GBIF. [cited 2025 Apr 8]. Available from: https://www.gbif.org/species/113619941

Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

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