What are the possible side effects of osteoporosis medicines?

The side effects vary depending on the medication. Oral bisphosphonates may cause stomach irritation, heartburn, or difficulty swallowing if not taken correctly. Injectable medicines may cause temporary flu-like symptoms or injection-site reactions. Rare but serious side effects, such as osteonecrosis of the jaw or unusual thigh bone fractures, have been reported with long-term use of certain medications. Patients should discuss the benefits and risks with their healthcare provider before starting treatment.