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Trayodashang Guggulu: Uses, Benefits and Side Effects By Dr. Smita Barode 

By Dr Smita Barode +2 more

Introduction

Trayodashang guggulu is one of the primary Ayurvedic polyherbal formulations. It consists of Babula (the stem bark of Acacia nilotica), Hapusa (the fruits of Juniperus communis), Shatavari (the roots of Aspargus recemosus), Ashwagandha (the roots of Withania somnifera), Sunthi (the rhizome of Zingiber officinale), Satavha (the fruits of Anethum sowa), Vradadaru (the roots of Argyeria nervosa), Sati (the rhizome of Hidichium spicatum), Shuddha guggulu (exudates of Commiphera mukul), Rasana (the roots and leaves of Pluchea lanceolata), Guduchi (the stem of Tinospora cordifolia), Gokshuara (the fruits Tribulus terrestris), Yavani (Trachyspermum ammi fruits) and Goghrat (ghee). The ayurveda formulation trayodashang guggulu is mentioned in the Ayurveda classic Bhaishaja Ratnavali and the Ayurveda Formulary of India. Trayodashang guggulu may be used for various ailments. Let us look at some of the health benefits of trayodashang guggulu.1 

Nutritional Value of Trayodashang Guggulu

The composition of trayodashang guggulu is as follows: 

trayodashang guggulu benefits
  • Ashwagandha: 1 part
  • Aabha (babbul): 1 part
  • Gokshur: 1 part
  • Hapusha: 1 part
  • Guduchi: 1 part
  • Shatavari: 1 part
  • Rasna: 1 part
  • Karchur: 1 part
  • Yavani: 1 part
  • Vriddhadaru: 1 part
  • Shunthi: 1 part
  • Ghee: 1/2 part
  • Guggulu: 13 parts

Did you know?

Properties of Trayodashang Guggulu

Several studies have shown that Trayodashang guggulu may have the following properties: 

  • It may be an antioxidant.1 
  • It may reduce inflammation.2 
  • It may relieve pain.3 
  • It may enhance the immune system.4 

From my experience, Trayodashang Guggulu may aid in gout. Studies suggest that Trayodashang Guggulu shows antioxidant and anti-inflammatory effects that make it a potential remedy in cases of inflammatory disease such as gout.

Dr. Siddharth Gupta, B.A.M.S, M.D (Ayu)

Potential Uses of Trayodashang Guggulu for Overall Health

Some of the potential uses of trayodashang guggulu are: 

1. Potential Uses of Trayodashang Guggulu for Spondylosis 

The worst diet habits with the western lifestyle and continuous work in front of laptops are the major reasons for spondylosis. Trayodashang guggulu may be used against spondylosis. A study by Sawant et al. in 2017 showed that Trayodashang guggulu might be beneficial for cervical spondylosis. Constituents like Shatavari, Ashwagandha and Guduchi are rejuvenators and may give stability to the muscles (dhatus). Whereas babbul acts on bones (asthidhatwagni) and may provide firmness.2 However, further studies are required to check if trayodashang guggulu may help in the case of cervical spondylosis. Therefore, you must consult your doctor if you experience any symptoms of cervical spondylosis. Do not self-medicate. 

2. Potential Use of Trayodashang Guggulu As an Antioxidant 

The phenols, alkaloids, flavonoids and other phenolic compounds present in trayodashang guggulu may show antioxidant activity. This was demonstrated by a study by Dadoriya et al. in 2018. It may deactivate the free radicals (harmful molecules present in the body) and protect them from various damages.1 Further studies are required to check the antioxidant activity of trayodashang guggulu. 

3. Potential Use of Trayodashang Guggulu for Inflammation 

Trayodashang guggulu may be beneficial for several inflammatory conditions like the stiffness of the knee, bone marrow disorder, lockjaw, inflammation of ligaments, neurological and musculoskeletal diseases, pain in the arm and cardiac failure and bone fracture due to the presence of bioactive compounds like flavonoids and phenols. A study by Dadoriya et al. in 2018 showed that trayodashang guggulu might inhibit proteinase and lipoxygenase (enzymes that promote inflammation).1 However, further studies are required to check if trayodahsang guggulu may reduce inflammation. Therefore, you must consult your doctor if you suspect inflammation.  

4. Potential Use of Trayodashang Guggulu for Arthritis 

Arthritis is a disease associated with inflammatory pain. Bioactive compounds like flavonoids and phenols present in trayodashang guggulu may be responsible for reducing inflammatory pain. A study by Gupta et al. in 2022 showed that trayodashang guggulu might inhibit inflammatory mediators like COX-2 and reduce inflammatory pain, which may be beneficial for arthritis. Inflammatory mediators are molecules in the body that cause inflammation.3 However. Further studies are required to check if trayodashang guggulu may be helpful in the case of arthritis. Therefore, you must consult your doctor if you experience any symptoms of arthritis.  

5. Potential Use of Trayodashang Guggulu for Sciatica 

Sciatica refers to the pain radiating down one or both legs from the lower back along the sciatic nerve. According to the studies by Moharana et al. in 2018, trayodashang guggulu may be beneficial in the case of sciatica. Effects of trayodashang guggulu are particularly noticeable in vata dosha, the primary cause of joint and bone-related disorders.5,3,7 However, further studies are required to check if trayodashang guggulu may be beneficial for sciatica. You must immediately consult your doctor if you suspect any symptoms of sciatica. 

6. Potential Use of Trayodashang Guggulu for Tennis Elbow 

The condition that causes pain in the forearm is known as the tennis elbow. Pain, tenderness, restricted movement, stiffness and diminished grip strength are the primary clinical signs of tennis elbow. The study by Rajurkar et al. in 2022 showed that the trayodashang guggulu tablet might reduce pain and functional disability related to the tennis elbow.6 However, further studies are required to check if trayodashang guggulu may be beneficial in the case of tennis elbow. Therefore, you must consult your doctor if you experience any symptoms of tennis elbow. 

7. Potential Use of Trayodashang Guggulu for Osteoporosis 

Trayodashanga Guggulu may directly affect the Asthigata Vata (bone and soft tissue pain) and brings the vitiated Vata Dosha back into balance. An imbalance in vata dosha causes conditions related to joints and bones. The Ayurvedic mind-body element associated with air and space is called vata dosha. It governs all movement and processes in your mind and body, including blood flow, elimination, breathing and thought action. A Vata imbalance may lead to bone thinning, according to Ayurveda. Therefore, trayodashang guggulu may be beneficial in case of osteoporosis. This was shown by a study conducted by Sannakki et al. in 2020.7 However; further studies are required to check if trayodashang guggulu may be beneficial for osteoporosis. Therefore, you must consult your doctor if you experience any symptoms of osteoporosis. 

8. Potential Use of Trayodashang Guggulu for Enhancing the Immune System 

According to the study by Prasad et al. in 2016, trayodashang guggulu may help improve the immune system. It may have immune-modulating properties, which may stimulate the immune system.4 However, further studies are required to check if trayodashang guggulu may affect the immune system. 

Though studies show the benefits of trayodashang guggulu in various situations, these are insufficient and further studies are needed to establish the true extent of trayodashang guggulu on human health. 

How to Use Trayodashang Guggulu?

Trayodashang guggulu is a polyherbal ayurveda preparation that is available as a tablet. It can be given with gruel (thin porridge), warm water and milk of meat soup.5 

You must consult a doctor before taking large quantities of trayodashang guggulu or herbal supplements. Do not discontinue an ongoing modern medical treatment with an ayurvedic/herbal preparation without consulting a qualified doctor. 

Side Effects of Trayodashang Guggulu

A high dose of trayodashang guggulu may have the following side effects: 

  • It may cause loss of appetite, indigestion, belching and stomach upset.8 

You must consult your doctor if you experience any side effects after consuming trayodashang guggulu. 

Precautions to Take with Trayodashang Guggulu

As with any other general medicine, general precautions should be taken while having trayodashang guggulu. You must consult your doctor before having trayodashang guggulu. Pregnant women and lactating mothers should take special care. Precaution should be taken before giving trayodashang guggulu to the elderly or children. In such cases, you must have trayodashang guggulu only if your doctor prescribes it. 

Interactions with Other Drugs

There is not enough evidence on the interaction of trayodashang guggulu with other drugs. Further studies on the interaction of trayodashang guggulu are required. Therefore, you must consult your doctor if you are on any other medication before consuming trayodashang guggulu. 

Frequently Asked Questions (FAQs)

What are the components of trayodashang guggulu?

Trayodashang guggulu is an essential Ayurvedic polyherbal formulation. It consists of Babula, Hapusa, Shatavari, Ashwagandha, Sunthi, Satavha, Vradadaru, Sati, Shuddha guggulu, Rasana, Guduchi, Gokshuara, Yavani and Goghrat (ghee).1 

What are the health benefits of trayodashang guggulu? 

Trayodashang guggulu may be used to reduce pain and inflammation. It may act against the conditions like tennis elbow, arthritis, osteoporosis, sciatica and cervical spondylosis. It may have antioxidant properties and may enhance the immune system. However, further studies are required to check whether trayodashang guggulu may benefit the mentioned conditions. Therefore, you must consult your doctor if you experience symptoms of the mentioned conditions.1-6 

How can you consume trayodashang guggulu? 

Trayodashang guggulu is a polyherbal ayurveda preparation that is available as a tablet. It can be given with gruel (thin porridge), warm water and milk of meat soup.4 

What are the side effects of trayodashang guggulu? 

Trayodashang guggulu may cause stomach upset, belching, indigestion and loss of appetite. You must consult your doctor if you experience any side effects.8 

How is trayodashang guggulu beneficial for arthritis? 

Bioactive compounds like flavonoids and phenols present in trayodashang guggulu may be responsible for reducing inflammatory pain. They might inhibit inflammatory mediators (molecules in the body that cause inflammation) and reduce inflammatory pain, which may be beneficial for arthritis.3 However, you must consult your doctor if you experience any symptoms of arthritis. 

References:

  1. Dadoriya P, Dey YN, Sharma D, Yadav M, Wanjari MM, Gaidhani SN, Subhose V. In-vitro anti-inflammatory and antioxidant activities of an Ayurvedic formulation–Trayodashang guggulu. Journal of Herbal Medicine. 2020 Oct 1;23:100366. Available from: https://www.sciencedirect.com/science/article/pii/S2210803320300385 
  1. Rathod HS, Sawant RS. Evaluation of efficacy of Trayodashang guggulu in management of Cervical spondylosis (Manyagata vata). J Biol Sci Opin. 2013;1(2):65-9. Available from: https://www.researchgate.net/publication/315330757_EVALUATION_OF_EFFICACY_OF_TRAYODASHANG_GUGGULU_IN_MANAGEMENT_OF_CERVICAL_SPONDYLOSIS_MANYAGATA_VATA 
  1. Gupta S, Dey YN, Kannojia P, Halder AK, Sharma D, Wanjari MM, Chougule S, Pawar S, Kaushik A, Gaidhani SN, Gurav S. Analgesic and Anti-inflammatory Activities of Trayodashang Guggulu, an Ayurvedic Formulation. Phytomedicine Plus. 2022 Aug 1;2(3):100281. Available from: https://www.sciencedirect.com/science/article/pii/S2667031322000641 
  1. Prasad R. Guggulu preparations: Gold standards in the management of Joint disorders. British Journal of Medical and Health Research. 2016 Jan. Available from: https://www.researchgate.net/publication/335716125_Guggulu_preparations_Gold_standards_in_the_management_of_Joint_disorders 
  1. Moharana PK, Patel A. Synergistic effect of Trayodashang Guggulu and yoga basti in the management of low back pain with special reference to Gridhrasi. Int J Health Sci Res. 2018;8:167-73. Available from: https://www.ijhsr.org/IJHSR_Vol.8_Issue.12_Dec2018/27.pdf 
  1. Rajurkar H, Misar S, Dandekar P, Kane S, Dawande P, Damahe LB. Assessment of comparative Efficacy of Nirgundipatra Upanaha and Trayodashang Guggulu with Diclofenac sodium Gel and Ibuprofen in the Management of Snayugata Vata Affecting Koorpara Sandhi (Tennis Elbow). Australasian Medical Journal. 2022 Feb 1;15(2). Available from: https://amj.net.au/index.php/AMJ/article/viewFile/3866/2018 
  1. Sannakki SY, Kalyani SS, MH M. Paryeshana International Journal of Ayurvedic Research. Available from: http://pijar.org/articles/Arch_Vol5_Issue5/13.Dr.Sumitkumar%20Y%20Sannakki.pdf 
  1. Sahiti M, Gurupadayya BM, Dinesh TK. Evaluation of in vitro anti-inflammatory activity of Trayodashang Guggulu: An ayurvedic formulation in comparison with allopathic drug. Int J Res Ayurveda Pharm. 2019;10(3):92-6. Available from: https://www.researchgate.net/publication/335188499_EVALUATION_OF_IN_VITRO_ANTI_INFLAMMATORY_ACTIVITY_OF_TRAYODASHANG_GUGGULU_-_AN_AYURVEDIC_FORMULATION_IN_COMPARISION_WITH_ALLOPATHIC_DRUGS 

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