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Home>QnA>Questions>Does Zerodol-SP cause heartburn or nausea?

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Raj****
Raj****
Asked: January 7, 20262026-01-07T08:39:03+00:00 2026-01-07T08:39:03+00:00

Does Zerodol-SP cause heartburn or nausea?

I take Zerodol-SP for my knee pain, and a few times after taking it, I’ve noticed heartburn and mild nausea. I’m not sure if it’s a side effect or if I should be taking it differently, like after food. Is this normal with Zerodol-SP?

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  1. Dr. Nikita Toshi
    Dr. Nikita Toshi
    2026-01-07T08:55:12+00:00Added an answer on January 7, 2026 at 8:55 am

    Dear Reader,

    Yes, what you’re experiencing is quite common. Zerodol-SP can cause heartburn, acidity, or mild nausea, especially if taken on an empty stomach.

    This happens because Zerodol-SP contains Aceclofenac and Paracetamol, which are painkillers that may irritate the stomach lining or increase acid production. Serratiopeptidase (the third ingredient) helps reduce swelling but can also slightly disturb digestion in some people.

    Why does it happen?

    • Taking the tablet without food or on an empty stomach
    • Having a sensitive stomach or a history of acidity/gastritis
    • Drinking coffee, spicy foods, or alcohol around the same time
    • Taking other painkillers or anti-inflammatory drugs

    What you can do:

    • Always take Zerodol-SP after meals with a full glass of water.
    • Avoid lying down immediately after taking it.
    • Eat light, non-spicy meals when using this medicine.
    • If your doctor agrees, you can take it with an antacid or acid reducer (like pantoprazole or omeprazole) to protect your stomach.
    • Do not use it for long durations without medical advice.

    If your heartburn or nausea keeps returning, or if you notice stomach pain, vomiting, or black stools, stop the medicine and consult your doctor.

    So yes, mild heartburn or nausea can happen, talk to your doctor and they will help you manage it better. Wishing you a comfortable and quick recovery.

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Disclaimer: The information provided here is for educational/awareness purposes only and is not intended to be a substitute for medical treatment/advice by a healthcare professional and should not be relied upon to diagnose or treat any medical condition. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. PharmEasy does not provide any guarantee or warranty (express or implied) regarding the accuracy, adequacy, completeness, legality, reliability or usefulness of the information; and disclaims any liability arising thereof.

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