Chlorpropamide
Molecule Description
Chlorpropamide belongs to a class of medicines called Sulfonylureas (anti-diabe
tic).
Uses of Chlorpropamide
Type 2 diabetes (used to control high blood sugar )
Contraindications of Chlorpropamide
When should one not use Chlorpropamide
- If you are allergic to this medicine or any of the other ingredients of this medicine
- If you have sulfa medicines allergy
- Type 1 diabetes
- Diabetes Ketoacidosis
- If you have uncontrolled diabetes, for example, severe hyperglycaemia (high blood glucose), nausea, vomiting, diarrhea, rapid weight loss
Side effects of Chlorpropamide
Common side effects of this drug are:
- Scaly skin
- Dizziness
- Dark-colored urine
- Lethargy
- Hemolytic anaemia (G6PD deficiency)
- Headache
- Hypoglycemia (low blood sugar)
- Nausea and Vomiting
- Indigestion
- Decreased urine output
- Muscle pain
- Confusion
- Swelling of face, ankles, and hands, itching
- Weight loss
- Irregular heartbeat
- Lightheadedness, unusual sweating
Precautions and Warnings of Chlorpropamide
Pregnancy
Q:
Can I take Chlorpropamide during pregnancy?
A:
The medicine should not be used in pregnant women. Make sure that you check with your doctor if you are planning on getting pregnant or are pregnant. If you use this medicine in the last trimester of pregnancy, it can result in respiratory depression in the new-born baby. During pregnancy, you need insulin to treat your diabetes so the doctor may change your treatment.
Breast Feeding
Q:
Can I take Chlorpropamide while breastfeeding?
A:
It is not advised to breastfeed while taking this medicine.
Driving
Q:
Can I drive if I have consumed Chlorpropamide?
A:
It can cause dizziness and lightheadedness. Be cautious while driving before you take the medicine.
Alcohol
Q:
Can I consume alcohol with Chlorpropamide?
A:
Patient should avoid intake of excess alcohol. It may affect the liver.
Other General Warnings
Talk to your doctor if
- Inform doctor if you:
- Suffer from severe kidney disease or liver problems
- Suffering from ketoacidosis (caused by excessively high blood sugars in diabetes)
- Suffering from a severe infection
- Suffering from stress or from any condition likely to make controlling your blood sugar difficult
- If you have undergone any surgeries
- If you have intolerance to some sugars
Mode of Action of Chlorpropamide
How Does It Work?
In diabetes, the pancreas does not make enough insulin or your body is not properly able to use the insulin that it produces, which leads to a high level of glucose in your blood. Chlorpropamide helps to lower your blood glucose to as normal level as possible by increasing the insulin secretion from beta cells of the pancreas. It also decreases the rate of hepatic glucose production, increases insulin receptor sensitivity and increases the number of insulin receptors....
Interactions of Chlorpropamide
Interactions with other medicines
- Medicines which increase urine production (Diuretics)
- Salbutamol or Terbutaline (used to treat asthma)
- Corticosteroids (used to treat a variety of conditions, such as severe inflammation of the skin or in asthma)
- Medicines used to treat pain and inflammation (NSAID such as Ibuprofen and Celecoxib)
- Certain medicines for the treatment of high blood pressure (ACE Inhibitors and Angiotensin II Receptor Antagonists, Verapamil)
- Medicines used to treat infections (Rifampicin, Trimethoprim, Isavuconazole)
- Medicines used to treat heartburn (Cimetidine)
- Medicines used to treat HIV/AIDS (Dolutegravir)
- Medicines used to treat heart conditions such as angina (Ranolazine)
- Medicines used to treat different types of cancers
Interactions with food items
The patient should avoid excess sugar, oily food, packed food, frozen food, etc.
Dosage of Chlorpropamide
Overdose
- The symptoms of overdose include shakiness, sweating, a fast-paced heartbeat, seizures, or a loss of consciousness, very low blood sugar. Doctor consultation is required.
Missed a Dose
If you forget to take a dose, follow the regular dosage schedule. Do not take a double dose.
Content Details
WRITTEN BY
Dr. Mansi Savla
B. Pharm, PharmD
REVIEWED BY
Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: How long does it take for Chlorpropamide to take effect?
A: The medicine usually takes about an hour to take action and show effect.
Q: How long does the effect of Chlorpropamide last?
A: The effect of the medicine is for 24 hours in the body.
Q: Is this medicine addictive?
A: No, there is no research that proves Chlorpropamide is addictive.
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