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G6PD (Qualitative)

About the test
What is this test done for?
G6PD (Glucose-6-phosphate dehydrogenase) qualitative, also known as G6PD Screening test, is a blood test that helps in identifying presence or absence of G6PD enzyme in the blood.
Why is it Done?

This is a specialized blood test performed for screening G6PD deficiency. This test can tell whether a person is G6PD deficient or no.

This test is done for

  • Children experiencing persistent jaundice as a new born
  • Patients who have developed hemolytic anemia at any age
  • Screening patients suffering from malaria, before receiving drugs like primaquine that can cause red blood cell damage in a G6PD deficient person.
When should it be performed?

This test is performed when a patient has

  • Symptoms of hemolytic anemia
    • Enlargement of spleen
    • Jaundice (yellow discoloration of skin, eyes & mouth)
    • Pale skin
    • Fever
    • Weakness
    • Dizziness
    • Confusion
    • Red or brown urine
    • Rapid heart rate
    • Shortness of breath
  • Persistent jaundice (especially in new born), which is unexplained
  • Diagnosed to have malaria and before starting preventive primaquine therapy
How is it done
A blood sample will be collected from a vein in your arm. No special preparations like fasting required.
Results

The test report is normal, if the result is negative. It means

  • No deficiency of G6PD enzyme
  • Cause of anemia is different than G6PD deficiency
  • In patients with malaria, primaquine can be safelygiven

The test report is abnormal, if the result is positive. It means

  • Patient is G6PD deficient
  • Cause of hemolytic anemia is G6PD deficiency
  • Primaquine and similar drugs which provoke red blood cell breakdown, should be avoided
Other Tests
  • CBC and Reticulocyte count
    • It is a routine blood test carried out to evaluate hemoglobin and red blood cell (RBC) levels of blood
    • Low hemoglobin and RBC along with high reticulocyte count suggest hemolytic anemia
  • Live function test (LFT)
    • It is a routine blood test carried out to check functioning of liver
    • Increased levels of bilirubin indicate hemolytic anemia
  • Peripheral Blood Smear
    • It is a routine blood test in which a drop of blood is spread over a glass slide and studied under microscope
    • Presence of Heinz bodies suggest G6PD deficiency
  • Urine for Hemosiderin
    • It is a specialized urine test that evaluates presence or absence of hemosiderin chemical in urine
    • Presence of hemosiderin indicate severe intravascular red blood cell breakdown
  • LDH (Lactate Dehydrogenase) level
    • It is a routine blood test that evaluates blood LDH levels
    • Increased levels of LDH along with increased bilirubin suggest hemolysis
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