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FIBRINOGEN

About the test
What is this test done for?
The test is used to evaluate fibrinogen levels, a protein produced by the liver, which is essential for blood clotting.
Why is it Done?
During an injury when bleeding occurs, the body starts forming blood clots, and fibrin threads are formed in the course, which stabilizes and adheres to the injury site till it has completely healed. This test is done as a part of investigations to evaluate the level and function of fibrinogen. It helps to evaluate the risk of developing a cardiovascular disease.
When should it be performed?

The test should be performed in the following conditions:

  • When a person has thrombosis
  • When a person gets a prolonged or unexplained bleeding
  • When a person has had abnormal results for prothombin time or partial prothrombin time
  • When person has acquired coagulation factor dysfunction.
  • When a person wants to get evaluated for the risk of developing cardiovascular disease.
How is it done
A blood sample will be collected from a vein in your arm. No fasting is required for this test.
Results
  • Normal values are between 200-400 mg/dL.
  • If the levels are chronically below 200 mg/dL it is called as afibrinogenemia or hypofibrinogenemia, which can be caused by conditions like end-stage liver diseases or in severe malnutrition.
  • Acutely low levels are seen in conditions like disseminated intravascular coagulation (DIC) or may also occur following rapid, large-volume blood transfusions.
  • If the levels are high, it could be possibly because of acute infections, cancer, cardiovascular diseases, stroke or trauma, pregnancy, or smoking.
Other Tests
A fibrinogen antigen test along with the fibrinogen test would help to give the final assessment. In cases of liver disorders, a liver function test is also ordered. In suspicion of cardiovascular diseases, ECG is performed and compared.
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